Journal of Oral and Maxillofacial Pathology最新文献

Unveiling the enigma: Navigating extranodal Rosai-Dorfman disease in the maxilla - A teen's journey. 揭开谜团：上颌结外罗塞-多夫曼病的导航——一个青少年的旅程。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_61_24

B Premalatha, K Barath Raj, P D Balamurali, M Arulvizhi

引用次数: 0

Atypical jaw swelling in children: An unusual clinical spectrum of Langerhans cell histiocytosis. 儿童非典型颌骨肿胀：朗格汉斯细胞组织细胞增多症的不寻常临床谱。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_102_24

K Sithara, Usha Balan, Pk Rajeesh Mohammed, Akhila S Stanly

{"title":"Atypical jaw swelling in children: An unusual clinical spectrum of Langerhans cell histiocytosis.","authors":"K Sithara, Usha Balan, Pk Rajeesh Mohammed, Akhila S Stanly","doi":"10.4103/jomfp.jomfp_102_24","DOIUrl":"10.4103/jomfp.jomfp_102_24","url":null,"abstract":"Langerhans cell histiocytosis (LCH), also called histiocytosis X or eosinophilic granuloma, is a local or systemic unusual clonal proliferative disorder of Langerhans cells. It has a wide spectrum of clinical presentations and can occur in any age group with predominance in children and young adults. This article presents a rare case of LCH in a 2-year-old girl child which was provisionally diagnosed as an infection of the jaw bone of unknown etiology. Correlating the clinical, radiologic, and histologic features with immunohistochemical analysis aided in arriving at a definitive diagnosis of LCH. Oral manifestations being the earliest presentation seen in around 5%-75% of LCH cases emphasize the role of a dentist in the early detection of this lesion. A myriad of clinical spectra due to pathologic infiltration of Langerhans cells into various systems necessitates oral diagnosis to be followed by a full body scan to detect any systemic involvement. Advanced targeted therapies can improve the survival rate and quality of life in patients with LCH.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"708-712"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory effects of Triphala and its constituents in oral squamous cell carcinoma and oral precancer. Triphala及其成分在口腔鳞状细胞癌和口腔癌前病变中的免疫调节作用。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_53_24

Thayalan Dineshkumar, Nirmala Anandan, Krishnan Rajkumar, Indumathi Nandhakumar

{"title":"Immunomodulatory effects of Triphala and its constituents in oral squamous cell carcinoma and oral precancer.","authors":"Thayalan Dineshkumar, Nirmala Anandan, Krishnan Rajkumar, Indumathi Nandhakumar","doi":"10.4103/jomfp.jomfp_53_24","DOIUrl":"10.4103/jomfp.jomfp_53_24","url":null,"abstract":"Oral squamous cell carcinoma shows increased occurrence in those who consume tobacco products, alcohol, betel quid, and areca nut, and is also considered to occur due to genetic alteration. Though there are numerous advancements in treatment, survival remains a question with late diagnosis. Hence, there are continuous inventions of new drugs. The introduction of Ayurveda in the therapy has paved the way for the longevity of the patients affected. One such introduction is the use of Triphala. The current study aims to review the anti-oxidant, anti-proliferative, anti-microbial, and apoptotic action of Triphala and thus evaluate the anti-cancer action of Triphala. A literature search was done, in various electronic databases and the data were extracted according to the predefined criteria. Original studies of 19 reports were included in the analysis. Nineteen (six studies with Triphala combination) In vitro/In vivo studies were included in this systematic review. The included study showed that Triphala effectively modulates the immune system. The effects included were anti-oxidative, immune modulation, anti-proliferative, tumor suppression, apoptotic effect, reversal of precancerous lesion, and anti-microbial action. The analyses also showed that there is no side effect of Triphala up to the recommended dosage. Triphala, is a nourishing supplement that is well-known in Ayurveda for its capacity to restore healthy tissues and promote aging gracefully through its properties such as anti-oxidant, ant-proliferative, anti-inflammatory, cytotoxic apoptotic, and immune-modulatory properties. Hence, Triphala can be a promising drug in the prevention and treatment of oral cancer.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"657-664"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journey of Oral Pathology in India: Academics to Artificial Intelligence. 印度口腔病理学之旅：学术到人工智能。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_322_24

