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Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis. 鹰嘴豆降低餐后血糖反应:一项系统回顾和荟萃分析。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-14 DOI: 10.1186/s12937-025-01176-8
Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu
{"title":"Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis.","authors":"Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu","doi":"10.1186/s12937-025-01176-8","DOIUrl":"10.1186/s12937-025-01176-8","url":null,"abstract":"<p><strong>Background: </strong>Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials.</p><p><strong>Methods: </strong>We screened PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from inception through March 21, 2024 for acute, controlled, experimental (randomized or non-randomized) trials comparing chickpea consumption with carbohydrate-matched controls that reported on postprandial glucose and insulin responses (iAUC and C<sub>max</sub>). Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.</p><p><strong>Results: </strong>A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose C<sub>max</sub> (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.</p><p><strong>Conclusion: </strong>Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. Future studies should explore the long-term effects of chickpea consumption, investigate the impact of processing methods, and include metabolically unhealthy populations to enhance generalizability.</p><p><strong>Registration: </strong>This review was registered on PROSPERO (CRD42022365074).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"111"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies. 修正:韩国成人血清25-羟基维生素D水平与整体和部位特异性癌症的风险:来自两项前瞻性队列研究的结果。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-12 DOI: 10.1186/s12937-025-01177-7
Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park
{"title":"Correction: Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.","authors":"Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park","doi":"10.1186/s12937-025-01177-7","DOIUrl":"10.1186/s12937-025-01177-7","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"109"},"PeriodicalIF":4.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study. 性激素结合球蛋白和肠易激综合征与2型糖尿病之间的性别特异性关联:一项前瞻性队列研究。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-10 DOI: 10.1186/s12937-025-01155-z
Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu
{"title":"Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study.","authors":"Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu","doi":"10.1186/s12937-025-01155-z","DOIUrl":"10.1186/s12937-025-01155-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the sex-specific association between irritable bowel syndrome (IBS) and type 2 diabetes (T2D), and further explore whether sex-hormone binding globulin (SHBG) was an associated factor of the sex-specific association.</p><p><strong>Methods: </strong>The study was a prospective analysis based on the UK biobank (UKB) data. We included 359 503 participants, all of whom were without diabetes diagnosis and had complete SHBG information at baseline. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using non-IBS group as the reference, further stratified by sex and SHBG levels in multivariable-adjusted models, including demographics, lifestyle factors, and disease history.</p><p><strong>Results: </strong>During a median follow-up of 10.4 years, 14 317 incident T2D cases had been documented. A statistically significant increased risk of T2D with IBS compared to those without IBS was observed in all multivariable-adjusted models (HR = 1.32, 95% CI = 1.23-1.42, P < 0.001). Additionally, a sex-specific association between IBS and T2D was found (P<sub>interaction</sub> = 0.004), with the risk in women (HR = 1.43, 95% CI = 1.31-1.57) being higher than in men (HR = 1.14, 95% CI = 1.01-1.29). A significant effect modification of SHBG was also observed in the association between IBS and T2D (P<sub>interaction</sub> = 0.001). The risk of incident T2D was higher in participants with higher SHBG levels (HR = 1.42, 95% CI = 1.25-1.63) than in those with lower SHBG levels (HR = 1.26, 95% CI = 1.16-1.37).</p><p><strong>Conclusions: </strong>A sex-specific association between prevalent IBS and T2D incidence was found, and SHBG level might modify the association.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"108"},"PeriodicalIF":4.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial. 补充发酵乳酸杆菌MN-LF23对14天标准四联疗法根除幽门螺杆菌的影响:一项随机、双盲、安慰剂对照试验
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01124-6
Yuyang Zhao, Xiaokang Niu, Yong Zhang, Liang Zhao, Liwei Zhang, Jingjing He, Qi Zhang, Yuejian Mao, Fuqing Wang, Xiaohui Zhao, Ran Wang
{"title":"Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial.","authors":"Yuyang Zhao, Xiaokang Niu, Yong Zhang, Liang Zhao, Liwei Zhang, Jingjing He, Qi Zhang, Yuejian Mao, Fuqing Wang, Xiaohui Zhao, Ran Wang","doi":"10.1186/s12937-025-01124-6","DOIUrl":"10.1186/s12937-025-01124-6","url":null,"abstract":"<p><strong>Background: </strong>The effect of probiotics on Helicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role of Limosilactobacillus fermentum MN-LF23 (MN-LF23) in Hp-infected populations.</p><p><strong>Methods: </strong>A total of 94 adult patients with confirmed Hp infection were enrolled in this study and randomly allocated to the placebo or MN-LF23 group. Patients initially received either placebo or probiotics along with standard quadruple therapy for 2 weeks, followed by continued administration of either placebo or probiotics for an additional 4 weeks. The eradication of Hp, serum levels of inflammatory factors, and alterations in gastrointestinal symptoms were assessed at weeks 0, 2, and 6, while fecal samples were collected for metagenomic sequencing.