Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Assessment of human papilloma virus as an independent risk factor in non-habituated oral tongue squamous cell carcinoma patients - An institutional study.","authors":"Litu Mary Thampy, Mahija Janardhanan, Rakesh Suresh, Vindhya Savithri, Diana Kuriachan, Thara Aravind","doi":"10.4103/jomfp.jomfp_294_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_294_25","url":null,"abstract":"<p><strong>Background: </strong>An increasing incidence of oral cancer in women and younger adults with no habit of using tobacco has been noticed in recent years, with human papilloma virus (HPV) infection considered to be the major causative factor especially about tongue. Though role of HPV in oropharyngeal carcinoma is well established, studies in tongue cancers had yielded conflicting results.</p><p><strong>Materials and methods: </strong>We carried out histopathological evaluation of HPV induced epithelial changes (koilocytes, karyorrhectic cells, and apoptotic bodies) followed by assessment of the presence of HPV deoxyribonucleic acid (DNA) in paraffinized tissue sections using multiplex polymerase chain reaction (PCR) in 40 cases of squamous cell carcinoma of lateral border of tongue belonging to both habit and non-habit group.</p><p><strong>Results: </strong>A significant difference in the mean value of apoptotic bodies (<i>P</i> < 0.05) was noticed between the habit and the non-habit groups. But the difference in the mean value of koilocytes, and karyorrhectic cells noticed between the groups was not significant. The presence of HPV DNA was detected only in 1 out of the 40 (2.5%) tongue squamous cell carcinoma cases subjected for the PCR study.</p><p><strong>Conclusion: </strong>Though a subset of HPV induced oral squamous cell carcinoma seems to exist, HPV does not seem to be the prime etiological agent in oral tongue cancers in the absence of associated risk factors.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From radiology to microscopy: Unveiling the mandibular - Molar angle ramus pathologies: A retrospective study.","authors":"Debarati Ray, S Aravindan, Dipto De, Nikita Kashyap, Snehanjan Sarangi, Sudipta Rakshit","doi":"10.4103/jomfp.jomfp_215_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_215_25","url":null,"abstract":"<p><strong>Context: </strong>The molar-angle-ramus region of the mandible is a frequent site for a diverse spectrum of pathologies, ranging from benign cysts and tumours to aggressive malignancies, each exhibiting varying degrees of destructive potential. Majority of these pathologies are indistinguishable solely based on radiological features, posing a diagnostic challenge. A precise diagnosis necessitates an integrated approach combining radiographic assessment with histopathological correlation.</p><p><strong>Aims: </strong>This study aims to analyse the prevalence, radiographic characteristics, and histopathological correlation of the pathologies occurring in the molar-angle-ramus region of the mandible.</p><p><strong>Methods and materials: </strong>This study evaluated 138 cases of pathologies occurring in the molar-angle-ramus region of the mandible. Radiographic evaluation was performed using orthopantomogram (OPG) or cone beam computed tomography (CBCT), assessing key parameters such as laterality, focality, locularity, radiodensity, periphery, shape, association with impacted teeth, and presence of pathological fracture followed by histopathological examination.</p><p><strong>Results: </strong>Ameloblastoma was the most common lesion (21%), followed by squamous cell carcinoma (14.5%) and odontogenic keratocyst (8.7%). Most lesions were unilateral, unifocal, and radiolucent, with variations in locularity, periphery, and shape. Association with impacted teeth and pathologic fractures was noted in 37.7% cases.</p><p><strong>Conclusion: </strong>This present study found ameloblastoma to be the most common lesion in the molar-angle-ramus, followed by squamous cell carcinoma highlighting the need for careful differentiation. Radiographic parameters such as locularity, periphery, and association with impacted teeth aid in diagnosis, but histopathological correlation remains essential for definitive identification.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor's desk.","authors":"Jayanthi Pazhani","doi":"10.4103/jomfp.jomfp_69_26","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_69_26","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and patterns of oral mucosal lesions among inpatient and outpatient substance users in rehabilitation and de-addiction centres in Bangalore: A cross-sectional study.","authors":"Krishnanand P Satelur, Vidya M Annegowda, Andrea M Fonseca, R Venkatasubramanian, Mohamed N A D Shah, T Preethi","doi":"10.4103/jomfp.jomfp_198_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_198_25","url":null,"abstract":"<p><strong>Context: </strong>Substance abuse is a growing public health challenge in India with significant oral health implications. Oral mucosal lesions (OMLs) are frequently observed among substance users due to the direct toxic effects and associated lifestyle factors. Despite this, oral screening is rarely integrated into de-addiction programmes.