Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI:10.1007/s10517-025-06460-5

L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh

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Abstract

Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.

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轴型脊椎关节炎患者单核细胞群中精氨酸酶-1和Mer酪氨酸激酶的表达。

轴性脊柱炎以先天免疫细胞活化为特征，表现为经典单核细胞升高和促炎表型为主。然而，单核细胞/巨噬细胞的免疫抑制潜力实际上尚未被探索。考虑到不同的临床特征，我们评估了轴型脊椎关节炎患者单核细胞亚群中Mer酪氨酸激酶（MerTK）和精氨酸酶-1 （Arg1）的表达。轴型脊柱炎患者的中间和非经典单核细胞中MerTK和Arg1的表达较正常人减少。最明显的MerTK和Arg1单核细胞表达的下降与更严重的病程（存在结肠炎、高疾病活动性、HLA-B27阳性）和对常规治疗缺乏反应有关。这些数据表明MerTK和Arg1在限制髓系炎症中的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.