M N Sergeicheva, M R Nazdracheva, M E Uspenskaya, A V Berezhnova, M V Burak, A Yu Ivanii, T A Fedotcheva
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Pharmacobiochemical Analysis of the Cytoprotective Action of New 5-Androstendiol Derivatives.
5-Androstenediol esters, dibutanoate and dipropionate, were synthesized as prototypes of effective cytoprotectors with prolonged action. The cytoprotective effect of the new 5-androstenediol derivatives was assessed in human lung and skin fibroblasts and human blood mononuclear cells exposed to UV radiation. 5-Androstenediol esters showed a regenerating, cytoprotective effect on different types of fibroblasts, but not on human peripheral blood mononuclear cells. The DNA comet assay revealed no genotoxic effect of the new steroids on the mononuclear fraction of human blood, which indicates their safety. The cytoprotective activity of 5-androstenediol dibutanoate and dipropionate in human fibroblasts attests to their possible use for creating ointments and liniments for the treatment of skin injuries requiring regeneration (including irradiation damage).
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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