</p><p><strong>Aims: </strong>To assess the incidence and clinical patterns of oral mucosal lesions among inpatient and outpatient substance users attending rehabilitation and de-addiction centres in Bangalore.</p><p><strong>Settings and design: </strong>A cross-sectional study was conducted over six months among 195 individuals with a history of substance abuse at Spandana Hospital and Rehabilitation Centre and Ummeed De-addiction and Rehabilitation Centre, Bangalore.</p><p><strong>Methods and materials: </strong>A pre-validated questionnaire (demographics, addiction history, KAP scores) was personally distributed to willing participants at the rehabilitation centres. All participants were clinically examined for the presence of mucosal lesions, discolorations, ulcerations, keratotic patches, and other pathological changes.</p><p><strong>Statistical analysis used: </strong>Statistical analysis was performed using SPSS version 22, with <i>P</i> < 0.05 considered significant.</p><p><strong>Results: </strong>The highest number of users was in the 32-40 years age group (36.4%). Alcohol (44.6%) and alcohol with smokeless tobacco (44.1%) were the most common substances used. Coated geographic glossitis was the most frequent lesion (45.1%), followed by hyperpigmentation (12.3%), oral ulcers (10.8%), and oral submucous fibrosis (9.2%). A statistically significant association (<i>P</i> < 0.05) was found between duration of substance use and lesion type, with potentially malignant disorders (OSMF, leucoplakia, erythroplakia) more common among long-term users (≥15 years).</p><p><strong>Conclusions: </strong>A high burden of oral mucosal lesions many with malignant potential was noted among substance users. Regular oral screening in rehabilitation centres is strongly recommended for early detection and prevention.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarker-based monitoring of orthodontically induced root resorption: Expression of cementum protein-1 in orthodontic patients with and without skeletal anchorage.","authors":"Vincy Antony, Anthony George, Prathapan Parayaruthottam, Syed Mustaq Ahmed","doi":"10.4103/jomfp.jomfp_173_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_173_25","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to estimate and compare changes in the cementum-specific biomarker, Cementum Protein-1 (CEMP-1), in gingival crevicular fluid (GCF) and the severity of orthodontically induced root resorption (OIRR), assessed radiographically, in patients undergoing orthodontic retraction with or without midline mini-implants. A secondary objective was to evaluate the influence of overall treatment duration on the extent of orthodontic root resorption.</p><p><strong>Materials and methods: </strong>This prospective cohort study consisted of 40 patients divided into two groups with equal gender distribution: Group 1 underwent retraction of anterior teeth following first premolar extraction, while Group 2 underwent simultaneous intrusion and retraction using midline mini-implants. GCF samples were collected at T1 (before treatment), T2 (beginning of retraction), T3 (3 months after start of retraction), and T4 (end of treatment). The samples were assayed using ELISA Kits specific for the biomarker. Radiovisiography (RVG) of the anterior maxillary teeth was obtained at T1, T3, and T4 to assess root resorption.</p><p><strong>Results: </strong>At T1, CEMP-1 levels were comparable in the two groups. The biomarker levels increased over time in both groups. At T4, Group 2 had significantly higher biomarker levels compared to Group 1. RVG at T4 revealed a statistically significant increase in grading of root resorption in both groups (<i>P</i> < 0.05) with a higher mean difference in Group 2 (2 ± 0.21).</p><p><strong>Conclusion: </strong>Elevated levels of CEMP-1 in GCF are associated with greater degrees of apical root resorption and are promising noninvasive prognostic biomarkers for monitoring OIRR in orthodontic patients. Moreover, an increase in duration of treatment was found to increase OIRR.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of salivary creatinine and urea as non-invasive biomarkers in chronic kidney disease - A cross-sectional study.","authors":"S Leena Sankari, T Alamelu Mangai, N Aravindha Babu, Krithika Chandrasekaran","doi":"10.4103/jomfp.jomfp_401_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_401_25","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a growing global health challenge characterized by metabolic alterations, particularly elevated serum urea and creatinine levels, requiring repeated blood investigations. Saliva, as a non-invasive and easily accessible bio-fluid, may serve as an alternative to serum for biochemical assessment. This study aimed to compare salivary and serum creatinine and urea levels in CKD patients and to evaluate the diagnostic utility of salivary biomarkers.