Sumintarti Sugiharto, Shelly Salmah, Eva Fauziah, Sri Ramadany, Ummi Wajdiyah, Harun Achmad
{"title":"The potential calcium content of anchovy <i>(Stolephorus sp.)</i> on mandibular bone growth through osteoprotegerin expression analysis.","authors":"Sumintarti Sugiharto, Shelly Salmah, Eva Fauziah, Sri Ramadany, Ummi Wajdiyah, Harun Achmad","doi":"10.4103/jomfp.jomfp_484_23","DOIUrl":"10.4103/jomfp.jomfp_484_23","url":null,"abstract":"<p><strong>Background: </strong>Anchovy <i>(Stolephorus sp.)</i> is a commonly used food ingredient due to its high calcium content, which supports craniofacial growth. Calcium stimulates the formation of osteoblasts, which produce osteoprotegerin (OPG). OPG binds to RANKL, blocking RANKL-RANK bonding and limiting osteoclast development.</p><p><strong>Objective: </strong>The objective of this study was to analyze OPG expression in mandibular bones to assess the potential calcium content of anchovies.</p><p><strong>Methods: </strong>Three groups of 27 male Wistar rats were created: control, anchovy, and milk. After 40 days, the rats were decapitated, and their mandibular bones were surgically extracted, decalcified, and prepared for microscopic examination. The results showed a significant difference in OPG expression of rat mandibles between control, anchovy, and milk groups (<i>P</i> < 0.05), as determined by one-way analysis of variance (ANOVA). Tukey's HSD test revealed a significant difference in the average quantity of rat mandibular OPG expression between the control group and each of the anchovy and milk groups, with probability values of 0.00 and 0.003 (<i>P</i> < 0.05), respectively. However, the average level of OPG expression in anchovy and milk groups did not differ significantly, as indicated by the probability value of 0.064 (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The mandibular development increases after feeding anchovies compared to the control group. Anchovy is not statistically superior to milk in terms of increasing mandibular development. However, as a high-calcium food, anchovy is well-suited to support children's craniofacial development and growth.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"374-380"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rashmi Kerketta, Sonalee Shah, Himanta Grihtlahare, Amit Wasti, Swatantrata Patel
{"title":"Comparative histologic evaluation of teeth decalcified by conventional method versus microwave induced decalcification.","authors":"Rashmi Kerketta, Sonalee Shah, Himanta Grihtlahare, Amit Wasti, Swatantrata Patel","doi":"10.4103/jomfp.jomfp_75_24","DOIUrl":"10.4103/jomfp.jomfp_75_24","url":null,"abstract":"<p><strong>Introduction: </strong>Complete demineralization of hard tissues with preservation of organic components to retain their tissue architecture and to obtain thin section for histological examination is done by a process known as \"decalcification\". Tooth decalcification may be achieved by subjecting the tissue to a decalcifying chemical agent and employing heat, vacuum, or electric current to enhance the procedure. Completion of decalcification is adjudged by determination of end-point. Histological examination of hard tooth tissues and pulp is essential for diagnosis of developmental pathologies, pulp pathologies, and forensic odontology analysis as well as for research purpose.</p><p><strong>Aim: </strong>In our study, we studied the time consumed for decalcification procedure by conventional decalcification method and with the microwave-assisted decalcification method for teeth, using 5% nitric acid, 5% trichloracetic acid, and 14% EDTA (Ethylenediaminetetraacetic acid), respectively, along with morphological preservation of dentin and pulp tissue by analyzing preservation of their issue structure (pulp shrinkage, odontoblastic layer damage) and staining efficacy (patchy staining) for the three types of decalcifying agents used.</p><p><strong>Materials and method: </strong>The sample for this study included 120 freshly extracted teeth consisting of teeth of mandibular dentition. Samples were divided into two study groups:Group I: Decalcified by Conventional methodGroup II: Decalcified by Microwave method.Each group consisted of, three sub-groups employing a different decalcifying agent from among the three decalcifying agents used, that is, 5% nitric acids, 5% trichloroacetic acid, and 14%EDTA respectively.</p><p><strong>Result: </strong>The difference in speed of decalcification for both groups showed significant result. In either group, decalcification was fastest using 5% nitric acid. The difference in number of decalcified teeth sections showing shrinkage of pulp was not statistically significant for both groups. Damaged odontoblastic layer was evident only in the teeth treated with 5% nitric acid by microwave method. Patchy staining was observed in a few samples of all sample groups except those decalcified with EDTA by conventional method but the results were not statistically different on intercomparison.</p><p><strong>Discussion and conclusion: </strong>Our results are similar to those of previous studies and we found that microwave method is an option that can reduce the time of decalcification. Tooth tissue morphology also was noted to be well preserved with 5% trichloracetic acid and 14% EDTA in comparison to 5% Nitric acid.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"393-398"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S S Vidya Srinidhi, Ambika Murugesan, Sekar Balakrishnan, Maya Ramesh, V Varrshana, Mathew Jacob
