Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Oral microbiome profiles in oral potentially malignant disorders and oral cancer - A diagnostic perspective.","authors":"Priya N Deo, Revati S Deshmukh, Akshay H Gaike, Anu Christopher, Mohak Gujare, Mitali Inamdar","doi":"10.4103/jomfp.jomfp_140_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_140_24","url":null,"abstract":"<p><strong>Background: </strong>Dysregulation of the oral microbiome has been correlated with many diseases, but oral microbiome in the etiopathogenesis of oral cancer remains a grey area and needs to be explored. It is imperative to understand the oral microbiome profiles so as to know the variations in the composition from normal to pre-cancer to cancer.</p><p><strong>Aim: </strong>To profile the oral microbiome of normal, oral potentially malignant disorders (leukoplakia - Leu, oral submucous fibrosis - OSMF) and oral squamous cell carcinoma (OSCC) by Next-Generation Sequencing of the 16S ribosomal rRNA gene.</p><p><strong>Material and methods: </strong>This is an observational cross-sectional study. A total of 50 subjects were selected for this study, which included the the normal, Leukoplakia, OSMF, and OSCC groups. Bacterial genomic DNA was extracted, and 16S rRNA gene sequencing of the V4 region was carried out using the Illumina MiSeq system. Bio-informatics data analysis was carried out using the DADA2 pipeline and phyloseq R package, and the <i>t</i>-test was used for statistical analysis.</p><p><strong>Results and conclusion: </strong>Variations in the composition of the oral microbiome were identified across all study groups, and significant differences were noted in certain microbial taxa across normal, pre-cancer, and cancer. Certain bacterial taxa were detected only in OSCC. An increase in relative abundance of Gram-negative bacteria as well as an increasing trend in the abundance of periodontal taxa was observed in OSCC. This study generated a baseline data which may provide a guideline for future functional and integrative oral microbiome studies. Variations in oral microbiome composition may be used as biomarkers and provide signatures during the progression from normal to pre-cancer to cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"87-97"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of salivary microRNA 301a as a potential non-invasive diagnostic biomarker in gastric carcinoma.","authors":"T Radhika, S Gopalakrishnan, R Sathish Muthukumar, Rajeswary Hari, Madhan Jeyaraman, G Vijetha","doi":"10.4103/jomfp.jomfp_39_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_39_25","url":null,"abstract":"<p><strong>Context: </strong>Early detection of cancer is key to good prognosis and improved survival rate. Gastric cancer (GC) is fatal and presents with poor prognosis as it is usually diagnosed only at advanced stages. Saliva is emerging as a preferred diagnostic tool due to its advantages of being non-invasive, easy to collect, and cost-effective. Salivary microRNAs (miRNA) are more reliable due to their stability, resistance to degradation and its abundant involvement in cancer progression.</p><p><strong>Aim: </strong>To estimate and validate the potential of salivary miRNA 301a in the diagnosis of Gastric cancer.</p><p><strong>Methods and materials: </strong>This Cross-sectional study comprised of 60 GC patients (Group I) and 60 normal controls (Group II). Fold change (FC) values of serum and salivary miRNA301a levels were estimated using the Real Time-Polymerisation Chain Reaction (RT-PCR) and compared between the study groups. Correlation between the serum and salivary miRNA301a levels was also evaluated. MiRNA301a levels were compared and correlated, with the clinical stage and histopathological grades of GC.</p><p><strong>Results: </strong>The mean FC of serum (Mean ± SD = 2.62 ± 0.75, Mean Rank = 90.5) and salivary (Mean ± SD = 2.03 ± 0.56, Mean Rank = 90.5) miRNA301a was significantly higher in Gastric cancer patients compared to controls (Mean ± SD = 0.99 ± 0.004, Mean Rank = 30.5). Salivary miRNA301a levels exhibited significant positive correlation with serum miRNA301a in gastric cancer patients (r = 0.941). The mean FC of serum and salivary microRNA 301a exhibited significant correlation with the clinical stages and histopathological grades of GC.</p><p><strong>Conclusion: </strong>Salivary miRNA301a is a potential reliable diagnostic tool for early screening of Gastric cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"104-108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of immune infiltrate in oral cancer: An immunohistochemical study.","authors":"Deepti Sharma, Abi M Thomas, Kanwardeep S Kwatra, George Koshy, Ranjeet S Mashon","doi":"10.4103/jomfp.jomfp_184_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_184_24","url":null,"abstract":"<p><strong>Background: </strong>The biomarkers of antitumour immune response provide valuable prognostic information and aid in the stratification and treatment of cancer. Tumour microenvironment (TME) defines the cancer biology, and assessment of tumour-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma is an arena of vigorous research.