稳定的Env三聚体HIV-1 CRF63_02A6蛋白和DNA疫苗的免疫原性

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-30 DOI:10.1007/s10517-025-06481-0

N B Rudometova, A P Rudometov, A A Fando, L A Kisakova, D N Kisakov, E V Tigeeva, V A Yakovlev, M B Borgoyakova, D N Shcherbakov, A A Ilyichev, L I Karpenko

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引用次数: 0

摘要

稳定的HIV-1 Env表面糖蛋白三聚体被认为是HIV-1疫苗设计的主要方向之一，无论是单独的还是初始-增强免疫策略。本文介绍了重组HIV-1 CRF63_02A6的Env三聚体以重组蛋白和DNA疫苗的形式以及在初始-增强免疫方案中的免疫原性的研究结果。以蛋白质和DNA疫苗形式存在的Env三聚体诱导形成了针对HIV-1 Env假病毒的具有病毒中和活性的特异性抗体。

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Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats.

Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a study of the immunogenicity of the Env trimer of the recombinant HIV-1 CRF63_02A6 in the form of a recombinant protein and a DNA vaccine, as well as in the prime-boost immunization scheme. The Env trimer in the form of a protein and a DNA vaccine induced the formation of specific antibodies with virus-neutralizing activity against HIV-1 Env-pseudoviruses.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.