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Biofilm Formation by Lactobacillus Strains of Modern Probiotics and Their Antagonistic Activity against Opportunistic Bacteria 现代益生菌中乳酸杆菌菌株的生物膜形成及其对机会性细菌的拮抗活性
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06211-y
O. A. Svitich, A. V. Poddubikov, N. O. Vartanova, A. Yu. Leonova, E. A. Kurbatova
{"title":"Biofilm Formation by Lactobacillus Strains of Modern Probiotics and Their Antagonistic Activity against Opportunistic Bacteria","authors":"O. A. Svitich, A. V. Poddubikov, N. O. Vartanova, A. Yu. Leonova, E. A. Kurbatova","doi":"10.1007/s10517-024-06211-y","DOIUrl":"https://doi.org/10.1007/s10517-024-06211-y","url":null,"abstract":"<p>The species identity of the studied lactobacillus strains was confirmed by matrix-activated laser desorption/ionization with time-of-flight ion separation (MALDI-TOF mass spectrometry). Lactobacillus strains differed in the dynamics of lactic acid accumulation and changes in the pH of the culture medium. The culture medium affected adhesion ability of lactobacilli. The ability to adhere does not affect the formation of biofilms by lactobacillus strains except for the <i>L. acidophilus</i> La5 strain, which has low adhesion ability and fewer microbial cells detected after mechanical destruction of the biofilm. The metabiotics of the lactobacillus culture medium have an antagonistic effect on conditionally pathogenic microorganisms. Adhesion, biofilm formation, and antagonistic activity of probiotic lactobacillus strains are strain-specific properties.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Human Chorionic Gonadotropin and Gonadotropin-Releasing Hormone Receptor Antagonist on Testicular Steroidogenesis in Normal and Obese Rats 人绒毛膜促性腺激素和促性腺激素释放激素受体拮抗剂对正常大鼠和肥胖大鼠睾丸类固醇生成的影响
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06204-x
I. A. Lebedev, V. S. Kuznetsova, A. A. Bakhtyukov, A. O. Shpakov
{"title":"The Effects of Human Chorionic Gonadotropin and Gonadotropin-Releasing Hormone Receptor Antagonist on Testicular Steroidogenesis in Normal and Obese Rats","authors":"I. A. Lebedev, V. S. Kuznetsova, A. A. Bakhtyukov, A. O. Shpakov","doi":"10.1007/s10517-024-06204-x","DOIUrl":"https://doi.org/10.1007/s10517-024-06204-x","url":null,"abstract":"<p>We studied the effect of a high-fat, high-carbohydrate diet (HFHCD) on basal testosterone levels in the blood and testosterone, its precursors, and expression of steroidogenic genes in the testes of rats treated with human chorionic gonadotropin (hCG, 10 IU/rat, subcutaneously, once), gonadotropin-releasing hormone receptor antagonist cetrorelix (75 μg/kg, subcutaneously, 3 days), and their combination. In HFHCD rats, no obvious signs of androgen deficiency were observed and the response of the testes to hCG stimulation was preserved. Unlike control rats (normal diet), the expression of the luteinizing hormone receptor gene in these rats did not change in response to hCG stimulation and cetrorelix administration; they also showed a paradoxical, more pronounced response to hCG administration under conditions of suppression of the gonadotropin secretion by cetrorelix. This suggests that the etiology and pathogenesis of obesity may have different effects on the hormonal status of the male reproductive system.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphometric Characteristics of Postmortem Changes in the Brain of Newborns Depending on the Duration of the Postmortem Period 新生儿大脑死后变化的形态计量特征取决于死后时间的长短
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06214-9
A. I. Shchegolev, U. N. Tumanova, O. V. Savva, G. T. Sukhikh
