Cytochrome C-Dependent Processes of Damage of Atherosclerotic Plaque Membranes Regulated by Anionic Phospholipids Containing Saturated and Unsaturated Fatty Acids.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI:10.1007/s10517-025-06477-w

G O Stepanov, V V Volkov, S P Konukhova, A A Struchkova, Yu A Vladimirov, A N Osipov, A V Tarasov, R S Akchurin, D M Galyautdinov, V P Masenko, O V Stepanova

引用次数: 0

Abstract

We have shown that changes in the phospholipid and fatty acid composition of atherosclerotic plaques in the carotid arteries of patients who underwent carotid endarterectomy in combination with coronary artery bypass surgery are linked with the development of the pathological process and highlight the importance of cytochrome C-mediated induction of oxidation of membrane phospholipids. An increase of the steady-state equilibrium constant of cytochrome C with atherosclerotic membranes to 10^-5 M and simultaneously a more than three-fold enhancement of LPO process are demonstrated.

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含饱和和不饱和脂肪酸的阴离子磷脂调控的细胞色素c依赖性动脉粥样硬化斑块膜损伤过程。

我们的研究表明，颈动脉内膜切除术合并冠状动脉搭桥手术患者颈动脉粥样硬化斑块的磷脂和脂肪酸组成的变化与病理过程的发展有关，并强调了细胞色素c介导的膜磷脂氧化诱导的重要性。细胞色素C与动脉粥样硬化膜的稳态平衡常数增加到10-5 M，同时LPO过程增加了三倍以上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.