Geerthanaa Muthu, Prasanth Thankappan, D Angelin, R Franklin
{"title":"Salivary duct carcinoma in the submandibular gland: A rare case report with differential diagnosis.","authors":"Geerthanaa Muthu, Prasanth Thankappan, D Angelin, R Franklin","doi":"10.4103/jomfp.jomfp_476_23","DOIUrl":"10.4103/jomfp.jomfp_476_23","url":null,"abstract":"<p><p>Salivary duct carcinoma (SDC) is a rare and highly aggressive malignant salivary gland neoplasm, accounting for only 0.2% of salivary gland tumours. It predominantly affects the parotid gland and represents a significant concern with limited prevalence (1-1.2 individuals per million). We present a case of a 65-year-old female patient with a clinical history of swelling and pain in the right lower jaw region for six months. Diagnostic investigations revealed a well-defined submandibular gland lesion. Subsequent histopathological and immunohistochemical findings confirmed the lesion to be SDC. This case report emphasises the challenges in diagnosing this aggressive malignancy, which stems from its rarity and resemblance to other neoplasms. It is worth noting that the involvement of the submandibular gland is observed in a mere 12% of SDC cases, while females account for only 25% of the reported instances.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"311-314"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ankita Mathur, Vini Mehta, Vishnu T Obulareddy, Praveen Kumar
{"title":"Narrative review on artificially intelligent olfaction in halitosis.","authors":"Ankita Mathur, Vini Mehta, Vishnu T Obulareddy, Praveen Kumar","doi":"10.4103/jomfp.jomfp_448_23","DOIUrl":"10.4103/jomfp.jomfp_448_23","url":null,"abstract":"<p><p>Halitosis, commonly known as oral malodor, is a multifactorial health concern that significantly impacts the psychological and social well-being of individuals. It is the third most frequent reason for individuals to seek dental treatment, after dental caries and periodontal diseases. For an in-depth exploration of the topic of halitosis, an extensive literature review was conducted. The review focused on articles published in peer-reviewed journals and only those written in the English language were considered. The search for relevant literature began by employing subject headings such as 'halitosis, oral malodor, volatile sulfur compounds, artificial intelligence, and olfaction' in databases such as PubMed/Medline, Scopus, Google Scholar, Web of Science, and EMBASE. Additionally, a thorough hand search of references was conducted to ensure the comprehensiveness of the review. After amalgamating the search outcomes, a comprehensive analysis revealed the existence of precisely 134 full-text articles that bore relevance to the study. Abstracts and editorial letters were excluded from this study, and almost 50% of the full-text articles were deemed immaterial to dental practice. Out of the remaining articles, precisely 54 full-text articles were employed in this review. As primary healthcare providers, dentists are responsible for diagnosing and treating oral issues that may contribute to the development of halitosis. To effectively manage this condition, dentists must educate their patients about the underlying causes of halitosis, as well as proper oral hygiene practices such as tongue cleaning, flossing, and selecting appropriate mouthwash and toothpaste. This narrative review summarises all possible AI olfaction in halitosis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"275-283"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shefali Mishra, Sujata R Kanetkar, Kailas D Datkhile
{"title":"Expression of caveolin 1 in oral squamous cell carcinoma.","authors":"Shefali Mishra, Sujata R Kanetkar, Kailas D Datkhile","doi":"10.4103/jomfp.jomfp_310_23","DOIUrl":"10.4103/jomfp.jomfp_310_23","url":null,"abstract":"<p><strong>Context: </strong>Caveolin-1 is a surface protein that is a major structural component of caveolae, which are vesicles of the plasma membrane integral to a variety of signal transduction molecules and transport functions. Caveolin-1 is a biomarker undergoing research & studies have shown an increased expression of Cav-1 in the stepwise carcinogenesis from the normal oral mucosa, hyperplastic mucosa, dysplastic mucosa, precancerous lesions to Oral Squamous Cell Carcinoma. In the present study Correlation between Caveolin-1 expression and grade of tumor was established statistically.</p><p><strong>Aims: </strong>To study immunohistochemical expression of Caveolin-1 in Oral Squamous Cell Carcinoma.</p><p><strong>Settings and design: </strong>Cross sectional study carried out in a tertiary care hospital.</p><p><strong>Materials and methods: </strong>A total of 90 cases of histopathologically diagnosed oral squamous cell carcinoma was evaluated. Grading of the cases into well, moderate and poorly differentiated carcinomas was done as per WHO guidelines . Margin and lymph node status were evaluated. Anti- Caveolin-1 antibody (E249)- Caveolae marker ab32577 was used in the dilution of 1:100. Results were expressed taking reference of the methodology used by Hung et al 2003.</p><p><strong>Statistical analysis used: </strong>Statistical Package for the Social Sciences (SPSS 25.0).</p><p><strong>Results: </strong>Correlation of tumor grade and lymph node metastasis was statistically significant <i>p</i>=0.0006. There was a significant statistical correlation between tumor grade and immunohistochemical expression of Caveolin-1, <i>p</i>- value=0.00. Correlation between Lymph node metastasis and Caveolin-1 was statistically significant, <i>p</i>-value=0.008.</p><p><strong>Conclusions: </strong>Caveolin-1 expression correlates with aggressive tumor behavior and poor prognostic outcome.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"200-204"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reshma Poothakulath Krishnan, S Srivatchava, Ashna Yuvaraj, Deepak Pandiar
