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Bulletin of Experimental Biology and Medicine最新文献

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The Effects of 3-Methylphenanthrene on Ion Currents Mediated by KV11.1 and NaV1.5 Channels in the Heterologous Expression System CHO-K1. 3-甲基菲对异源表达系统CHO-K1中KV11.1和NaV1.5通道离子电流的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-30 DOI: 10.1007/s10517-025-06418-7
I Dzhumaniiazova, O B Pustovit, D V Abramochkin
{"title":"The Effects of 3-Methylphenanthrene on Ion Currents Mediated by K<sub>V</sub>11.1 and Na<sub>V</sub>1.5 Channels in the Heterologous Expression System CHO-K1.","authors":"I Dzhumaniiazova, O B Pustovit, D V Abramochkin","doi":"10.1007/s10517-025-06418-7","DOIUrl":"https://doi.org/10.1007/s10517-025-06418-7","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbons are widespread environmental pollutants that can accumulate in tissues and affect numerous physiological functions. Using the patch-clamp technique, we characterized the effects of an aromatic hydrocarbon 3-methylphenanthrene (3-MP) on currents mediated by the α-subunits of Na<sub>V</sub>1.5 (I<sub>hSCN5A</sub>) and K<sub>V</sub>11.1 (I<sub>hERG</sub>) channels in the CHO-K1 heterologous expression system. 3-MP caused a dose-dependent blockade of I<sub>hERG</sub> tail current (IC<sub>50</sub> = 38.2 μM). At a concentration of 10 μM, 3-MP induced a shift in the half-activation potential (V<sub>0.5</sub>) from -46.5 to -51.3 mV and reduced the time required for 50% of channels to become available from 120.9 to 99.6 msec. Significant changes were observed in inactivation parameters (V<sub>0.5</sub> increased from -79.9 to -73.4 mV) and deactivation kinetics (time constant decreased from 63.5 to 46.3 msec). In contrast, I<sub>hSCN5A</sub> remained tolerant to the effects of 3-MP. Therefore, it can be assumed that 3-MP can lead to lengthening of the action potential in human working cardiomyocytes, without significantly altering its amplitude or the rate of its propagation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the Protective Effect of Combined Use of Some Substances in Acute Exposure to Ionizing Radiation in Mice by the Survival Criterion. 用生存标准评价急性电离辐射照射小鼠几种物质联合使用的保护作用。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-30 DOI: 10.1007/s10517-025-06403-0
L A Romodin, O V Nikitenko, T M Bychkova, E D Rodionova
{"title":"Assessment of the Protective Effect of Combined Use of Some Substances in Acute Exposure to Ionizing Radiation in Mice by the Survival Criterion.","authors":"L A Romodin, O V Nikitenko, T M Bychkova, E D Rodionova","doi":"10.1007/s10517-025-06403-0","DOIUrl":"https://doi.org/10.1007/s10517-025-06403-0","url":null,"abstract":"<p><p>The radioprotective effect of the combined use of radioprotective drugs was studied in a 30-day survival test on male ICR(CD-1) mice exposed to X-ray radiation at a dose of 6.5 Gy. A combination of phenylephrine prior to irradiation, glutathione immediately after irradiation, tocopherol on the next day, and granulocyte CSF for 2 weeks after irradiation ensured complete survival of the irradiated mice. Combined use of chlorophyllin and trolox ensured survival of a half of the irradiated mice. Other schemes were little effective. In some cases, the combined use of certain substances aggravated the condition of irradiated mice. Addition of riboxin to the combination of chlorophyllin and trolox increased mouse mortality compared to the irradiated control group. Copper chlorophyllin and granulocyte CSF were found to be incompatible.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Efficiency of an Artificial Intelligence-Based Technology in Dental Radiography. 基于人工智能的牙科x线摄影诊断效率研究。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-30 DOI: 10.1007/s10517-025-06420-z
A A Obrubov, E A Solovykh, A G Nadtochiy
{"title":"Diagnostic Efficiency of an Artificial Intelligence-Based Technology in Dental Radiography.","authors":"A A Obrubov, E A Solovykh, A G Nadtochiy","doi":"10.1007/s10517-025-06420-z","DOIUrl":"https://doi.org/10.1007/s10517-025-06420-z","url":null,"abstract":"<p><p>We present results of the development of Dentomo artificial intelligence model based on two neural networks. The model includes a database and a knowledge base harmonized with SNOMED CT that allows processing and interpreting the results of cone beam computed tomography (CBCT) scans of the dental system, in particular, identifying and classifying teeth, identifying CT signs of pathology and previous treatments. Based on these data, artificial intelligence can draw conclusions and generate medical reports, systematize the data, and learn from the results. The diagnostic effectiveness of Dentomo was evaluated. The first results of the study have demonstrated that the model based on neural networks and artificial intelligence is a valuable tool for analyzing CBCT scans in clinical practice and optimizing the dentist workflow.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of If Current Blockade on Contractility of the Isolated Rat Heart after Acute Myocardial Infarction. 电流阻断对急性心肌梗死后离体大鼠心脏收缩力的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-30 DOI: 10.1007/s10517-025-06402-1