</p><p><strong>Aims and objectives: </strong>The present study is designed to determine the association of CD8⁺ and CD3⁺ T lymphocytes with clinicopathological parameters and their role as prognostic biomarkers.</p><p><strong>Materials and methods: </strong>This is an observational and institution-based study. Tissue blocks of histologically proven oral squamous cell carcinoma patients were retrieved from archives, and all clinicopathological parameters were noted. The semiquantitative and quantitative methods of TILs assessment were meticulously applied both in the stromal and intratumoural regions using immunohistochemistry. The standard statistical methods were employed for data analysis.</p><p><strong>Results: </strong>A significant association of CD8⁺ T lymphocytes with clinical tumour size (<i>P</i> = 0.012), clinical (<i>P</i> = 0.011), and pathological (<i>P</i> = 0.048) staging was observed. CD3⁺ T lymphocytes were significantly associated with clinical node involvement. However, no survival benefits were observed with both biomarkers.</p><p><strong>Conclusion: </strong>CD8⁺ T lymphocytes showed a significant association with clinical tumour size, clinical, and pathological staging. However, the study did not provide evidence for the prognostic value of the presence of CD3⁺ and CD8⁺ T lymphocytes in the tumour epithelium and stroma of oral cancer patients.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"66-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angioleiomyoma of cheek - A case report highlighting immunohistochemical diagnostic approach.","authors":"Shamala Sivanandham, Sri Sruthi Preman, Adhithya Baskaran, Kokila Sivakumar","doi":"10.4103/jomfp.jomfp_138_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_138_24","url":null,"abstract":"<p><p>Benign smooth muscle tumours, known as leiomyomas, are comparatively frequent, with uterine cases accounting for 95% incidence. Oral leiomyomas typically appear as asymptomatic, slowly-growing submucosal lumps in the tongue, hard palate, or buccal mucosa. Three histologic kinds of leiomyomas are recognized: epithelioid leiomyoma, solid leiomyoma, and angioleiomyoma. The most prevalent type of leiomyomas affecting the oral cavity are solitary forms called angioleiomyomas, which typically develop in the subcutis. The diagnosis is commonly determined by histopathological and Immunohistochemistry (IHC) procedures. This case reports a 30-year-old female patient with a lesion on her right cheek region. The postsurgical specimen was routinely processed and stained with hematoxylin and eosin staining, and IHC studies confirmed the diagnosis of 'Benign spindle cell neoplasm-Angioleiomyoma'.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of staining efficacy of calcofluor white and acridine orange in detecting fungal elements in oral potentially malignant disorders and oral squamous cell carcinoma - A retrospective study.","authors":"Amberpreet K Khangura, Shally Gupta, Anubha Gulati, Manjula Mehta","doi":"10.4103/jomfp.jomfp_117_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_117_24","url":null,"abstract":"<p><strong>Background: </strong>Candida is an opportunistic fungal pathogen that frequently colonizes the oral mucosa. Depending on multiple etiological factors, Candida can transform from a harmless commensal into a pathogenic organism, leading to the development of oral potentially malignant disorders (OPMDs) and oral cancer. Although various laboratory diagnostic methods for Candida have been developed, there remains a need for more rapid and sensitive diagnostic aids for infections associated with Candida. The present study aimed to compare the efficacy of Calcofluor white and acridine orange fluorescent stains and evaluate the most efficacious stain.</p><p><strong>Materials and methods: </strong>Two fluorescent stains, calcofluor white and acridine orange, were used to identify Candida elements in formalin-fixed, paraffin-embedded tissue sections of oral potentially malignant disorders (n = 16), including leukoplakia without dysplasia, mild dysplasia, moderate dysplasia, severe dysplasia, oral lichen planus, and oral sub mucous fibrosis as well as oral squamous cell carcinoma (n = 16), encompassing well-differentiated, moderately differentiated, and poorly differentiated grades. All stained slides were examined using a fluorescence microscope equipped with a blue filter at 20× and 40× magnifications. The comparison between the two stains was conducted based on the expression of fungal elements or the grade of Candida within the given sections, staining quality, and cost-effectiveness.</p><p><strong>Results: </strong>The results of the present study confirmed that both stains produced similar outcomes in terms of the expression of fungal elements within the sections of oral potentially malignant disorders and oral squamous cell carcinoma. Using both stains, all cases were positive (n = 32), with no negative cases reported. Grade I and II Candida was identified in the sections of oral potentially malignant disorders, whereas Grade III and IV Candida were observed within the sections of oral squamous cell carcinoma and sever dysplasia. Calcofluor white stain demonstrated higher efficiency in terms of staining quality and cost-effectiveness.