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Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications. 有术后并发症风险的心脏病患者血液中HIF-1α和VNN1水平及白细胞中HIF1A和NFKB1表达的差异
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06399-7
M V Silina, D Sh Dzhalilova, M A Diatroptova, O O Grin, M A Babaev, O V Makarova
{"title":"Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications.","authors":"M V Silina, D Sh Dzhalilova, M A Diatroptova, O O Grin, M A Babaev, O V Makarova","doi":"10.1007/s10517-025-06399-7","DOIUrl":"10.1007/s10517-025-06399-7","url":null,"abstract":"<p><p>The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of HIF1A expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"691-696"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Metabolites of Vaginal Lactobacilli on Neutrophils Function. 阴道乳酸杆菌代谢物对中性粒细胞功能的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI: 10.1007/s10517-025-06410-1
Yu L Myachina, A V Sgibnev, Yu I Cherkasova
{"title":"Effect of Metabolites of Vaginal Lactobacilli on Neutrophils Function.","authors":"Yu L Myachina, A V Sgibnev, Yu I Cherkasova","doi":"10.1007/s10517-025-06410-1","DOIUrl":"10.1007/s10517-025-06410-1","url":null,"abstract":"<p><p>We studied the effect of metabolites produced by lactobacilli on the metabolic and killing activities of neutrophil. Treatment with lactic acid at a concentration of 5.6 mM increased dehydrogenase activity and killing activity of neutrophils and slightly decreased the mitochondrial potential in cells; at concentrations of 11.1 and 22.2 mM, lactate decreased dehydrogenase activity, which was accompanied by a decrease in the mitochondrial potential in cells; at a concentration of 11.1 mM, lactate decreased killing activity of neutrophils. Hydrogen peroxide increased the dehydrogenase and killing activities at concentrations of 0.59 and 2.36 mM and decreased these parameters at a concentration of 1.18 mM; these changes were accompanied by a decrease in the number of cells with high mitochondrial potential. It is assumed that the ability of vaginal lactobacilli to modulate neutrophil activity has important evolutionary significance and allows regulating the number of opportunistic microorganisms.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"750-754"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta. 精氨酸和β-氨基异丁酸对大鼠主动脉平滑肌细胞迁移和增殖的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06401-2
D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev
{"title":"The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta.","authors":"D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev","doi":"10.1007/s10517-025-06401-2","DOIUrl":"10.1007/s10517-025-06401-2","url":null,"abstract":"<p><p>Non-protein amino acids homoarginine (hArg) and β-aminoisobutyric acid (BAIBA) inhibit atherogenesis by weakening the inflammatory response in the vascular wall. The influence of these amino acids on growth factor-induced migration and proliferation of smooth muscle cells (SMC) of rat aorta was studied in vitro. It was found that hArg and BAIBA did not affect these processes, though the latter were suppressed by NO. Thus, hArg and BAIBA do not directly affect the migration and proliferation of aortic SMC, but can affect these processes indirectly through hArg modulation of NO production by endothelial cells, and, probably, due to the anti-inflammatory properties of these amino acids.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"702-706"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors. 在年轻献血者卵泡液细胞外泡的影响下，高龄产妇积云细胞基因转录的变化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI: 10.1007/s10517-025-06417-8
B V Zingerenko, O V Burmenskaya, A P Sysoeva, J A Shevtsova, D N Silachev, N P Makarova, E A Kalinina
{"title":"Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors.","authors":"B V Zingerenko, O V Burmenskaya, A P Sysoeva, J A Shevtsova, D N Silachev, N P Makarova, E A Kalinina","doi":"10.1007/s10517-025-06417-8","DOIUrl":"10.1007/s10517-025-06417-8","url":null,"abstract":"<p><p>An attempt was made to rejuvenate cumulus cells (CCs) of women of advanced maternal age (AMA) using extracellular vesicles (EV) isolated from the follicular fluid (FF) of young donors. FF samples were taken from healthy women aged 23-26 during the ART program. CCs from patients of advanced maternal age (36-47 years) were co-cultured with EV of young donors. The target genes were selected based on their functions in CC and early embryogenesis (PFKP, EREG, UBE2T, HAS2, VCAN, CYP19A, GREM1, STS, BAX, PTGS2, BCL2, SPSB2, AREG, CCNB1, EGFR). Comparative analysis of all women without stratification by the type of final follicle maturation drug (hCG or gonadotropin-releasing hormone agonist, GnRHa) revealed no statistically significant difference in the expression of the selected genes. In the group treated with GnRHa, a statistically significant increase in the expression of HAS2 (by 1.8 times, p = 0.04), GREM1 (by 1.4 times, p = 0.08), and BAX (by 1.4 times, p = 0.04) in CCs was observed after their co-culturing with FF EVs from young donors. The findings suggest the potential for the \"rejuvenation\" of CC in women of advanced maternal age when aGnRH is used in combination with FF EVs from young women, because the expression of apoptosis genes decreases and the expression cell proliferation gene increases during co-culturing of CC with FF EVs.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"782-787"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control. 用于反兴奋剂控制的钴和氙制剂摄入后表达的特异性microrna分析。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI: 10.1007/s10517-025-06406-x
