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Cytochrome C-Dependent Processes of Damage of Atherosclerotic Plaque Membranes Regulated by Anionic Phospholipids Containing Saturated and Unsaturated Fatty Acids. 含饱和和不饱和脂肪酸的阴离子磷脂调控的细胞色素c依赖性动脉粥样硬化斑块膜损伤过程。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06477-w
G O Stepanov, V V Volkov, S P Konukhova, A A Struchkova, Yu A Vladimirov, A N Osipov, A V Tarasov, R S Akchurin, D M Galyautdinov, V P Masenko, O V Stepanova
{"title":"Cytochrome C-Dependent Processes of Damage of Atherosclerotic Plaque Membranes Regulated by Anionic Phospholipids Containing Saturated and Unsaturated Fatty Acids.","authors":"G O Stepanov, V V Volkov, S P Konukhova, A A Struchkova, Yu A Vladimirov, A N Osipov, A V Tarasov, R S Akchurin, D M Galyautdinov, V P Masenko, O V Stepanova","doi":"10.1007/s10517-025-06477-w","DOIUrl":"10.1007/s10517-025-06477-w","url":null,"abstract":"<p><p>We have shown that changes in the phospholipid and fatty acid composition of atherosclerotic plaques in the carotid arteries of patients who underwent carotid endarterectomy in combination with coronary artery bypass surgery are linked with the development of the pathological process and highlight the importance of cytochrome C-mediated induction of oxidation of membrane phospholipids. An increase of the steady-state equilibrium constant of cytochrome C with atherosclerotic membranes to 10<sup>-5</sup> M and simultaneously a more than three-fold enhancement of LPO process are demonstrated.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"296-299"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Morphological Features of gPALB2-Associated Breast Cancer in the Russian Population. 俄罗斯人群中gpalb2相关乳腺癌的临床和形态学特征
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06488-7
V A Fedko, E V Artamonova, A M Stroganova, V A Mileyko, T S Lisitsa, A K Novikov, E I Kovalenko
{"title":"Clinical and Morphological Features of gPALB2-Associated Breast Cancer in the Russian Population.","authors":"V A Fedko, E V Artamonova, A M Stroganova, V A Mileyko, T S Lisitsa, A K Novikov, E I Kovalenko","doi":"10.1007/s10517-025-06488-7","DOIUrl":"10.1007/s10517-025-06488-7","url":null,"abstract":"<p><p>The analysis included 3,800 cases of breast cancer. Next-generation sequencing (NGS) of DNA extracted from peripheral blood leukocytes revealed mutations in the gPALB2 gene in 39 (1.03%) patients. The most frequent mutations were c.509_510del (25.64%), c.1592del (20.51%), and c.172_175del (10.26%). The predominant histological variant was invasive ductal carcinoma (84.62%) with moderate differentiation (G2) (48.72%). In most cases, luminal HER2<sup>-</sup> subtype (69.23%) was revealed, HER2<sup>+</sup> and triple-negative were less frequent (12.82 and 17.95%, respectively). Neoadjuvant chemotherapy was administered to 9 patients; a clinical response observed in 100% of cases. RCB-0 (pCR) was noted in 33.3%; RCB-I in 11.1%, RCB-II in 44.4%, and RCB-III in 11.1% of observations. All recorded cases of contralateral breast cancer (10.26%) were metachronous and presented as estrogen receptor-positive HER2<sup>-</sup> tumors.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"355-358"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats. 稳定的Env三聚体HIV-1 CRF63_02A6蛋白和DNA疫苗的免疫原性
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-30 DOI: 10.1007/s10517-025-06481-0
N B Rudometova, A P Rudometov, A A Fando, L A Kisakova, D N Kisakov, E V Tigeeva, V A Yakovlev, M B Borgoyakova, D N Shcherbakov, A A Ilyichev, L I Karpenko
{"title":"Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats.","authors":"N B Rudometova, A P Rudometov, A A Fando, L A Kisakova, D N Kisakov, E V Tigeeva, V A Yakovlev, M B Borgoyakova, D N Shcherbakov, A A Ilyichev, L I Karpenko","doi":"10.1007/s10517-025-06481-0","DOIUrl":"10.1007/s10517-025-06481-0","url":null,"abstract":"<p><p>Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a study of the immunogenicity of the Env trimer of the recombinant HIV-1 CRF63_02A6 in the form of a recombinant protein and a DNA vaccine, as well as in the prime-boost immunization scheme. The Env trimer in the form of a protein and a DNA vaccine induced the formation of specific antibodies with virus-neutralizing activity against HIV-1 Env-pseudoviruses.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"317-321"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified Method for Double Cannulation of Rat Bile Duct and Intestine for Pharmacokinetic Studies. 改良的大鼠胆管肠双管药代动力学研究方法。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06494-9
G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova
