哈萨克斯坦共和国新城疫灭活单价疫苗的安全性和免疫原性效果。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI:10.1007/s10517-025-06408-9

N Zh Akmyrzayev, N N Assanzhanova, Zh K Kydyrbayev, Sh Zh Ryskeldinova, A T Zhunushov, Ye M Kozhamkulov, A M Mailybayeva, A M Sagymbayeva, Ye T Myrzakhmetov

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引用次数: 0

摘要

我们研制的新城疫病毒灭活疫苗在鸡感染高毒力Alatau-98株后进行了有效性研究。以Montanide ISA 70vg佐剂制备了稳定的水-油乳剂形式的疫苗。在给药后7、14、21和28天检测疫苗的免疫原性。有效性取决于疫苗制剂预防疾病的能力和感染高毒力Alatau-98菌株后的死亡率。我们研制的灭活疫苗在保护鸟类免受新城疫方面显示出良好的效果，可以显著改善家禽疫病控制。

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Safety and Immunogenic Efficacy of Inactivated Monovalent Vaccines against Newcastle Disease in the Republic of Kazakhstan.

The effectiveness of the inactivated vaccines developed by us against the Newcastle disease virus was studied in chickens after infection with a highly virulent Alatau-98 strain. The vaccines in the form of a stable water-oil emulsion were prepared using Montanide ISA 70 VG adjuvant. The immunogenicity of the vaccines was checked 7, 14, 21, and 28 days after administration. The effectiveness was determined by the ability of the vaccine preparations to protect against the disease and by mortality after infection with a highly virulent Alatau-98 strain. Inactivated vaccines developed by us have shown promising results in protecting birds from Newcastle disease and can significantly improve disease control in domestic poultry.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.