活体恶性疟原虫的药理活性：实验室研究

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-04-03 DOI:10.1080/10496475.2021.1891177

Liton Sikder, Mirxat Alim, Bushra Saieda, M. T. Islam, M. Martorell, J. Sharifi‐Rad, S. Khan

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引用次数: 4

摘要

摘要:采用圆盘扩散法、卵白蛋白(体外)法、凝块溶解法和蓖麻油致小鼠腹泻模型(体内)法测定了活荆醇提物的植物化学成分，并考察了其抗菌、抗炎、溶栓和抗腹泻活性。结果表明，该植物粗乙醇提取物中含有生物碱、单宁、黄酮类化合物、甾体和萜类化合物。提取物对大肠杆菌、枯草芽孢杆菌、金黄色葡萄球菌和肠炎沙门氏菌具有一定的抗菌作用。其抗炎和溶栓活性呈浓度依赖性。在250和500 mg kg−1剂量下，胎草提取物对瑞士白化小鼠具有抗腹泻作用。

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Pharmacological Activities of Crinum viviparum: A Laboratory-based Study

ABSTRACT The phytochemical composition of the ethanolic extract of Crinum viviparum was determined and the anti-bacterial, anti-inflammatory, thrombolytic, and anti-diarrheal activities were investigated by applying disc diffusion, egg albumin (in vitro), clot lysis, and castor oil-induced diarrhea model in mice (in vivo), respectively. The results suggested that the crude ethanolic extract of the plant contained alkaloids, tannins, flavonoids, steroids, and terpenoids. The extract was anti-bacterial against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Salmonella enterica. The plant showed anti-inflammatory and thrombolytic activities in a concentration-dependent manner. C. viviparum extract was anti-diarrheal in Swiss albino mice at 250 and 500 mg kg−1.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.