Journal of Herbs, Spices and Medicinal Plants最新文献_第9页

In Vivo Antioxidant, anti-Inflammatory and anti-Hyperglycemic Effects of Salvia Splendens Aerial Parts in Male Albino Rat Models 丹参离体部位在雄性白化大鼠体内的抗氧化、抗炎和抗高血糖作用

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI: 10.1080/10496475.2021.1891173

S. E. El Sawi, A. Sleem, Rana M. Merghany

引用次数: 0

Antioxidant and Anti-proliferative Activities of Smilax Zeylanica Root and Rhizome Extract against Liver Carcinoma Cells 泽兰根和根茎提取物对肝癌细胞的抗氧化和抗增殖活性

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI: 10.1080/10496475.2021.1891178

N. Malge, A.M.P.W. Bandara, W. Keerthirathna, D. Dissanayake, Patharage Kamal Perera, C. Witharana, L. Peiris

{"title":"Antioxidant and Anti-proliferative Activities of Smilax Zeylanica Root and Rhizome Extract against Liver Carcinoma Cells","authors":"N. Malge, A.M.P.W. Bandara, W. Keerthirathna, D. Dissanayake, Patharage Kamal Perera, C. Witharana, L. Peiris","doi":"10.1080/10496475.2021.1891178","DOIUrl":"https://doi.org/10.1080/10496475.2021.1891178","url":null,"abstract":"ABSTRACT The antioxidant, cytotoxic, and anti-cancer potential of aqueous root and rhizome extract (ARRE) of Smilax zeylanica was investigated against human liver carcinoma cells. The phytochemical composition was evaluated by standard methods, and confirmed by thin-layer chromatography. Free radical scavenging activity was determined by DPPH assay, cytotoxic activity by brine shrimp lethality assay, and anti-cancer potential was investigated using liver carcinoma HepG2 cells. Phytochemical analysis revealed the presence of saponins, flavonoids, proanthocyanins, tannins, and polyphenols. The total phenolic and flavonoid content varied from 0.28 to 5.26 mg gallic acid equivalent 100 mg−1 and 0.25–50.26 quercetin equivalent 100 mg−1, respectively. There was a linear relationship between the free radical scavenging activity and phytochemical concentrations with an IC50 value of 108 ± 1.2 µg mL−1 compared to the standard (IC50: 2.59 ± 0.02 µg mL−1). The brine shrimp lethality assay showed strong cell killing ability (IC50: 84 ± 0.7 µg mL−1) and the extract induced apoptosis of HepG2 cells (77 ± 1.52%) at 300 µg mL−1, comparable to the positive control (camptothecin).","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10496475.2021.1891178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46976574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phoenix dactylifera polyphenols improve plasma lipid profile in hyperlipidemic rats and oxidative stress on HepG2 cells 凤凰多酚改善高脂血症大鼠血脂及对HepG2细胞氧化应激的影响

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI: 10.1080/10496475.2021.1891175

Selma Silabdi, M. Khali, G. Tenore, P. Stiuso, D. Vanacore, E. Novellino

引用次数: 0

Pharmacological Activities of Crinum viviparum: A Laboratory-based Study 活体恶性疟原虫的药理活性：实验室研究

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI: 10.1080/10496475.2021.1891177

Liton Sikder, Mirxat Alim, Bushra Saieda, M. T. Islam, M. Martorell, J. Sharifi‐Rad, S. Khan

引用次数: 4

Phytochemical and Pharmacological Evaluation of Methanolic Extract of Knoxia sumatrensis Leaves 漆树叶甲醇提取物的植物化学和药理学评价

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI: 10.1080/10496475.2021.1891179

S. Loganathan, K. Selvam, Vairakkannu Sivasakthi, P. Prakash, Myilswamy Yamuna, K. Lalitha, M. Shivakumar, S. Senthil Nathan