{"title":"Morphometric Characteristics of Postmortem Changes in the Brain of Newborns Depending on the Duration of the Postmortem Period","authors":"A. I. Shchegolev, U. N. Tumanova, O. V. Savva, G. T. Sukhikh","doi":"10.1007/s10517-024-06214-9","DOIUrl":"https://doi.org/10.1007/s10517-024-06214-9","url":null,"abstract":"<p>The morphometric characteristics of brain tissue were studied based on autopsy material from 49 deceased newborns divided into 7 groups based on the time after death. Samples were taken from the upper (frontal lobe) and lower (occipital lobe) regions relative to the supine position of the body. Paraffin sections were prepared from these samples and stained with hematoxylin and eosin. Histological preparations were analyzed using an image analysis system to determine the area of gliocyte nuclei, cross-cut blood vessels, and expanded area around them in the white matter of the brain. Based on these data, severity indices were calculated for both cellular (pericellular) and vascular (perivascular) expansion. The dynamics of changes in morphometric parameters within the range of cellular and vascular alterations on brain tissue specimens, which reflect the development of postmortem hypostasis and autolysis in this organ, can be used to estimate the duration of the postmortem interval. At the same time, these changes, when combined with other non-specific postmortem findings, should be distinguished from long-term pathological processes and diseases that may have occurred during life.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy 妊娠期肾脏的线粒体功能和抗氧化能力
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06205-w
V. A. Popkov, M. I. Buyan, K. I. Makievskaya, A. A. Brezgunova, I. B. Pevzner, L. D. Zorova, D. B. Zorov, E. Yu. Plotnikov, N. V. Andrianova
{"title":"Mitochondrial Function and Resistance to Oxidative Stress in the Kidney during Pregnancy","authors":"V. A. Popkov, M. I. Buyan, K. I. Makievskaya, A. A. Brezgunova, I. B. Pevzner, L. D. Zorova, D. B. Zorov, E. Yu. Plotnikov, N. V. Andrianova","doi":"10.1007/s10517-024-06205-w","DOIUrl":"https://doi.org/10.1007/s10517-024-06205-w","url":null,"abstract":"<p>We demonstrated that the serum of pregnant rats increases viability of kidney epithelial cells and promotes their proliferation. The intensity of oxidative stress in the kidneys was also reduced during pregnancy, but only in rats that were not exposed to acute ischemic kidney injury. This decrease in oxidative stress was not associated with changes in transmembrane mitochondrial potential, the size of mitochondria, time of opening of mitochondrial permeability transition pore (mPTP), mitochondrial respiration rate, antioxidant activity, or nitric oxide level.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Neurotrophic Factors as a Promising Strategy for the Treatment of Neurodegenerative Diseases (Review) 将神经营养因子作为治疗神经退行性疾病的有效策略（综述）
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06218-5
G. A. Fursa, S. S. Andretsova, V. S. Shishkina, A. D. Voronova, E. K. Karsuntseva, A. V. Chadin, I. V. Reshetov, O. V. Stepanova, V. P. Chekhonin
{"title":"The Use of Neurotrophic Factors as a Promising Strategy for the Treatment of Neurodegenerative Diseases (Review)","authors":"G. A. Fursa, S. S. Andretsova, V. S. Shishkina, A. D. Voronova, E. K. Karsuntseva, A. V. Chadin, I. V. Reshetov, O. V. Stepanova, V. P. Chekhonin","doi":"10.1007/s10517-024-06218-5","DOIUrl":"https://doi.org/10.1007/s10517-024-06218-5","url":null,"abstract":"<p>The review considers the use of exogenous neurotrophic factors in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and others. This group of diseases is associated with the death of neurons and dysfunction of the nervous tissue. Currently, there is no effective therapy for neurodegenerative diseases, and their treatment remains a serious problem of modern medicine. A promising strategy is the use of exogenous neurotrophic factors. Targeted delivery of these factors to the nervous tissue can improve survival of neurons during the development of neurodegenerative processes and ensure neuroplasticity. There are methods of direct injection of neurotrophic factors into the nervous tissue, delivery using viral vectors, as well as the use of gene cell products. The effectiveness of these approaches has been studied in numerous experimental works and in a number of clinical trials. Further research in this area could provide the basis for the creation of an alternative treatment for neurodegenerative diseases.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and Characterization of Salmonella Bacteriophages as Potential Agents for Phage Therapy of Antibiotic-Resistant Intestinal Infections 沙门氏菌噬菌体的分离与特征描述--噬菌体疗法治疗耐抗生素肠道感染的潜在药物