</p><p><strong>Conclusion: </strong>Calcofluor white stain exhibited better expression of Candida elements in cases of oral potentially malignant disorders and oral cancer in terms of staining efficacy and is also more cost-effective.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"98-103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of stress related physiological parameters with biological parameters of saliva among college students - An observational study.","authors":"Sreeja Gobu, B Bhavana, Bhuvaneswari Mahalingam, Nachiammai Nachiappan, R Sathish Muthukumar, Vl Premika Sri","doi":"10.4103/jomfp.jomfp_92_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_92_24","url":null,"abstract":"<p><strong>Background: </strong>Stress can also be defined as a physical, mental, or emotional response to events that causes bodily or mental tension. Starting with a lack of concentration, it creates a lot of inconveniences and problems with a snowball effect. Saliva, a prime component of the oral cavity, plays an important role in oral health. Under any stressful situation, this unstimulated salivary flow rate decreases, leading to an increase in salivary acidity, which in turn leads to a reduction in the salivary pH, leading to a lot of other complications.</p><p><strong>Aim and objectives: </strong>This study was conducted to understand the difference in the levels of salivary pH and the sleep pattern of dental students during their exams. The objective is to prove that there is a marked decrease in the salivary pH and a reduction in the number of hours of sleep when the students are subjected to a stressor.</p><p><strong>Settings and design: </strong>180 male and female college-going students were selected for a cross-sectional questionnaire study based on a random sampling method.</p><p><strong>Materials and methods: </strong>A questionnaire was circulated among the subjects as Google forms, and their responses were retrieved in excel sheets. Unstimulated salivary sample were collected in a sterile manner, and pH was estimated using a pH meter. An understanding of the sleep pattern was gained using a questionnaire.</p><p><strong>Statistical analysis used: </strong>This study is a descriptive analysis of varied information on stress and salivary parameters. The responses recorded were made into graphical representation; the pH analysis and flow rate were estimated, and it showed variations in subjects during the examination.</p><p><strong>Results and conclusion: </strong>This study is the first-of-its-kind in comparing parameters of saliva, sleep quality and quantity in association with stress. We concluded that psychological variables-anxiety and stress-have a significant effect on reducing salivary flow rate which ultimately leads to a reduction in salivary pH.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of <i>Rosa chinensis, Rosa cymosa</i>, and <i>Rosa indica</i> in oral disease prevention: A multifaceted approach.","authors":"Monisha Prasad, Lithesh M Balasubramaniam, Malareni D L Priya, B R Varun, Ramya Sekar","doi":"10.4103/jomfp.jomfp_36_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_36_25","url":null,"abstract":"<p><strong>Introduction: </strong>Rose species that are well-known for their therapeutic qualities include <i>Rosa chinensis, Rosa cymosa</i>, and <i>Rosa indica</i>. The study employs <i>in vitro</i> assays and <i>in silico</i> molecular docking to investigate their phytochemical composition and antioxidant properties.</p><p><strong>Methods: </strong>Phytochemicals were detected in flower petals of <i>Rosa chinensis, Rosa cymosa</i>, and <i>Rosa indica</i> that had been extracted using methanol. Ascorbic acid was utilised as the standard reference for assessing antioxidant activity and its hydrogen peroxide scavenging potential. Superoxide dismutase (SOD) interactions with berberine, emodin, and limonene were assessed by molecular docking using PyRx software.</p><p><strong>Results: </strong>Various beneficial substances were found in all species according to phytochemical investigation. Among the three Rosa species, <i>R. chinensis</i> demonstrated the highest antioxidant activity, followed by <i>R. cymosa</i> and <i>R. indica</i>. Docking studies demonstrated that berberine and emodin had substantial binding affinity with SOD. The extracts showed strong antioxidant properties, suggesting that they could be used as naturally occurring antioxidants.</p><p><strong>Conclusions: </strong><i>Rosa chinensis, Rosa cymosa</i>, and <i>Rosa indica</i> show promise as medicinal plants and have strong antioxidant properties. The results validate the development of these rose species as naturally occurring antioxidants for the treatment of ailments related with oxidative stress.