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Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies. 氨基酸摄入、血浆代谢物和2型糖尿病发病风险:前瞻性队列研究的系统方法
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-16 DOI: 10.1186/s12937-025-01157-x
Siyue Wang, Yanping Li, Molin Wang, Jeffrey Yuan, Oana A Zeleznik, A Heather Eliassen, Andrew T Chan, Frank B Hu, Yang Hu, Qi Sun
{"title":"Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies.","authors":"Siyue Wang, Yanping Li, Molin Wang, Jeffrey Yuan, Oana A Zeleznik, A Heather Eliassen, Andrew T Chan, Frank B Hu, Yang Hu, Qi Sun","doi":"10.1186/s12937-025-01157-x","DOIUrl":"https://doi.org/10.1186/s12937-025-01157-x","url":null,"abstract":"<p><strong>Background: </strong>Amino acid (AA) intake is thought to be closely related to the etiology of type 2 diabetes (T2D), although few prospective human studies have examined the association. The study prospectively examined inter-relationships among the intake of all 20 AAs, blood metabolome, and T2D incidence.</p><p><strong>Methods: </strong>Prospective associations between 20 individual AA intake and T2D were examined among 201,113 participants from the Health Professionals Follow-up Study (HPFS), Nurses' Health Study (NHS), and NHSII who did not have T2D, cardiovascular disease, or cancer at baseline. Next, a multi-metabolite signature responsive to AA intake was derived through two sets of 7-day diet record (7DDR) assessments, and subsequently replicated in multiple cohorts. Finally, Cox regression models were used to determine and confirm the prospective associations of AA intake, plasma metabolite signatures, with T2D incidence.</p><p><strong>Results: </strong>During 5,037,848 person-years of follow-up, 20,619 T2D cases were documented. Sulfur AAs (SAAs) and aromatic amino acids were significantly associated with higher T2D risk independent of other AAs. Comparing the highest with lowest quintiles of intake, the multivariable adjusted pooled hazard ratios (HRs) for T2D were 1.20 (95% CI: 1.13-1.27) for total SAA (P <sub>for trend</sub> < 0.0001) and 1.14 (95% CI: 1.08-1.21) for total aromatic AAs (P <sub>for trend</sub> < 0.0001). A total of 73 plasma metabolites were identified as responsive markers for total SAA intake, and 87 metabolites for total aromatic AA intake. Approximately 75% of these metabolites were commonly responsive within the individual AAs within the same class. The multi-metabolite signatures for SAAs and aromatic AAs intakes were replicated in an independent study [β = 0.30 or 0.31 per SD increase of SAA and aromatic AA intake, respectively, P < 0.0001 for both associations). Moreover, the signatures were associated with T2D incidence: the HRs for per SD change were 1.14 (95%CI: 1.08-1.20, P < 0.00001) for SAA signature and 1.18 (95%CI: 1.12-1.24, P < 0.00001) for aromatic AA signature. Mediation analysis showed that the metabolite signatures explained various degree (% ranging from 10.5(95%CI: 3.8-26.1) to 29.9(95%CI: 13.5-53.9)) for the associations between dietary SAAs/aromatic AAs and T2D incidence risk.</p><p><strong>Conclusions: </strong>This study provides novel evidence that higher intake of sulfur and aromatic AAs is independently associated with an increased risk of T2D. Multiple plasma metabolites are responsive to these dietary AAs, potentially serving as objective markers for AA intake. Collectively, the metabolite signatures significantly predict a higher T2D risk, and mediate the positive associations to various degrees, corroborating findings from long-term dietary assessments.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"112"},"PeriodicalIF":4.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycemic response to SSBs and ASBs: the role of mixed meals and individual variability. 对SSBs和ASBs的血糖反应:混合膳食的作用和个体差异。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-16 DOI: 10.1186/s12937-025-01181-x
Sejin Kim, YoonJu Song