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 70 participants, 35 patients with chronic renal disease and 35 age and sex-matched healthy controls. Blood and unstimulated saliva samples were collected and centrifuged. Creatinine and urea levels in both serum and saliva were measured with an automated analyser. Group comparisons were performed using Student's <i>t</i>-test. Correlation between serum and salivary parameters was assessed using Spearman's rho correlation. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Serum and salivary creatinine and urea levels were significantly higher in CKD patients compared to controls. A positive correlation was observed between serum and salivary creatinine and urea levels. The area under the ROC curve was 0.702 for salivary creatinine and 0.922 for salivary urea. The optimal cut-off values were 0.45 mg/dl for salivary creatinine and 45 mg/dl for salivary urea with sensitivities of 82.9% and 91.4% and specificities of 45.7% and 65.7%, respectively.</p><p><strong>Conclusion: </strong>Salivary creatinine and urea levels correlate significantly with serum levels in CKD patients. Saliva may serve as a non-invasive alternative for renal function assessment, with salivary urea demonstrating higher diagnostic accuracy.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"110-116"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of miR-760 expression as a potential diagnostic biomarker in oral squamous cell carcinoma: A RT-PCR study.","authors":"Sriram Kaliamoorthy, Jeyakumar Balakrishnan, Suganya Kannan, Ganesan Vinitha, Sreeja Gobu, P Sai Archana","doi":"10.4103/jomfp.jomfp_131_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_131_25","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is an important global health burden and is often diagnosed at an advanced stage. MicroRNAs (miRNAs) are evolving as key regulators of cancer development and progression, with potential roles as diagnostic and prognostic biomarkers. Among them, microRNA-760 (miR-760) has shown tumour-suppressive activity in several cancers; however, its role in oral squamous cell carcinoma remains unclear.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the expression pattern of miRNA-760 in tissues of oral squamous cell carcinoma compared to normal oral mucosa using quantitative real-time polymerase chain reaction (qRT-PCR), and to assess its potential clinical utility as a diagnostic biomarker.</p><p><strong>Methods: </strong>Thirty histologically confirmed oral squamous cell carcinoma tissue samples and 20 healthy oral mucosal tissue samples were analysed. Total ribonucleic acid was extracted from formalin-fixed paraffin-embedded sections, converted to complementary deoxyribonucleic acid (cDNA), and subjected to (qRT-PCR). Small nuclear RNA U6 was used as the internal reference gene. Delta cycle (ΔCt) threshold values were calculated, and relative expression of miR-760 was determined using the method described as 'two to the power of negative delta cycle threshold (2^-ΔΔCt)'. The Mann-Whitney <i>U</i> test was used to compare the two groups statistically.</p><p><strong>Results: </strong>The expression of miR-760 was significantly higher in oral squamous cell carcinoma tissues. The mean (ΔCt) threshold value for the OSCC group was 1.93 ± 4.04, compared to -1.56 ± 5.11 in the healthy control group (<i>P</i> < 0.001). Relative quantification using the (2^-ΔΔCt) cycle threshold method showed a 1.79-fold up-regulation of miR-760 in OSCC tissues. These findings differ from its downregulation in other malignancies and suggest a possible tissue-specific function in oral carcinogenesis.</p><p><strong>Conclusion: </strong>The up-regulation of miR-760 was found in OSCC tissues. This proves that the distinct expression pattern highlights its potential role as a biomarker for early detection. Further studies are needed to explore its biological role and clinical relevance in oral cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of histological artefacts in oral pathology laboratory: A cross-sectional study.","authors":"Priyadharshini Muthumanickam, Deepak Pandiar, Reshma Poothakulath Krishnan","doi":"10.4103/jomfp.jomfp_7_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_7_25","url":null,"abstract":"<p><strong>Background: </strong>Artefacts are tissue alterations on a prepared microscopic slide due to external factors. Artefacts cause morphological and cytological alterations, which lead to misdiagnosis and result during biopsy procedures, particularly fixation artefacts due to inappropriate use/concentration of fixative agents, followed by artefacts during tissue processing, embedding, staining, sectioning, and poor handling of tissues. The present study aims to assess various histological artefacts encountered in our laboratory over four years.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, oral and maxillofacial histological slides prepared by haematoxylin and eosin staining were collected from the archives of our department from 2021 to 2024. A total of 3793 histopathological slides were evaluated. Two oral and maxillofacial pathologists evaluated the histopathological sections for the presence or absence of various artefacts. The results were tabulated in a Microsoft Excel sheet and were analysed descriptively.