Bulletin of Experimental Biology and Medicine最新文献_第2页

Dechorionation at an Early Stage of Embryogenesis Modifies the Behavior and Biogenic Amines in the Brain of Adult Zebrafish (Danio rerio). 胚胎发生早期脱毛改变成年斑马鱼大脑中的行为和生物胺。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-25 DOI: 10.1007/s10517-026-06661-6

V S Evsyukova, I E Sorokin, P A Kulikov, A V Kulikov

{"title":"Dechorionation at an Early Stage of Embryogenesis Modifies the Behavior and Biogenic Amines in the Brain of Adult Zebrafish (Danio rerio).","authors":"V S Evsyukova, I E Sorokin, P A Kulikov, A V Kulikov","doi":"10.1007/s10517-026-06661-6","DOIUrl":"https://doi.org/10.1007/s10517-026-06661-6","url":null,"abstract":"The removal of the cuticular membrane (chorion) in developing Danio rerio embryos was used as a model of mild and long-acting influences to study their consequences for adult D. rerio. We studied the effect of dechorionation 12 h after fertilization on survival, body weight, sex ratio, behavior in the home tank and in the novel tank test, the level of serotonin (5-HT), dopamine (DA), norepinephrine (NE), and their metabolites 5-hydroxyindoleacetic (5-HIAA) and 3,4-dihydroxyphenylalanine acetic (DOPAC) acids in the brain of 6-month-old fish. Dechorionation did not affect survival, body weight, sex ratio, and locomotor activity of adult fish. At the same time, it significantly affected vertical activity of adult fish: the time spent in the upper third of the tank increased in a familiar environment (in a school and in a home tank), but decreased under stressful conditions (novel tank test). Dechorionation did not affect the levels of DA, DOPAC, 5-HT, 5-HIAA, the DOPAC/DA ratio and 5-HIAA/5-HT, but significantly decreased the level of NE in the brain of adult fish. Thus, we have demonstrated the critical role of the chorion for tuning of the brain NE system and the formation of defensive behavior in adult D. rerio: dechorionation causes long-term changes in the brain NE system and in the defensive behavior in the novel tank test in adult fish.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression in Mature Male Rhesus Macaques (Macaca mulatta): Direct and Delayed Consequences of Deprivation. 成年雄性恒河猴的抑郁：剥夺的直接和延迟后果。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-25 DOI: 10.1007/s10517-026-06660-7

N V Meishvili, V G Chalyan, A E Anikaeva

引用次数: 0

Differentiation of Late Latent Syphilis and False-Positive Serological Reactions: A Combination of ELISA and Discriminant Analysis. 晚潜伏梅毒与假阳性血清学反应的鉴别：ELISA与判别分析相结合。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-25 DOI: 10.1007/s10517-026-06659-0

N V Arbuzova, M V Shpilevaya, G L Katunin, O E Kuznetsov, N Yu Nosov, A A Kubanov

引用次数: 0

Reproductive Toxicity of Wildfire Smoke. 野火烟雾的生殖毒性。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-25 DOI: 10.1007/s10517-026-06658-1

L M Sosedova, V A Vokina, A A Pankova, V S Rukavishnikov

引用次数: 0

Human Multipotent Mesenchymal Stromal Cells Exhibit Resistance to Long-Term Simulated Microgravity. 人类多能间充质间质细胞表现出对长期模拟微重力的抵抗。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06666-1

E A Tyrina, I V Andrianova, E R Andreeva, Yu A Romanov, L B Buravkova

引用次数: 0

Variability of the Immunosuppressive Properties of Glioma Cell Lines. 胶质瘤细胞系免疫抑制特性的变异性。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06665-2

I V Kholodenko, R Yu Saryglar, A Y Lupatov, K V Kovalskaya, O A Bystrykh, A V Kuprin, K N Yarygin