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"41-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic sialadenosis mimicking neoplasms: Clinical and histopathological considerations.","authors":"S NishaJaisree, Pratibha Ramani, R Abilasha, B R Varun","doi":"10.4103/jomfp.jomfp_230_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_230_24","url":null,"abstract":"<p><p>Soft tissue lesions involving the posterior palate region are unusual cases, especially among children. In such scenarios, it is essential to arrive at an accurate and conclusive diagnosis and also rule out malignancies. Several allergic diseases resulting in sialadenitis have been identified which include Kimura's disease, eosinophilic sialodochitis, and IgG4-related sialadenitis. In the current case report, we have described the unique histopathological findings of a rare lesion involving the posterior palate linked to elevated levels of serum IgE. Primary hyper-IgE-related salivary gland disease has been described as the homogenous enlargement of multiple salivary glands associated with elevated serum IgE levels. They may also be associated with allergic anaphylaxis or autoimmune dysfunction. Literature has revealed similar lesions involving the major glands; however, the current study describes a rare and de-novo finding in which the minor glands of the palate are involved along with a review of literature of various cases of idiopathic sialadenosis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the varied expressions of basic fibroblast growth factor in different histopathological grades of oral submucous fibrosis.","authors":"Geetpriya Kaur, Vijay Wadhwan, Kiran Kumar, Aparna Pathak, Farnaz Y Shah, Pallak Arora","doi":"10.4103/jomfp.jomfp_173_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_173_24","url":null,"abstract":"<p><strong>Context: </strong>Oral submucous fibrosis (OSMF) is a chronic disorder with multi-factorial aetiology. The OSMF pathophysiology includes the homeostatic equilibrium disruption between synthesis and degradation of extracellular matrix. Thus, various growth factors produced by activated inflammatory cells may promote fibrosis by inducing fibroblast proliferation, collagen synthesis upregulation, and reduced collagenase production.</p><p><strong>Aims: </strong>To correlate the role of basic fibroblast growth factor (bFGF) in the endothelial cells, fibroblasts, and connective tissue stroma in varying grades of OSMF. The bFGF expression was also correlated with the amount of inflammation.</p><p><strong>Settings and design: </strong>This retrospective study was designed to evaluate bFGF expression in 30 histopathologically diagnosed cases of OSMF from the Department of Oral and Maxillofacial Pathology, I.T.S CDSR, Muradnagar.</p><p><strong>Materials and methods: </strong>We included 30 cases, ten each of early, intermediate, and advanced stages of OSMF. Immunohistochemical staining using bFGF antibody was performed, and bFGF expression was noted in the blood vessels, fibroblasts, and connective tissue stroma in all the study cases.</p><p><strong>Statistical analysis used: </strong>Different variables were analysed using the ANOVA test, <i>post</i> <i>hoc</i> test, and Bonferroni test.</p><p><strong>Results: </strong>The bFGF-labelled blood vessels and fibroblasts were significantly higher in early OSMF cases than in the intermediate and advanced groups. bFGF expression was significantly observed in the connective tissue stroma in most of the cases.</p><p><strong>Conclusions: </strong>The bFGF intensity was mild, moderate, and severe in early, intermediate, and advanced OSMF cases, respectively. Moreover, bFGF expression was noted in the blood vessels, fibroblasts, and connective tissue stroma in the majority of the cases.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"76-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of blanching, fibrosis, and uvular changes with the extent of mouth opening in oral submucous fibrosis - A 9-year retrospective analysis.","authors":"Sneha R Sharma, Samiksha Chavan, Freny R Karjodkar, Kaustubh Sansare, Prajakta Khelkar, Aswathi Unnikrishnan","doi":"10.4103/jomfp.jomfp_27_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_27_24","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis (OSF) has one of the highest malignant transformation rates among all potentially malignant disorders. An early diagnosis and staging of the condition with the help of clinical findings may help in the improvement of the prognosis.</p><p><strong>Aim: </strong>To evaluate the correlation of stages of OSF based on mouth opening with the presence of blanching, fibrous bands, and shape of the uvula.</p><p><strong>Materials and methods: </strong>A retrospective, observational study was conducted in the Department of Oral Medicine and Radiology, and 1,267 case records were included in the study after the evaluation of patient data. Changes in mouth opening, fibrosis, blanching, and uvula were noted and analyzed using the Chi-square test.</p><p><strong>Results: </strong>The highest incidence of fibrous bands and blanching was seen on buccal mucosa in Group C. Blanching ranged from 65% to 93% in all stages of the disease, and blanching on the palate was seen to be the highest in Group A. The percentage of Group D patients with deviated uvula (26%) was lower than that of Group A patients (38%).</p><p><strong>Conclusion: </strong>Clinical findings like the fibrous bands, blanching, and deviation of the uvula contribute to the assessment of severity of the disease, and grading OSF only based on mouth opening, though simple and convenient, might inadequately represent the disease severity.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}