Nutrition Journal最新文献

{"title":"Sustainable HEalthy Diet practices: a cross-sectional analysis of an adult Greek sample.","authors":"Ioanna Alexandropoulou, Arriana Gkouvi, Katerina Maria Kontouli, Symela Papadopoulou-Maniki, Alexandra Giannioti, Dimitrios P Bogdanos, Tonia Vassilakou, Varvara A Mouchtouri, Dimitrios G Goulis, Maria G Grammatikopoulou","doi":"10.1186/s12937-025-01096-7","DOIUrl":"10.1186/s12937-025-01096-7","url":null,"abstract":"<p><strong>Background: </strong>Sustainable nutrition is based on foods with a low environmental impact, accessible and affordable, ensuring protection of the biodiversity, while including the cultural elements of each geographical region. The present cross-sectional study aimed to evaluate adherence to a sustainable diet and the perceived environmental benefit of adopting a sustainable diet among adults in Greece.</p><p><strong>Methods: </strong>The Sustainable HEalthy Diet (SHED) questionnaire evaluated sustainable nutrition practices and awareness in a sample of 607 adult Greeks recruited through social media.</p><p><strong>Results: </strong>A positive association was revealed between healthy eating, a plant-based diet and organic awareness. Healthy eating was related to the consumption of low-salt and low-sugar products, avoiding added salt and ultra-processed foods (UPFs), as well as limiting sweets and soft drinks. Most participants (94.6%) were flexitarians, consuming meat instead of plant-based foods, although showing a preference for legumes over meat products. Most (86.8%) failed to meet the 5-a-day recommendations for fruit and vegetables, which were bought mainly from supermarket chains, with men resolving to electronic commerce purchases, while women preferring small, local grocery shops. Most responders consumed tap water (54.9%) and homemade meals daily (75.0%). Many participants (32.8%) reported separating and recycling food scraps at home, using neighborhood composters. When organic produce was selected, this involved mainly fruits and vegetables. Between men and women, the latter adopted a plant-based diet to a greater extent, consumed fewer soft drinks, were keener to consume local produce, limit meat intake and eat crops that are pesticide- and herbicide-free. Overall, Greek consumers show preference to local products. Most of them fail to compost and cut down on meat intake. The tool's internal consistency measured by Cronbach alpha was 0.702 and 0.736 for the healthy eating and sustainable eating domains respectively, 0.798 for the environmental domain, while the other domains had lower scores due to contradictory questions. Our Confirmatory Factor Analysis (CFA) demonstrated a good fit (CFI = 0.896, TLI = 0.87) with strong positive relationships between healthy eating, a plant-based diet and organic awareness.</p><p><strong>Conclusions: </strong>The results indicate that adult Greeks more easily implement some aspects of sustainable nutrition (organic, local foods), while others appear more difficult (compost, reduce meat intake). Nonetheless, the results can be useful in designing interventions to increase dietary sustainability awareness among Greeks, including educational programs and improved infrastructures.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"32"},"PeriodicalIF":4.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of mediterranean diet and chrononutrition on sleep quality: a scoping review.","authors":"Anshum Patel, Joseph Cheung","doi":"10.1186/s12937-025-01095-8","DOIUrl":"10.1186/s12937-025-01095-8","url":null,"abstract":"<p><strong>Background: </strong>The relationship between diet and sleep quality is intricate, with growing evidence suggesting that dietary patterns and meal timing (chrononutrition) can significantly influence sleep outcomes. This scoping review aims to compare the impact of Mediterranean diet and chrononutrition methods on sleep variables, including sleep quality, duration, and efficiency. While the Mediterranean diet is renowned for its health benefits in chronic diseases, chrononutrition focuses on how the timing of food intake affects health and circadian biology.