凤凰多酚改善高脂血症大鼠血脂及对HepG2细胞氧化应激的影响

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI:10.1080/10496475.2021.1891175

Selma Silabdi, M. Khali, G. Tenore, P. Stiuso, D. Vanacore, E. Novellino

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引用次数: 0

摘要

摘要利用人肝癌细胞（HepG2）建立大鼠模型，研究了阿尔及利亚椰枣果实[Deglet nour（DN），Ghars（GH），Degla baida（DB）]的抗高脂血症潜力及其对氧化应激的影响。提取物的酚类物质和总酚类物质含量显示了体外抗氧化潜力，这一点在HepG2细胞中得到了证实。在细胞培养基中观察到TBARS水平的降低和NO水平的增加。体内试验表明，椰枣提取物的给药通过降低总胆固醇（DB为−51%，GH为−31%，DN为−30%）、三酰甘油（DN为−61%，DB为−54%，GH为–32%）和低密度脂蛋白胆固醇来影响大鼠的降血脂作用，同时提高高密度脂蛋白的胆固醇水平，表明椰枣具有很强的心脏保护作用。

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Phoenix dactylifera polyphenols improve plasma lipid profile in hyperlipidemic rats and oxidative stress on HepG2 cells

ABSTRACT The anti-hyperlipidemic potential of Algerian date palm fruits of three varieties [Deglet nour (DN), Ghars (GH), Degla baida (DB)] and its influence on oxidative stress were explored in rat models using human hepatocellular carcinoma cells (HepG2). Phenolic profile and total phenolic content of the extracts revealed in vitro antioxidant potential, which was confirmed using HepG2 cells. Reduction of TBARS level and increase in NO levels were observed in cell medium. In vivo assays showed that administration of date extracts influenced the hypolipidemic effect in rats by decreasing total cholesterol (−51% for DB, −31% for GH and −30% for DN), triacylglycerol (−61% for DN, −54% for DB and −32% for GH) and LDL-Cholesterol, while increasing HDL-Cholesterol level, indicating strong cardioprotective properties of date fruit.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.