晚期口腔黏膜下纤维化与恶性口腔黏膜下纤维化的血管形态学比较分析。

Q3 Medicine

Journal of Oral and Maxillofacial Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-28 DOI:10.4103/jomfp.jomfp_89_24

Tathagata Bhattacharjee, Supratim Ghosh, Dipto De, Pratik Sarkar, Jay Gopal Ray

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引用次数: 0

摘要

口腔黏膜下纤维化（OSF）是一种潜在的口腔恶性疾病。本病粘膜下层的血管分布可预测其恶性转化。目的：本研究试图探讨晚期OSF的不同血管参数，如平均血管面积、管腔直径等，并与恶性肿瘤合并OSF进行比较。材料和方法：对临床诊断为晚期OSF和恶性肿瘤的OSF患者进行切口活检。制备切片，用血红素和伊红染色，在研究显微镜下进行组织形态学分析。结果：与晚期OSF相比，OSF相关恶性肿瘤的平均血管面积和管腔直径有统计学意义的增加。结论：为了支持癌变的营养需求，需要增加血供；因此，血液供应以新生血管或扩张血管的形式增加。这些更改可以用作此转换的预测标记。

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Comparative analysis of blood vessel morphometry in advanced oral submucous fibrosis and malignancy associated with oral submucous fibrosis.

Introduction: Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral cavity. The vascularity of submucosa in this disease can predict its malignant transformation.

Aim: In this study, attempts have been made to investigate different parameters of vascularity, such as mean vascular area, luminal diameter etc., in advanced OSF and make a comparison with malignancy associated with OSF.

Materials and methods: Incisional biopsy was taken from clinically diagnosed cases of advanced OSF and malignancy associated with OSF. Sections were prepared and stained with haematoxylin and eosin for histomorphometric analysis using a research microscope.

Results: A statistically significant increase in mean vascular area and luminal diameter of blood vessels was noticed in malignancy associated with OSF compared to advanced OSF.

Conclusion: To support the nutritional demand of carcinogenesis, increased blood supply is required; hence blood supply increased in the form of budding blood vessels or enlarged dilated blood vessels. These changes can be used as a predictive marker for this transformation.

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来源期刊

Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology

CiteScore

1.40

自引率

0.00%

发文量

115

期刊介绍： The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.