Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Crystals and crystalloids in oral pathology - An overview.","authors":"S Leena Sankari, Radhika Sridharan","doi":"10.4103/jomfp.jomfp_148_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_148_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"2-4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of blood vessel morphometry in advanced oral submucous fibrosis and malignancy associated with oral submucous fibrosis.","authors":"Tathagata Bhattacharjee, Supratim Ghosh, Dipto De, Pratik Sarkar, Jay Gopal Ray","doi":"10.4103/jomfp.jomfp_89_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_89_24","url":null,"abstract":"<p><strong>Introduction: </strong>Oral submucous fibrosis (OSF) is a potentially malignant disorder of oral cavity. The vascularity of submucosa in this disease can predict its malignant transformation.</p><p><strong>Aim: </strong>In this study, attempts have been made to investigate different parameters of vascularity, such as mean vascular area, luminal diameter etc., in advanced OSF and make a comparison with malignancy associated with OSF.</p><p><strong>Materials and methods: </strong>Incisional biopsy was taken from clinically diagnosed cases of advanced OSF and malignancy associated with OSF. Sections were prepared and stained with haematoxylin and eosin for histomorphometric analysis using a research microscope.</p><p><strong>Results: </strong>A statistically significant increase in mean vascular area and luminal diameter of blood vessels was noticed in malignancy associated with OSF compared to advanced OSF.</p><p><strong>Conclusion: </strong>To support the nutritional demand of carcinogenesis, increased blood supply is required; hence blood supply increased in the form of budding blood vessels or enlarged dilated blood vessels. These changes can be used as a predictive marker for this transformation.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of CD20 in labial minor salivary gland biopsies in Sjogren's syndrome.","authors":"Ayesha Tabassum, Malathi Narasimhan, Thamizhchelvan Hari, Sharada T Rajan, Vijaya Nirmala Subramani","doi":"10.4103/jomfp.jomfp_547_23","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_547_23","url":null,"abstract":"<p><strong>Context: </strong>Sjogren's syndrome (SjS) is an auto-immune disease with a chronic inflammation causing dysfunction of salivary and lacrimal glands, leading to dry eyes and dry mouth. Focal lymphocytic sialadenitis (FLS) and focus score (FS) are significant diagnostic criteria in SjS.</p><p><strong>Aims: </strong>To evaluate the FLS and FS and quantify FS in H&E sections of normal salivary gland, inflammatory conditions, and SjS group.</p><p><strong>Settings and design: </strong>A total of 60 cases were included and divided equally among the groups - SjS, inflammatory conditions, and normal salivary gland.</p><p><strong>Methods and material: </strong>The clinical symptoms, associated disease, and serological tests (ANA, SSA, SSB, RF) were obtained from the records of the patient. Immunohistochemistry (IHC) staining was done (anti-CD20 monoclonal antibody). All the H&E and IHC slides were assessed by independent observers and were taken up for evaluation.</p><p><strong>Results and conclusions: </strong>In H&E sections, FLS and FS were found only in the SjS patients and not in normal and inflammatory conditions. CD20 expression was found to be positive in 55% of SjS cases but negative in the normal and inflammatory groups. FS had been upgraded in IHC CD20 staining. FLS and FSs should be strictly evaluated according to the criteria. It was found only in SjS patients and not in normal and inflammatory conditions. Furthermore, CD20 can be used as an adjunct marker to decide the theranostic and prognostic markers of SjS. The results showed that criteria for scoring FS should be strictly followed and CD20 IHC can be used as a prognostic marker.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of mast cells in dental follicle and dentigerous cyst: A histopathological study.","authors":"Jayaraman Sindhumati, Sanjai Karpagaselvi, Kumaraswamy Jayalakshmi, Papaiah Lokesh, Keshavaiah Roopavathi, Pandey Bhavna","doi":"10.4103/jomfp.jomfp_479_23","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_479_23","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Mast cells are large granular cells that arise from multipotent CD 34+ precursors in the bone marrow normally distributed throughout the connective tissues. Following activation of immunologic or nonimmunologic stimuli, mast cells release secretory granules which give the characteristic metachromatic appearance with toluidine blue stain. Release of numerous mediators on degranulation of mast cells plays an important role in the pathogenesis of odontogenic cysts.