{"title":"Modified Cajal's trichrome stain in oral squamous cell carcinoma.","authors":"S S Vidya Srinidhi, Ambika Murugesan, Sekar Balakrishnan, Maya Ramesh, V Varrshana, Mathew Jacob","doi":"10.4103/jomfp.jomfp_542_23","DOIUrl":"10.4103/jomfp.jomfp_542_23","url":null,"abstract":"<p><strong>Background: </strong>Modified Cajal's trichrome stain (MCTS) is a good differential stain that allows one to visibly distinguish between connective tissue and epithelial elements with different tonalities of colour.</p><p><strong>Aim: </strong>Our study aims to evaluate and analyse the effectiveness of oral squamous cell carcinoma (OSCC) using MCTS.</p><p><strong>Materials and methods: </strong>A study was conducted retrospectively with 30 tissue blocks embedded in paraffin from cases of OSCC that have been confirmed by histopathology. Both standard haematoxylin and eosin (H&E) and MCTS were applied to each section. Then all the sections were analysed by two observers for nucleus cytoplasmic intensity, break in the basement membrane, and advancing front of the tumour, muscle, and surrounding stroma. The efficacy of the stain was assessed and was graded as 1, poor; 2, fair; and 3, good based on the staining intensity.</p><p><strong>Statistical analysis: </strong>The parameters were graded for H&E and modified Cajal's stain. The results were subjected to the Chi-square test.</p><p><strong>Result: </strong>The above-mentioned parameters analysed showed a uniformly significant <i>P</i> value of 0.001 for comparing modified Cajal's trichrome stain to H&E stain. Measurement of the agreement was done based on Kappa statistics between two observers, and the values for each expression show that there was good agreement between the two for all the parameters.</p><p><strong>Conclusion: </strong>MCTS can also be used as a diagnostic aid to pathologists for better distinction of cellular components and easier identification, thereby solving difficulties in diagnosis at earlier stages.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"399-402"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B H Harshitha Gowda, Ravishankar Krishna, Srikari Srinivasan, Madhusudan Astekar
{"title":"Comparing the release of growth factors when partially demineralized tooth matrix is mixed with platelet rich fibrin and injectable platelet rich fibrin: An <i>in-vitro</i> observational study.","authors":"B H Harshitha Gowda, Ravishankar Krishna, Srikari Srinivasan, Madhusudan Astekar","doi":"10.4103/jomfp.jomfp_545_23","DOIUrl":"10.4103/jomfp.jomfp_545_23","url":null,"abstract":"<p><strong>Context: </strong>Platelet concentrates are rich in growth factors that assist in regenerative medicine to promote healing and tissue regeneration. Similarly, partially demineralized tooth is a storehouse of many growth factors, assisting in bone regeneration. Hence, the present study aimed to quantify the release of growth factors from different platelet concentrates individually and when mixed with a partially demineralized tooth matrix.</p><p><strong>Method: </strong>Human growth factors such as bFGF, EGF, PDGF-AB, TGF-beta-1, and VEGF-A present in platelet-rich fibrin and injectable platelet-rich fibrin from young and old male and female donors were quantified separately. Then these platelet concentrates were then mixed with a partially demineralized tooth matrix, which was powdered using a Smart Dentin Grinder. An enzyme-linked immunosorbent assay was used for the quantification of growth factors.</p><p><strong>Results: </strong>The release of growth factors, such as platelet-rich fibrin and injectable platelet-rich fibrin, was not statistically significant; however, it was significantly greater when i-PRF was mixed with a partially demineralized tooth matrix.</p><p><strong>Conclusion: </strong>The study revealed that the expression of growth factors was significantly greater when a partially demineralized tooth matrix was mixed with injectable platelet-rich fibrin than when combined with platelet-rich fibrin.