A M Kuptsova, A L Zefirov, N I Ziyatdinova, L T Mosolov, T L Zefirov
{"title":"Effect of If Current Blockade on Contractility of the Isolated Rat Heart after Acute Myocardial Infarction.","authors":"A M Kuptsova, A L Zefirov, N I Ziyatdinova, L T Mosolov, T L Zefirov","doi":"10.1007/s10517-025-06402-1","DOIUrl":"https://doi.org/10.1007/s10517-025-06402-1","url":null,"abstract":"<p><p>The blockade of hyperpolarization-activated currents (I<sub>f</sub>) (10<sup>-9</sup> and 10<sup>-5</sup> M) had a multidirectional effect on the left ventricular developed pressure and the maximum contraction rate of the isolated heart in healthy, sham-operated rats, and rats with experimental acute myocardial infarction (AMI). The duration of isolated heart contraction in the presence of the I<sub>f</sub> blocker at both concentrations decreased in the group of healthy animals and did not change in sham-operated rats and rats with AMI. I<sub>f</sub> blockade increased the duration of isolated heart relaxation in all groups. The duration of the contraction cycle under conditions of I<sub>f</sub> blockade (10<sup>-9</sup> M) increased in sham-operated rats and rats with AMI and decreased in healthy rats. The maximum concentration of the blocker increased the duration of contraction cycle in all experimental groups.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proportion of Immunoregulatory Cells in Inflammatory Infiltrate in Rheumatoid Arthritis Model and Its Correction by Antisense Oligonucleotides. 类风湿关节炎模型炎症浸润免疫调节细胞比例及其反义寡核苷酸校正。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-30 DOI: 10.1007/s10517-025-06407-w
T P Makalish, N N Pilyavskiy, I O Golovkin, G V Maslova
{"title":"Proportion of Immunoregulatory Cells in Inflammatory Infiltrate in Rheumatoid Arthritis Model and Its Correction by Antisense Oligonucleotides.","authors":"T P Makalish, N N Pilyavskiy, I O Golovkin, G V Maslova","doi":"10.1007/s10517-025-06407-w","DOIUrl":"https://doi.org/10.1007/s10517-025-06407-w","url":null,"abstract":"<p><p>Autoimmune inflammation in rheumatoid arthritis is caused by various immunocompetent cells secreting a wide range of cytokines. Macrophages, CD4<sup>+</sup>, and CD8<sup>+</sup> T cells are the most active in this process. We propose using antisense oligonucleotides (ASO) that block the synthesis of TNFα and IL-6. In the adjuvant-induced arthritis model, changes in the number of CD4<sup>+</sup>, CD8<sup>+</sup>, and CD68<sup>+</sup> cells in the inflammatory infiltrate after correction with ASO were assessed. The number of immunopositive inflammatory infiltrate cells in the area of bone damage was counted. CD8<sup>+</sup> cells turned out to be the most numerous. Blockade of IL-6 led to a statistically significant decrease in the number of CD4<sup>+</sup> cells. The use of ASO reduced the number of macrophages. The combination of ASO against IL-6 and TNFα administered by electrophoresis most effective.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats. 胸腺原类似物对联氨性肝病大鼠的保肝作用。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06405-y
A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova
{"title":"Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.","authors":"A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova","doi":"10.1007/s10517-025-06405-y","DOIUrl":"https://doi.org/10.1007/s10517-025-06405-y","url":null,"abstract":"<p><p>We studied the reparative and antioxidant effects of thymogen (10 and 100 μg/kg) and its modifications in equimolar doses (12 and 120 μg/kg) obtained by attaching the amino acid D-alanine (D-Ala) to the N- or C-terminus of the peptide molecule. A single intraperitoneal injection of hydrazine hydrochloride caused a decrease in catalase activity and an increase in molondialdehyde (MDA) concentration. Administration of peptides in lower doses inhibited LPO and stimulated reparative regeneration of hepatocytes. Thymogen analogue with D-Ala at the C-terminus was most effective. Increasing the doses of thymogen (100 μg/kg) and its analogues (120 μg/kg) did not lead to further increase in their hepatoprotective activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control. 用于反兴奋剂控制的钴和氙制剂摄入后表达的特异性microrna分析。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06406-x
P V Postnikov, I V Pronina, D S Polyansky, Yu A Efimova, Z G Ordzhonikidze, V A Badtieva, D B Nikityuk
