Journal of Oral and Maxillofacial Pathology最新文献

{"title":"A novel technique for documenting the orientation of resection specimens in head and neck surgery using a 3D scanner.","authors":"Jeroen van Rijssel, Jordan Verburg, Arico Verhulst, Ilse van Engen-van Grunsven, Eric Dik","doi":"10.4103/jomfp.jomfp_344_24","DOIUrl":"10.4103/jomfp.jomfp_344_24","url":null,"abstract":"<p><strong>Introduction: </strong>Documenting orientation of resection specimens in head and neck surgery can be challenging.</p><p><strong>Purpose: </strong>The primary objective of this study was to investigate an enhanced documentation method for orientation of the resection specimen.</p><p><strong>Methods: </strong>A feasibility study was conducted to explore the potential of using a 3D scanner to improve documentation of the orientation of the resection specimen. 3D scans of the resection specimen were registered on a CT-based 3D model of the patient's original anatomy, resulting in 3D models of the resection specimen in the correct anatomical position and orientation.</p><p><strong>Results: </strong>The scanning, orientation, and verification processes are explained in detail.</p><p><strong>Conclusion: </strong>This innovative approach for documenting the orientation of resection specimens can improve the understanding of precise anatomical locations of close or positive margins. This understanding is crucial for determining the necessity and precise location of adjuvant therapy, minimising adverse effects and lowering the risk of local recurrence.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"659-663"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of perineural invasion in oral squamous cell carcinoma is improved by immunohistochemistry and correlates with locoregional recurrence.","authors":"Alexandre Augusto Sarto Dominguette, Maria Clara Avila de Oliveira, Ana Claudia Couto de Abreu, Bruno Henrique Figueiredo Matos, Cleverton Roberto de Andrade","doi":"10.4103/jomfp.jomfp_34_25","DOIUrl":"10.4103/jomfp.jomfp_34_25","url":null,"abstract":"<p><strong>Aims: </strong>In oral squamous cell carcinoma (OSCC), we investigated whether perineural invasion (PNI) and cell proliferation are associated with locoregional metastasis and recurrence.</p><p><strong>Settings and design: </strong>Thirty-nine cases of OSCC were included in this retrospective study.</p><p><strong>Materials and methods: </strong>Clinical-histopathological data were obtained from medical records. New slides were performed, and PNI status was assessed using hematoxylin and eosin-stained (H&E) and immunostaining for S100. PNI was described as tumour cells infiltrating >33% of the nerve circumference, complete nerve encirclement or intraneural infiltration. The status of proliferation was assessed by immunohistochemistry using Ki-67.</p><p><strong>Statistical analysis used: </strong>PNI and cell proliferation were associated with OSCC outcomes by univariate and multivariate regression.</p><p><strong>Results: </strong>PNI was positive in 17.9% H&E cases, increasing to 51.2% immunostaining (S100) analysis (0.004). All PNI-positive patients were ≤50 years. Intraneural invasion was the most common PNI-positive feature, followed by complete encirclement. All PNI-positive cases with locoregional recurrence showed intraneural invasion (0.001). PNI-positive tumours were most common in the soft palate and oropharyngeal subsites (66.7%), and smokers + alcoholics represented 80.0% of all PNI-positive cases. N0 and M0 tumours represented most PNI-positive cases. High cell proliferation represents an increased risk of PNI and is associated with lymph node metastasis in OSCC (0.001).</p><p><strong>Conclusions: </strong>S100 immunohistochemistry is useful to improve the diagnostic accuracy of PNI in OSCC by reducing the alpha and beta errors. PNI is common in OSCC, and PNI S100 diagnosis correlates with locoregional OSCC recurrence. High cell proliferation (Ki-67) was useful in predicting lymph node metastasis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"502-510"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of efficacy of topical Coconut-Licorice-Purslane cream with topical 0.1% triamcinolone acetonide gel for the treatment of oral lichen planus: A randomised controlled trial.","authors":"Disha V Alhat, Ashish Lanjekar, Nilesh Dinesh Pardhe, Stuti Nilesh Pardhe, Pradkhshana Vijay, Priyanka