Experimental Model of Partially Recovered Blood Loss in Awake Rats.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI:10.1007/s10517-025-06416-9

A M Ismailova, M S Severyukhina, V A Palikov, N A Borozdina, S G Semushina, A V Cholina, O N Khokhlova, D I Rzhevsky, G A Slascheva, I A Dyachenko, A N Murashev

引用次数: 0

Abstract

We propose a new model of blood loss in awake rats with volume loss up to 40% of total blood volume in the phase of hemorrhagic shock and partial blood replacement up to final blood loss up to 30% of total blood volume. During blood withdrawal, the rats showed manifestation of baroreflex, increased blood levels of glucose and lactate, and decreased concentration of oxyhemoglobin. Partial blood volume compensation was followed by recovery of hemodynamics the levels of glucose and oxyhemoglobin. Thus, taking into account the awake status of rats and compensatory mechanisms, our model of blood loss with a fixed volume of blood drawing and its partial compensation is a relevant model for studying the efficacy of blood substitutes.

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清醒大鼠部分恢复失血的实验模型。

我们提出了一种新的清醒大鼠失血量模型，在失血性休克和部分补血阶段，失血量高达总血容量的40%，最终失血量高达总血容量的30%。在停血过程中，大鼠表现出压力反射，血糖、乳酸水平升高，血氧血红蛋白浓度降低。部分血容量补偿后血液动力学恢复，血糖和血红蛋白水平恢复。因此，考虑到大鼠的清醒状态和代偿机制，我们的固定采血量失血量及其部分代偿模型是研究血液代用品功效的相关模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.