</p><p><strong>Methods: </strong>Literature search following PRISMA guidelines using PubMed and Google Scholar focused on Mediterranean diet and chrononutrition effects on sleep quality. Studies assessed sleep quality using subjective methods like Pittsburgh Sleep Quality Index, analyzing data on study type, sample size, age group, diet, duration, sleep parameters, and outcomes.</p><p><strong>Results: </strong>Thirty three studies met inclusion criteria, 24 focusing on Mediterranean diet and 9 on chrononutrition. Among the 24 Mediterranean diet studies, most of which were observational studies, 17 reported a positive association between adherence to Mediterranean diet and improved self-reported sleep quality, while the remaining studies found no significant association. In contrast, evidence supporting the positive effects of chrononutrition on sleep quality was limited, with only two out of nine studies having found improvement in sleep quality.</p><p><strong>Conclusions: </strong>Mediterranean diet demonstrates a more consistent and positive influence on sleep quality compared to chrononutrition. However, a limitation of review is that the reviewed Mediterranean diet studies were mainly cross-sectional or observational, while the reviewed chrononutrition studies were mainly interventional trials. Larger interventional clinical trials are needed to determine optimal dietary strategies and meal timing for promoting healthy sleep.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"31"},"PeriodicalIF":4.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea and coffee consumption and the 15-Year risk of cardiovascular events: the Isfahan cohort study (ICS).","authors":"Raza Amani-Beni, Masoumeh Sadeghi, Fatemeh Nouri, Bahar Darouei, Noushin Mohammadifard, Maryam Boshtam, Ramesh Hosseinkhani, Nizal Sarrafzadegan","doi":"10.1186/s12937-025-01093-w","DOIUrl":"10.1186/s12937-025-01093-w","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the association between tea and coffee consumption and the 15-year incidence of cardiovascular events and mortality among the Iranian population.</p><p><strong>Methods: </strong>The present study Data were obtained from the Isfahan Cohort Study (ICS), a prospective cohort study of ≥ 35-year-old healthy adults in central Iran from 2001 to 2017. This study was conducted using baseline data on tea and/or coffee consumption per day/week from ICS to identify the occurrence of any new cardiovascular events, including acute myocardial infarction (AMI), unstable angina (UA), stroke, cardiovascular disease (CVD), sudden cardiac death (SCD), cardiovascular mortality, and all-cause mortality.</p><p><strong>Results: </strong>5248 participants with complete data were included in the study. After full adjustments, compared to participants with the lowest tea intake, the risk of AMI was significantly higher for participants with the highest tea intake (hazard ratio (HR) = 1.83; 95% confidence interval (CI): 1.10, 3.07; p for trend = 0.060). Also, moderate-tea drinking was associated with a 66% increased risk of AMI compared to the lowest-tea drinking (HR = 1.66; 95%CI: 1.03, 2.70). No significant association was observed between tea consumption and other CVD events or all-cause mortality. Moreover, after full adjustment, no significant association was observed between tea intake above the median and cardiovascular events or all-cause mortality or between coffee consumption and study outcomes.</p><p><strong>Conclusions: </strong>High tea consumption significantly increases the risk of AMI; however, high tea and coffee consumption had no significant association with other cardiovascular events. Future research is needed, especially in Iran and the Middle East, to clarify and evaluate more factors related to the complex nature of tea and coffee consumption and cardiovascular events.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"30"},"PeriodicalIF":4.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planetary health diet index and mortality among US cancer survivors: mediating roles of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio.","authors":"Haolin Chen, Qinglong Yang, Huihui Zheng, Jianhui Tan, Jiayi Xie, Miaojie Xu, Xue Ouyang, Zhiyang Li, Yexi Chen","doi":"10.1186/s12937-025-01097-6","DOIUrl":"10.1186/s12937-025-01097-6","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related deaths and environmental issues pose significant global challenges. The Planetary Health Diet (PHD) is a healthy dietary pattern that simultaneously promotes human health and ecology. This study aims to investigate the association between the Planetary Health Diet Index (PHDI) and mortality among cancer survivors, as well as the mediating role of inflammation between PHDI and all-cause mortality.