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06209-6
M. A. Pasivkina, M. N. Anurova, I. A. Kiseleva, A. A. Andreeva, A. M. Vorobev, T. E. Mizaeva, E. R. Mekhtiev, E. S. Zubkova, K. M. Alieva, A. R. Kuzmin, A. V. Karaulov, A. V. Aleshkin
{"title":"Isolation and Characterization of Salmonella Bacteriophages as Potential Agents for Phage Therapy of Antibiotic-Resistant Intestinal Infections","authors":"M. A. Pasivkina, M. N. Anurova, I. A. Kiseleva, A. A. Andreeva, A. M. Vorobev, T. E. Mizaeva, E. R. Mekhtiev, E. S. Zubkova, K. M. Alieva, A. R. Kuzmin, A. V. Karaulov, A. V. Aleshkin","doi":"10.1007/s10517-024-06209-6","DOIUrl":"https://doi.org/10.1007/s10517-024-06209-6","url":null,"abstract":"<p>Two bacteriophages specifically active against to pathogenic strains of the <i>Salmonella</i> genus were isolated. The morphology of phage colonies (size, transparency, and shape of the plaque edge, and halo) and the spectrum of their lytic activity and interaction with microbial cells (adsorption rate, duration of the latency, and reproductive efficiency) were examined. Using genome-wide sequencing, we determined the taxonomic position of bacteriophages and verified the absence of unwanted genes encoding toxins, adhesins, and invasins, as well as pathogenicity islands responsible for antibiotic resistance. In addition, phage stability under different physical conditions and their productivity were studied.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Polysaccharides Isolated from Saussurea salicifolia (L.) DC on Th2-Dependent Immune Response 从盐肤木（Saussurea salicifolia (L.) DC）中分离出的多糖对 Th2 依赖性免疫反应的影响
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06210-z
A. A. Ligacheva, M. G. Danilets, E. I. Gulina, N. S. Selivanova, E. S. Trofimova, E. Yu. Sherstoboev, E. Yu. Avdeeva, Ya. E. Reshetov, S. V. Krivoshchekov, V. V. Zhdanov, M. V. Belousov
{"title":"Effect of Polysaccharides Isolated from Saussurea salicifolia (L.) DC on Th2-Dependent Immune Response","authors":"A. A. Ligacheva, M. G. Danilets, E. I. Gulina, N. S. Selivanova, E. S. Trofimova, E. Yu. Sherstoboev, E. Yu. Avdeeva, Ya. E. Reshetov, S. V. Krivoshchekov, V. V. Zhdanov, M. V. Belousov","doi":"10.1007/s10517-024-06210-z","DOIUrl":"https://doi.org/10.1007/s10517-024-06210-z","url":null,"abstract":"<p>The effect of polysaccharides isolated from the aboveground parts of <i>Saussurea salicifolia</i> (L.) DC on Th2 type immune response reactions was studied. Administration of water-soluble polysaccharides presented by arabino-galacturonans (weight average molecular weight 158.49 kDa) to mice against the background of experimental Th2 immunity reduced the severity of anaphylactic and local immediate type hypersensitivity reactions. It also suppressed the production of ovalbumin-specific IgE and IgG1 and increased the stability of mast cell membranes. The studied polysaccharide complex increased IFNγ secretion and inhibited IL-4 synthesis. These findings suggest that these polysaccharides may be considered as potential anti-allergic agents that suppress the development of allergy in its early stages.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation 冻土层岩石中的芽孢杆菌属微生物代谢物对 T 淋巴细胞分化的影响
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06212-x
S. A. Petrov, Yu. G. Sukovey, L. F. Kalenova, E. G. Kostolomova, A. M. Subbotin, M. V. Narushko, A. S. Bazhin
