Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Vestibular Schwannoma in a paediatric case-A rare entity.","authors":"Jeyaseelan Augustine, Aadithya B Urs, Kuldeep Singh, Sunita Gupta","doi":"10.4103/jomfp.jomfp_489_22","DOIUrl":"10.4103/jomfp.jomfp_489_22","url":null,"abstract":"<p><p>Neurilemmoma, also known as Schwannoma, is a benign, slow-growing, encapsulated neoplasm that arises from Schwann cells of the peripheral nerve sheath. Although it is extremely rare, it affects the head and neck region in roughly 25-45% of all cases. Intraorally, the tongue is the most common site and is rarely involves vestibular mucosa. Here, we report a rare case of Schwannoma of vestibular mucosa in a 13-year-old girl and contribute a review to the current literature. Clinically, based on age, site, and appearance, a diagnosis of a benign tumour such as lipoma, fibroma, neurofibroma, and benign lesions of salivary glands was made. An excisional biopsy showed solely Antoni type A tissue with central acellular eosinophilic Verocay bodies surrounded by spindle-shaped neurilemma cells arranged compactly with wavy, twisted nuclei arranged in a palisaded manner. The patient was recurrence-free after 6 months. Hence, this case is of interest due to its rarity in terms of age, site, and histopathology (Antoni type A neurilemmoma) for a presumed initial diagnosis. Here, we also hypothesize regarding the type of growth pattern in the earlier diagnosed cases.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"297-300"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>in vitro</i> anti-cancer potential and apoptotic profile of ethanolic plant extract of <i>Wrightia tinctoria</i> against oral cancer cell line.","authors":"Magesh Karuppur Thiagarajan, Deepak Chandrasekharan, Ramya Mahalingam, Aravindhan Ravi","doi":"10.4103/jomfp.jomfp_32_24","DOIUrl":"10.4103/jomfp.jomfp_32_24","url":null,"abstract":"<p><strong>Background: </strong>For decades, <i>Wrightia tinctoria</i> (<i>W. tinctoria</i>) has been important in the field of traditional medicine. The identification and isolation of numerous chemically potent and pharmaceutically advantageous phytochemicals isolated from this plant extract has contributed to its resurrection into evidence-based modern medicine. This plant is inexpensive and indigenous to the Indian subcontinent.</p><p><strong>Materials and method: </strong>An <i>in vitro</i> study was carried out using KB (KERATIN-forming tumour cell line HeLa) oral cancer cell line. The control drug doxorubicin along with the test drug <i>W. tinctoria</i> was tested for anti-cancer potential by using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay and for apoptotic activity by using DNA fragmentation assay and western blotting assay.</p><p><strong>Results: </strong>The study was conducted using MTT assay to determine the cytotoxicity of plant extract against oral cancer cell line by determining the IC50 values at the end of 24 hours by the MTT calorimetric assay. The IC50 value of 48.89 and 9.62 was arrived for the <i>W. tinctoria</i> extract and doxorubicin, respectively, by using MTT calorimetric assay. DNA fragmentation assay showed a ladder pattern when treated with 59 μg/mL extract of <i>W. tinctoria</i>, and western blot analysis revealed the presence of cleaved caspase 3, confirming the apoptotic potential of the extract.</p><p><strong>Conclusion: </strong>The current study demonstrated that the plant extract has effective anti-cancer and apoptotic potential and can be used as a natural source for the production of new anti-cancer and cytotoxic agents against oral cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"211-215"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoexpression of CD44, p16 and VEGF in oral cancer.","authors":"Priscila Marinho de Abreu, Marcella Sol, Patrícia Roccon Bianchi Molini, Camila Batista Daniel, Danielle Resende Camisasca, Sandra Ventorin von Zeidler","doi":"10.4103/jomfp.jomfp_195_23","DOIUrl":"10.4103/jomfp.jomfp_195_23","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to examine the immunoexpression of CD44, p16 and VEGF in oral squamous cell carcinoma (OSCC) and correlate them to clinicopathological parameters and survival outcomes in order to clarify their prognostic impact.</p><p><strong>Material and methods: </strong>A total of 68 individuals with OSCC recruited between 2011 and 2015 from two referral centres were enrolled in the study. The samples were placed on silanized glass slides and subjected to immunohistochemistry using anti-p16, anti-CD44 and anti-VEGF antibodies. The H Score was used for p16 and VEGF, while CD44 was scored according to the percentage of stained cells. Chi-square tests and Fisher's exact probability tests were used to compare clinicopathological characteristics according to the immunohistochemical expression, while overall survival and disease-free survival were estimated and compared using the Kaplan-Meier method and log-rank test, respectively. For all hypothesis tests, the level of significance was set at <i>P</i> ≤ 0.05.