</p><p><strong>Methods: </strong>This study analyzed data from 3,442 cancer survivors enrolled in the United States National Health and Nutrition Examination Survey between 1999 and 2018. To investigate the association between PHDI and mortality, we applied weighted multivariate Cox proportional hazards regression, restricted cubic spline analysis, subgroup analysis, and sensitivity analysis. The mediating effects of the Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR) were assessed using the bootstrap method with 1000 simulations.</p><p><strong>Results: </strong>In the fully adjusted model, each 10-point PHDI increase correlated with a 9% decrease in all-cause mortality (HR, 0.91; 95% CI, 0.86-0.95), a 10% decrease in cancer mortality (HR, 0.90; 95% CI, 0.83-0.99), and a 10% decrease in non-cancer mortality (HR, 0.90; 95% CI, 0.85-0.96). The PHDI was significantly inversely correlated with SII and NLR, which were positively related to all-cause mortality. The mediation proportions of SII and NLR between the PHDI and all-cause mortality were 6.52% and 8.52%, respectively.</p><p><strong>Conclusions: </strong>Adherence to the PHD is associated with reduced all-cause, cancer, and non-cancer mortality among cancer survivors. Additionally, SII and NLR may mediate the relationship between PHDI and all-cause mortality.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"28"},"PeriodicalIF":4.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of serum carotenoids on mortality among metabolic syndrome patients: attenuated by lipid-lowering drugs.","authors":"Chunxiang Li, Yanlan Liang, Qiuyuan Lu, Yuanxin Lin, Shifeng Wen, Xiaoyu Luo, Shiping Huang, Xue Zhong, ZhangJian Xu, Fei Wang","doi":"10.1186/s12937-025-01092-x","DOIUrl":"10.1186/s12937-025-01092-x","url":null,"abstract":"<p><strong>Background: </strong>Limited evidence exists about the relationship between serum carotenoid and mortality in metabolic syndrome (MetS) patients, and the effects of medication use on this association remains unclear.</p><p><strong>Methods: </strong>The study encompassed 2,521 MetS patients from the National Health and Nutrition Examination Survey (NHANES) 2001-2006 and 2017-2018. A total of 7 serum carotenoids were evaluated. Death data were sourced from the National Death Index, with causes assessed using ICD-10 codes. Bayesian kernel machine regression (BKMR) and random survival forest (RSF) were utilized to investigate serum carotenoid mixture on mortality and identify key carotenoids. \"Qgcompint\" R package was used to explore the modifying effects of medication use.</p><p><strong>Results: </strong>The serum carotenoid levels at baseline ranged from 0.04 to 1.37 µmol/L. During a follow-up of 15.1 years, there were 696 deaths (27.61%), with 247 (35.49%) by cardiovascular disease (CVD), 148 (21.26%) by cancer, and 301 (43.25%) by other diseases. Individual and combined serum carotenoids were negatively associated with all-cause mortality (HR range:0.70-0.88, 95%CI range:0.56-0.99, all P < 0.05). α-carotene (VIMP = 0.223 in RSF) and lutein/zeaxanthin (PIP = 1.000 in BKMR) emerged as the greatest contributors to all-cause mortality. Lipid-lowering drugs attenuate the negative effect of serum carotenoids on MetS patients' mortality (P_int = 0.014).</p><p><strong>Conclusion: </strong>The present study identified a protective effect of serum carotenoid on mortality in MetS patients, which was probably weakened by lipid-lowering drugs. Early dietary interventions for MetS patients taking lipid-lowering drugs, particularly those rich in carotenoids like α-carotene and lutein/zeaxanthin, could help reduce mortality.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"27"},"PeriodicalIF":4.