{"title":"Phytochemical and Pharmacological Evaluation of Methanolic Extract of Knoxia sumatrensis Leaves","authors":"S. Loganathan, K. Selvam, Vairakkannu Sivasakthi, P. Prakash, Myilswamy Yamuna, K. Lalitha, M. Shivakumar, S. Senthil Nathan","doi":"10.1080/10496475.2021.1891179","DOIUrl":"https://doi.org/10.1080/10496475.2021.1891179","url":null,"abstract":"ABSTRACT Knoxia sumatrensis leaf extracts in methanol were analyzed for the phytochemical compositions, antioxidant properties (DPPH, ABTS, and hydroxyl radical assay), anti-proliferative activity (lung cancer A549 and breast cancer MCF-7 cell lines), and mosquito larvicidal properties. The GC-MS analysis showed the presence of eight bioactive compounds of which the hexadecanoic Acid, 2-Propyl-, methyl Ester, and 2,3-anhydro-D-Mannosan were the two major compounds present. The bioactive compounds present included phenolics and flavonoids (55.0 ± 1.3 mg GAE g−1 d.w. and 42.5 ± 0.5 mg RE g−1 d.w.). FT-IR analysis detected the presence of aldehydes and anhydrites functional groups. Antioxidant properties were positively associated with the secondary metabolites. The anti-proliferative activity of methanolic leaf extracts showed the IC50 values 135.82 and 181.73 μg mL−1 for A549 and MCF-7, respectively. The methanolic extract also showed larvicidal activity on three mosquito species with highest toxicity on Culex quinquefasciatus larvae with LC50 4.84 mg mL−1 and LC90 19.33 mg mL−1.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10496475.2021.1891179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47221570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis 阿尔及利亚胸腺的植物化学物质、抗溶血、抗炎、抗氧化和抗菌活性

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-03-12 DOI: 10.1080/10496475.2021.1891174

Mouna Mokhtari, S. Chabani, Soumia Mouffouk, M. Aberkane, A. Dibi, M. Benkhaled, Hamada Haba

引用次数: 9

Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats 银银酮对Wistar白化大鼠抗尿石作用的内在评价

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-03-09 DOI: 10.1080/10496475.2021.1891181

Chilivery Ravi Kiran, C. Rajkuberan, A. Sangilimuthu, F. Hakkim, H. Bakshi, Sowmya Priya Manoharan

引用次数: 3

Methanol extract of Peltophorum Pterocarpum stem bark modulates Plasmodium berghei ANKA 65-Induced hypoglycemia and lipid dysfunction in Mice 紫檀茎皮甲醇提取物对伯氏疟原虫ANKA65诱导的小鼠低血糖和脂质功能障碍的调节作用

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-03-02 DOI: 10.1080/10496475.2021.1891182

O. Enechi, I. Okagu, C. Ezumezu

{"title":"Methanol extract of Peltophorum Pterocarpum stem bark modulates Plasmodium berghei ANKA 65-Induced hypoglycemia and lipid dysfunction in Mice","authors":"O. Enechi, I. Okagu, C. Ezumezu","doi":"10.1080/10496475.2021.1891182","DOIUrl":"https://doi.org/10.1080/10496475.2021.1891182","url":null,"abstract":"ABSTRACT This study evaluated the effects of methanol extract of Peltophorum pterocarpum stem bark (MEPTS) on blood glucose level and lipid profile of Plasmodium berghei ANKA 65-parasitized mice. The levels of total cholesterol (TC), low- and high-density lipoproteins (LDL and HDL, respectively), triacylglycerols (TAG) and blood glucose in parasitized mice treated with MEPTS (100, 200 or 400 mg kg−1 b.w. d−1, p.o) and artemether/lumenfantrin (28 mg kg−1 b.w. d−1, p.o) were determined and compared with malaria control. Alkaloids, saponins, flavonoids, tannins, glycosides, steroids, carotenoids, anthocyanins, anthraquinones, terpenoids, and phenols were detected in the extract. On days 1, 2, and 3, there were progressive increase in malaria parasitemia in malaria control compared with parasitized-MEPTS-administered mice that had dose-dependent decrease in malaria parasitemia. Malaria control group showed hyperlipidemia and hypoglycemia compared to normal mice, which was ameliorated by the administration of MEPTS, and artemether/lumenfantrin. These findings suggest that MEPTS may have potent antimalarial activity and modulated lipid dysfunction and hypoglycemia generated by malaria.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10496475.2021.1891182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46868933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bioactive Fraction of Mentha piperita Leaves Extract Stimulates Lipoprotein Lipase at Cellular and Molecular Levels via Augmentation of Antioxidant Defense System in Hyperlipidemic Rats 薄荷叶提取物生物活性组分通过增强高脂血症大鼠抗氧化防御系统在细胞和分子水平上刺激脂蛋白脂肪酶