{"title":"Glycemic response to SSBs and ASBs: the role of mixed meals and individual variability.","authors":"Sejin Kim, YoonJu Song","doi":"10.1186/s12937-025-01181-x","DOIUrl":"https://doi.org/10.1186/s12937-025-01181-x","url":null,"abstract":"<p><strong>Background: </strong>While artificially sweetened beverages (ASBs) are widely reported to have minimal glycemic impact compared to sugar-sweetened beverages (SSBs), their effects in mixed meal conditions and individual variability in response remain poorly understood. This study aimed to evaluate postprandial glycemic response (PPGR) and individual variability in response to an SSB (regular cola) and an ASB (zero cola), both in single and mixed conditions, using continuous glucose monitoring (CGM).</p><p><strong>Methods: </strong>A total of 66 healthy young adults participated in this 14-day, non-randomized crossover intervention study. Test meals included 75 g oral glucose load as a reference, muffin, regular cola, zero cola, muffin with regular cola (MRC), and muffin with zero cola (MZC). PPGR was evaluated using incremental area under the curve. The glucose dip was assessed as the minimum glucose reduction from baseline. Participants were classified as MZC-High (n = 17) if their glycemic response to MZC was higher than to MRC, and as MZC-Stable (n = 44) if MRC showed the higher response.</p><p><strong>Results: </strong>The 75 g oral glucose load reference exhibited a typical glycemic pattern, peaking at 45 min before steadily declining. The muffin induced a moderate glycemic response, while regular cola led to a rapid glucose rise followed by a sharp decline. When combined with a muffin, MRC exhibited a slightly higher glycemic response (iAUC<sub>180</sub>:161.6 mmol∙min/L), whereas MZC showed a similar response to the muffin alone (113.3 and 111.1 mmol∙min /L, respectively). At 120 min, the glucose dip was most pronounced for regular cola, whereas oral glucose load and muffin showed smaller reductions. These patterns persisted at 180 min, with oral glucose load showing the largest drop. Mixed meals attenuated glucose dips, with MRC and MZC preventing excessive declines. Individual responses analysis revealed that while the overall iAUC was not significantly different between muffin alone and MZC, 26 participants (MZC-High Responders) exhibited a higher iAUC with MZC than with MRC, suggesting variability in glucose regulation. Comparisons between MZC-High Responders and MZC-Stable participants showed no significant differences in age or body composition.</p><p><strong>Conclusion: </strong>While zero cola alone or in combination with a muffin had a minimal overall glycemic impact, some individuals exhibited higher glycemic responses in mixed conditions. These findings suggest that individual variability and mixed condition should be considered when consuming artificially sweetened beverages.</p><p><strong>Trial registration: </strong>Clinical Research Information Service (CRIS, cris.nih.go.kr) No. KCT0009921.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"113"},"PeriodicalIF":4.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis. 鹰嘴豆降低餐后血糖反应:一项系统回顾和荟萃分析。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-14 DOI: 10.1186/s12937-025-01176-8
Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu
{"title":"Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis.","authors":"Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu","doi":"10.1186/s12937-025-01176-8","DOIUrl":"10.1186/s12937-025-01176-8","url":null,"abstract":"<p><strong>Background: </strong>Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials.</p><p><strong>Methods: </strong>We screened PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from inception through March 21, 2024 for acute, controlled, experimental (randomized or non-randomized) trials comparing chickpea consumption with carbohydrate-matched controls that reported on postprandial glucose and insulin responses (iAUC and C<sub>max</sub>). Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.</p><p><strong>Results: </strong>A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose C<sub>max</sub> (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.</p><p><strong>Conclusion: </strong>Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. Future studies should explore the long-term effects of chickpea consumption, investigate the impact of processing methods, and include metabolically unhealthy populations to enhance generalizability.</p><p><strong>Registration: </strong>This review was registered on PROSPERO (CRD42022365074).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"111"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of long-term oral nutritional supplementation with dietary counseling on growth, body composition and bone mineralization in children with or at risk for undernutrition: a randomized controlled trial. 长期口服营养补充剂与饮食咨询对营养不良或有营养不良风险的儿童生长、身体成分和骨矿化的疗效:一项随机对照试验
