Journal of Oral and Maxillofacial Pathology最新文献

{"title":"Mutational analysis of BRAFV600E in a case of sialadenoma papilliferum of oral cavity.","authors":"Kiran Jot, Reddipalli Sharath, Ongkila Bhutia, Varun Surya","doi":"10.4103/jomfp.jomfp_72_24","DOIUrl":"10.4103/jomfp.jomfp_72_24","url":null,"abstract":"<p><p>This case report presents a rare benign salivary gland tumour called sialadenoma papilliferum. It comprises 3 to 5% of head and neck tumours and about 1% of all minor salivary gland tumours. The focus is on discussing the BRAFV600E mutation analysis and exploring its clinical implications, along with delving into the histopathological differentials. We documented a 73-year-old male, who had a white patch in the left retromolar trigone region for 6 months. The tumour was excised with a clinical diagnosis of verrucous lesion. Microscopic examination revealed exophytic hyperplastic parakeratotic stratified squamous epithelium and endophytic ductal papillary proliferation. The BRAFV600E mutation was present in the patient. Subsequent regular follow-ups were conducted, revealing no recurrence of the condition. This case underscores the pivotal role of BRAFV600E analysis as an invaluable diagnostic tool when confronted with the intricacies of intraoral salivary gland neoplasms.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"488-492"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oral cancer site with addiction and sociodemographic characteristics: A cross-sectional study conducted at a tertiary health centre.","authors":"Praful Maroti Hulke, Jalindhar Pandurang Baravakar, Vinod Genu Bagade, Alka Modi Asati, Sonali Tripathi","doi":"10.4103/jomfp.jomfp_62_24","DOIUrl":"10.4103/jomfp.jomfp_62_24","url":null,"abstract":"<p><strong>Introduction: </strong>In contemporary epidemic scenarios, oral cancer ranks the top 3 cancer types afflicting the Indian population. The primary risk factors include alcohol consumption, tobacco usage in various forms, such as cigarettes and smokeless tobacco, betelnut chewing, and infection with the human papillomavirus. This article submitted in preprint in medRxiv on 20 February 2024.</p><p><strong>Materials and methods: </strong>This study, conducted at a tertiary healthcare center, adopted a hospital-based cross-sectional approach involving 233 oral cancer patients who sought medical care from January 1 to December 31, 2017.</p><p><strong>Results: </strong>The findings indicate that males above the age of 60 (40.11%) and females aged between 41 and 50 years (45.45%) were the most affected groups. A statistically significant association (<i>P</i> < 0.05) was found. The primary sites for oral cancer were the cheek (40.36%) and tongue (31.78%). Remarkably, the majority of male patients exhibited a combination of addictions, including tobacco chewing, smoking, and alcohol use, whereas most female patients were exclusively involved in tobacco chewing.</p><p><strong>Conclusion: </strong>To curb the increasing prevalence of oral cancer in India, it is imperative to implement comprehensive public education initiatives and health promotion strategies aimed at reducing both smoking and alcohol consumption.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"422-427"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of an aggressive polymorphous adenocarcinoma of minor salivary gland in the retro-maxilla.","authors":"Mehul Saha, Adarsh Kudva, Swati Sharma, Radhika Singh","doi":"10.4103/jomfp.jomfp_13_24","DOIUrl":"10.4103/jomfp.jomfp_13_24","url":null,"abstract":"<p><p>Polymorphous adenocarcinoma (PAC) is a low-grade malignant tumour of minor salivary glands of the oral cavity, which rarely presents with invasive features. Low metastatic and excellent survival rates are some of its favorable features. A 36-year-old woman reported with swelling, pain, and mobility of teeth in the left upper inner cheek region. Contrast enhanced computed tomography (CECT) revealed a large, lobulated, heterogenous mass in the left retro-maxillary region with a few enlarged left cervical lymph nodes (levels IB and II). After surgery, the final histopathology report gave a definitive diagnosis of PAC with certain invasive characteristics - perineural invasion, infiltration into skeletal muscle, and depth of invasion of 10 mm, which recurred in a different location 1.5 years later. A few predictable features of PAC include incidence in elderly women, asymptomatic presentation, occurrence in the posterior hard of soft palate, very low incidence of nodal or distant metastases, perineural spread, skeletal muscle infiltration, and low rates of recurrence with good survival outcomes. However, in our case, the patient appeared to present with a relatively aggressive form of PAC, considering her young age, symptomatic presentation, uncommon anatomic location in the retro-maxilla, cervical nodal metastasis, perineural and skeletal muscle infiltration, and local recurrence within a short period. Although PAC is a low-grade tumour with excellent prognosis, it may occasionally present with invasive characteristics, and early diagnosis and prompt management with strict adherence to post-operative regimens and follow-up is of prime importance to prevent any untoward outcomes.