Phytochemical and Pharmacological Evaluation of Methanolic Extract of Knoxia sumatrensis Leaves

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI:10.1080/10496475.2021.1891179

S. Loganathan, K. Selvam, Vairakkannu Sivasakthi, P. Prakash, Myilswamy Yamuna, K. Lalitha, M. Shivakumar, S. Senthil Nathan

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引用次数: 5

Abstract

ABSTRACT Knoxia sumatrensis leaf extracts in methanol were analyzed for the phytochemical compositions, antioxidant properties (DPPH, ABTS, and hydroxyl radical assay), anti-proliferative activity (lung cancer A549 and breast cancer MCF-7 cell lines), and mosquito larvicidal properties. The GC-MS analysis showed the presence of eight bioactive compounds of which the hexadecanoic Acid, 2-Propyl-, methyl Ester, and 2,3-anhydro-D-Mannosan were the two major compounds present. The bioactive compounds present included phenolics and flavonoids (55.0 ± 1.3 mg GAE g−1 d.w. and 42.5 ± 0.5 mg RE g−1 d.w.). FT-IR analysis detected the presence of aldehydes and anhydrites functional groups. Antioxidant properties were positively associated with the secondary metabolites. The anti-proliferative activity of methanolic leaf extracts showed the IC50 values 135.82 and 181.73 μg mL−1 for A549 and MCF-7, respectively. The methanolic extract also showed larvicidal activity on three mosquito species with highest toxicity on Culex quinquefasciatus larvae with LC50 4.84 mg mL−1 and LC90 19.33 mg mL−1.

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漆树叶甲醇提取物的植物化学和药理学评价

摘要：分析了在甲醇中的苏梅子叶提取物的植物化学成分、抗氧化特性（DPPH、ABTS和羟基自由基测定）、抗增殖活性（肺癌癌症A549和癌症MCF-7细胞系）和蚊子幼虫特性。GC-MS分析显示存在八种生物活性化合物，其中十六烷酸、2-丙基、甲酯和2，3-羟基-D-甘露聚糖是存在的两种主要化合物。存在的生物活性化合物包括酚类化合物和黄酮类化合物（55.0±1.3 mg GAE g−1 d.w.和42.5±0.5 mg RE g−1 d.w.）。FT-IR分析检测到醛和酸酐官能团的存在。抗氧化特性和次生代谢产物呈正相关。甲醇叶提取物对A549和MCF-7的抗增殖活性分别为135.82和181.73μg mL−1。甲醇提取物对致倦库蚊幼虫毒性最高的三种蚊子也显示出杀幼虫活性，LC50为4.84 mg mL−1，LC90为19.33 mg mL−1。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.