Journal of Oral and Maxillofacial Pathology最新文献_第4页

ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis. ENDOGLIN (CD105)：用于评估口腔黏膜下纤维化恶性潜能的肿瘤血管标志物。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_67_24

Subraj Shetty, Treville Pereira, Sandhya Tamgadge, Sandeep Kale, Pooja Kamat, Sourab Kumar

{"title":"ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis.","authors":"Subraj Shetty, Treville Pereira, Sandhya Tamgadge, Sandeep Kale, Pooja Kamat, Sourab Kumar","doi":"10.4103/jomfp.jomfp_67_24","DOIUrl":"10.4103/jomfp.jomfp_67_24","url":null,"abstract":"Background: Oral submucous fibrosis (OSMF) is a precancerous condition associated with the use of betel/areca nut in various forms. It is characterized by restricted mouth opening, tongue protrusion and cheek rigidity. Oral submucous fibrosis, is primarily prevalent among the people of the Indian subcontinent and it has been reported that about one third of the OSMF patients develop squamous cell carcinoma.Endoglin (CD-105) is a hypoxia induced protein and a potential marker for activated endothelial cells which signify tumorigenic neoangiogenesis.Aim: To determine expression of CD105 and study relation of neoangiogenesis with the clinical staging and histopathological grading of oral submucous fibrosis.Material and method: Immunohistochemical expression of CD105 was evaluated on forty nine (49) paraffin-embedded tissue sections of diagnosed cases of OSF and seven (7) control samples of healthy volunteers.Results: There were 13 cases in Stage A, 11 cases in Stage B, 13 cases in Stage C, and 12 cases in Stage D. There were 4 cases in Grade 1 (Very early), 19 cases in Grade 2 (Early), 19 cases in Grade 3 (Moderately advance) and 7 cases in Grade 4 (Advance).Conclusion: The present study was first immunohistochemical study to demonstrate MVD, MVP and MVAP with CD105 expression in OSMF cases. However, well-designed studies with larger sample size is required to validate CD105 as a reliable biomarker for malignant transformation in future research.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"589-595"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the Editor's desk. 从编辑的桌子上。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_334_24

Radhika M Bavle

引用次数: 0

Gingival exophytic lesions - A proposed diagnostic algorithm to approach the clinical enigma. 牙龈外生性病变-一种提出的诊断算法，以接近临床之谜。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_250_24

Shweta Rehani, Sneha Sethi, Sonia Khorana

引用次数: 0

Potential of phosphatase and tensin gene polymorphisms as salivary biomarkers in oral squamous cell carcinoma - A cross-sectional study. 磷酸酶和紧张素基因多态性作为口腔鳞状细胞癌唾液生物标志物的潜力-一项横断面研究。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_118_24

Bindiya R Narang, Revati S Deshmukh, Sangeeta J Palaskar, Anirudha Bartake, Swati Patil, Priyanka Nitin

{"title":"Potential of phosphatase and tensin gene polymorphisms as salivary biomarkers in oral squamous cell carcinoma - A cross-sectional study.","authors":"Bindiya R Narang, Revati S Deshmukh, Sangeeta J Palaskar, Anirudha Bartake, Swati Patil, Priyanka Nitin","doi":"10.4103/jomfp.jomfp_118_24","DOIUrl":"10.4103/jomfp.jomfp_118_24","url":null,"abstract":"Background: PTEN (phosphatase and tensin homologue) is a tumour suppressor gene which is well known for its negative regulation on phosphatidylinositol 3-kinase (PI3K) pathway, thereby controlling the cellular growth and proliferation in the process of carcinogenesis. In the present study, the frequency of the genotypes of the PTEN gene, (rs2943773, rs1234224, rs9651495, rs3827678, and rs11202600) has been observed in individuals with oral squamous cell carcinoma (OSCC) using real-time polymerase chain reaction (RTPCR).Methodology: Saliva samples were collected from healthy individuals and individuals with OSCC. DNA extraction was done, followed by PCR using fluidigmn technique to observe the frequency of the genotypes.Results: Variation was observed in the distribution of frequencies of the alleles (rs9651495 and rs1234224) of the PTEN gene between the healthy individual and those with occurrence of OSCC. The other genotypes did not show any statistically significant difference in the distribution between the study group and the control group, nor any association was observed with OSCC.Conclusion: The variation in the frequency of rs9651495 and rs1234224 of the PTEN gene suggests an association between the \"PTEN\" gene and \"OSCC\" and hence its use in the panel of diagnostic markers. This also opens the field for future research in the therapeutic applications of the PTEN gene.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"596-601"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spindle cell variant of ameloblastic carcinoma: A diagnostic challenge. 成釉细胞癌的梭形细胞变异：一个诊断挑战。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_272_24