</p><p><strong>Results: </strong>No correlation was observed between the expression of tumour VEGF, p16 and CD44, and the clinicopathological characteristics analysed. Patients with high stromal VEGF expression had better disease-free survival than patients with low VEGF expression (<i>P</i> = 0.023).</p><p><strong>Conclusion: </strong>In summary, P16, CD44 and tumour VEGF did not prove to be good prognostic biomarkers. Stromal VEGF expression is suggested to be a good candidate prognostic biomarker, although additional studies are needed.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"253-260"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical analysis of p53 and p63 in selected odontogenic cysts and tumours.","authors":"Anirudha R Bartake, Sachin Sarode, Rekha Krishnapillai, Gargi Sarode, Bindiya Narang, Kaveri Hallikeri","doi":"10.4103/jomfp.jomfp_417_23","DOIUrl":"10.4103/jomfp.jomfp_417_23","url":null,"abstract":"<p><strong>Background: </strong>It is a well-recognized fact that abnormal cell proliferation plays a crucial role in the development of odontogenic lesions. p53 is a tumour-suppressor gene which assists in cell cycle regulation and p63 is a homolog of p53 responsible for ectodermal differentiation and maintenance of stratified epithelial progenitor-cell. Analysing the tissue expression of p53 and p63 in odontogenic lesions may provide us with an insight into their potential role in the development of these lesions.</p><p><strong>Objective: </strong>The objective is to study the expression of p53 and p63 in selected odontogenic lesions using immunohistochemistry.</p><p><strong>Materials and methods: </strong>Formalin-fixed paraffin-embedded tissues of 15 ameloblastomas, 10 adenomatoid odontogenic tumours (AOT), 15 odontogenic keratocysts (OKCs), 10 dentigerous cysts (DCs) along with 10 cases of normal mucosa were retrieved from the departmental archives. These specimens were then subjected to immunohistochemical staining using p53 and p63 oncoproteins.</p><p><strong>Results: </strong>p53 and p63 immune-expression showed mainly intranuclear localization. The mean positivity of p53 in ameloblastoma (59.45%) and OKC (26.38%) was significantly higher than AOT (6.77%) and DC (4%). In contrast, there was no significant difference in the positivity of p63 in between ameloblastoma (77.55%), AOT (69.50%), OKC (76.47%), and DC (50.69%).</p><p><strong>Conclusion: </strong>p53 expression can be correlated with the clinical behaviour of the odontogenic lesions and it can be used as a prognostic marker in odontogenic cysts and tumours. In contrast, p63 expression does not corelate with the biological behaviour of odontogenic lesions.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"186-191"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-based immunosensors for enhanced DNA analysis in oral cancer: A systematic review.","authors":"Neha Gupta, Ankur Bhargava, Sonal Saigal, Vini Mehta","doi":"10.4103/jomfp.jomfp_345_23","DOIUrl":"10.4103/jomfp.jomfp_345_23","url":null,"abstract":"<p><p>To investigate the diagnostic and therapeutic potential of nanoparticle (NP)-based immunosensors in the field of oral cancer. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases were explored for NP applications in oral cancer. Data extraction in terms and quality assessment of all the articles were done. Out of 147, 17 articles were included in this review. A majority of the studies showed improved sensitivity and specificity for saliva analysis using an enzyme-linked immunosorbent assay based on gold NPs, improving early identification. Additionally, novel therapeutic approaches, utilising NP-based immunosensors, demonstrated targeted drug delivery, coupled chemo-photothermal therapy, and gene silencing. Imaging methods have made it possible to distinguish between malignant and healthy states, such as surface-enhanced Raman scattering and optical coherence tomography. The reviews' findings highlight the transformational potential of NP-based immunosensors in addressing the difficulties associated with diagnosing and treating oral cancer. However, for an accurate interpretation and application of NP-based solutions in clinical practise, it is essential to be thoroughly aware of the intricacies involved, and the synthesised data in this review support the continued investigation and improvement of NP-based therapies in the ongoing effort to improve the management of oral cancer.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"284-292"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antioxidant activity in saliva among young adults having diverging food habits and its relation to oral health: A pilot study.","authors":"Kangan Manjunathan, Mrinalini Menon, Radhika Manoj Bavle, Soumya Makarla, Reshma Venugopal, Ann Jisa Santo","doi":"10.4103/jomfp.jomfp_83_24","DOIUrl":"10.4103/jomfp.jomfp_83_24","url":null,"abstract":"<p><strong>Introduction: </strong>Saliva enables the maintenance of oral and systemic health. Evaluation of saliva is very valuable for multiple parameters to be evaluated as they are easy to collect, allow easy and safe sample collection, are non-traumatic, can be repeated with ease, and are non-invasive in nature. Salivary enzyme systems have antimicrobial, antioxidant, and similar functions which aid in the maintenance of homeostasis in the oral cavity. Antioxidants scavenge free radicals from cells and prevent or reduce the damage caused by oxidation.