{"title":"The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation","authors":"S. A. Petrov, Yu. G. Sukovey, L. F. Kalenova, E. G. Kostolomova, A. M. Subbotin, M. V. Narushko, A. S. Bazhin","doi":"10.1007/s10517-024-06212-x","DOIUrl":"https://doi.org/10.1007/s10517-024-06212-x","url":null,"abstract":"<p>We studied the influence of metabolites of permafrost microorganisms obtained at different temperature incubation conditions on activity of differentiation of regulatory (Treg) and effector T lymphocytes. It was found that the effect of metabolites is largely regulated by their type that depends on the temperature of production (“cold” at 5°C, “medium temperature” at 22°C, and “warm” at 37°C). The studied metabolites influenced the differentiation of Tregs (CD4<sup>+</sup>CD25<sup>hi</sup>CD127<sup>—</sup>) and the expression of markers of early (CD69), middle (CD25), and late (HLA DR) activation of CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes. In the case of “cold” metabolites, the increase in Treg levels was associated with a decrease in the intensity of CD4<sup>+</sup> T lymphocyte differentiation, and under the influence of “warm” metabolites — with a decrease in the activity of CD8<sup>+</sup> T lymphocyte differentiation. Under the influence of “medium-temperature” metabolites, Tregs had approximately the same effect on the intensity of CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocyte differentiation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Assessment of the Influence of Embolizing Agents on the Adrenal Parenchyma 栓塞药物对肾上腺实质影响的比较评估
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06215-8
M. S. Annayev, K. V. Stegniy, B. I. Geltser, R. A. Goncharuk, S. M. Seliutin, E. V. Maslyantsev, V. G. Fisenko, E. R. Dvoinikova, L. V. Zvereva
{"title":"Comparative Assessment of the Influence of Embolizing Agents on the Adrenal Parenchyma","authors":"M. S. Annayev, K. V. Stegniy, B. I. Geltser, R. A. Goncharuk, S. M. Seliutin, E. V. Maslyantsev, V. G. Fisenko, E. R. Dvoinikova, L. V. Zvereva","doi":"10.1007/s10517-024-06215-8","DOIUrl":"https://doi.org/10.1007/s10517-024-06215-8","url":null,"abstract":"<p>A comparative analysis of morphological and functional changes in the adrenal glands after embolization of supplying arteries with Lifepearl microspheres (100±25 μm; Terumo) and with a solution of polidocanol (Aethoxysklerol, Kreussler Pharma) was performed in male Vietnamese Lop-Bellied pigs (<i>n</i>=20). The introduction of the microspheres into the arterial bed did not affect the adrenal parenchyma. However, the injection of the liquid sclerosing agent caused foci of productive inflammation leading to the formation of sclerotic tissue and reduction of the volume of glandular tissue. Administration of the sclerosant was accompanied by arterial hypotension, an indirect indication of a decrease in vasoactive hormone production by the adrenal cortex. These findings suggest that polidocanol can be used as an embolization agent for hyperplastic diseases of the adrenal cortex.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats 噻吩嘧啶衍生物口服和腹腔注射 5 天对大鼠甲状腺状态的调节作用
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06223-8
K. V. Derkach, V. N. Sorokoumov, I. Yu. Morina, V. S. Kuznetsova, I. V. Romanova, A. O. Shpakov
{"title":"Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats","authors":"K. V. Derkach, V. N. Sorokoumov, I. Yu. Morina, V. S. Kuznetsova, I. V. Romanova, A. O. Shpakov","doi":"10.1007/s10517-024-06223-8","DOIUrl":"https://doi.org/10.1007/s10517-024-06223-8","url":null,"abstract":"<p>In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of the production of thyroid hormones by the thyroid gland developed by us, on the blood levels of thyroxine, triiodothyronine, and thyroid-stimulating hormone and on morphology of the thyroid gland. With both routes of administration, TPY3m caused a sustained moderate elevation of thyroid hormones, mainly thyroxine, with little effect on the level of thyroid-stimulating hormone. TPY3m did not reduce the stimulating effect of thyroliberin on the levels of thyroid hormones and had no damaging effect on the thyroid gland. During long-term administration, compound TPY3m stimulates the production of thyroid hormones without weakening the activity of the thyroid axis. Thus, TPY3m is a prototype of drugs for correcting thyroid hormone deficiency.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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