Jagdish V Tupkari

引用次数: 0

ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis. ENDOGLIN (CD105)：用于评估口腔黏膜下纤维化恶性潜能的肿瘤血管标志物。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_67_24

Subraj Shetty, Treville Pereira, Sandhya Tamgadge, Sandeep Kale, Pooja Kamat, Sourab Kumar

{"title":"ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis.","authors":"Subraj Shetty, Treville Pereira, Sandhya Tamgadge, Sandeep Kale, Pooja Kamat, Sourab Kumar","doi":"10.4103/jomfp.jomfp_67_24","DOIUrl":"10.4103/jomfp.jomfp_67_24","url":null,"abstract":"Background: Oral submucous fibrosis (OSMF) is a precancerous condition associated with the use of betel/areca nut in various forms. It is characterized by restricted mouth opening, tongue protrusion and cheek rigidity. Oral submucous fibrosis, is primarily prevalent among the people of the Indian subcontinent and it has been reported that about one third of the OSMF patients develop squamous cell carcinoma.Endoglin (CD-105) is a hypoxia induced protein and a potential marker for activated endothelial cells which signify tumorigenic neoangiogenesis.Aim: To determine expression of CD105 and study relation of neoangiogenesis with the clinical staging and histopathological grading of oral submucous fibrosis.Material and method: Immunohistochemical expression of CD105 was evaluated on forty nine (49) paraffin-embedded tissue sections of diagnosed cases of OSF and seven (7) control samples of healthy volunteers.Results: There were 13 cases in Stage A, 11 cases in Stage B, 13 cases in Stage C, and 12 cases in Stage D. There were 4 cases in Grade 1 (Very early), 19 cases in Grade 2 (Early), 19 cases in Grade 3 (Moderately advance) and 7 cases in Grade 4 (Advance).Conclusion: The present study was first immunohistochemical study to demonstrate MVD, MVP and MVAP with CD105 expression in OSMF cases. However, well-designed studies with larger sample size is required to validate CD105 as a reliable biomarker for malignant transformation in future research.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"589-595"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the Editor's desk. 从编辑的桌子上。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_334_24

Radhika M Bavle

引用次数: 0

Gingival exophytic lesions - A proposed diagnostic algorithm to approach the clinical enigma. 牙龈外生性病变-一种提出的诊断算法，以接近临床之谜。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_250_24

Shweta Rehani, Sneha Sethi, Sonia Khorana

引用次数: 0

Potential of phosphatase and tensin gene polymorphisms as salivary biomarkers in oral squamous cell carcinoma - A cross-sectional study. 磷酸酶和紧张素基因多态性作为口腔鳞状细胞癌唾液生物标志物的潜力-一项横断面研究。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_118_24

Bindiya R Narang, Revati S Deshmukh, Sangeeta J Palaskar, Anirudha Bartake, Swati Patil, Priyanka Nitin

{"title":"Potential of phosphatase and tensin gene polymorphisms as salivary biomarkers in oral squamous cell carcinoma - A cross-sectional study.","authors":"Bindiya R Narang, Revati S Deshmukh, Sangeeta J Palaskar, Anirudha Bartake, Swati Patil, Priyanka Nitin","doi":"10.4103/jomfp.jomfp_118_24","DOIUrl":"10.4103/jomfp.jomfp_118_24","url":null,"abstract":"Background: PTEN (phosphatase and tensin homologue) is a tumour suppressor gene which is well known for its negative regulation on phosphatidylinositol 3-kinase (PI3K) pathway, thereby controlling the cellular growth and proliferation in the process of carcinogenesis. In the present study, the frequency of the genotypes of the PTEN gene, (rs2943773, rs1234224, rs9651495, rs3827678, and rs11202600) has been observed in individuals with oral squamous cell carcinoma (OSCC) using real-time polymerase chain reaction (RTPCR).Methodology: Saliva samples were collected from healthy individuals and individuals with OSCC. DNA extraction was done, followed by PCR using fluidigmn technique to observe the frequency of the genotypes.Results: Variation was observed in the distribution of frequencies of the alleles (rs9651495 and rs1234224) of the PTEN gene between the healthy individual and those with occurrence of OSCC. The other genotypes did not show any statistically significant difference in the distribution between the study group and the control group, nor any association was observed with OSCC.Conclusion: The variation in the frequency of rs9651495 and rs1234224 of the PTEN gene suggests an association between the \"PTEN\" gene and \"OSCC\" and hence its use in the panel of diagnostic markers. This also opens the field for future research in the therapeutic applications of the PTEN gene.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"596-601"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spindle cell variant of ameloblastic carcinoma: A diagnostic challenge. 成釉细胞癌的梭形细胞变异：一个诊断挑战。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_272_24

