L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh
{"title":"轴型脊椎关节炎患者单核细胞群中精氨酸酶-1和Mer酪氨酸激酶的表达。","authors":"L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh","doi":"10.1007/s10517-025-06460-5","DOIUrl":null,"url":null,"abstract":"<p><p>Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"211-216"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.\",\"authors\":\"L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh\",\"doi\":\"10.1007/s10517-025-06460-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"211-216\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06460-5\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06460-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.
Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
