E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev
{"title":"微针的生物降解及经皮给药植入方法研究。","authors":"E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev","doi":"10.1007/s10517-025-06496-7","DOIUrl":null,"url":null,"abstract":"<p><p>Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"392-396"},"PeriodicalIF":0.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration.\",\"authors\":\"E V Edemskaya, G G Zasypkin, E Yu Podyacheva, Y G Toropova, D V Korolev\",\"doi\":\"10.1007/s10517-025-06496-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"392-396\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06496-7\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06496-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
An Assessment of the Biodegradation of Microneedles and Methods of Their Implantation for Transdermal Drug Administration.
Transdermal drug delivery is an effective method of drug administration, and for certain substances, it may be the only viable option. The most efficient and advanced approach to implementation of this method is the use of microneedles made from biodegradable materials. The method for producing transdermal patches with microneedles has been proposed, including techniques for their biodegradation and implantation in vivo. This method involves creating a 3D model of the patch master form, printing it with a 3D printer, creating a mold from polydimethylsiloxane, and then casting the patch from a biopolymer such as PLGA, PLA, DL-PLA, or PDLLA. Among these biopolymers, PLGA has demonstrated better biodegradation properties in comparison with the others. The implantation of patches with a universal animal harness has been found to be the most effective method.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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