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-14 DOI: 10.1186/s12937-025-01133-5
Mandy Y L Ow, Nga Thuy Tran, Yatin Berde, Tu Song Nguyen, Van Khanh Tran, Morgan J Jablonka, Geraldine E Baggs, Dieu T T Huynh
{"title":"Efficacy of long-term oral nutritional supplementation with dietary counseling on growth, body composition and bone mineralization in children with or at risk for undernutrition: a randomized controlled trial.","authors":"Mandy Y L Ow, Nga Thuy Tran, Yatin Berde, Tu Song Nguyen, Van Khanh Tran, Morgan J Jablonka, Geraldine E Baggs, Dieu T T Huynh","doi":"10.1186/s12937-025-01133-5","DOIUrl":"10.1186/s12937-025-01133-5","url":null,"abstract":"<p><strong>Background: </strong>Impaired growth, accompanied by low lean mass and poor bone mineralization in undernourished children, is linked to adverse short- and long-term health outcomes. Oral nutritional supplements (ONS) promote catch-up growth, but their efficacy in improving lean mass and bone mineralization remains uninvestigated. This study aims to compare the efficacy of long-term ONS with dietary counseling (DC) versus DC alone on growth, body composition, bone mineralization, and health outcomes in children with or at risk of undernutrition.</p><p><strong>Methods: </strong>Children (n = 330) aged 24-60 months with WHO Growth Standard z-scores of weight-for-age < - 1, height-for-age < - 1, and weight-for-height < 0 were randomized in a multisite controlled trial to receive two servings of a complete and balanced ONS formula with DC, or DC-only, for 240 days. Anthropometric measurements, dietary intake, and parent-reported measures of illness-related and other health outcomes were assessed at baseline and days 30, 120, and 240. Dual X-ray absorptiometry-assessed body composition and bone mineralization, and nutritional blood biomarkers were measured at baseline and day 240.</p><p><strong>Results: </strong>ONS supplementation augmented growth in height and weight through day 240, with increasing between-group differences over visits (P < 0.01 for treatment-by-visit interaction in height, weight, height-for-age and weight-for-age z-scores). Energy and protein intake levels were 26% and 22% higher, respectively, in the ONS + DC compared to the DC-group at day 240 (both P < 0.001). The ONS + DC group also had a higher lean mass index of 11.06 (0.05) versus 10.92 (0.05) kg/m2 (P = 0.048) and total body less head bone mineral density of 0.407 (0.003) versus 0.399 (0.003) g/cm2 (P = 0.03) at day 240, with no differences in fat mass index compared to DC. The ONS + DC group also had better serum vitamin D and K status, fewer sick and missed school days, better parent-reported sleep habits, appetite, energy, and physical activity levels versus DC-group (all P < 0.05).</p><p><strong>Conclusion: </strong>Adding ONS to DC for 8 months improved linear catch-up growth and supported quality growth, as evidenced by greater lean mass and bone mineral accretion. These findings, alongside parent-reported improvements in child health, suggest that improved nutrient intake with ONS improves multiple domains of child health and well-being.</p><p><strong>Trial registration: </strong>This clinical trial was registered on ClinicalTrials.gov (registration number: NCT05239208) on 14 February 2022. Video Abstract.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"110"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies. 修正:韩国成人血清25-羟基维生素D水平与整体和部位特异性癌症的风险:来自两项前瞻性队列研究的结果。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-12 DOI: 10.1186/s12937-025-01177-7
Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park
{"title":"Correction: Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.","authors":"Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park","doi":"10.1186/s12937-025-01177-7","DOIUrl":"10.1186/s12937-025-01177-7","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"109"},"PeriodicalIF":4.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study. 性激素结合球蛋白和肠易激综合征与2型糖尿病之间的性别特异性关联:一项前瞻性队列研究。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-10 DOI: 10.1186/s12937-025-01155-z
Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu
{"title":"Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study.","authors":"Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu","doi":"10.1186/s12937-025-01155-z","DOIUrl":"10.1186/s12937-025-01155-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the sex-specific association between irritable bowel syndrome (IBS) and type 2 diabetes (T2D), and further explore whether sex-hormone binding globulin (SHBG) was an associated factor of the sex-specific association.</p><p><strong>Methods: </strong>The study was a prospective analysis based on the UK biobank (UKB) data. We included 359 503 participants, all of whom were without diabetes diagnosis and had complete SHBG information at baseline. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using non-IBS group as the reference, further stratified by sex and SHBG levels in multivariable-adjusted models, including demographics, lifestyle factors, and disease history.</p><p><strong>Results: </strong>During a median follow-up of 10.4 years, 14 317 incident T2D cases had been documented. A statistically significant increased risk of T2D with IBS compared to those without IBS was observed in all multivariable-adjusted models (HR = 1.32, 95% CI = 1.23-1.42, P < 0.001). Additionally, a sex-specific association between IBS and T2D was found (P<sub>interaction</sub> = 0.004), with the risk in women (HR = 1.43, 95% CI = 1.31-1.57) being higher than in men (HR = 1.14, 95% CI = 1.01-1.29). A significant effect modification of SHBG was also observed in the association between IBS and T2D (P<sub>interaction</sub> = 0.001). The risk of incident T2D was higher in participants with higher SHBG levels (HR = 1.42, 95% CI = 1.25-1.63) than in those with lower SHBG levels (HR = 1.26, 95% CI = 1.16-1.37).</p><p><strong>Conclusions: </strong>A sex-specific association between prevalent IBS and T2D incidence was found, and SHBG level might modify the association.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"108"},"PeriodicalIF":4.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial. 补充发酵乳酸杆菌MN-LF23对14天标准四联疗法根除幽门螺杆菌的影响:一项随机、双盲、安慰剂对照试验
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01124-6
Yuyang Zhao, Xiaokang Niu, Yong Zhang, Liang Zhao, Liwei Zhang, Jingjing He, Qi Zhang, Yuejian Mao, Fuqing Wang, Xiaohui Zhao, Ran Wang
{"title":"Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial.","authors":"Yuyang Zhao, Xiaokang Niu, Yong Zhang, Liang Zhao, Liwei Zhang, Jingjing He, Qi Zhang, Yuejian Mao, Fuqing Wang, Xiaohui Zhao, Ran Wang","doi":"10.1186/s12937-025-01124-6","DOIUrl":"10.1186/s12937-025-01124-6","url":null,"abstract":"<p><strong>Background: </strong>The effect of probiotics on Helicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role of Limosilactobacillus fermentum MN-LF23 (MN-LF23) in Hp-infected populations.</p><p><strong>Methods: </strong>A total of 94 adult patients with confirmed Hp infection were enrolled in this study and randomly allocated to the placebo or MN-LF23 group. Patients initially received either placebo or probiotics along with standard quadruple therapy for 2 weeks, followed by continued administration of either placebo or probiotics for an additional 4 weeks. The eradication of Hp, serum levels of inflammatory factors, and alterations in gastrointestinal symptoms were assessed at weeks 0, 2, and 6, while fecal samples were collected for metagenomic sequencing.</p><p><strong>Results: </strong>The results showed no significant difference (P = 1) in the eradication rate between the placebo group (85.11%) and the probiotic group (82.98%). Following treatment, the incidence of constipation, dyspepsia, and Gastrointestinal Symptom Rating Scale (GSRS) scores in the probiotic group were markedly lower (P < 0.05) compared to those observed in the placebo group. Throughout the treatment process, there were no significant differences in TNF-α and IL-1β levels between the two groups. Compared to the placebo group, the probiotic group exhibited a significant increase in beneficial bacteria such as Limosilactobacillus fermentum, Lactiplantibacillus plantarum, Bifidobacterium longum, Coprococcus caltus, and Clostridium butyricum.</p><p><strong>Conclusion: </strong>MN-LF23 supplementation did not improve the eradication rate of standard quadruple therapy. However, it significantly reduced the overall GSRS score, improved digestive and constipation symptoms, and promoted the proliferation of beneficial bacteria in the intestine.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"106"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches. 饮食质量、生物老化、心血管-肾脏-代谢综合征进展和死亡率的关联:来自调解和机器学习方法的见解。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01175-9
Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu
{"title":"Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.","authors":"Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu","doi":"10.1186/s12937-025-01175-9","DOIUrl":"10.1186/s12937-025-01175-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.</p><p><strong>Methods: </strong>Data of 7,918 participants were derived from the National Health and Nutrition Examination Survey 2005-2018. Cross-sectional analyses using multivariable logistic regression were conducted to evaluate the relationship between DII and CKM staging. Cox proportional hazards models were employed to assess the impact of DII on mortality in CKM patients. Mediation analyses were performed to determine whether biological aging mediated DII-staging and DII-mortality association. Machine learning models were developed to classify CKM stages 3/4 and predict all-cause mortality, with SHapley Additive exPlanations (SHAP) used to interpret the contribution of DII components.</p><p><strong>Results: </strong>Over a median follow-up of 9.3 years, 819 deaths were recorded. Higher DII were associated with an increased risk of advanced CKM stages [OR (95% CI): tertile 2, 1.39 (1.17, 1.65); tertile 3, 1.85 (1.56, 2.20)], and all-cause mortality [(HR (95% CI): tertile 2, 1.20 (1.01-1.43); tertile 3: 1.45 (1.21-1.73)]. The optimal risk stratification threshold for DII to predict all-cause mortality was 1.93. Mediation analyses revealed that biological aging accounted for 23% (95% CI: 18-28%) of the effect of DII on advanced CKM stages and 13% (95% CI: 8-22%) of the effect of DII on all-cause mortality. Furthermore, the Light Gradient Boosting Machine model showed strong performance in predicting advanced CKM staging (AUC: 0.896, 95% CI: 0.882-0.911), while Logistic regression performed better in predicting all-cause mortality (AUC: 0.857, 95% CI: 0.831-0.884). SHAP analysis revealed that intake of magnesium and n-3 fatty acid were associated with reduced risk of both advanced CKM stages and all-cause mortality.</p><p><strong>Conclusion: </strong>DII, a marker of pro-inflammatory dietary patterns, was significantly linked to CKM syndrome progression and mortality, partly by influencing biological aging. This underscores the importance of diet quality in managing CKM staging and mortality risk.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"105"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort. 膳食常量营养素质量与高脂血症发生率之间的关系:来自NEC-Biobank队列的研究结果。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01174-w
Xiao-Ying Li, Dong-Hui Huang, Xin Xu, Xi-Meng Zhang, Jia-Le Lv, Yu-Xin Nan, Fan Cao, Qi-Jun Wu, Yu-Hong Zhao
{"title":"Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort.","authors":"Xiao-Ying Li, Dong-Hui Huang, Xin Xu, Xi-Meng Zhang, Jia-Le Lv, Yu-Xin Nan, Fan Cao, Qi-Jun Wu, Yu-Hong Zhao","doi":"10.1186/s12937-025-01174-w","DOIUrl":"10.1186/s12937-025-01174-w","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"107"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study. 含硫微生物饮食与痴呆风险之间的关系:一项大规模前瞻性队列研究。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-03 DOI: 10.1186/s12937-025-01172-y
Jigen Na, Celi Yang, Muzi Na, Xiaona Na, Yuefeng Tan, Xiaojin Shi, Zhihui Li, John S Ji, Ai Zhao
{"title":"Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study.","authors":"Jigen Na, Celi Yang, Muzi Na, Xiaona Na, Yuefeng Tan, Xiaojin Shi, Zhihui Li, John S Ji, Ai Zhao","doi":"10.1186/s12937-025-01172-y","DOIUrl":"10.1186/s12937-025-01172-y","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"104"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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