{"title":"Modified Method for Double Cannulation of Rat Bile Duct and Intestine for Pharmacokinetic Studies.","authors":"G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova","doi":"10.1007/s10517-025-06494-9","DOIUrl":"10.1007/s10517-025-06494-9","url":null,"abstract":"<p><p>An improved method of cannulation of the bile duct and duodenum in rats has been developed to study the kinetics of medicinal compounds in the bile. The proposed double cannulation method ensures reliable fixation and accurate placement of the catheters, prevents their twisting and loss, and allows for a comprehensive study of the processes of substance absorption and elimination. The bile was collected from animals without anesthesia, the circulation of bile acids between the liver and intestine was preserved. This method has been tested in a study of the kinetics of 2,6-diisobornyl-4-methylphenol in rat bile over 24 h after oral administration (25 mg/kg in 0.5 ml of linseed oil). The pharmacokinetic profile of the substance has been shown to be a plateau with an indistinct maximum (216.87 ± 74.39 ng/ml, after 8 h), and its slow excretion with bile is observed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"383-387"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connexin 43 Production by Ex Vivo Incubated NK Cells in the Presence of Relevant Cytokine Combinations. 在相关细胞因子组合存在的情况下，体外培养NK细胞产生连接蛋白43
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06483-y
T Markova, I Sainova, I Dimova, K Kavaldzhieva, D Dimitrova-Dikanarova, M Markova
{"title":"Connexin 43 Production by Ex Vivo Incubated NK Cells in the Presence of Relevant Cytokine Combinations.","authors":"T Markova, I Sainova, I Dimova, K Kavaldzhieva, D Dimitrova-Dikanarova, M Markova","doi":"10.1007/s10517-025-06483-y","DOIUrl":"10.1007/s10517-025-06483-y","url":null,"abstract":"<p><p>Mouse spleen natural killer (NK) cells were incubated ex vivo in the presence of interleukins (IL)-15 and -18 with or without IL-12 in order to study NK cell proliferation, cluster formation, and expression of gap junction protein connexin 43 (Cx43). While all applied cytokine combinations stimulated all of these functions in treated cells in comparison with control cells incubated without cytokines, IL-12 was found to increase cluster formation and decrease proliferation. Western blotting studies revealed upregulation of Cx43 expression in NK cells treated with IL-12. These results suggest that Cx43 is a marker of cluster formation of NK cells, forming contacts between them after activation of its expression by IL-12. The observed inhibition of proliferation might also be mediated by Cx43, though another possibility is that it could be an independent effect of IL-12 on NK cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"326-330"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of Recombinant Nucleocapsid Protein SARSN1 and Its Use for Assessing the Immune Response in Mice after Vaccination with a Live Probiotic Vaccine Containing the Coronavirus Nucleocapsid Protein. 重组核衣壳蛋白SARSN1的制备及其在冠状病毒核衣壳蛋白活菌疫苗接种小鼠免疫应答评价中的应用
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06482-z
T V Gupalova, E A Bormotova, G F Leontieva, T A Kramskaya, Yu A Desheva, A N Suvorov
{"title":"Production of Recombinant Nucleocapsid Protein SARSN1 and Its Use for Assessing the Immune Response in Mice after Vaccination with a Live Probiotic Vaccine Containing the Coronavirus Nucleocapsid Protein.","authors":"T V Gupalova, E A Bormotova, G F Leontieva, T A Kramskaya, Yu A Desheva, A N Suvorov","doi":"10.1007/s10517-025-06482-z","DOIUrl":"10.1007/s10517-025-06482-z","url":null,"abstract":"<p><p>The nucleocapsid (N) protein of the severe acute respiratory syndrome coronavirus (SARSCoV) is the most abundant structural protein in virus-infected cells. Its primary function is to pack ~30 kb positive-sense viral RNA genome that includes a 5' cap into a ribonucleoprotein (RNP) complex known as capsid. Among the 4 major structural proteins of SARS-CoV, the N protein exhibits the highest expression levels in the host cells. We produced a recombinant SARS-CoV N protein (SARSN1) and used it to detect specific antibodies in mice vaccinated with a live probiotic vaccine containing the coronavirus nucleocapsid protein.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"322-325"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypermethylated Long Non-Coding RNA Genes KCNK15-AS1, MAGI2-AS3, and SSTR5-AS1 in Ovarian Cancer and Their Diagnostic Potential. 高甲基化的长链非编码RNA基因KCNK15-AS1、MAGI2-AS3和SSTR5-AS1在卵巢癌中的作用及其诊断潜力
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-29 DOI: 10.1007/s10517-025-06486-9
S S Lukina, A M Burdenyy, E A Filippova, V I Loginov, I V Pronina, N A Ivanova, Al D Selezneva, An D Selezneva, N A Arzhanukhina, T P Kazubskaya, N E Kushlinskii, E A Braga