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"415-421"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Merkel cell: Friend or felon.","authors":"Ankita Tandon, Narendra N Singh, Nikita Gulati","doi":"10.4103/jomfp.jomfp_503_23","DOIUrl":"10.4103/jomfp.jomfp_503_23","url":null,"abstract":"<p><p>Merkel cells are perceived as tactile receptors within skin and oral mucosa containing abundant intermediate filaments but lacking characteristic condensation of tonofilaments, hence are also referred to as non-keratinocytes. Merkel cell carcinomas (MCCs) are primary aggressive neuroendocrine neoplasms occurring in elderly individuals. Toker in 1972 reported MCC of skin pointing towards sweat glands as the source of origin which was later rectified by Tang with the aid of ultrastructural studies as Merkel cells to be a lineage of such tumours. Normally, Merkel cells are abundant in the gingiva and vermillion border of the lip and thus these are the common sites for this neoplasm. Histopathologically, MCC mimics varied other carcinomas, hence requiring a thorough diagnostic protocol. We present a case of challenging histopathology which on immunohistochemical analysis with a unique cytokeratin profile and neurofilament staining pattern helped in reaching a definitive diagnosis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"467-473"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: A histochemical study.","authors":"Yusra Khan, Shweta Rehani, Mohit Sharma","doi":"10.4103/jomfp.jomfp_17_24","DOIUrl":"10.4103/jomfp.jomfp_17_24","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer is the sixth most common cancer, and 90% of them are oral squamous cell carcinomas (OSCC). As most OSCC are asymptomatic and are only detected at an advanced stage, the 5-year survival rate is only 50%. Thus, using novel prognosticators can minimise mortality and morbidity associated with OSCC. This study aims to evaluate the relationship between mast cells and angiogenesis in different grades of OSCC to analyse their role in its progression.</p><p><strong>Material and methods: </strong>A total of 45 cases were included, comprising 10 well-differentiated SCCs (WDOSCC), 10 moderately differentiated SCCs (MDOSCC), and 10 poorly differentiated SCCs (PDOSCC). Additionally, five normal buccal mucosae (NBM) samples served as negative controls for OSCC. Five cases of neurofibroma and pyogenic granuloma were used as positive controls for mast cells and angiogenesis, respectively.</p><p><strong>Results: </strong>The mean MCD in WDOSCC, MDOSCC, and PDOSCC were 3.2620 ± 2.65177, 3.0310 ± 1.38276, and 4.1580 ± 2.49482, respectively. The MVD in WDOSCC, MDOSCC, and PDOSCC were 10.2850 ± 4.35032, 9.9240 ± 2.72533, and 7.1520 ± 2.26966, respectively.</p><p><strong>Discussion: </strong>MCD was the highest in PDOSCC, followed by WDOSCC and MDOSCC. These results indicate a redundant role of mast cells in OSCC, or they might jumpstart malignancy but are retarded with OSCC progression. The MVD decreased with higher grades, in contrast to the prevalent literature. The correlation analysis between MVD and MCD revealed no significant correlation between them.</p><p><strong>Conclusion: </strong>We found a non-significant role of mast cells in tumour biology and a decrease in vascularity with advancing grades. These results indicate a lower need for mast cell activation to augment vascularisation. A study with a larger sample size is needed to confirm our results.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"403-408"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidya Viswanathan, Mangesh Londhe, Sushama Gurwale, Archana Buch
{"title":"Clear cell myoepithelioma of palate: A rare case report with brief review of literature.","authors":"Vidya Viswanathan, Mangesh Londhe, Sushama Gurwale, Archana Buch","doi":"10.4103/jomfp.jomfp_372_23","DOIUrl":"10.4103/jomfp.jomfp_372_23","url":null,"abstract":"<p><p>Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology. Histopathology, along with immunohistochemistry, is needed for its confirmative diagnosis. We present a 28-year-old female with slow-growing, painless palatal swelling diagnosed as clear cell myoepithelioma on histopathology and immunohistochemistry.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"493-496"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gingival acquired lymphangiectasia as a long-term effect of post-oncology intervention: A 20-year institutional audit.","authors":"Pratibha Ramani, Abilasha Ramasubramanian, Suvarna Kizhakkoottu, Georgia Benitha","doi":"10.4103/jomfp.jomfp_26_24","DOIUrl":"10.4103/jomfp.jomfp_26_24","url":null,"abstract":"<p><strong>Background: </strong>Gingiva is a keratinised mucosa akin to the skin and is exposed in all modalities of treatment of oral cancer. Acquired lymphangiectasia are acquired dilatations of lymphatic channels secondary to an external cause. They are extremely rare in the oral cavity despite that oral cancers are treated with different treatment modalities.