Changes in Dendritic Spine Density and Morphology during Therapy with Acetylcholinesterase Inhibitors in a Mouse Model of Alzheimer's Disease.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI:10.1007/s10517-025-06493-w

G P Belyaev, K A Petrov, V E Semenov, I V Zueva

引用次数: 0

Abstract

We performed a comparative study of the effect of a new acetylcholinesterase inhibitor 1,3-bis[5-(o-nitrobenzylethylamino)pentyl]-6-methyluracil (C-35) and a commercial drug donepezil on the density and morphology of dendritic spines in the entorhinal cortex of transgenic APP/PS1 mice with a model of Alzheimer's disease. Administration of donepezil to transgenic mice did not significantly change spine density or morphology. In contrast, treatment with C-35 increased dendritic spine density by 56 and 34% in comparison with donepezil and the control group (untreated transgenic mice), respectively. This effect of C-35 was associated with an increase in the number of thin spines and a decrease number of stubby spines.

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阿尔茨海默病小鼠模型中乙酰胆碱酯酶抑制剂治疗期间树突棘密度和形态的变化

我们比较研究了新型乙酰胆碱酯酶抑制剂1,3-双[5-（o-硝基苄基乙胺）戊基]-6-甲基尿嘧啶（C-35）和商业药物多奈哌齐对转基因APP/PS1阿尔茨海默病模型小鼠内嗅皮质树突棘密度和形态的影响。给药多奈哌齐对转基因小鼠的脊柱密度和形态没有显著改变。相比之下，与多奈哌齐和对照组（未经处理的转基因小鼠）相比，C-35处理的树突棘密度分别增加了56%和34%。C-35的这种作用与细棘数量的增加和粗棘数量的减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.