Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI:10.1007/s10517-025-06405-y

A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova

引用次数: 0

Abstract

We studied the reparative and antioxidant effects of thymogen (10 and 100 μg/kg) and its modifications in equimolar doses (12 and 120 μg/kg) obtained by attaching the amino acid D-alanine (D-Ala) to the N- or C-terminus of the peptide molecule. A single intraperitoneal injection of hydrazine hydrochloride caused a decrease in catalase activity and an increase in molondialdehyde (MDA) concentration. Administration of peptides in lower doses inhibited LPO and stimulated reparative regeneration of hepatocytes. Thymogen analogue with D-Ala at the C-terminus was most effective. Increasing the doses of thymogen (100 μg/kg) and its analogues (120 μg/kg) did not lead to further increase in their hepatoprotective activity.

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胸腺原类似物对联氨性肝病大鼠的保肝作用。

我们研究了胸腺原（10和100 μg/kg）的修复和抗氧化作用，以及通过将氨基酸d -丙氨酸（D-Ala）连接到肽分子的N端或c端而获得的等摩尔剂量（12和120 μg/kg）的修饰。单次腹腔注射盐酸肼引起过氧化氢酶活性降低和丙二醛（MDA）浓度升高。低剂量多肽抑制LPO并刺激肝细胞修复再生。在c端具有D-Ala的胸腺原类似物是最有效的。增加胸腺原（100 μg/kg）及其类似物（120 μg/kg）的剂量并没有导致它们的肝保护活性进一步增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.