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"478-482"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUCORMYCOSIS: Re-emerging opportunistic fungal infections in COVID-19 pandemic times in Indian patients (South Indian) - A series of seven cases.","authors":"Satyajit S Topajiche, Prasoon S Babu, Balasubramanya Kumar, L Phani Raghava","doi":"10.4103/jomfp.jomfp_236_24","DOIUrl":"10.4103/jomfp.jomfp_236_24","url":null,"abstract":"<p><p>Opportunistic fungal infections are associated with patients having compromised systemic health. In India, a slow rise in cases of mucormycosis has been observed as the country has seen a rising number of diabetes mellitus cases in the recent decades. This apart, an enormous increase in case numbers was seen in association with COVID-19 infections in the Asian subcontinent, Southeast Asia, markedly in India. Many cases of mucormycosis were reported in association with COVID-19 positive history and post-treatment for COVID-19. They were presented in the form of rhino-cerebral-mucormycosis, in patients with and without diabetes. The presentation of the disease differed at different times of the pandemic to some extent. Some of the cases initially came in an acute format, but at the later end of the epidemic, they presented in an indolent form. A compilation of cases is provided to illustrate the variation in presentations and findings of mucormycosis cases diagnosed at different times of infection of the COVID-19 waves.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"497-505"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation therapy: Ushering in a new era in personalized supportive cancer care.","authors":"Ridham Varsani, Moiz Khan, Pranavi Nannuri, Praveen R Arany","doi":"10.4103/jomfp.jomfp_193_24","DOIUrl":"10.4103/jomfp.jomfp_193_24","url":null,"abstract":"<p><p>The human body can utilize light for a broad range of pathophysiological responses, such as circadian rhythm, Vitamin D metabolism, and vision, among others. The therapeutic use of light has spanned many ancient health practices. Recent advances in using low-dose light therapy, termed photobiomodulation (PBM), have made tremendous progress in unravelling precise biological mechanisms and clinical dosimetry, enabling this treatment modality's clinical safety and effectiveness. The evidence for PBM has received its strongest endorsement via recent systematic reviews and meta-analyses recommending its routine use to address various acute and chronic side effects associated with cancer treatment. Carefully done studies have noted unequivocal evidence demonstrating its effectiveness in managing oral mucositis in patients undergoing radiotherapy for head and neck cancer, chemotherapy, or hematopoietic stem cell transplantation. This brief narrative review will explore the therapeutic benefits of PBM therapy, supported by recent research findings, to provide a comprehensive understanding of its potential in clinical settings. Additionally, the review will highlight our current understanding of molecular mechanisms underlying PBM and the importance of novel harmonized dosing that enables its optimal clinical implementation and utilization.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"362-367"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agenesis of all premolars - the first reported case.","authors":"Paul Chalakkal, Vernon Pires, Ramya Ramanathan, Nidhi Rangnekar","doi":"10.4103/jomfp.jomfp_396_23","DOIUrl":"10.4103/jomfp.jomfp_396_23","url":null,"abstract":"<p><p>The agenesis of teeth is the most common developmental anomaly in humans. Although third molars, mandibular second premolars, maxillary lateral incisors and maxillary second premolars are frequently found to be missing, the absence of all premolars has never been reported in the literature. This case report highlights the first-ever case of the complete agenesis of premolars in a 10-year-old male patient. It also discusses related definitions; commonly missing teeth and their prevalence; associated dental and skeletal features; genetic, drug-related and pathogenic etiological factors; and considerations for the future management of such cases.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"526-528"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antifungal efficacy of albedo extract of <i>Punica granatum</i> on <i>Candida albicans</i> - An <i>in vitro</i> study.","authors":"Vatsalya Kommalapati, N Govind Rajkumar, Roja Lakshmi Karri, Sahana Ashok, A Sudarshan Kumar, D Srilakshmi","doi":"10.4103/jomfp.jomfp_301_23","DOIUrl":"10.4103/jomfp.jomfp_301_23","url":null,"abstract":"<p><strong>Introduction: </strong>The study aims to investigate the antifungal efficacy of albedo extract of Punica grantum on candida albicans by evaluating the inhibitory capacity of alcoholic albedo extracts by disc diffusion method and by comparing the antifungal efficacy of alcoholic extract of albedo with clotrimazole and ethanol.