Spicy food consumption and biological aging across multiple organ systems: a longitudinal analysis from the China Multi-Ethnic cohort.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-05-23 DOI:10.1186/s12937-025-01147-z

Ning Zhang, Feng Hong, Yi Xiang, Yuan Zhang, Wen Qian, Xuehui Zhang, Liling Chen, Zhuoma Duoji, Xiong Xiao, Xing Zhao

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引用次数: 0

Abstract

Background: Biological aging is a common starting point for many chronic diseases and multimorbidity. Spicy food consumption is showing a growing trend worldwide. However, the association of spicy food consumption with the comprehensive biological age (BA) and organ-specific BAs remains unclear.

Methods: This study included 7874 participants from the China Multi-Ethnic Cohort (CMEC), all participating in baseline and follow-up surveys. The CMEC was located in Southwest China, which has become one of the most prominent and typical regions regarding spicy food consumption in China and the world. We constructed comprehensive BA and organ-specific BAs based on composite indicators using the widely validated Klemera-Doubal method. The frequency of intake of spicy food was obtained by an electronic questionnaire. Follow-up analyses adjusted for baseline data were then employed to assess the longitudinal associations of spicy food consumption at baseline with both the comprehensive BA and the organ-specific BAs at follow-up.

Results: Compared with non-spicy consumers, spicy consumers showed a decrease in comprehensive BA acceleration, with adjusted β = -0.23 (- 0.60 to 0.13) for 1-2 days/week, β = -0.69 (- 1.10 to - 0.29) for 3-5 days/week and - 0.32 (- 0.63 to - 0.01) years for 6-7 days/week, respectively. Higher estimates were observed for metabolic and kidney BA accelerations than for cardiopulmonary and liver BA accelerations. Compared to non-spicy consumers, spicy consumers showed a decrease in metabolic BA acceleration (3-5 days/week: β = -0.76 (- 1.28 to - 0.24) years) and kidney BA acceleration (3-5 days/week: β = -1.89 (- 2.76 to - 1.02) years).

Conclusion: Spicy foods may have potential benefits for biological aging. Our findings highlight that spicy foods may slow comprehensive and organ-specific biological aging, especially metabolic and kidney biological aging.

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辛辣食物消费与多器官系统的生物衰老：来自中国多民族队列的纵向分析。

背景：生物衰老是许多慢性疾病和多病的共同起点。在世界范围内，辛辣食品的消费量呈增长趋势。然而，食用辛辣食物与综合生物年龄（BA）和器官特异性BA之间的关系尚不清楚。方法：本研究纳入7874名来自中国多民族队列（CMEC）的参与者，所有参与者均参与基线和随访调查。CMEC位于中国西南部，已成为中国乃至世界辣味消费最突出、最典型的地区之一。我们使用广泛验证的klemera - double方法构建了基于复合指标的综合BA和器官特异性BA。通过电子问卷的方式获取辛辣食物的摄入频率。然后采用基线数据调整的随访分析来评估基线时辛辣食物消费与随访时综合BA和器官特异性BA的纵向关联。结果：与非辛辣饮食者相比，辛辣饮食者的综合BA加速度在1-2天/周时呈下降趋势，调整后的β = -0.23(- 0.60 ~ 0.13)，在3-5天/周时β = -0.69(- 1.10 ~ - 0.29)，在6-7天/周时β = - 0.32（- 0.63 ~ - 0.01）。代谢和肾脏BA加速的估计值高于心肺和肝脏BA加速。与不吃辣的人相比，吃辣的人代谢BA加速（3-5天/周：β = -0.76（- 1.28 ~ - 0.24）年）和肾脏BA加速（3-5天/周：β = -1.89（- 2.76 ~ - 1.02）年）下降。结论：辛辣食品可能对生物衰老有潜在的益处。我们的研究结果强调，辛辣食物可能减缓全面和器官特异性的生物衰老，特别是代谢和肾脏的生物衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.