Singh","doi":"10.4103/jomfp.jomfp_73_25","DOIUrl":"10.4103/jomfp.jomfp_73_25","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus is a chronic inflammatory cell-mediated immunological disease. As it has a multifactorial aetiology, treatment is symptomatic. Corticosteroids are used as first-line treatment; however, it has various side effects, resulting in the search for new therapeutic options. Coconut has therapeutic, anti-inflammatory, antioxidant and immunomodulatory effects. Liquorice reduces the enzymatic activity of cyclooxygenase and lipoxygenase, limits the generation of oxygen free radicals and cell migration and inhibits arachidonic acid metabolism. Thus, it lessens the inflammatory response and pain. Purslane has wound healing, antibacterial, antiulcerogenic, anti-inflammatory and antioxidant qualities. Thus, all the above properties suggest the use of coconut-liquorice-purslane in the management of oral lichen planus (OLP).</p><p><strong>Method: </strong>Following approval from the Institutional Ethical Committee, 40 participants who met the inclusion criteria and were seeking treatment at the research hospital were randomly assigned to two groups. 'Group A' received coconut-liquorice-purslane cream, while 'Group B' received topical 0.1% triamcinolone acetonide gel. Both groups were instructed to apply the ointment to the affected area thrice a day for 90 days and were to refrain from eating and drinking for 15 minutes after application. The intensity of pain was measured using a visual analogue scale at baseline before treatment and on days 14, 30, 60 and 90.</p><p><strong>Results: </strong>Both groups showed statistically significant reduction in pain intensity, but the coconut-liquorice-purslane group showed better results when compared to the 0.1% Triamcinolone Acetonide group.</p><p><strong>Conclusion: </strong>Coconut-Liquorice-Purslane cream can be safely used as an alternative treatment modality in the management of OLP for reducing pain intensity as compared to topical 0.1% triamcinolone acetonide gel with no systemic, as well as topical side effects.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"612-616"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> evaluation of cytoproliferative activity of areca nut varieties on murine fibroblasts.","authors":"Soniya Adyanthaya, Ashwini Prabhu, Yashodhar Bhandary, Akarsha Balnadupete, Riaz Abdulla","doi":"10.4103/jomfp.jomfp_172_25","DOIUrl":"10.4103/jomfp.jomfp_172_25","url":null,"abstract":"<p><strong>Introduction: </strong>Areca nut, derived from the <i>Areca catechu</i> palm, is consumed by 10-20% of the global population and is linked to oral submucous fibrosis (OSMF), a potentially malignant oral disorder marked by increased fibroblast proliferation. The processing of areca nut involves husking, nut removal, drying, roasting, boiling, and fermentation.</p><p><strong>Aim: </strong>This study aims to examine how various processing methods and storage conditions of areca nut affect L929 fibroblastic cell lines.</p><p><strong>Materials and methods: </strong>Five areca nut varieties which underwent different processing methods and five commercial areca nut products (without tobacco) from Karnataka, Kerala, and Gujarat were collected and extracted using a triple solvent solution. Cytoproliferative activity was assessed using the methyl thiazolyl tetrazolium (MTT) and Trypan blue dye exclusion assays. Varieties with the highest proliferative activity were further analysed by Reverse transcription-Polymerase chain reaction (RT-PCR) and immunofluorescence, targeting collagen, fibronectin, and α-SMA expression.</p><p><strong>Results: </strong>Certain areca nut extracts stimulated fibroblast proliferation. However, there were no significant differences across processing methods, storage conditions, or chemical treatments. Two areca nut varieties and one commercial product exhibited the highest expression of collagen, fibronectin, and α-SMA, confirmed by both RT-PCR and immunofluorescence.</p><p><strong>Conclusion: </strong>The elevated expression of fibrosis-related proteins in two areca nut varieties with differing processing and storage suggests a potential role in fibrosis development. Only one of five commercial products showed similar activity, indicating variability in commercial preparations. These findings underscore the importance of further research into how processing and storage influence areca nut's role in OSMF.