</p><p><strong>Methods: </strong>Using a conventional disc diffusion method, the effectiveness of Punica Granatum albedo extract against Candida albicans was assessed and evaluated depending on the presence or absence of inhibition zones, as well as the average diameter of inhibition zones. Albedo extract of Punica granatum serial dilutions were prepared ranging from 1%, 5%, 10%, 15%, 20% and 25% and its antifungal efficacy was tested against Candida albicans in comparison with clotrimazole and ethanol.</p><p><strong>Results: </strong>When compared to clotrimazole, the albedo extract of punica granatum showed significant anticandidal activity. The mean zone of inhibition of extract was recorded at 27.6 mm whereas clotrimazole was 21.6 mm and no zone of inhibition was recorded for ethanol. Statistically significant p value 0.015 was recorded within the different dilutions of albedo extract of Punica grantum which is less than 0.05.</p><p><strong>Conclusion: </strong>The present investigation found that Punica Granatum albedo extract had greater potent antifungal activity when compared to clotrimazole and ethanol.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"369-373"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and oral potentially malignant disorders - A comparative cross-sectional South Indian study.","authors":"Venkata Naga Sirisha Chundru, R Nirmal Madhavan, Lalitha Chintala, Ramanarayana Boyapati, Meka Srikar","doi":"10.4103/jomfp.jomfp_122_24","DOIUrl":"10.4103/jomfp.jomfp_122_24","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of oral malignancies and represents a major global health care problem. It is often preceded by oral potentially malignant disorders (OPMD). Although regular clinical examination forms the backbone for oral cancer screening, subtle lesions go unnoticed and there is a need for more sensitive and specific molecular biomarkers in mass screening of population. Salivary proteomics offer an attractive alternative to serum and tissue testing.</p><p><strong>Aims: </strong>To find the diagnostic utility of salivary interleukin-6 (IL-6) in the differential diagnosis of OSCC, OPMD from healthy controls.</p><p><strong>Study design: </strong><i>In vivo</i> study.</p><p><strong>Methods: </strong>After approval from the Institutional Review Board, unstimulated whole saliva was collected from 90 subjects, 30 in each group of OSCC, OPMD and controls after ethical clearance. Salivary IL-6 was measured by ELISA, and the results were statistically analysed.</p><p><strong>Results: </strong>Significant difference in salivary IL-6 was seen between OSCC, OPMD and controls. Receiver operating characteristic curve analysis showed the highest area under a curve of 0.982 in distinguishing OSCC from controls. It showed a sensitivity of 71% and specificity of 100% at a cut-off value of 33.4 pg/mL (<i>P</i> = 0.000). Moderately differentiated OSCC (MDSCC) showed a significant increase in salivary IL-6 concentration compared to well-differentiated OSCC (WDSCC).</p><p><strong>Conclusion: </strong>Results of the present study showed strong predictive power of salivary IL-6 in distinguishing OSCC from controls. Its levels also increased with tumor aggressiveness from WDSCC to MDSCC. Thus, salivary IL-6 could have a diagnostic and/or prognostic significance in identifying high-risk groups in mass screening of the population.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"387-392"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large cell neuroendocrine carcinoma of oral cavity: A rare case report with review of literature.","authors":"Anurag Singh, Gulshan Kumar, Uma S Singh, Mala Sagar","doi":"10.4103/jomfp.jomfp_522_23","DOIUrl":"10.4103/jomfp.jomfp_522_23","url":null,"abstract":"<p><p>Neuroendocrine tumours (NETs) primarily affect the lungs and larynx. Primary neuroendocrine carcinomas (NECs) rarely occur in the oral cavity. The classification of these tumours is ambiguous; however, the literature acknowledges their aggressiveness. Merkel cell carcinoma (MCC) is rare and more common in the skin but could occur intraorally. MCC and NECs are aggressive neoplasms and recommend intensive treatment. In this case report, a 22-year-old female presented with an ulceroinfiltrative lesion in the left buccal mucosa of the cheek, which was diagnosed as primary NEC in the oral cavity. This patient underwent wide local lesion excision of oral cavity mass, ipsilateral selective neck node dissection of levels 1-4 and postoperative chemotherapy. This aggressive tumour type requires large local excisions with margins like Merkel cell skin carcinomas. To our knowledge, this is the youngest oral cavity primary neuroendocrine cancer patient to date in the literature.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"474-477"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Pathologists: Following the Dinosaurs.","authors":"Vijay Wadhwan","doi":"10.4103/jomfp.jomfp_189_24","DOIUrl":"https://doi.org/10.4103/jomfp.jomfp_189_24","url":null,"abstract":"","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"28 3","pages":"359-360"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}