{"title":"Gender determination using mandibular intercanine distance and mesiodistal width of right mandibular molar.","authors":"Reshma Poothakulath Krishnan, S Srivatchava, Ashna Yuvaraj, Deepak Pandiar","doi":"10.4103/jomfp.jomfp_454_23","DOIUrl":"10.4103/jomfp.jomfp_454_23","url":null,"abstract":"<p><strong>Background: </strong>Forensic odontology plays an important role in mass disasters, house fires, criminal deaths, identification of missing persons, and child abuse cases. Teeth are the most stable part of the human body and are resistant to thermal, mechanical, and chemical insults. The aim of this study was to evaluate the effectiveness of mandibular intercanine distance and mesiodistal width of mandibular first molar in gender determination.</p><p><strong>Materials and methods: </strong>The study comprised 100 participants (50 males and 50 females) in the age group of 18-23 years. The mandibular impressions were made, and casts were prepared using dental stone. The intercanine distance and mesiodistal width of the right mandibular first molar were measured using digital vernier callipers. The data obtained was statistically analysed using SPSS software version 23.</p><p><strong>Results: </strong>The mean mandibular intercanine distance was found to be 27.2 ± 2.3 in males and 25.94 ± 1.76 in females (<i>P</i> = 0.03). There was no statistical difference in the mesiodistal width of the mandibular molar between males and females (<i>P</i> = 0.166). However, the mean mesiodistal width of males was higher when compared to females.</p><p><strong>Conclusion: </strong>Males have a greater intercanine width and mesiodistal dimension when compared to females. This result will be helpful in forensic medicine, anthropology, orthodontic treatments, and clinical dentistry.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"347-350"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gnanambigai Kalaimani, B Sivapathasundharam, Lekha Priyadarshini, Mrc Rajeswari, B Prem Karthick
{"title":"Mucous extravasation phenomenon: A clinicopathologic evaluation of 68 cases.","authors":"Gnanambigai Kalaimani, B Sivapathasundharam, Lekha Priyadarshini, Mrc Rajeswari, B Prem Karthick","doi":"10.4103/jomfp.jomfp_373_23","DOIUrl":"10.4103/jomfp.jomfp_373_23","url":null,"abstract":"<p><strong>Background: </strong>A mucocele is a benign, mucus-containing cystic lesion of the minor salivary gland also called a sialocele and ptyalocele. Two types are recognized as mucus extravasation cyst and the other is retention type.</p><p><strong>Objective: </strong>To evaluate the clinicopathologic features of oral mucocele cases.</p><p><strong>Materials and methods: </strong>The archival blocks which were signed out as mucocele were taken for the study. The following parameters such as age, gender, history of trauma, site, histological features, and clinical presentations were taken into consideration.</p><p><strong>Results: </strong>68 cases of mucous extravasation cysts were analysed, among which 58% were males and 42% were females. Age of the patients ranged from 4 to 70 years with an average of 20 years. The most common locations were the lower lip (87%), tongue (5%) and buccal mucosa (8%). Almost 53% of cases are seen on the left side of the oral cavity. Most of the cases presented a history of trauma. Histopathologically 23% of cases presented with muciphages in the lumen and connective tissue.</p><p><strong>Conclusion: </strong>The commonly encountered benign salivary lesion of the oral cavity is the mucus extravasation phenomenon of the mucocele. Various histopathological features were discussed in this study to avoid misdiagnosis of this common lesion in dental practice.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"182-185"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revathi Krishna, Priya Kumar, Sujata Mohanty, Aadithya B Urs
{"title":"Juvenile trabecular ossifying fibroma associated with central giant cell granuloma and aneurysmal bone cyst like changes - A triple hybrid tumour? Or a pathologic sequelae?","authors":"Revathi Krishna, Priya Kumar, Sujata Mohanty, Aadithya B Urs","doi":"10.4103/jomfp.jomfp_554_23","DOIUrl":"10.4103/jomfp.jomfp_554_23","url":null,"abstract":"<p><p>Hybrid tumours encompass lesions containing two or more pathologic entities. The pathogenesis of these lesions is barely understood and described. Juvenile trabecular ossifying fibroma (JTOF) is a benign but locally aggressive fibro-osseous neoplasm commonly affecting the maxilla of the adolescent age group. Hybrid lesions of JTOF have been reported along with central giant cell granuloma (CGCG), aneurysmal bone cyst (ABC) and traumatic bone cyst, respectively. However, the co-occurrence of JTOF with CGCG and ABC in a single patient has not yet been reported in the literature, hence, making ours the first case report of this kind. Theories describing the pathogenesis of this rare phenomenon have also been proposed and elaborated.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"337-342"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interdisciplinary Research - the Right Path?","authors":"Nirmal R Madhavan","doi":"10.4103/jomfp.jomfp_131_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_131_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"169"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nivedhitha Maraimalai, Akshay C Trimukhe, Tabita J Chettiankandy, Saumya Tiwari
