{"title":"不同强度运动时肝脏TGF-β1基因表达及TGF-β1水平的变化","authors":"O V Alpidovskaya, I I Malyshev, L P Romanova","doi":"10.1007/s10517-025-06464-1","DOIUrl":null,"url":null,"abstract":"<p><p>Male Wistar rats were subjected to physical exercise of mild (group 1), moderate (group 2), and high (group 3) intensity. Ten swimming sessions were conducted, after which the animals were sacrificed (immediately and 30 days after the last session). Liver samples were studied by histological methods; the expression of the tgfb1 gene and the level of TGF-β1 in the liver were evaluated. Moderate degenerative processes were observed in the liver of rats with mild to moderate physical activity, and no significant changes were detected in the expression of tgfb1 gene and TGF-β1 content in the liver. In case of hard physical exercise, degenerative changes, necrosis, and cell infiltration were observed in the liver, and the level of TGF-β1 decreased. In 30 days after the last swimming session, an increase in both the level of TGF-β1 in the cytoplasmic fraction of the liver and the expression of the tgfb1 gene was observed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"232-236"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes in the Expression of the tgfb1 Gene and the Level of TGF-β1 in the Liver during Exercise of Varying Intensity.\",\"authors\":\"O V Alpidovskaya, I I Malyshev, L P Romanova\",\"doi\":\"10.1007/s10517-025-06464-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Male Wistar rats were subjected to physical exercise of mild (group 1), moderate (group 2), and high (group 3) intensity. Ten swimming sessions were conducted, after which the animals were sacrificed (immediately and 30 days after the last session). Liver samples were studied by histological methods; the expression of the tgfb1 gene and the level of TGF-β1 in the liver were evaluated. Moderate degenerative processes were observed in the liver of rats with mild to moderate physical activity, and no significant changes were detected in the expression of tgfb1 gene and TGF-β1 content in the liver. In case of hard physical exercise, degenerative changes, necrosis, and cell infiltration were observed in the liver, and the level of TGF-β1 decreased. In 30 days after the last swimming session, an increase in both the level of TGF-β1 in the cytoplasmic fraction of the liver and the expression of the tgfb1 gene was observed.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"232-236\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06464-1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06464-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Changes in the Expression of the tgfb1 Gene and the Level of TGF-β1 in the Liver during Exercise of Varying Intensity.
Male Wistar rats were subjected to physical exercise of mild (group 1), moderate (group 2), and high (group 3) intensity. Ten swimming sessions were conducted, after which the animals were sacrificed (immediately and 30 days after the last session). Liver samples were studied by histological methods; the expression of the tgfb1 gene and the level of TGF-β1 in the liver were evaluated. Moderate degenerative processes were observed in the liver of rats with mild to moderate physical activity, and no significant changes were detected in the expression of tgfb1 gene and TGF-β1 content in the liver. In case of hard physical exercise, degenerative changes, necrosis, and cell infiltration were observed in the liver, and the level of TGF-β1 decreased. In 30 days after the last swimming session, an increase in both the level of TGF-β1 in the cytoplasmic fraction of the liver and the expression of the tgfb1 gene was observed.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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