{"title":"Pathomorphological Evaluation of the Efficiency of Modeling Osteoarthritis of Vascular-Metabolic Genesis in Female Wistar Rats.","authors":"K V Korochina","doi":"10.1007/s10517-025-06472-1","DOIUrl":null,"url":null,"abstract":"<p><p>The article examines the issue of sexual dimorphism in experimental non-traumatic osteoarthritis (OA). The study analyzed the articular structures and internal organs of 8-month-old female Wistar rats after inducing chronic heart failure and obesity, which served as the author's OA model. The results were compared with those from a control group of females and existing literature on OA modeling in males, using histochemical and morphometric techniques, as well as semi-quantitative assessments using the Mankin and OARSI scales and the Krenn synovitis scale. The findings indicate the onset of early OA in the experimental female group, supporting the effectiveness of this modeling approach based on vascular-metabolic factors. Additionally, the comparative analysis showed that joint tissue changes were more significant in males than in females, suggesting that male rats are more suitable for OA modeling.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"270-276"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06472-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
The article examines the issue of sexual dimorphism in experimental non-traumatic osteoarthritis (OA). The study analyzed the articular structures and internal organs of 8-month-old female Wistar rats after inducing chronic heart failure and obesity, which served as the author's OA model. The results were compared with those from a control group of females and existing literature on OA modeling in males, using histochemical and morphometric techniques, as well as semi-quantitative assessments using the Mankin and OARSI scales and the Krenn synovitis scale. The findings indicate the onset of early OA in the experimental female group, supporting the effectiveness of this modeling approach based on vascular-metabolic factors. Additionally, the comparative analysis showed that joint tissue changes were more significant in males than in females, suggesting that male rats are more suitable for OA modeling.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
