Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-03-09 DOI:10.1080/10496475.2021.1891181

Chilivery Ravi Kiran, C. Rajkuberan, A. Sangilimuthu, F. Hakkim, H. Bakshi, Sowmya Priya Manoharan

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引用次数: 3

Abstract

ABSTRACT The calcium oxalate reduction capacity of Argemone mexicana was demonstrated in vivo in ethylene glycol-induced urolithic rats. A. mexicana leaves extract at 400 and 750 mg kg−1 b.w. demonstrated protection of renal tubes, kidney cells and reduced the levels of serum creatinine and calcium compared to the urolithiasis induced group. Further, A. mexicana restored blood and urine markers to normal before and after treatment in urolithiasis rats and caused the breakdown of calcium oxalate crystals in the urinary tract as observed by microscopy. The A. mexicana extract protected from renal damage and repaired and increased diuresis activity thereby completely excreted calcium oxalate crystals in renal tubes. Analysis of methanolic extract of A. mexicana showed the presence of a 3,4-dihydro-3-hydroxy-7-(7-methyloctyl)naphthalen-2(1 H)-one as the bioactive compound which may be attributed to the antiurolithiatic activity.

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银银酮对Wistar白化大鼠抗尿石作用的内在评价

摘要:在乙二醇诱导的尿结石大鼠体内，研究了银银酮还原草酸钙的能力。与尿石症诱导组相比，400和750 mg kg - 1 b.w.的墨西哥牛蒡叶提取物显示出对肾管、肾细胞的保护作用，并降低了血清肌酐和钙的水平。此外，在显微镜下观察到，墨西哥刺槐使尿石症大鼠治疗前后的血液和尿液指标恢复正常，并引起尿路草酸钙晶体的分解。墨西哥菊提取物保护肾脏免受损害，修复和增加利尿活性，从而完全排出肾管中的草酸钙晶体。对墨西哥香甲醇提取物进行分析，发现其主要活性物质为3,4-二氢-3-羟基-7-(7-甲基新基)萘-2(1 H)- 1，其抗尿石活性可能与此有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.