</p><p><strong>Methods: </strong>The archives of the Oral and Maxillofacial Pathology Department of our institute were retrospectively reviewed from 2001 to 2021. Of the 9566 cases of oral biopsies, 4596 were confirmed cases of oral cancer including salivary gland carcinoma. These cases were followed up for the presence of post-neoplastic and post-therapeutic gingival lesions.</p><p><strong>Results: </strong>Of the 4596 patients, <10% patients reported recurrence or new primary of squamous cell carcinoma in the gingiva. Two patients were histopathologically diagnosed with acquired lymphangiectasia of gingiva after 12 years following surgery and radiation therapy as treatment for oral squamous cell carcinoma and mucoepidermoid carcinoma, which has been described in our report for the first time in the literature.</p><p><strong>Conclusion: </strong>Even though acquired lymphangiectasia of gingiva is very rare, lymphatic malformations should be included in the clinical differential diagnosis of post-therapeutic gingival proliferative pathologies in order to ensure appropriate treatment and prevent over-diagnosis of this benign condition.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"428-433"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathophysiology of oral lesions subsequent to SARS-CoV-2 vaccination: A systematic review.","authors":"Preeti Sharma, Sangeeta Malik, Vijay Wadhwan, Rishabh Sharma","doi":"10.4103/jomfp.jomfp_511_23","DOIUrl":"10.4103/jomfp.jomfp_511_23","url":null,"abstract":"<p><p>Amidst worldwide reports of adverse oral lesions subsequent to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, the current systematic review planned to determine the prevalence of adverse oral events in adult individuals (≥18 years) after SARS-CoV-2 vaccination, emphasizing upon the type and dose of vaccine, time of onset, and underlying pathophysiology. The registered protocol (PROSPERO CRD42023421307), conforming with PRISMA guidelines, included an all-inclusive literature search through online databases, consisting of Scopus, PubMed/MEDLINE, Web of Science, Lilacs, Livivo, and PROSPERO, completed on 2 May 2023, followed by assessment of risk of bias by Joana Briggs Institute Evaluation Checklist. Due to the paucity of literature, case reports and case series were included. Self-reported lesions were excluded. Qualitative synthesis employing Microsoft Excel software 2019 revealed low prevalence (43 subjects) from 26 case reports and two case series. There were multiple erosive oral ulcers on gingiva, palate, burning pain in the mouth, xerostomia, tongue fissuring and glossitis, palatal petechiae, diffuse erythematous lesions and loss of smell (16.2%), primary herpetic gingivostomatitis (21%), oral lichen planus (16.2%), Stevens-Johnson syndrome (6.9%), Bell's palsy in four cases where two cases were Guillain-Barré syndrome (9.3%), erythema multiforme (11.6%), pemphigus (4.6%), idiopathic thrombocytopenic purpura (6.9%), unilateral hypoglossal nerve palsy (4.6%), and trigeminal neuralgia (2.3%). Maximum cases (22 subjects) presented oral lesions after Pfizer (BNT162b2) SARS-CoV-2 vaccine. No association was found between the vaccine type and dose with oral side effects. Dentists must be aware of the oral adverse effects after coronavirus disease 2019 vaccination to better understand the pathogenesis and the risk factors associated with such reactions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"443-454"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adesh S Manchanda, Harmandeep K Rai, Manvir Kaur, Paras Arora
{"title":"Cancer stem cells targeted therapy: A changing concept in head and neck squamous cell carcinoma.","authors":"Adesh S Manchanda, Harmandeep K Rai, Manvir Kaur, Paras Arora","doi":"10.4103/jomfp.jomfp_248_24","DOIUrl":"10.4103/jomfp.jomfp_248_24","url":null,"abstract":"<p><p>Identification of cancer stem cells (CSCs), their multilineage potential, and their ability of self-renewal have revolutionised the current concepts of cancer treatment. The suspected role of CSCs in cancer initiation, progression and relapse with the observed resistance to conventional cancer treatments has led to the development of more specific and targeted therapies. Identification of the properties of stem cells (SCs) and their potential for localisation in cancer has made targeted anti-cancer treatment possible by incorporating some modifications into these SCs. The same concept has been applied to the treatment strategy for head and neck squamous cell carcinoma (HNSCC) to control the relapse and improve the mortality rates in patients. This review aims to discuss the role of CSCs in the course and relapse of HNSCC, various surface markers for their identification and SC-targeted therapy options for the treatment of HNSCC, with a highlight on the advantages, shortcomings, opportunities and challenges to SC therapy in head and neck squamous cell carcinoma, treatment and scope for future research.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"455-463"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}