P V Postnikov, I V Pronina, D S Polyansky, Yu A Efimova, Z G Ordzhonikidze, V A Badtieva, D B Nikityuk
{"title":"Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control.","authors":"P V Postnikov, I V Pronina, D S Polyansky, Yu A Efimova, Z G Ordzhonikidze, V A Badtieva, D B Nikityuk","doi":"10.1007/s10517-025-06406-x","DOIUrl":"10.1007/s10517-025-06406-x","url":null,"abstract":"<p><p>Xenon and cobalt are representatives of hypoxia-inducible factor (HIF) activators stimulating erythropoiesis and are prohibited by the World Anti-Doping Agency (WADA). The expression profiles of 84 microRNAs circulating in blood plasma and involved in the regulation of the HIF-1α transcription factor and its downstream signaling pathways were analyzed in volunteers before and after intake of cobalt (II) and xenon preparations using quantitative real-time PCR and certified miRCURY LNA miRNA Focus Panel (Qiagen) for analysis of microRNA expression profiles. Intake of cobalt aspartate increased the expression of hsa-miR-15b-5p, while inhalation of the Xe/O<sub>2</sub> mixture significantly increased the plasma levels of hsa-miR-378a-3p and hsa-miR-491-5p. Thus, we for the first time revealed differential expression of microRNAs circulating in plasma in response to various HIF activators. Potential microRNA markers for identification of cobalt and xenon abuse for anti-doping control are proposed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"726-732"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of 3-Methylphenanthrene on Ion Currents Mediated by KV11.1 and NaV1.5 Channels in the Heterologous Expression System CHO-K1. 3-甲基菲对异源表达系统CHO-K1中KV11.1和NaV1.5通道离子电流的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06418-7
I Dzhumaniiazova, O B Pustovit, D V Abramochkin
{"title":"The Effects of 3-Methylphenanthrene on Ion Currents Mediated by K<sub>V</sub>11.1 and Na<sub>V</sub>1.5 Channels in the Heterologous Expression System CHO-K1.","authors":"I Dzhumaniiazova, O B Pustovit, D V Abramochkin","doi":"10.1007/s10517-025-06418-7","DOIUrl":"10.1007/s10517-025-06418-7","url":null,"abstract":"<p><p>Polycyclic aromatic hydrocarbons are widespread environmental pollutants that can accumulate in tissues and affect numerous physiological functions. Using the patch-clamp technique, we characterized the effects of an aromatic hydrocarbon 3-methylphenanthrene (3-MP) on currents mediated by the α-subunits of Na<sub>V</sub>1.5 (I<sub>hSCN5A</sub>) and K<sub>V</sub>11.1 (I<sub>hERG</sub>) channels in the CHO-K1 heterologous expression system. 3-MP caused a dose-dependent blockade of I<sub>hERG</sub> tail current (IC<sub>50</sub> = 38.2 μM). At a concentration of 10 μM, 3-MP induced a shift in the half-activation potential (V<sub>0.5</sub>) from -46.5 to -51.3 mV and reduced the time required for 50% of channels to become available from 120.9 to 99.6 msec. Significant changes were observed in inactivation parameters (V<sub>0.5</sub> increased from -79.9 to -73.4 mV) and deactivation kinetics (time constant decreased from 63.5 to 46.3 msec). In contrast, I<sub>hSCN5A</sub> remained tolerant to the effects of 3-MP. Therefore, it can be assumed that 3-MP can lead to lengthening of the action potential in human working cardiomyocytes, without significantly altering its amplitude or the rate of its propagation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"788-793"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternative Combinations of IL17A Polymorphic Variants with the Variants of TNF, IL1B, IL6, and IL8 Proinflammatory Cytokines Genes in Uterine Leiomyoma. 子宫平滑肌瘤中IL17A多态性变异与TNF、IL1B、IL6和IL8促炎因子基因变异的替代组合
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI: 10.1007/s10517-025-06412-z
V I Konenkov, V F Prokofiev, A V Shevchenko, E G Koroleva, Yu S Timofeeva, S V Aidagulova, I O Marinkin
{"title":"Alternative Combinations of IL17A Polymorphic Variants with the Variants of TNF, IL1B, IL6, and IL8 Proinflammatory Cytokines Genes in Uterine Leiomyoma.","authors":"V I Konenkov, V F Prokofiev, A V Shevchenko, E G Koroleva, Yu S Timofeeva, S V Aidagulova, I O Marinkin","doi":"10.1007/s10517-025-06412-z","DOIUrl":"10.1007/s10517-025-06412-z","url":null,"abstract":"<p><p>Genetic analysis of DNA samples from 180 patients with uterine leiomyoma (UL) and 98 women of the control group without UL showed that the frequency of homozygous AA variant of IL17A -197G/A gene polymorphism was significantly increased in UL (odds ratio, OR = 4.33; p = 0.0096). The frequency of this variant was even more increased when it is combined with homozygote variants GG at positions 238 and 308 of the TNF gene. The combination of the genotypes of these polymorphisms in the AA-GG-GG positions is not only widespread among patients with UL (OR = 12.22; p = 0.0054), but also was not detected in the control group. On the contrary, heterozygous IL17A -197 GA in combination with TNF-863C/A, TNF-308G/A, TNF-238G/A, IL1B-31T/C, IL6-174C/G, and IL8-251T/A are detected significantly less frequently among patients with UL than in the control, with taking into account Bonferroni's correction for the multiplicity of comparisons. The results obtained can be used in the personalized prognosis of predisposition to UL.