Mamata S Kamat, Uma V Datar, Sanjay S Byakodi, Amit A Basannavar

{"title":"Spindle cell variant of ameloblastic carcinoma: A diagnostic challenge.","authors":"Mamata S Kamat, Uma V Datar, Sanjay S Byakodi, Amit A Basannavar","doi":"10.4103/jomfp.jomfp_272_24","DOIUrl":"10.4103/jomfp.jomfp_272_24","url":null,"abstract":"An 18-year-old male presented with a 3-week history of progressively enlarging nodular growth in the posterior right mandibular region. The patient denied the use of tobacco in any form or history of trauma, and his family history was unremarkable. Clinical examination revealed a 2 × 3 cm reddish-pink, firm lesion with palpable submandibular lymph nodes. Radiological imaging showed a well-defined radiolucency distal to tooth #47. An incisional biopsy revealed the proliferation of spindle cells and ameloblastomatous epithelium showing features like pleomorphism, cellular crowding, and mitotic figures. Immunohistochemical analysis confirmed odontogenic origin. Based on the above findings, the diagnosis of the spindle cell variant of ameloblastic carcinoma (AC) was rendered. AC, constituting less than 2% of odontogenic tumours, and the spindle cell variant, a rare subtype with fewer than 15 reported cases, pose diagnostic challenges, necessitating careful histopathological and immunohistochemical evaluation for accurate diagnosis and treatment planning.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"713-715"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of Fascin-1 with clinicopathological parameters and recurrence in oral squamous cell carcinoma. fasin -1与口腔鳞状细胞癌临床病理参数及复发率的比较评价。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_146_24

Fatema Saify, Minal Chaudhary, Nidhi Tiwari, Shilpa Jain, Sarbani Deb Sikhdar, Meenakshi Sood

{"title":"Comparative evaluation of Fascin-1 with clinicopathological parameters and recurrence in oral squamous cell carcinoma.","authors":"Fatema Saify, Minal Chaudhary, Nidhi Tiwari, Shilpa Jain, Sarbani Deb Sikhdar, Meenakshi Sood","doi":"10.4103/jomfp.jomfp_146_24","DOIUrl":"10.4103/jomfp.jomfp_146_24","url":null,"abstract":"Background: Squamous cell carcinoma is the most common epithelial malignancy of the oral cavity. The 5-year survival rate is approximately 50% and is even lower, that is, 30% in the patients with recurrence of this disease. Because recurrence has a major influence on 5-year survival, it becomes imperative to identify the molecular elements responsible for the recurrence of oral squamous cell carcinoma.Aim: To evaluate the expression of fascin-1 and its correlation with clinicopathological parameters and recurrence in the patients of oral squamous cell carcinoma.Materials and methods: A cohort study was conducted in the Department of Oral Pathology, SPDC, Wardha. A 4 μm thick section from paraffin-embedded blocks of formalin-fixed biopsy tissues of 60 cases having primary oral squamous cell carcinoma was processed and stained with mouse monoclonal fascin-1 (Clone: SPM133) antibodies.Results: In the present study, all cases which had a final score above 2, denotes a strong positive immunostaining of fascin in OSCC. Tumour size was significantly correlated with fascin expression, whereas no significant association was found for other parameters, such as age, gender, node involvement, and grade of the tumour and recurrence.Conclusion: Fascin was found to be significantly correlated with tumour size. Fascin expression was found to be related with recurrence but no significant association exists. As recurrence is directly related to the poor prognosis and survival rate; so, it is essential to identify molecular markers indicative of recurrence. Fascin can be used to identify a subset of oral squamous cell carcinoma patients that are prone to recurrence.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"555-559"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of dermatofibrosarcoma protuberance with myoid differentiation - A rare occurrence. 皮肤纤维肉瘤突出并肌样分化1例-罕见。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_30_24