Mamata S Kamat, Uma V Datar, Sanjay S Byakodi, Amit A Basannavar

{"title":"Spindle cell variant of ameloblastic carcinoma: A diagnostic challenge.","authors":"Mamata S Kamat, Uma V Datar, Sanjay S Byakodi, Amit A Basannavar","doi":"10.4103/jomfp.jomfp_272_24","DOIUrl":"10.4103/jomfp.jomfp_272_24","url":null,"abstract":"An 18-year-old male presented with a 3-week history of progressively enlarging nodular growth in the posterior right mandibular region. The patient denied the use of tobacco in any form or history of trauma, and his family history was unremarkable. Clinical examination revealed a 2 × 3 cm reddish-pink, firm lesion with palpable submandibular lymph nodes. Radiological imaging showed a well-defined radiolucency distal to tooth #47. An incisional biopsy revealed the proliferation of spindle cells and ameloblastomatous epithelium showing features like pleomorphism, cellular crowding, and mitotic figures. Immunohistochemical analysis confirmed odontogenic origin. Based on the above findings, the diagnosis of the spindle cell variant of ameloblastic carcinoma (AC) was rendered. AC, constituting less than 2% of odontogenic tumours, and the spindle cell variant, a rare subtype with fewer than 15 reported cases, pose diagnostic challenges, necessitating careful histopathological and immunohistochemical evaluation for accurate diagnosis and treatment planning.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"713-715"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of Fascin-1 with clinicopathological parameters and recurrence in oral squamous cell carcinoma. fasin -1与口腔鳞状细胞癌临床病理参数及复发率的比较评价。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_146_24

Fatema Saify, Minal Chaudhary, Nidhi Tiwari, Shilpa Jain, Sarbani Deb Sikhdar, Meenakshi Sood

{"title":"Comparative evaluation of Fascin-1 with clinicopathological parameters and recurrence in oral squamous cell carcinoma.","authors":"Fatema Saify, Minal Chaudhary, Nidhi Tiwari, Shilpa Jain, Sarbani Deb Sikhdar, Meenakshi Sood","doi":"10.4103/jomfp.jomfp_146_24","DOIUrl":"10.4103/jomfp.jomfp_146_24","url":null,"abstract":"Background: Squamous cell carcinoma is the most common epithelial malignancy of the oral cavity. The 5-year survival rate is approximately 50% and is even lower, that is, 30% in the patients with recurrence of this disease. Because recurrence has a major influence on 5-year survival, it becomes imperative to identify the molecular elements responsible for the recurrence of oral squamous cell carcinoma.Aim: To evaluate the expression of fascin-1 and its correlation with clinicopathological parameters and recurrence in the patients of oral squamous cell carcinoma.Materials and methods: A cohort study was conducted in the Department of Oral Pathology, SPDC, Wardha. A 4 μm thick section from paraffin-embedded blocks of formalin-fixed biopsy tissues of 60 cases having primary oral squamous cell carcinoma was processed and stained with mouse monoclonal fascin-1 (Clone: SPM133) antibodies.Results: In the present study, all cases which had a final score above 2, denotes a strong positive immunostaining of fascin in OSCC. Tumour size was significantly correlated with fascin expression, whereas no significant association was found for other parameters, such as age, gender, node involvement, and grade of the tumour and recurrence.Conclusion: Fascin was found to be significantly correlated with tumour size. Fascin expression was found to be related with recurrence but no significant association exists. As recurrence is directly related to the poor prognosis and survival rate; so, it is essential to identify molecular markers indicative of recurrence. Fascin can be used to identify a subset of oral squamous cell carcinoma patients that are prone to recurrence.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"555-559"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0