</p><p><strong>Materials and methods: </strong>In the present study, the pH and antioxidant capacity of the saliva were evaluated. Subjects were categorized as GROUP A: Vegetarians: Diets were entirely devoid of eggs or meat of any type (for more than 20 years). GROUP B: Non-vegetarians: Diets included both red and white meat, consumed either daily or frequently. GROUP C: Eggetarians: Otherwise vegetarian diets which includes eggs, consumed frequently. Ten samples of each group were collected. The pH profile and antioxidant activity of the samples were analysed. Each of the individuals was subjected to oral examination for grading of the status of oral hygiene, caries teeth, missing and extracted teeth, and the health of gingiva. For the same Oral Hygiene Index Simplified (OHIS), Decayed, Missing, and Filled Teeth (DMFT) and Gingival Status indices were used and the observations were noted.</p><p><strong>Observations and results: </strong>The average salivary pH for the vegetarians was 7 ± 0.5, that for eggetarians was 7.1 ± 0.5, and in the non-vegetarian group, the average pH was equal to 7.3 ± 0.5. Using the DPPH method, the percentage antioxidant activity of saliva in vegetarians was 20.9 ± 2.1%, while those of eggetarians and non-vegetarians were equal to 5 ± 0.6% and 11.4 ± 2%, respectively. Each individual was subjected to oral examination for grading of the status of oral hygiene (OHIS); decayed, missing, extracted teeth, filled teeth index (DMFT); and the health of gingiva (gingival status index). Overall, eggetarians had a high OHIS index (mean 1.08). The DMFT index was high in non-vegetarians with values ranging from 1 to 8. Statistical analysis using the T-test revealed that the antioxidant potential of the vegetarian group was significantly higher than those of the eggetarian and non-vegetarian dietary groups (<i>P</i> < 0.001). However, the eggetarian and non-vegetarian dietary groups did not significantly differ from each other with respect to this parameter.</p><p><strong>Conclusion: </strong>The antioxidant capacity is markedly high in vegetarians, 20.9+/- 2.1%, as compared to non-vegetarians, 11.4+/- 2.1%, and was the lowest in eggetarians, 5+/- 0.6%.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"226-231"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An enigmatic combined tumour of oral malignant melanoma and oral squamous cell carcinoma - A rare case report.","authors":"S Renuga, N S Sahana, G Suganya, Meghashyama Kulkarni","doi":"10.4103/jomfp.jomfp_330_22","DOIUrl":"10.4103/jomfp.jomfp_330_22","url":null,"abstract":"<p><p>Combined tumours are those composed of two benign tumours or a benign and malignant tumour or two malignant tumours occurring within the same tumour population. The incidence of combined tumours is very rare. Due to the rarity of these tumours, their biological behaviour remains unlashed. Incisional biopsy of a 48 years old female patient with single, diffuse tumour mass in the oral cavity showed combined tumour or collision tumour of malignant melanoma and squamous cell carcinoma. This was confirmed with immunohistochemistry study. The incidence of combined tumour of malignant melanoma and squamous cell carcinoma in oral cavity is extremely rare. To the best of our knowledge based on the previous literature records, this is the first case report of its kind where there is incidence in the human oral cavity.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"343-346"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamous odontogenic tumour-like proliferation in a maxillary dentigerous cyst - An unusual finding.","authors":"Ngairangbam Sanjeeta, Brajbushan Mall, Sumita Banerjee, Praveen B Reddy","doi":"10.4103/jomfp.jomfp_51_24","DOIUrl":"10.4103/jomfp.jomfp_51_24","url":null,"abstract":"<p><p>Squamous odontogenic tumour-like proliferations (SOTLPs) in the wall of odontogenic cysts are rare occurrences. Due to the histopathological similarity of these proliferations to neoplasms, such as squamous odontogenic tumour, intraosseous well-differentiated squamous cell carcinoma, and acanthomatous ameloblastoma, their correct elucidation is of paramount importance to avoid unnecessary and unwanted treatment. SOTLPs are uncommon in dentigerous cysts and rare in those that occur in the maxilla particularly the anterior region. This paper presents a case of maxillary dentigerous cyst involving 33 and a mesiodens in a 32 year old male which on histopathological examination showed SOTLPs in a dentigerous cyst.