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-03-01 DOI: 10.1080/10496475.2021.1891176

H. Mohammed, A. Sallau, Humphrey Chukwu Nzelibe, A. Muhammad, O. Erukainure, B. Musa, M. K. Anigo

{"title":"Bioactive Fraction of Mentha piperita Leaves Extract Stimulates Lipoprotein Lipase at Cellular and Molecular Levels via Augmentation of Antioxidant Defense System in Hyperlipidemic Rats","authors":"H. Mohammed, A. Sallau, Humphrey Chukwu Nzelibe, A. Muhammad, O. Erukainure, B. Musa, M. K. Anigo","doi":"10.1080/10496475.2021.1891176","DOIUrl":"https://doi.org/10.1080/10496475.2021.1891176","url":null,"abstract":"ABSTRACT The antihyperlipidemic and antioxidant effects of Mentha piperita leaves extracts in Poloxamer 407-induced hyperlipidemic rats were investigated. Antihyperlipidemic activities of hexane, ethyl acetate, and methanol extracts (100, 200, or 300 mg kg−1 b.w.) were evaluated by lipid profile analysis. Twelve (12) fractions (F1 to F12) were collected from the most antihyperlipidemic extract (ethyl acetate at 100 mg kg−1) and, assayed in vivo for antihyperlipidemic activity. The effects of the most antihyperlipidemic fraction (F2) on redox sensitive biomarkers (SOD, CAT, GSH, MDA) and lipoprotein lipase (LPL) activity at cellular and molecular levels were evaluated. Fraction-2 (F2) was further subjected to GC-MS and LC-MS analysis for identification of nonpolar and polar components. The F2 treatment decreased the level of MDA with concomitant enhancement of GSH, LPL activity in the liver and serum and up regulated the expression of SOD, CAT, and LPL genes in liver and blood relative to the untreated rats. GC-MS and LC-MS revealed oleic acid, vaccenic acid, 3, 4-dicaffeoylquinic acid, coumarin, and triacontane as the probable bioactive components with reported antihyperlipidemic and antioxidant effects.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10496475.2021.1891176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41417554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-inflammatory and Antibacterial Potentials of the Leaf Extract and Fractions of Chrysanthemum procumetens 菊花叶提取物及其组分的抗炎抗菌作用

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-02-26 DOI: 10.1080/10496475.2021.1891180

K. Akinwunmi, Esther Odunsi, C. Amadi, Ezekiel G Ajayi

{"title":"Anti-inflammatory and Antibacterial Potentials of the Leaf Extract and Fractions of Chrysanthemum procumetens","authors":"K. Akinwunmi, Esther Odunsi, C. Amadi, Ezekiel G Ajayi","doi":"10.1080/10496475.2021.1891180","DOIUrl":"https://doi.org/10.1080/10496475.2021.1891180","url":null,"abstract":"ABSTRACT The anti-inflammatory and antibacterial activity of the methanolic extract and fractions of Chrysanthemum procumetens leaves were evaluated. The extract was obtained from dried leaf samples using 70% methanol and screened for phytochemical constituents. The crude extract was partitioned successively with n-hexane, ethyl acetate and butanol. Membrane stability and inhibition of albumin denaturation assays were done to evaluate the in vitro anti-inflammatory activity. Antibacterial activity was determined using six test bacteria strains of both Gram negative and Gram positive bacteria. Phytochemical screening tested positive for flavonoids, alkaloids, saponins, steroids, tannins and cardiac glycosides. The crude extract had the highest total phenol (344.67 ± 11.26 mg GAE g−1) and flavonoids (230.30 ± 22.11 mg RE g−1) while the butanol fraction had the lowest total phenol and total flavonoids (117.57 ± 9.40 mg GAE g−1 and 100.60 ± 1.99 mg RE g−1, respectively). The crude extracts and fractions exhibited concentration-dependent anti-inflammatory activity, comparable to Ibuprofen. The anti-bacterial activity of the crude extract and ethyl acetate fraction of C. procumetens were positive for Pseudomonas aeruginosa with inhibition zone of 24.30 ± 0.02 mm; 15.5 ± 0.02 mm and MIC of 1.70 ± 0.01 mg mL−1 and 2.00 ± 0.03 mg mL−1, respectively.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10496475.2021.1891180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46439568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0