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive effects of advanced lung cancer inflammation index and serum vitamin D on mortality in patients with asthma.","authors":"Ting Li, Qi Wang, Yuhan Li, Wenyong Zhang, Manyu Chen, Bihua Deng, Lin Liang, Weixian Lin, Yuying Lin, Ying Meng","doi":"10.1186/s12937-024-01065-6","DOIUrl":"10.1186/s12937-024-01065-6","url":null,"abstract":"<p><strong>Background: </strong>Changes in systemic inflammation, nutritional status and serum vitamin D level are important characteristics of asthma. However, role and importance of nutritional inflammatory indicators or serum vitamin D concentrations in predicting the prognosis of asthma remain unclear. The advanced lung cancer inflammation index (ALI), based on body mass index (BMI), serum albumin and neutrophil-lymphocyte ratio (NLR), is a comprehensive index to assess systemic inflammation and nutrition. This study aimed to evaluate their independent and combined predictive value of mortality in asthma patients.</p><p><strong>Methods: </strong>This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2001-2018. Cox regression analysis was used to assess the independent or joint effect of ALI and serum vitamin D on mortality risks of asthma. Receiver operator characteristic curve analysis was used to compare the prognostic ability of ALI with its component factors, including NLR, albumin, neutrophil, lymphocyte and BMI.</p><p><strong>Results: </strong>A total of 2870 eligible asthma patients were included. After adjustment, higher ALI correlated significantly with reduced all-cause and respiratory disease mortality (adjusted hazard ratio [aHR] = 0.64 and 0.34; P < 0.05). Meanwhile, vitamin D deficiency correlated significantly with increased all-cause and respiratory disease mortality (aHR = 2.06 and 2.73; P < 0.05). The area under the curve of ALI in predicting 1-year, 5-year or 10-year all-cause mortality surpassed that of its five component indices. Joint analyses showed that individuals with higher levels of ALI and vitamin D had the lowest risks of all-cause and respiratory disease mortality (aHR = 0.31 and 0.17; P < 0.05).</p><p><strong>Conclusions: </strong>ALI and serum vitamin D are robust independent and combined predictors of mortality in asthma patients. ALI offers superior predictive capability over its components, and sufficient vitamin D levels are beneficial for survival outcomes. The synergistic effect of high ALI and adequate vitamin D highlights the benefit of integrating both metrics into clinical practice for enhanced prognostic accuracy.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"26"},"PeriodicalIF":4.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum carotenoids and osteoarthritis or degenerative arthritis: A cross-sectional study using the National Health and Nutrition Examination Survey.","authors":"Bowen Zhu, Guochun Li, Kaiwen Wu, Qian Luo, Xie Wu","doi":"10.1186/s12937-025-01087-8","DOIUrl":"10.1186/s12937-025-01087-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Carotenoids possess essential antioxidant and anti-inflammatory properties; however, the relationships between carotenoids and osteoarthritis or degenerative arthritis (OA) remain inadequately understood. This study aimed to investigate the correlation between diverse serum carotenoid concentrations and OA in a large American cohort and to examine the influence of various factors on the association between carotenoids and OA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data from the 2001-2006 and 2017-2018 National Health and Nutrition Examination Surveys were utilized. In our analysis, we utilized a directed acyclic graph to identify potential confounding variables. The associations between serum carotenoids (including total carotenoid, trans-lycopene, β-cryptoxanthin, lutein/zeaxanthin, α-carotene, and β-carotene) and OA were comprehensively evaluated via a weighted generalized linear model (GLM) and restricted cubic spline models. Threshold effect analyses were used to identify potential cutoff points, subgroup analyses were used to explore heterogeneity, interaction analyses were used to examine potential modifiers, and sensitivity analyses were used to validate the robustness of the findings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The weighted GLM results revealed that, overall, the concentrations of various serum carotenoids did not exhibit a significant linear correlation with the probability of OA. Dose‒response curves and threshold effect analysis revealed a significant nonlinear relationship (P &lt;sub&gt;for overall&lt;/sub&gt; = 0.027; P &lt;sub&gt;for nonlinearity&lt;/sub&gt; = 0.019; P &lt;sub&gt;for likelihood ratio&lt;/sub&gt; = 0.0128) between trans-lycopene (threshold effect) and OA, with an inflection point at 19.49 µg/dl. Further subgroup weighted linear regression analysis indicated that when the serum trans-lycopene concentration exceeded 19.49 µg/dl, there was a significant association [odds ratio (OR) = 0.89 (0.80-0.99); P = 0.027] between the per standard deviation trans-lycopene increase and a lower probability of OA after adjusting for other variables. Moreover, individuals with elevated trans-lycopene [0.70 (0.52-0.94); P = 0.018] in the fifth quintile had notably reduced odds of OA compared with those in the first quintile. When the trans-lycopene level is less than 19.49 µg/dl, no correlation exists between the two variables. Linear subgroup and interaction analyses revealed that when the concentration of carotenoids exceeded 19.49 µg/dl, various categorical factors did not significantly influence the relationship between trans-lycopene and OA overall. However, pairwise comparisons revealed that lower serum trans-lycopene concentrations are more closely associated with a greater probability of OA in elderly individuals [OR (95% CI) = 0.270 (0.112-0.654); P = 0.005; P &lt;sub&gt;for trend&lt;/sub&gt; = 0.003] than in younger individuals [0.973 (0.385-2.463); P = 0.954; P &lt;sub&gt;for trend&lt;/sub&gt; = 0.61] (P &lt;sub&gt;for interaction&lt;/sub&gt; = 0.007).&lt;/p&gt;&lt;p&gt;&lt;strong","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"25"},"PeriodicalIF":4.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of diseases attributable to excess body weight in 204 countries and territories, 1990-2019.","authors":"Saeid Safiri, Jessica A Grieger, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Asra Fazlollahi, Mark J M Sullman, Nahid Karamzad, Fikrettin Sahin, Kuljit Singh, Gary S Collins, Ali-Asghar Kolahi","doi":"10.1186/s12937-025-01082-z","DOIUrl":"10.1186/s12937-025-01082-z","url":null,"abstract":"<p><strong>Background: </strong>To investigate the global, regional, and national burden of the diseases attributable to excess body weight (EBW) from 1990 to 2019, stratified by age, sex, underlying cause, and sociodemographic index (SDI).</p><p><strong>Methods: </strong>Using the Comparative Risk Assessment approach of the Global Burden of Disease (GBD) study 2019, the burden of diseases attributable to EBW was reported for the period from 1990 to 2019. For adults, EBW was defined as a body mass index (BMI) exceeding 25 kg/m², while for children aged 1 to 19 years, EBW was determined according to the standards set by the International Obesity Taskforce. The burden was reported in terms of numbers, proportions, and age-standardised rates per 100,000, accompanied by corresponding 95% uncertainty intervals (UIs).</p><p><strong>Results: </strong>In 2019, there were an estimated 5.0 million deaths (95% UI: 3.2-7.1) and 160.3 million DALYs (106.0-218.9) attributable to EBW worldwide. The age-standardised DALY rate attributable to EBW increased by 18.0% (2.2-42.3) from 1990 to 2019, with notable regional variations. Southeast Asia and South Asia exhibited the highest age-standardised DALY rates. Conversely, the age-standardised death rate due to EBW showed no significant change, with an increase of 4.9% (-7.3 to 24.6) over the same period. Significant regional variations were again observed, particularly in Southeast Asia and South Asia, which recorded the highest age-standardised death rates. Moreover, a non-linear association was observed between the SDI and the regional age-standardised DALY rate of diseases attributable to EBW.</p><p><strong>Conclusions: </strong>The global burden of EBW has increased over the past three decades. This trend aligns with socio-demographic indices and is influenced by the physical activity levels and dietary habits of these populations.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"23"},"PeriodicalIF":4.