{"title":"Animal metaphors in oral pathology-A review.","authors":"Nivedhitha Maraimalai, Akshay C Trimukhe, Tabita J Chettiankandy, Saumya Tiwari","doi":"10.4103/jomfp.jomfp_196_23","DOIUrl":"10.4103/jomfp.jomfp_196_23","url":null,"abstract":"<p><p>Oral pathology is a challenging yet intriguing subject. By comparing pathological traits to things we typically encounter, it is possible to reduce the difficulty of memorising these qualities. Hence, the usage of various analogical methods, like the usage of metaphors, conveys likeliness or similarities between two items and can help the students. A lot of pathological features have a resemblance to animals we see on a frequent basis. Students might find comparing, examining and comprehending oral pathology easier when the information is compared with familiar animals. This article is an attempt to compile animal metaphors related to oral pathology.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"293-296"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Snega Thamilselvan, Deepak Pandiar, Reshma P Krishnan, S Chitra
{"title":"Cytokeratin 8 depicts nodal metastasis in head and neck squamous cell carcinoma.","authors":"Snega Thamilselvan, Deepak Pandiar, Reshma P Krishnan, S Chitra","doi":"10.4103/jomfp.jomfp_168_23","DOIUrl":"10.4103/jomfp.jomfp_168_23","url":null,"abstract":"<p><strong>Background: </strong>Nodal involvement in squamous cell carcinoma is an important feature directly associated with the poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC). There are no clear cut indicators available currently to identify the lymph node metastases and overall prognosis in HNSCC. Thus, the current study was conducted to correlate the immunoexpression of cytokeratins (CK) 8, 10, and 14 with lymph node metastases and tumour differentiation in patients with HNSCC.</p><p><strong>Material and methods: </strong>The study population included 61 retrospective cases of HNSCC with lymph node metastases (n = 31) and without lymph node metastases (n = 30). Expression of CK 8, 10, and 14 was assessed by immunohistochemical staining procedure. Using Pearson's Chi-square test and Spearman's correlation coefficient, the correlation of these markers with lymph node metastases and tumour differentiation was statistically analysed.</p><p><strong>Results: </strong>The expression of CKs in HNSCC cases was higher than in controls. In nodal metastasis cases, CK 8 expression was noted in >50% of the tumour cells at the invasive tumour front (ITF) (<i>P</i> value 0.008), and in cases without nodal metastasis, <1% or negative expression was noted. CK 10 expression gradually decreased as the tumour grade increased. Association of CK 10 expression and tumour differentiation exhibited statistically significant results (<i>P</i> value 0.03). CK 14 expression was noted in the entire epithelium and at the ITF, strongly in most cases; however, CK 14 did not correlate with the lymph node metastasis and tumour differentiation as well.</p><p><strong>Conclusion: </strong>We found a strong correlation of CK 8 expression with nodal metastasis in HNSCC, and it can be utilised as a reliable prognostic indicator.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Imran Khan, Abhisheik Khare, Khushboo Arif, Sameera Shamim Khan, Abdullah Nasir, Shafik Lari
{"title":"Dental pulp stones and their correlation with metabolic diseases.","authors":"Mohammad Imran Khan, Abhisheik Khare, Khushboo Arif, Sameera Shamim Khan, Abdullah Nasir, Shafik Lari","doi":"10.4103/jomfp.jomfp_536_23","DOIUrl":"10.4103/jomfp.jomfp_536_23","url":null,"abstract":"<p><strong>Background: </strong>Dental pulp calcifications or pulp stones are calcified structures found in dental pulp, mostly around or enclosing a blood vessel. The formation of these calcifications begins with concentric layers of calcified tissue within which remnants of necrotic and calcified cells may be present. The calcifications of thrombi in blood vessels, called phleboliths, may also serve as nidi for denticles. In metabolic diseases such as diabetes, hypertension or poor periodontal health, there are obvious changes in blood vessels and vascularization. In our study, we observed histopathological sections of dental pulp and correlated systemic diseases such as diabetes and hypertension with poor periodontal health and dental pulp stones.</p><p><strong>Aim: </strong>The aim of our study was to evaluate the histopathology of dental pulp stones, their distribution among various age groups and sexes and to identify any correlations between pulp stone formation and systemic diseases such as type II diabetes and hypertension.</p><p><strong>Materials and methods: </strong>Samples from 100 patients with metabolic diseases such as type II diabetes and hypertension were collected. The pulp was extirpated from the teeth that were undergoing root canal treatment, and the teeth were extracted. The collected pulp sample was fixed in 10% formaline neutral buffer, subjected to routine histopathological procedures and stained with haematoxylin and eosin. The pulp of teeth extracted for orthodontic treatment was considered a control for patients with no metabolic disease.</p><p><strong>Results: </strong>There was a definite relationship between increased pulp stones and metabolic diseases such as type II diabetes and hypertension; likewise, poor periodontal health was significantly related to pulp stones.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"192-199"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}