Protective Effect of Conditioned Medium from Bone Marrow Mesenchymal Stem Cells on the Cornea of Rabbits with Impaired Blink Reflex.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI:10.1007/s10517-025-06491-y

V V Tiulina, S V Lavrushkina, A I Dovgii, I I Senin

引用次数: 0

Abstract

We studied the efficiency of a conditioned medium containing the secretome of bone marrow mesenchymal stem cells in preventing corneal damage in rabbits using an experimental model of dry eye syndrome caused by impaired blinking reflex. The conditioned medium produced a pronounced protective effect on the epithelial layer of the cornea of rabbits and suppressed the activation of MMP-9 in the tear film. As is known, an increase in MMP-9 activity leads to degradation of extracellular matrix components and disruption of the corneal epithelial barrier function. Our results indicate the possibility of using the bone marrow mesenchymal stem cell secretome in the treatment of dry eye syndrome.

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骨髓间充质干细胞条件培养基对眨眼反射受损兔角膜的保护作用。

本研究利用含骨髓间充质干细胞分泌组的条件培养基预防因眨眼反射受损引起的干眼综合征实验模型兔角膜损伤的效果。条件培养基对兔角膜上皮有明显的保护作用，并抑制泪膜中MMP-9的活化。众所周知，MMP-9活性的增加导致细胞外基质成分的降解和角膜上皮屏障功能的破坏。我们的研究结果表明，利用骨髓间充质干细胞分泌组治疗干眼综合征的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.