{"title":"碱性磷酸酶和酸性磷酸酶在健康和疾病中的系统综述。","authors":"S Swetha, Gururaj N Rao, V Mahalakshmi, R Sathya","doi":"10.4103/jomfp.jomfp_304_24","DOIUrl":null,"url":null,"abstract":"<p><p>Bone growth and remodelling are the outcomes of osteoblastic and osteoclastic cell activity which may be assessed by the biochemical markers. Alkaline phosphatase (ALP) is a hydrolase enzyme associated with osteoblastic activity, and in contrast, acid phosphatase (AP) is associated with osteoclastic activity and is widely used as a prognostic and diagnostic marker for bone-related lesions. This systematic review aims to analyse the applicability of alkaline phosphatase and acid phosphatase as diagnostic and prognostic markers in various pathological conditions. A systematic review was conducted using PRISMA guidelines. Electronic databases such as PubMed and Cochrane were searched for relevant articles with the keywords ALKALINE PHOSPHATASE and ACID PHOSPHATASE from 1990 to 2023. Studies on alkaline phosphatase and acid phosphatase levels in bone lesions and chronic kidney disease were included. After thorough scrutiny, 55 articles fulfilled our inclusion criteria and exclusion criteria. On tabulating the extracted data, 15% of studies stated that pre-operative serum ALP levels differ in fibro-osseous lesions with fibrous dysplasia having the highest level. 11% of studies used a centrifugal autoanalyser and 10% of studies used colorimetry and ELISA for detecting serum ALP. This systematic review reveals the most widely used method of detection of ALP and AP in pathologic situations and also highlights its diagnostic and prognostic significance.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 2","pages":"324-334"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283044/pdf/","citationCount":"0","resultStr":"{\"title\":\"Alkaline phosphatase and acid phosphatase in health and disease - A systematic review.\",\"authors\":\"S Swetha, Gururaj N Rao, V Mahalakshmi, R Sathya\",\"doi\":\"10.4103/jomfp.jomfp_304_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bone growth and remodelling are the outcomes of osteoblastic and osteoclastic cell activity which may be assessed by the biochemical markers. Alkaline phosphatase (ALP) is a hydrolase enzyme associated with osteoblastic activity, and in contrast, acid phosphatase (AP) is associated with osteoclastic activity and is widely used as a prognostic and diagnostic marker for bone-related lesions. This systematic review aims to analyse the applicability of alkaline phosphatase and acid phosphatase as diagnostic and prognostic markers in various pathological conditions. A systematic review was conducted using PRISMA guidelines. Electronic databases such as PubMed and Cochrane were searched for relevant articles with the keywords ALKALINE PHOSPHATASE and ACID PHOSPHATASE from 1990 to 2023. Studies on alkaline phosphatase and acid phosphatase levels in bone lesions and chronic kidney disease were included. After thorough scrutiny, 55 articles fulfilled our inclusion criteria and exclusion criteria. On tabulating the extracted data, 15% of studies stated that pre-operative serum ALP levels differ in fibro-osseous lesions with fibrous dysplasia having the highest level. 11% of studies used a centrifugal autoanalyser and 10% of studies used colorimetry and ELISA for detecting serum ALP. This systematic review reveals the most widely used method of detection of ALP and AP in pathologic situations and also highlights its diagnostic and prognostic significance.</p>\",\"PeriodicalId\":38846,\"journal\":{\"name\":\"Journal of Oral and Maxillofacial Pathology\",\"volume\":\"29 2\",\"pages\":\"324-334\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283044/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral and Maxillofacial Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jomfp.jomfp_304_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jomfp.jomfp_304_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Alkaline phosphatase and acid phosphatase in health and disease - A systematic review.
Bone growth and remodelling are the outcomes of osteoblastic and osteoclastic cell activity which may be assessed by the biochemical markers. Alkaline phosphatase (ALP) is a hydrolase enzyme associated with osteoblastic activity, and in contrast, acid phosphatase (AP) is associated with osteoclastic activity and is widely used as a prognostic and diagnostic marker for bone-related lesions. This systematic review aims to analyse the applicability of alkaline phosphatase and acid phosphatase as diagnostic and prognostic markers in various pathological conditions. A systematic review was conducted using PRISMA guidelines. Electronic databases such as PubMed and Cochrane were searched for relevant articles with the keywords ALKALINE PHOSPHATASE and ACID PHOSPHATASE from 1990 to 2023. Studies on alkaline phosphatase and acid phosphatase levels in bone lesions and chronic kidney disease were included. After thorough scrutiny, 55 articles fulfilled our inclusion criteria and exclusion criteria. On tabulating the extracted data, 15% of studies stated that pre-operative serum ALP levels differ in fibro-osseous lesions with fibrous dysplasia having the highest level. 11% of studies used a centrifugal autoanalyser and 10% of studies used colorimetry and ELISA for detecting serum ALP. This systematic review reveals the most widely used method of detection of ALP and AP in pathologic situations and also highlights its diagnostic and prognostic significance.
期刊介绍：
The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.
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