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials.","authors":"Mitra Hariri, Masoudreza Sohrabi, Ali Gholami","doi":"10.1186/s12937-025-01085-w","DOIUrl":"10.1186/s12937-025-01085-w","url":null,"abstract":"<p><strong>Background: </strong>Some evidence suggests magnesium might reduce serum levels of lipid profile. Due to the significance of this matter on hand, we centralized our aim to conduct a systematic review and meta-analysis to interrogate the effect of magnesium supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in the general population aged ≥ 18 years.</p><p><strong>Methods: </strong>In line with conducting this study first, relevant articles were found through searching databases, including five databases: Cochrane Library, ClinicalTrials.gov, ISI Web of Science, Scopus, and PubMed until January 2024. Following fulfilling the first aim, their mean differences and standard deviations were calculated to conduct the meta-analysis. Ultimately, an assessment of the statistical heterogeneity of intervention effects was performed using I-squared statistics and Cochran's Q test.</p><p><strong>Results: </strong>Regarding serum levels of TC, TG, LDL-C, and HDL-C, twenty-one, twenty-three, twenty, and twenty-five studies were included in the meta-analysis. The pooled estimates showed no significant differences in serum levels of TC, TG, and LDL-C between the magnesium group and comparison group (weighted mean difference (WMD) = 0.34 mg/dl, 95% confidence interval (CI): -1.75 to 2.43, P = 0.749, I² = 99.1%; WMD=-2.06 mg/dl, 95% CI: -6.35 to 2.23, P = 0.346, I² = 99.1; WMD = 1.71 mg/dl, 95% CI: -0.81 to 4.24, P = 0.183, I² = 99.4, respectively). However, magnesium significantly increased HDL-C (WMD = 1.21 mg/dl, 95% CI: 0.58 to 1.85, P < 0.001, I² = 99.5).</p><p><strong>Conclusion: </strong>In conclusion, our study showed that magnesium significantly increased HDL-C levels. However, due to high heterogeneity, we must note that more research is needed to make robust recommendations regarding magnesium supplementation in clinical practice.</p><p><strong>Registry number: </strong>This study was registered in PROSPERO under the protocol number CRD42024505142.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"24"},"PeriodicalIF":4.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition.","authors":"Cong Chen, Xin Luo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Tianhong Teng, Heguang Huang, Fengchun Lu","doi":"10.1186/s12937-025-01084-x","DOIUrl":"10.1186/s12937-025-01084-x","url":null,"abstract":"<p><strong>Background: </strong>Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. This study investigated whether preoperative serum CK is associated with the survival of patients with pancreatic cancer.</p><p><strong>Methods: </strong>Data were obtained from patients with pathologically confirmed pancreatic cancer between June 2016 and March 2022. The prognostic significance of CK was analyzed based on sex-stratified groups. The Kaplan-Meier method was used to compare overall survival (OS) and disease-free survival (DFS). Multivariate Cox proportional hazards models were used to determine prognostic factors. Body composition was analyzed based on preoperative abdominal CT images to explore the sex-specific associations between skeletal muscle area (SMA) and serum CK levels.</p><p><strong>Results: </strong>A total of 166 patients were included in this study. Sarcopenia was presented in 70 patients (42.2%). A low serum CK level showed a significant correlation with the diagnosis of sarcopenia in male patients (P = 0.026). The levels of CK did not predict the outcome in female patients, while a low preoperative CK was notably linked to shorter OS in male patients (median OS: 15 months vs. 33 months, P = 0.011; median DFS: 5 months vs. 14 months, P = 0.007). Multivariate analyses further confirmed the effect of CK in predicting OS (CK>44 IU/L, HR:0.226, 95% CI:0.107-0.478, P < 0.001) and DFS (CK>44 IU/L, HR:0.272, 95% CI:0.139-0.529, P < 0.001) of male patients. Correlation analysis revealed a significant association between SMA and CK levels in male patients (r = 0.225, P = 0.025), and such a correlation was not observed in female patients (r = 0.088, P = 0.478).</p><p><strong>Conclusion: </strong>The pretherapeutic CK may represent a simple marker for predicting poor survival in male patients with resectable pancreatic cancer, thereby aiding in the selection of therapeutic strategies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"22"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}