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Context: &lt;/strong&gt;Odontogenic cysts, such as dentigerous cysts, arise due to the accumulation of fluid between the crown of an unerupted tooth and the reduced enamel epithelium. Dental follicles, which surround developing teeth, can also undergo cystic transformation. Mast cells activity might contribute to cyst expansion and bone resorption, highlighting their potential role in cystic pathology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;To study the presence of mast cells in the dental follicle and dentigerous cyst. To quantify the mast cells in the abovementioned subjects. To study the pattern of distribution of mast cell distribution in different zones of the study groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Settings and design: &lt;/strong&gt;This was histopathological study conducted at the Department of Oral Pathology and Microbiology, Vydehi College of Dental Sciences and Research Centre, Bengaluru, between 2012 and 2015.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and material: &lt;/strong&gt;Our study was conducted in the Department of Oral Pathology and Microbiology at Vydehi College of Dental Sciences and Research Centre in the year 2012 to 2015. Histopathologically analyzed 30 cases each of dental follicle, and dentigerous cysts were taken and 4-5 micron sections were stained with toluidine blue. Counting of mast cells was done in three different zones which included subepithelial, intermediate, and deep zone. The results were tabulated and statistically analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical analysis used: &lt;/strong&gt;Kruskal-Wallis Chi-squared test.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Both dental follicles and dentigerous cysts showed the presence of mast cells, and highest numbers of mast cells were seen in subepithelial zone followed by intermediate and deep zones. There was statistically significant relation in the number of mast cells in dentigerous cysts and dental follicle along subepithelial and intermediate zone with a &lt;i&gt;P&lt;/i&gt; value of &lt;0.05. In our study, we also found increased mast cell count in inflamed cases of dental follicle and dentigerous cyst compared with noninflamed cases with a &lt;i&gt;P&lt;/i&gt; value of &lt;0.01.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;It is well known that mast cells play a role in the initiation of inflammation, and this inflammatory process may be associated with pericoronal follicle enlargement, a process that could result in cystic transformation of the follicle. Hence, regular radiographic follow-up is necessary especially for teeth with a maximum dental follicle width of 2-3","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling a solitary gingival swelling: A unique case report of clear cell calcifying epithelial odontogenic tumour.","authors":"Latha M Cherian, P C Rasla, M Indu, Sabu Paul","doi":"10.4103/jomfp.jomfp_9_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_9_24","url":null,"abstract":"<p><p>Gingiva is one of the common sites for many reactive, benign and malignant lesions. Localized gingival overgrowths usually present with a wide variety of clinical and histopathological features, and it will create a challenge for proper diagnosis. We report a case of a 48-year-old male patient with a slow-growing swelling on the lower anterior gingiva, extending to the floor of the mouth. A differential diagnosis of pyogenic granuloma or salivary gland neoplasm was considered. The lesion was diagnosed as clear cell variant of calcifying epithelial odontogenic tumour after the histopathological and immunohistochemical evaluation of multiple biopsy specimens from different sites of the lesion. Clear cell variant of calcifying epithelial odontogenic tumour is a very rare, aggressive variant of CEOT which demands proper clinicopathologic and radiographic examination for diagnosis. It also highlights the necessity for multiple biopsies in case of larger gingival lesions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"140-144"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary biomarker profile in rheumatoid arthritis and its interlinkage in oral manifestations: A comprehensive review.","authors":"Anitha K Pandarathodiyil, K Hema Shree, B Sivapathasundharam, Ramya Ramadoss","doi":"10.4103/jomfp.jomfp_23_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_23_24","url":null,"abstract":"<p><p>This study, a collaborative effort that delves into the interlinkage of salivary biomarkers in rheumatoid arthritis (RA), combines literature review with STRING and Cytoscape data. The discovery of elevated matrix metalloproteinases (MMPs) and pro-inflammatory cytokines, such as TNF-<i>α</i>, IL-6, and IL-17 in saliva, and their link to joint and oral tissue damage in RA, is a significant finding. These biomarkers are crucial in understanding RA's inflammatory and destructive processes and oral manifestations. The analysis revealed significant interactions among biomarkers, with IL1B demonstrating strong coexpression with MMP1 and TIMP1, while MMP1 and TIMP1 showed a robust relationship. Cytoscape data further highlighted vital interactions, such as the solid functional relationship between IL2RB and IL2RG and the central role of MMP1 in matrix remodelling. The integration of these data, a result of our collective efforts, provides profound insights into the pathogenesis of RA and its impact on oral health, supporting the development of targeted diagnostic and therapeutic approaches.