{"title":"Hypermethylated Long Non-Coding RNA Genes KCNK15-AS1, MAGI2-AS3, and SSTR5-AS1 in Ovarian Cancer and Their Diagnostic Potential.","authors":"S S Lukina, A M Burdenyy, E A Filippova, V I Loginov, I V Pronina, N A Ivanova, Al D Selezneva, An D Selezneva, N A Arzhanukhina, T P Kazubskaya, N E Kushlinskii, E A Braga","doi":"10.1007/s10517-025-06486-9","DOIUrl":"10.1007/s10517-025-06486-9","url":null,"abstract":"<p><p>We identified new diagnostic markers for ovarian cancer based on the analysis of aberrant methylation in a group of long non-coding RNA (lncRNA) genes. Using quantitative methyl-specific PCR with the nonparametric Mann-Whitney test, a significant (p < 0.01) increase in the methylation levels of three lncRNA genes (KCNK15-AS1, MAGI2-AS3, SSTR5-AS1) was demonstrated in a representative cohort of 56 clinical ovarian cancer samples. Using quantitative reverse transcription PCR on the same sample set, a significant decrease in the expression of these three lncRNA genes (p < 0.01) and a statistically significant inverse correlation between changes in methylation and expression levels (r < -0.5) were demonstrated, which confirms the functional role of methylation in suppressing their expression in tumor tissues. ROC analysis was used to assess the diagnostic potential of these genes. It was shown that the detection of methylation in at least one of the three genes in tissue DNA samples allows for identification of ovarian cancer with 98% sensitivity and 100% specificity (test > 0, AUC = 0.989). The developed marker panel may be of interest for the molecular assessment of at-risk patients when determining a preliminary diagnosis. However, the method requires validation on a larger, more representative sample set.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"342-347"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematological Parameters in Colitis-Associated Colorectal Cancer in Animals with Different Resistance to Hypoxia. 不同缺氧抵抗动物结肠炎相关结直肠癌的血液学参数。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06490-z
D Sh Dzhalilova, M V Silina, I S Tsvetkov, O V Makarova
{"title":"Hematological Parameters in Colitis-Associated Colorectal Cancer in Animals with Different Resistance to Hypoxia.","authors":"D Sh Dzhalilova, M V Silina, I S Tsvetkov, O V Makarova","doi":"10.1007/s10517-025-06490-z","DOIUrl":"10.1007/s10517-025-06490-z","url":null,"abstract":"<p><p>Hematological parameters were evaluated, proinflammatory immune response indices lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) were calculated, and iron was detected in tumor tissues by Perls' staining of histological sections in high (HR) and low resistant (LR) to hypoxia male C57BL/6 mice with colitis-associated colorectal cancer (CAC) induced by intraperitoneal injection of azoxymethane and three cycles of consumption of dextran sulfate sodium. The animals were euthanized on day 141 after azoxymethane administration. The relative number of monocytes in the blood increased in HR mice of the experimental group in comparison with the control group, and was higher than in LR animals. In LR mice with CAC, the relative number of lymphocytes and monocytes, absolute number of monocytes in the blood decreased and the NLR increased in comparison with the control; the LMR was higher than in HR animals. Regardless of hypoxia resistance, the mice developed normocytic hypochromic anemia; iron accumulation in the tumor was observed only in LR animals. The obtained data on more pronounced changes in hematological parameters in LR animals should be taken into account in the development of new approaches to the inflammatory and tumor diseases therapy, including CAC.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"363-367"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration. 微针的生物降解及经皮给药植入方法研究。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06496-7
E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev
{"title":"An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration.","authors":"E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev","doi":"10.1007/s10517-025-06496-7","DOIUrl":"10.1007/s10517-025-06496-7","url":null,"abstract":"<p><p>Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"392-396"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Dendritic Spine Density and Morphology during Therapy with Acetylcholinesterase Inhibitors in a Mouse Model of Alzheimer's Disease. 阿尔茨海默病小鼠模型中乙酰胆碱酯酶抑制剂治疗期间树突棘密度和形态的变化
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06493-w
G P Belyaev, K A Petrov, V E Semenov, I V Zueva
{"title":"Changes in Dendritic Spine Density and Morphology during Therapy with Acetylcholinesterase Inhibitors in a Mouse Model of Alzheimer's Disease.","authors":"G P Belyaev, K A Petrov, V E Semenov, I V Zueva","doi":"10.1007/s10517-025-06493-w","DOIUrl":"10.1007/s10517-025-06493-w","url":null,"abstract":"<p><p>We performed a comparative study of the effect of a new acetylcholinesterase inhibitor 1,3-bis[5-(o-nitrobenzylethylamino)pentyl]-6-methyluracil (C-35) and a commercial drug donepezil on the density and morphology of dendritic spines in the entorhinal cortex of transgenic APP/PS1 mice with a model of Alzheimer's disease. Administration of donepezil to transgenic mice did not significantly change spine density or morphology. In contrast, treatment with C-35 increased dendritic spine density by 56 and 34% in comparison with donepezil and the control group (untreated transgenic mice), respectively. This effect of C-35 was associated with an increase in the number of thin spines and a decrease number of stubby spines.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"378-382"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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