{"title":"Variability of the Immunosuppressive Properties of Glioma Cell Lines.","authors":"I V Kholodenko, R Yu Saryglar, A Y Lupatov, K V Kovalskaya, O A Bystrykh, A V Kuprin, K N Yarygin","doi":"10.1007/s10517-026-06665-2","DOIUrl":"https://doi.org/10.1007/s10517-026-06665-2","url":null,"abstract":"Immunotherapeutic methods, such as the use of checkpoint inhibitors, CAR T cells, dendritic cell vaccines, etc., offer promising approach to the treatment of glioblastomas. Dendritic cell (DC)-based vaccines used in glioma therapy have been well studied and are effective in some cases. However, the use of DC vaccines for the treatment of patients with gliomas, though shows promising results, is still limited by the suboptimal choice of tumor antigen and the method of its loading, as well as the immunosuppressive nature of the tumor cell microenvironment. In this work, we showed that glioma cell lines express a broad spectrum of immune checkpoints, suppress the maturation of allogeneic DCs during direct co-culturing, and do not stimulate the proliferation of allogeneic lymphocytes. Lymphocytes primed with dendritic cells loaded with the corresponding tumor lysates effectively lysed only two of three glioma cell lines, T98G and U373 MG, whereas 1321N1 cells completely suppressed the cytotoxic activity of lymphocytes primed by co-culturing with DCs loaded with the lysate of these cells. Thus, the efficacy of DC vaccines may be related to the individual characteristics of glioma cells.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral and Neurochemical Effects of Chronic Predatory Stress in Danio rerio Fish. 慢性掠食性应激对达尼奥鱼行为和神经化学的影响。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06649-2

O B Tseilikman, I A Buksha, I A Lipatov, A E Epitashvili, A K Shonina, M V Shamshurin, E R Tepikina, M S Zhukov, V A Shatilov, V E Tseilikman, M A Grabchuk, A R Mustafaeva

引用次数: 0

Biomolecular Changes in the Myocardium of Female and Male BALB/c Mice with Autoimmune Myocarditis. 自身免疫性心肌炎雌雄BALB/c小鼠心肌的生物分子变化

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06664-3

E A Melnikova, A V Sentyabreva, I S Tsvetkov, A M Kosyreva

{"title":"Biomolecular Changes in the Myocardium of Female and Male BALB/c Mice with Autoimmune Myocarditis.","authors":"E A Melnikova, A V Sentyabreva, I S Tsvetkov, A M Kosyreva","doi":"10.1007/s10517-026-06664-3","DOIUrl":"https://doi.org/10.1007/s10517-026-06664-3","url":null,"abstract":"Autoimmune myocarditis is a disease with pronounced sex-related differences. It is known that the incidence of myocarditis is higher in men; however, other autoimmune diseases are more commonly observed in women. The aim of this study was to assess molecular and biological changes in the myocardium of male and female BALB/c mice on days 14 and 60 of experimental autoimmune myocarditis. We examined the morphological properties of the myocardium, the expression of pro- and anti-inflammatory markers in the myocardium, and the concentrations of IL-1β and IL-10 in blood serum. Sex-specific differences in the molecular and biological changes in the myocardium were identified at both time points of autoimmune myocarditis. In males, a pronounced lymphoid-histiocytic infiltration was observed, along with alterations in the balance of pro- and anti-inflammatory cytokines. Males showed increased expression of Il1b, Il6, Hif1a, and Tgfb mRNA on day 14 and Il1b, Nfkb, Il10, and Tgfb mRNA on day 60. In females, changes were less pronounced: the expression of Il1b mRNA was elevated on day 14, but no significant changes were observed on day 60. The serum levels of IL-10 and IL-1β in males increased on days 14 and 60, respectively. These findings may explain the sex-specific differences in the course of autoimmune myocarditis.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CK19 and PDX1 as Markers of Differentiation and Maturation of Pancreatic Islet Endocrine Cells. CK19和PDX1作为胰岛内分泌细胞分化和成熟的标志物。

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06663-4

A E Proshchina, Yu S Krivova, A S Kharlamova, G A Sonin, S V Saveliev

引用次数: 0

Possible Ways of Reducing Adverse Events Associated with mRNA Vaccines Encapsulated in Lipid Nanoparticles. 减少脂质纳米颗粒包裹mRNA疫苗相关不良事件的可能方法

IF 0.6 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-24 DOI: 10.1007/s10517-026-06645-6

L A Kisakova, S A Ilyicheva, A P Rudometov

引用次数: 0