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 1","pages":"117-126"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the enigma: Navigating extranodal Rosai-Dorfman disease in the maxilla - A teen's journey.","authors":"B Premalatha, K Barath Raj, P D Balamurali, M Arulvizhi","doi":"10.4103/jomfp.jomfp_61_24","DOIUrl":"10.4103/jomfp.jomfp_61_24","url":null,"abstract":"<p><p>Rosai-Dorfman disease (RDD), a rare histiocytic disorder, typically manifests as widespread lymphadenopathy. We present a unique case of extranodal RDD in a 14-year-old with a solitary maxillary lesion and mild bilateral submandibular lymphadenopathy. Clinical, radiological, and histopathological assessments confirmed RDD, highlighting the importance of a comprehensive approach. Immunohistochemistry, including CD68, CD45, CD 1a, and S100, played a crucial role in diagnosis. Differential diagnoses encompassed Langerhans cell histiocytosis, Erdheim-Chester disease, lymphomas, and histiocytic sarcoma, necessitating meticulous evaluation. Surgical excision was performed due to bone involvement, leading to successful healing in six months. Our case underscores the significance of a multidisciplinary and scientific approach for accurate RDD diagnosis and management, especially in atypical intraoral presentations.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"677-682"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical jaw swelling in children: An unusual clinical spectrum of Langerhans cell histiocytosis.","authors":"K Sithara, Usha Balan, Pk Rajeesh Mohammed, Akhila S Stanly","doi":"10.4103/jomfp.jomfp_102_24","DOIUrl":"10.4103/jomfp.jomfp_102_24","url":null,"abstract":"<p><p>Langerhans cell histiocytosis (LCH), also called histiocytosis X or eosinophilic granuloma, is a local or systemic unusual clonal proliferative disorder of Langerhans cells. It has a wide spectrum of clinical presentations and can occur in any age group with predominance in children and young adults. This article presents a rare case of LCH in a 2-year-old girl child which was provisionally diagnosed as an infection of the jaw bone of unknown etiology. Correlating the clinical, radiologic, and histologic features with immunohistochemical analysis aided in arriving at a definitive diagnosis of LCH. Oral manifestations being the earliest presentation seen in around 5%-75% of LCH cases emphasize the role of a dentist in the early detection of this lesion. A myriad of clinical spectra due to pathologic infiltration of Langerhans cells into various systems necessitates oral diagnosis to be followed by a full body scan to detect any systemic involvement. Advanced targeted therapies can improve the survival rate and quality of life in patients with LCH.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"708-712"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effects of Triphala and its constituents in oral squamous cell carcinoma and oral precancer.","authors":"Thayalan Dineshkumar, Nirmala Anandan, Krishnan Rajkumar, Indumathi Nandhakumar","doi":"10.4103/jomfp.jomfp_53_24","DOIUrl":"10.4103/jomfp.jomfp_53_24","url":null,"abstract":"<p><p>Oral squamous cell carcinoma shows increased occurrence in those who consume tobacco products, alcohol, betel quid, and areca nut, and is also considered to occur due to genetic alteration. Though there are numerous advancements in treatment, survival remains a question with late diagnosis. Hence, there are continuous inventions of new drugs. The introduction of Ayurveda in the therapy has paved the way for the longevity of the patients affected. One such introduction is the use of Triphala. The current study aims to review the anti-oxidant, anti-proliferative, anti-microbial, and apoptotic action of Triphala and thus evaluate the anti-cancer action of Triphala. A literature search was done, in various electronic databases and the data were extracted according to the predefined criteria. Original studies of 19 reports were included in the analysis. Nineteen (six studies with Triphala combination) In vitro/In vivo studies were included in this systematic review. The included study showed that Triphala effectively modulates the immune system. The effects included were anti-oxidative, immune modulation, anti-proliferative, tumor suppression, apoptotic effect, reversal of precancerous lesion, and anti-microbial action. The analyses also showed that there is no side effect of Triphala up to the recommended dosage. Triphala, is a nourishing supplement that is well-known in Ayurveda for its capacity to restore healthy tissues and promote aging gracefully through its properties such as anti-oxidant, ant-proliferative, anti-inflammatory, cytotoxic apoptotic, and immune-modulatory properties. Hence, Triphala can be a promising drug in the prevention and treatment of oral cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"657-664"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journey of Oral Pathology in India: Academics to Artificial Intelligence.","authors":"Jagdish V Tupkari","doi":"10.4103/jomfp.jomfp_322_24","DOIUrl":"10.4103/jomfp.jomfp_322_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"532-534"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}