Nisha Shetty, Swati Sharma, Adarsh Kudva

引用次数: 0

Papillon-Lefevre syndrome: Case series. Papillon-Lefevre综合征：病例系列。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_25_24

Vasumati I Patel, Karan R Thakkar, Shalini S Gupta, Meghna J Pujara

引用次数: 0

Anti-biofilm effect of clove oil against Candida albicans: A systematic review. 丁香油抗白色念珠菌生物膜作用的系统综述。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_225_24

J Palaskar Sangeeta, O Balsaraf Aishwarya, D Balsaraf Omkar, N Bhave Madhura

{"title":"Anti-biofilm effect of clove oil against Candida albicans: A systematic review.","authors":"J Palaskar Sangeeta, O Balsaraf Aishwarya, D Balsaraf Omkar, N Bhave Madhura","doi":"10.4103/jomfp.jomfp_225_24","DOIUrl":"10.4103/jomfp.jomfp_225_24","url":null,"abstract":"In recent years, Candida albicans has emerged as a significant opportunistic pathogen, causing various infections, particularly in immunocompromised geriatric individuals. One of the major hindrances in managing Candida infections lies in its potential to develop and survive in biofilms, which demonstrate resistance to conventional antifungal therapies, thereby complicating treatment strategies. While clove oil has shown promising results as a potential antifungal agent, its specific anti-biofilm effects against Candida albicans biofilms remain relatively underexplored. Therefore, there is a need for a comprehensive review to evaluate the existing literature on the anti-biofilm properties of clove oil and its mechanisms of action against Candida albicans biofilms. Such a review will provide valuable insights into the potential therapeutic applications of clove oil in combating biofilm-associated Candida infections. This review will enable us to infer and understand the potential effects of clove oil against Candida albicans. This systematic review aims to determine the anti-biofilm efficacy of clove oil against Candida albicans. This systematic review was registered in 'PROSPERO' (CRD42024524134) and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The literature searches used Google Scholar, PubMed, and Science Direct databases. All original studies published in English from 2004 to 2023 were included. From 37 studies found online, only four were reviewed. Results showed that clove oil had significant anti-biofilm activity when assessed against Candida albicans. Our systematic review provides insights into clove oil's potential as a therapeutic agent against Candida albicans biofilms. Clove oil also represents a promising avenue for future research and development in managing Candida biofilms.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"665-671"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histomorphometric analysis of lichen planus and lichenoid lesions - Retrospective study. 扁平地衣和类地衣病变的组织形态学分析-回顾性研究。

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-10-01 Epub Date: 2024-12-31 DOI: 10.4103/jomfp.jomfp_29_24

Manti Vijayalakshmi, Bandela Rajasekhar, Vishwaprakash Shetty, Animelli Jacob Prakash, Thokala Madhusudhan Rao, H Aparna Latha

{"title":"Histomorphometric analysis of lichen planus and lichenoid lesions - Retrospective study.","authors":"Manti Vijayalakshmi, Bandela Rajasekhar, Vishwaprakash Shetty, Animelli Jacob Prakash, Thokala Madhusudhan Rao, H Aparna Latha","doi":"10.4103/jomfp.jomfp_29_24","DOIUrl":"10.4103/jomfp.jomfp_29_24","url":null,"abstract":"Introduction: Though it has a different aetiology, lichenoid lesions and lichen planus are both chronic inflammatory mucocutaneous conditions with similar clinical and histological characteristics. Uncertainty persists despite the development of recommendations for distinguishing oral lichen planus from lichenoid diseases.Materials and methodology: A retrospective analysis was conducted on 25 cases of oral lichen planus (OLP), oral lichenoid lesions (OLL), and normal oral mucosa (NOM) that had been histologically diagnosed. Using imagej analysis software, morphometric assessments of the cellular area, nuclear area, nucleus cytoplasmic ratio, nuclear diameter, and cellular diameter of suprabasal cells were performed on sections stained with haematoxylin and eosin. The data were then analysed using ANOVA.Results: Our study's findings demonstrated that, in comparison to the normal oral mucosa, the mean values of the nuclear area, cellular area, nuclear diameter, and cellular diameter in oral lichen planus and oral lichenoid lesions were higher.Conclusion: In the current investigation, we also found that, in comparison to normal mucosa, the nuclear-cytoplasmic ratio was lower in oral lichen planus and oral lichenoid lesions.","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 4","pages":"570-575"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11819632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0