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"511-518"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin G (IgG) in oral submucous fibrosis and oral squamous cell carcinoma - An <i>ex vivo</i> study.","authors":"Aanchal Tandon, Pallavi Khare, Rohit Jaiswal, Amol Jain, Apoorva Sharma, Pawan Rebello","doi":"10.4103/jomfp.jomfp_94_25","DOIUrl":"10.4103/jomfp.jomfp_94_25","url":null,"abstract":"<p><strong>Context: </strong>Elevated IgG levels signify immune activation during the transition from OSMF to OSCC. Integrating IgG profiling with molecular diagnostics enhances early detection, risk prediction, and personalized treatment.</p><p><strong>Aims: </strong>The aim is to estimate and evaluate the serum immunoglobulin G (IgG) levels in OSMF and OSCC patients and compare them with the control group.</p><p><strong>Settings and design: </strong>Sardar Patel Postgraduate Institute of Dental and Medical Sciences Cross-sectional, Observational, Quantitative Study.</p><p><strong>Methods and materials: </strong>This study involved 36 participants aged 18 and older. After informed consent and oral examination, 2 mL blood samples were drawn, processed, and serum separated. Serum IgG levels were measured using Nephelometry (AGAPPE MISPA i2).</p><p><strong>Statistical analysis used: </strong>Statistical analysis was performed using the Chi-square test and ANOVA.</p><p><strong>Results: </strong>The mean serum IgG levels were highest in the OSCC group (1606.86 ± 500.44 mg/dL), followed by the OSMF group (1217.06 ± 136.95 mg/dL), and lowest in the control group (1113.58 ± 88.92 mg/dL). One-way ANOVA demonstrated a statistically significant difference in mean IgG levels among the three groups (<i>P</i> = 0.00087), indicating a progressive elevation of IgG with disease severity.</p><p><strong>Conclusions: </strong>IgG levels were highest in OSCC, with a positive correlation to OSMF severity, suggesting its potential as a biomarker. Age, gender, and lifestyle factors significantly influenced disease onset and progression across the studied groups.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"550-556"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of tumour budding in oral squamous cell carcinomas - A histological assessment of oral cancer cases from a tertiary care centre.","authors":"Pavithra Velusamy, Chetana Chandrashekar, Mary Mathew, Adarsh Kudva, Monica Charlotte Solomon","doi":"10.4103/jomfp.jomfp_261_25","DOIUrl":"10.4103/jomfp.jomfp_261_25","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the most common diagnostic entity of head and neck malignant neoplasms. The classic histopathologic grading system does not provide insights for predicting the prognosis. Tumour budding (TB) has been evolving as a promising histopathological tool for predicting prognosis in OSCC.</p><p><strong>Aims and objectives: </strong>This study was conducted to study the prognostic value of TB in OSCC patients.</p><p><strong>Materials and methods: </strong>The study included a cohort of clinically and histopathologically diagnosed 120 excisional biopsy cases of OSCC. TB was evaluated on the hematoxylin and eosin-stained sections. The cut value of less than 5 buds or greater than five buds per field was used to assess the TB. Chi-squared test was used to study the effect of TB with various clinicopathologic parameters. The Kaplan-Meier curve was used for survival analysis. <i>P</i> ≤0.05 was considered statistically significant.</p><p><strong>Results: </strong>High TB (more than five buds) had a significant statistical association with perineural invasion (<i>P</i> = 0.05), the worst pattern of invasion (<i>P</i> = 0.05), and with recurrence/metastasis (<i>P</i> = 0.02).</p><p><strong>Conclusion: </strong>TB is a marker of aggressive tumor behavior in OSCC. Assessment of TB can help in planning adjuvant therapy for better clinical outcomes.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"600-606"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation of light microscopic features of normal oral mucosa and its time dependent autolytic changes in deceased individuals - An observational study.","authors":"Jyotirmoy Roy, Sk Abdul Mahmud, Neha Shah, Sayan Biswas, Arunit Chatterjee, Mousumi Pal","doi":"10.4103/jomfp.jomfp_120_25","DOIUrl":"10.4103/jomfp.jomfp_120_25","url":null,"abstract":"<p><strong>Context: </strong>The postmortem interval refers to the amount of time elapsed between death and discovery of the body and estimation of which is challenging with the traditional methods.