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"307-310"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular expression of Forkhead Box C2 gene (FOXC2) and Prospero homeobox gene (PROX-1) in oral squamous carcinoma and their correlation with clinicopathological parameters: A prospective cohort study.","authors":"Georgia Benitha, Pratibha Ramani, Selvaraj Jayakumar, Karthikeyan Ramalingam","doi":"10.4103/jomfp.jomfp_394_23","DOIUrl":"10.4103/jomfp.jomfp_394_23","url":null,"abstract":"<p><strong>Background: </strong>Forkhead box C2 gene (FOXC2) acts as an epithelial-mesenchymal transition (EMT) inducer while Prospero homeobox 1 gene (PROX-1) function as a regulator of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma (OSCC). It is presumed that PROX-1 has both tumour-suppressive and oncogenic effects. The main aim of this study is to evaluate the role of PROX-1 and FOXC2 in the invasion and progression of OSCC cases and to correlate their expression with various histopathological parameters.</p><p><strong>Materials and methods: </strong>A prospective cohort study was conducted in a total sample size of 52 OSCC tissues and histologically tumour-free margins of 20. mRNA expression and protein levels of FOXC2 and PROX-1 were evaluated using real-time PCR and sandwich enzyme-linked immunosorbent assay techniques. Chi-square analysis and correlation analysis were done. Kaplan-Meier analysis evaluated the survival rate.</p><p><strong>Results: </strong>Mean Ct values of FOXC2 were 1.915 ± 0.519 and PROX-1 was 0.061 ± 0.173. There was a significant 2-fold increase in the FOXC2 expression and a 0.5-fold decrease in the PROX-1 expression in OSCC tissue. Increased levels of FOXC2 protein and decreased levels of PROX-1 with a mean difference of 1.64 ± 0.73 ng/ml and 1.27 ± 0.33 ng/ml were observed in OSCC compared to histologically tumour-free margins. A significant positive correlation was found between the FOXC2 expression and clinicopathological parameters such as staging, perineural invasion (PNI) and lymphovascular invasion (LVI) whereas PROX-1 showed a significant negative correlation with histopathological parameters such as staging, PNI, LVI and tumour staging. There was a significant positive correlation between the PROX-1 and histologically tumour-free margins in disease-free survival patients (<i>P</i>-value = 0.03).</p><p><strong>Conclusion: </strong>FOXC2 and PROX-1 expressions were correlated with lymphovascular invasion, OSCC tumour staging and PNI. Thus, FOXC2 and PROX-1 could be possible therapeutic targets in the treatment of OSCC that can inhibit the EMT in OSCC and thereby favouring a better prognosis.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"216-225"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral squamous cell carcinoma: A 26 years institutional cross-sectional study.","authors":"Dipak D Ghatage, Ashwini G Kendre, Devendra H Palve, Akshay Dhobley, Divya Ghodichor, Akhil Lakawath","doi":"10.4103/jomfp.jomfp_38_24","DOIUrl":"10.4103/jomfp.jomfp_38_24","url":null,"abstract":"<p><strong>Context: </strong>The variance in the prevalence of oral squamous cell carcinoma (OSCC) around the world has been associated with a number of sociocultural traits, significant regional variations in risk factors, variations in data gathering, and the degree of health service development in different populations. Here, we undertake a 26 years institutional review and analysis of OSCC cases.</p><p><strong>Aim: </strong>To evaluate and analyse 26 years Institutional Data of OSCC.</p><p><strong>Settings and design: </strong>Department of Oral and Maxillofacial Pathology's archives, Government Dental College and Hospital, Nagpur, Maharashtra, and observational cross-sectional study.</p><p><strong>Methods and material: </strong>This study examines instances of OSCC that were histologically diagnosed between 1997 and 2022. All information pertaining to cases of OSCC was obtained from the departmental archives.</p><p><strong>Statistical analysis used: </strong>Data tabulated and then subjected to descriptive statistical analysis with the SPSS statistical software.</p><p><strong>Results: </strong>The total number of the patients included 1508 (69.6%) males and 660 (30.4%) females, whose age ranged from the second decade to the tenth decade of life with a mean age of 55.5 years with a range of 20-91 years. The incidence was the highest in the fifth and sixth decades (<i>n</i> = 603, 27.8% and <i>n</i> = 572, 26.4%), respectively. The left buccal mucosa recorded the maximum number of cases (left buccal mucosa 559, 25.8%). There were 1405 (64.8%) cases of well-differentiated SCC, 301 (13.9%) cases of moderately differentiated SCC, and 51 (2.4%) cases of poorly differentiated SCC.</p><p><strong>Conclusions: </strong>The overall incidence and prevalence of OSCC can be estimated using baseline epidemiological data from our institution.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 2","pages":"240-246"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}