{"title":"Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control.","authors":"P V Postnikov, I V Pronina, D S Polyansky, Yu A Efimova, Z G Ordzhonikidze, V A Badtieva, D B Nikityuk","doi":"10.1007/s10517-025-06406-x","DOIUrl":"https://doi.org/10.1007/s10517-025-06406-x","url":null,"abstract":"<p><p>Xenon and cobalt are representatives of hypoxia-inducible factor (HIF) activators stimulating erythropoiesis and are prohibited by the World Anti-Doping Agency (WADA). The expression profiles of 84 microRNAs circulating in blood plasma and involved in the regulation of the HIF-1α transcription factor and its downstream signaling pathways were analyzed in volunteers before and after intake of cobalt (II) and xenon preparations using quantitative real-time PCR and certified miRCURY LNA miRNA Focus Panel (Qiagen) for analysis of microRNA expression profiles. Intake of cobalt aspartate increased the expression of hsa-miR-15b-5p, while inhalation of the Xe/O<sub>2</sub> mixture significantly increased the plasma levels of hsa-miR-378a-3p and hsa-miR-491-5p. Thus, we for the first time revealed differential expression of microRNAs circulating in plasma in response to various HIF activators. Potential microRNA markers for identification of cobalt and xenon abuse for anti-doping control are proposed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells. x射线能量对人间充质干细胞γ - h2ax和53BP1病灶定量产量的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06404-z
M A Ignatov, A K Chigasova, A A Osipov, Yu A Fedotov, N Yu Vorobyeva, A N Osipov
{"title":"Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells.","authors":"M A Ignatov, A K Chigasova, A A Osipov, Yu A Fedotov, N Yu Vorobyeva, A N Osipov","doi":"10.1007/s10517-025-06404-z","DOIUrl":"https://doi.org/10.1007/s10517-025-06404-z","url":null,"abstract":"<p><p>We compared the influence of X-rays generated at the peak anode voltages of 50, 100, and 200 kVp on the quantitative yield of foci (localized dynamic microclusters) of proteins involved in repair critical radiation-induced DNA damage, double-strand breaks (γH2AX and 53BP1), in cultured human mesenchymal stem stromal cells. Calculations of the relative biological effectiveness (RBE) based on the experimentally obtained dose curves of changes in the number of γH2AX and 53BP1 foci indicate that relative to the standard 200 kVp X-ray radiation taken as 1, the RBE of 100 kVp radiation is ~1.15, and that of 50 kVp is ~1.50. The obtained results indicate the necessity for thorough fundamental studies for evaluation of the real RBE of low-energy X-rays with subsequent correction of the weighting factor values.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metagenomic Analysis of Caseum of Tuberculosis Foci. 结核疫源地病例的宏基因组分析。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.1007/s10517-025-06384-0
E A Orlova, V V Sinkov, O B Ogarkov, A E Suzdalnitsky, I G Kondratov, S N Zhdanova, L V Rychkova, L I Kolesnikova
{"title":"Metagenomic Analysis of Caseum of Tuberculosis Foci.","authors":"E A Orlova, V V Sinkov, O B Ogarkov, A E Suzdalnitsky, I G Kondratov, S N Zhdanova, L V Rychkova, L I Kolesnikova","doi":"10.1007/s10517-025-06384-0","DOIUrl":"https://doi.org/10.1007/s10517-025-06384-0","url":null,"abstract":"<p><p>The microbiota of the deep lung regions significantly differs from that of the upper respiratory tract by much lower biomass and dynamic diversity. In our previous studies we found that the biodiversity of the satellite microbiota of tuberculosis foci is sharply reduced in comparison with intact lung tissues. These findings allowed us to classify microbial communities in the caseous necrosis of tuberculomas into two types: (i) mycobacterial caseoma (tuberculoma), where 70% or more of the genomes correspond to Mycobacterium tuberculosis, and (ii) a polymicrobial community, where the concentration of M. tuberculosis varies from 0 to 10%. Using shotgun metagenomic sequencing, 14 tuberculomas from 13 patients were analyzed on a NextSeq 550 platform (Illumina). Taxonomic classification of short reads was performed using Kraken 2. The results show that, on average, 99.95% of the short reads belonged to human DNA or were unclassified. However, the classified reads related to bacterial genomes confirmed the concept that in many cases, tuberculomas contained polymicrobial communities that either replaced or supplemented the original mycobacterial microbiota of the caseous material.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"610-614"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Markers of Abnormal Placental Attachment in Pregnant Women. 孕妇胎盘附着异常的血清标志物。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.1007/s10517-025-06397-9
K A Artemyeva, I A Kulikov, N V Nizyaeva, I I Stepanova, N B Tikhonova, L M Mikhaleva
{"title":"Serum Markers of Abnormal Placental Attachment in Pregnant Women.","authors":"K A Artemyeva, I A Kulikov, N V Nizyaeva, I I Stepanova, N B Tikhonova, L M Mikhaleva","doi":"10.1007/s10517-025-06397-9","DOIUrl":"https://doi.org/10.1007/s10517-025-06397-9","url":null,"abstract":"<p><p>The changes in serum concentrations of glycodelin A, placental α1-microglobulin, and adiponectin in pregnant women were studied and the possibility of using them for predicting placenta accreta spectrum (PAS) was evaluated. Significantly reduced serum levels of all studied proteins and higher number cases of cesarean sections were found in women with PAS. A formula for predicting PAS was developed. It was found that patient's score ⩾ 8 indicates the presence of PAS with high sensitivity and specificity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"681-684"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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