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"760-763"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the Protective Effect of Combined Use of Some Substances in Acute Exposure to Ionizing Radiation in Mice by the Survival Criterion. 用生存标准评价急性电离辐射照射小鼠几种物质联合使用的保护作用。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06403-0
L A Romodin, O V Nikitenko, T M Bychkova, E D Rodionova
{"title":"Assessment of the Protective Effect of Combined Use of Some Substances in Acute Exposure to Ionizing Radiation in Mice by the Survival Criterion.","authors":"L A Romodin, O V Nikitenko, T M Bychkova, E D Rodionova","doi":"10.1007/s10517-025-06403-0","DOIUrl":"10.1007/s10517-025-06403-0","url":null,"abstract":"<p><p>The radioprotective effect of the combined use of radioprotective drugs was studied in a 30-day survival test on male ICR(CD-1) mice exposed to X-ray radiation at a dose of 6.5 Gy. A combination of phenylephrine prior to irradiation, glutathione immediately after irradiation, tocopherol on the next day, and granulocyte CSF for 2 weeks after irradiation ensured complete survival of the irradiated mice. Combined use of chlorophyllin and trolox ensured survival of a half of the irradiated mice. Other schemes were little effective. In some cases, the combined use of certain substances aggravated the condition of irradiated mice. Addition of riboxin to the combination of chlorophyllin and trolox increased mouse mortality compared to the irradiated control group. Copper chlorophyllin and granulocyte CSF were found to be incompatible.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"713-716"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Efficiency of an Artificial Intelligence-Based Technology in Dental Radiography. 基于人工智能的牙科x线摄影诊断效率研究。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06420-z
A A Obrubov, E A Solovykh, A G Nadtochiy
{"title":"Diagnostic Efficiency of an Artificial Intelligence-Based Technology in Dental Radiography.","authors":"A A Obrubov, E A Solovykh, A G Nadtochiy","doi":"10.1007/s10517-025-06420-z","DOIUrl":"10.1007/s10517-025-06420-z","url":null,"abstract":"<p><p>We present results of the development of Dentomo artificial intelligence model based on two neural networks. The model includes a database and a knowledge base harmonized with SNOMED CT that allows processing and interpreting the results of cone beam computed tomography (CBCT) scans of the dental system, in particular, identifying and classifying teeth, identifying CT signs of pathology and previous treatments. Based on these data, artificial intelligence can draw conclusions and generate medical reports, systematize the data, and learn from the results. The diagnostic effectiveness of Dentomo was evaluated. The first results of the study have demonstrated that the model based on neural networks and artificial intelligence is a valuable tool for analyzing CBCT scans in clinical practice and optimizing the dentist workflow.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"798-802"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells. x射线能量对人间充质干细胞γ - h2ax和53BP1病灶定量产量的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI: 10.1007/s10517-025-06404-z
M A Ignatov, A K Chigasova, A A Osipov, Yu A Fedotov, N Yu Vorobyeva, A N Osipov
{"title":"Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells.","authors":"M A Ignatov, A K Chigasova, A A Osipov, Yu A Fedotov, N Yu Vorobyeva, A N Osipov","doi":"10.1007/s10517-025-06404-z","DOIUrl":"10.1007/s10517-025-06404-z","url":null,"abstract":"<p><p>We compared the influence of X-rays generated at the peak anode voltages of 50, 100, and 200 kVp on the quantitative yield of foci (localized dynamic microclusters) of proteins involved in repair critical radiation-induced DNA damage, double-strand breaks (γH2AX and 53BP1), in cultured human mesenchymal stem stromal cells. Calculations of the relative biological effectiveness (RBE) based on the experimentally obtained dose curves of changes in the number of γH2AX and 53BP1 foci indicate that relative to the standard 200 kVp X-ray radiation taken as 1, the RBE of 100 kVp radiation is ~1.15, and that of 50 kVp is ~1.50. The obtained results indicate the necessity for thorough fundamental studies for evaluation of the real RBE of low-energy X-rays with subsequent correction of the weighting factor values.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"717-721"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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