</p><p><strong>Aims: </strong>This study aims to investigate the potential of histologic autolytic features of buccal mucosa for the assessment of postmortem interval.</p><p><strong>Settings and design: </strong>The study was conducted between February 2023 and November 2024 in the Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, in collaboration with the Department of Forensic Medicine and Toxicology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal.</p><p><strong>Materials and methods: </strong>A total of 75 postmortem and 10 ante-mortem tissue samples were compared using hematoxylin and eosin and van Gieson's stains. The postmortem samples were categorized according to three PMI stages as early (<10 hours since death), intermediate (10-20 hours since death), and late (>20 hours since death up to the bloat stage).</p><p><strong>Statistical analysis used: </strong>Kruskal-Wallis test was performed to statistically analyze the obtained data.</p><p><strong>Results: </strong>The epithelial connective tissue separation was found to be significantly different among the three postmortem interval groups, whereas significant changes in the connective tissue, such as myofibril degradation, fatty tissue degeneration, and neural tissue degeneration were also noted. Moreover, decreased staining intensity of connective tissue through van Gieson's stain was also found to be statistically significant with the progression of postmortem interval.</p><p><strong>Conclusion: </strong>These findings indicate that microscopic evaluation of the buccal mucosa may be helpful for postmortem interval prediction.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"634-639"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146053884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell characterization of extranodal lymphoproliferative disorders.","authors":"Priyadharshini Muthumanickam, Pratibha Ramani","doi":"10.4103/jomfp.jomfp_127_25","DOIUrl":"10.4103/jomfp.jomfp_127_25","url":null,"abstract":"<p><strong>Background: </strong>Lymphoproliferative disorders (LPDs) comprise a broad range of conditions characterized by abnormal lymphocyte proliferation. Extranodal manifestations are relatively rare, particularly in the oral cavity. A detailed understanding of their histopathological and immunophenotypic features is essential for accurate diagnosis and effective management.</p><p><strong>Objective: </strong>This study aimed to evaluate the cellular composition of intraoral extranodal LPDs and assess their diagnostic significance.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 14 confirmed cases of extranodal LPDs retrieved from the Department of Oral Pathology, Saveetha Dental College, spanning the period from 2004 to 2024. Clinical records, histopathological slides and immunohistochemical profiles were reviewed. The study focused on evaluating key cellular components, including centroblasts, centrocytes, immunoblasts and plasma cells. Statistical analysis was performed using SPSS software.</p><p><strong>Results: </strong>Non-Hodgkin lymphoma (NHL) constituted 74% of the cases, with a slight male predominance (7:6). The maxilla was more frequently affected than the mandible (8:2). A diffuse growth pattern was observed in 70% of cases, with centroblasts being the most prominent cell type (38%). Immunohistochemical analysis demonstrated significant positivity for CD45, CD20 and CD138 (<i>P</i> = 0.006), highlighting their role in distinguishing lymphoid and plasma cell neoplasms.</p><p><strong>Conclusion: </strong>Intraoral extranodal LPDs, though uncommon, exhibit distinct histopathological and immunophenotypic characteristics that support accurate classification and diagnosis. The predominance of centroblasts in aggressive cases reinforces their prognostic value. This study underscores the importance of a multidisciplinary diagnostic approach and emphasizes the need for further research into molecular markers to enhance detection and targeted therapy.