</p><p><strong>Result: </strong>The most common defect was folds in the sections, accounting for 34% of all samples (1,317 occurrences), with peaks in the years 2022 (363 cases) and 2023 (396 cases). Crush defects followed, noted in 14% of the samples (554 cases), with a notable rise in 2024 (198 cases).</p><p><strong>Conclusion: </strong>The study found that a large percentage of artefacts in histopathological sections were caused by technical or human faults. Folding artefact, which can cause tissues to become deformed and unclear, was reported to occur most frequently.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of inflammatory markers in oral squamous cell carcinoma - A prognostic systematic literature review with emphasis on gingival squamous cell carcinoma.","authors":"Sajid T Hussain, Sunayana Manipal, Nadeem Jeddy, T Radhika, Khadijah Mohideen","doi":"10.4103/jomfp.jomfp_324_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_324_25","url":null,"abstract":"<p><p>Gingival squamous cell carcinoma (GSCC) is a rare subset of oral squamous cell carcinoma (OSCC), often mimicking benign or inflammatory lesions, which complicates early diagnosis. Chronic inflammation plays a pivotal role in oral carcinogenesis, yet its molecular implications in GSCC remain underexplored. This Prognostic Systematic Literature Review (SLR) presents a case-based review of GSCC and evaluates the immunohistochemical expression of key inflammatory markers - COX-2, TNF-α, IL-6, NF-κB, VEGF, iNOS, Bcl-2/Bax ratio, and HDAC6 - in OSCC to assess their diagnostic, prognostic, and therapeutic relevance. Literature search was done (1999-2025) across PubMed, Scopus, Web of Science, Cochrane, and Google Scholar to identify studies on biomarker analysis in histopathologically confirmed cases of OSCC. Data extraction focused on clinical presentation, tumour grade, invasion, metastasis, and survival. Study quality was assessed using NOS and JBI tools. From 1055 screened records,18 studies met inclusion criteria. GSCC is often masqueraded as desquamative gingivitis or periodontal abscess, causing diagnostic delays. Immunohistochemistry revealed frequent overexpression of COX-2, TNF-α, VEGF, and Bcl-2, correlating with tumour aggressiveness, angiogenesis, higher histological grade, and poor prognosis. Temporal trends indicate a shift from apoptotic dysregulation to cytokine-driven inflammatory phenotypes as key drivers of OSCC progression. To Conclude, GSCC requires high clinical vigilance due to its deceptive presentation. Biomarkers such as COX-2, TNF-α, IL-6, NF-κB, and VEGF provide critical prognostic and therapeutic insights, emphasising the role of inflammation in tumour progression and supporting biomarker-guided early detection strategies.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of CDK1 expression in normal mucosa, oral epithelial dysplasia and oral squamous cell carcinoma - An immunohistochemical study.","authors":"J Angeline, Gururaj Narayana Rao, N Sachindharan, G Pradeepa Lakshmi, F Sonalini, V Vigneshwari","doi":"10.4103/jomfp.jomfp_301_25","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_301_25","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) accounts for about 90% of oral malignancies, with a higher occurrence among males than females. Use of molecular biomarkers acts as a reliable predictor of tumour aggressiveness. CDK1 modulates the centrosome cycle and mitotic onset, promoting G2-M transition and regulation of G1-S transition associated with multiple interphase cyclins. Inhibiting CDK1 and its substrates could increase the efficacy of OSCC treatment by overcoming immune or apoptotic resistance.</p><p><strong>Aim: </strong>To compare the immunohistochemical (IHC) expression of CDK1 in normal mucosa (NOM), oral epithelial dysplasia (OED), OSCC, to assess the prognostic value of CDK1 in OSCC and to compare and correlate those three groups.</p><p><strong>Materials and methods: </strong>This study includes 55 cases, which consist of 20 cases of OSCC, 20 cases of OED and 15 cases of NOM, which were retrieved from the archives of our department and were subjected to IHC staining. The Mann-Whitney test was utilised to find out the association among the categorical variables. The Wilcoxon test was used to compare the continuous parameters between three groups.</p><p><strong>Results: </strong>On IHC analysis, CDK1 expression was found to be 80% positive in the OED group, 85% in the OSCC group, and negative in the NOM group. Negative CDK1 expression was seen in NOM.</p><p><strong>Conclusion: </strong>CDK1 can be used as a predictor in the prognosis of OSCC and determine the degree of malignancy at an early stage of OSCC. Targeting CDK1 interacting proteins and their signalling pathways produces less toxicity in treating oral carcinogenesis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"30 1","pages":"74-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}