精氨酸和β-氨基异丁酸对大鼠主动脉平滑肌细胞迁移和增殖的影响。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI:10.1007/s10517-025-06401-2

D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev

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引用次数: 0

摘要

非蛋白氨基酸同精氨酸（hArg）和β-氨基异丁酸（BAIBA）通过削弱血管壁炎症反应抑制动脉粥样硬化。在体外研究了这些氨基酸对生长因子诱导的大鼠主动脉平滑肌细胞迁移和增殖的影响。发现hArg和BAIBA对这些过程没有影响，而后者受到NO的抑制。因此，hArg和BAIBA不直接影响主动脉SMC的迁移和增殖，但可以通过hArg调节内皮细胞NO的产生间接影响这些过程，并且可能是由于这些氨基酸的抗炎特性。

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The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta.

Non-protein amino acids homoarginine (hArg) and β-aminoisobutyric acid (BAIBA) inhibit atherogenesis by weakening the inflammatory response in the vascular wall. The influence of these amino acids on growth factor-induced migration and proliferation of smooth muscle cells (SMC) of rat aorta was studied in vitro. It was found that hArg and BAIBA did not affect these processes, though the latter were suppressed by NO. Thus, hArg and BAIBA do not directly affect the migration and proliferation of aortic SMC, but can affect these processes indirectly through hArg modulation of NO production by endothelial cells, and, probably, due to the anti-inflammatory properties of these amino acids.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.