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"494-501"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring salivary gland lesions: Unveiling malignancy risks using the Milan classification.","authors":"Heer Dabhi, Komal Patel, Pinkal Dalal, Sayantani Das","doi":"10.4103/jomfp.jomfp_27_25","DOIUrl":"10.4103/jomfp.jomfp_27_25","url":null,"abstract":"<p><strong>Introduction: </strong>Salivary gland tumours (SGTs) are characterized by exceptional heterogeneity, diversity, and frequent morphological overlap among different entities. Fine needle aspiration cytology (FNAC) plays a pivotal role in evaluating salivary gland lesions (SGLs), facilitating prompt and accurate diagnosis and treatment. The Milan System of Reporting Salivary Gland Cytology (MSRSGC) is a six-tiered reporting system that aims to standardize SG reporting, fostering consistency in clinical management.</p><p><strong>Aims/objectives: </strong>To assess the cytomorphological patterns of various SGLs and categorize them according to MSRSGC. To study the frequency of SGLs by demographics, evaluate the efficacy of FNAC, and determine the risk of malignancy (ROM) through cyto-histo correlation.</p><p><strong>Materials and methods: </strong>This descriptive cross-sectional study involved 80 FNAC cases of SGLs sent to the pathology department from January 2018 to September 2022 (five years). Cytological findings were meticulously evaluated, categorized according to the MSRSGC, and correlated with histology wherever available.</p><p><strong>Observation and results: </strong>Out of a total of 80 cases, 34 were available for histopathological examination. The predominant age group affected was 51-60 years (23.75%) and the male-to-female ratio was 1.9:1. The parotid gland was most commonly involved (69%), followed by the submandibular gland (26%) and the minor salivary gland (5%). The frequency of case distribution according to MSRSGC in Categories I, II, III, IVA, IVB, V, and VI was 8%, 11%, 5%, 53%, 16%, 3%, and 5%, respectively. The ROM reported for each category was 0%, 0%, --, 6.25%, 40%, 100%, and 100%, respectively. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were of 80%, 100%, 100%, 94.44%, and 95.45%, respectively, underscoring its clinical utility. Among the available histological follow-up cases, maximum cases were available in Category IVB (77%), followed by Category VI (75%).</p><p><strong>Conclusion: </strong>FNAC proves to be a reliable diagnostic tool for SGLs, despite the inherent challenges of heterogeneity. Employing the MSRSGC enhances diagnostic precision, mitigating the risk of false positives and false negatives, thereby improving clinical outcome.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"543-549"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of immuno-expression of galectin-3 in oral submucous fibrosis and healthy oral mucosa.","authors":"Hetvi Sheth, Arpan K Shah, Rashmi G S Phulari, Yashsrajsinh Rathore, Dharmesh G Vasavada, Mehul R Ojha","doi":"10.4103/jomfp.jomfp_24_25","DOIUrl":"10.4103/jomfp.jomfp_24_25","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis (OSMF) is a potentially premalignant disorder involving oral mucosa presented with 7-13% rate of malignant transformation. Galectin-3 is a chimeric protein presented in the human body which plays an important role in certain physiologic conditions as well as pathologic conditions.</p><p><strong>Aim: </strong>This study aims to assess the impact of Gal-3 on connective tissue remodelling in both normal oral mucosa and OSMF.</p><p><strong>Materials and methods: </strong>The study sample included 40 individuals who visited the outpatient department of Manubhai Patel Dental College and a private dental clinic. The study samples were divided into two groups: Group I consisted of 20 patients with clinically diagnosed OSMF, and group II consisted of 20 patients with healthy oral mucosa. A punch biopsy was conducted to obtain the mucosal tissue from the appropriate site in each case of group 1. Tissues from healthy buccal mucosa were obtained during minor oral surgical procedures in group 2 cases. The statistical analysis was conducted using the SPSS software, version 20.0, developed by IBM in USA.</p><p><strong>Results: </strong>Based on the examination done according to TFM staging system, most of the cases belonged to stage 3. The majority of the OSMF cases were belonging to the grade III OSMF. Gal-3 immunoreactivity in epithelial cells in OSMF and in normal oral mucosa (NOM) was observed as membranous and cytoplasmic expression.</p><p><strong>Conclusion: </strong>The immuno-expression of Gal-3 was observed to be significantly elevated in the connective tissue near the epithelium in OSMF when compared to NOM.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 4","pages":"571-577"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}