</p><p><strong>Results: </strong>The results showed no significant difference (P = 1) in the eradication rate between the placebo group (85.11%) and the probiotic group (82.98%). Following treatment, the incidence of constipation, dyspepsia, and Gastrointestinal Symptom Rating Scale (GSRS) scores in the probiotic group were markedly lower (P < 0.05) compared to those observed in the placebo group. Throughout the treatment process, there were no significant differences in TNF-α and IL-1β levels between the two groups. Compared to the placebo group, the probiotic group exhibited a significant increase in beneficial bacteria such as Limosilactobacillus fermentum, Lactiplantibacillus plantarum, Bifidobacterium longum, Coprococcus caltus, and Clostridium butyricum.</p><p><strong>Conclusion: </strong>MN-LF23 supplementation did not improve the eradication rate of standard quadruple therapy. However, it significantly reduced the overall GSRS score, improved digestive and constipation symptoms, and promoted the proliferation of beneficial bacteria in the intestine.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"106"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches. 饮食质量、生物老化、心血管-肾脏-代谢综合征进展和死亡率的关联:来自调解和机器学习方法的见解。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01175-9
Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu
{"title":"Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.","authors":"Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu","doi":"10.1186/s12937-025-01175-9","DOIUrl":"10.1186/s12937-025-01175-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.</p><p><strong>Methods: </strong>Data of 7,918 participants were derived from the National Health and Nutrition Examination Survey 2005-2018. Cross-sectional analyses using multivariable logistic regression were conducted to evaluate the relationship between DII and CKM staging. Cox proportional hazards models were employed to assess the impact of DII on mortality in CKM patients. Mediation analyses were performed to determine whether biological aging mediated DII-staging and DII-mortality association. Machine learning models were developed to classify CKM stages 3/4 and predict all-cause mortality, with SHapley Additive exPlanations (SHAP) used to interpret the contribution of DII components.</p><p><strong>Results: </strong>Over a median follow-up of 9.3 years, 819 deaths were recorded. Higher DII were associated with an increased risk of advanced CKM stages [OR (95% CI): tertile 2, 1.39 (1.17, 1.65); tertile 3, 1.85 (1.56, 2.20)], and all-cause mortality [(HR (95% CI): tertile 2, 1.20 (1.01-1.43); tertile 3: 1.45 (1.21-1.73)]. The optimal risk stratification threshold for DII to predict all-cause mortality was 1.93. Mediation analyses revealed that biological aging accounted for 23% (95% CI: 18-28%) of the effect of DII on advanced CKM stages and 13% (95% CI: 8-22%) of the effect of DII on all-cause mortality. Furthermore, the Light Gradient Boosting Machine model showed strong performance in predicting advanced CKM staging (AUC: 0.896, 95% CI: 0.882-0.911), while Logistic regression performed better in predicting all-cause mortality (AUC: 0.857, 95% CI: 0.831-0.884). SHAP analysis revealed that intake of magnesium and n-3 fatty acid were associated with reduced risk of both advanced CKM stages and all-cause mortality.</p><p><strong>Conclusion: </strong>DII, a marker of pro-inflammatory dietary patterns, was significantly linked to CKM syndrome progression and mortality, partly by influencing biological aging. This underscores the importance of diet quality in managing CKM staging and mortality risk.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"105"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort. 膳食常量营养素质量与高脂血症发生率之间的关系:来自NEC-Biobank队列的研究结果。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-07 DOI: 10.1186/s12937-025-01174-w
Xiao-Ying Li, Dong-Hui Huang, Xin Xu, Xi-Meng Zhang, Jia-Le Lv, Yu-Xin Nan, Fan Cao, Qi-Jun Wu, Yu-Hong Zhao
{"title":"Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort.","authors":"Xiao-Ying Li, Dong-Hui Huang, Xin Xu, Xi-Meng Zhang, Jia-Le Lv, Yu-Xin Nan, Fan Cao, Qi-Jun Wu, Yu-Hong Zhao","doi":"10.1186/s12937-025-01174-w","DOIUrl":"10.1186/s12937-025-01174-w","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"107"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study. 含硫微生物饮食与痴呆风险之间的关系:一项大规模前瞻性队列研究。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-03 DOI: 10.1186/s12937-025-01172-y
Jigen Na, Celi Yang, Muzi Na, Xiaona Na, Yuefeng Tan, Xiaojin Shi, Zhihui Li, John S Ji, Ai Zhao
{"title":"Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study.","authors":"Jigen Na, Celi Yang, Muzi Na, Xiaona Na, Yuefeng Tan, Xiaojin Shi, Zhihui Li, John S Ji, Ai Zhao","doi":"10.1186/s12937-025-01172-y","DOIUrl":"10.1186/s12937-025-01172-y","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"104"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between vitamin D intake and the prevalence and mortality of asthma in the US adults. 维生素D摄入量与美国成人哮喘患病率和死亡率之间的关系
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-02 DOI: 10.1186/s12937-025-01171-z
Yu Lei, Yu Luo, Yi Wang, Caiyang Liu, Lei Luo, Ji Li
{"title":"The association between vitamin D intake and the prevalence and mortality of asthma in the US adults.","authors":"Yu Lei, Yu Luo, Yi Wang, Caiyang Liu, Lei Luo, Ji Li","doi":"10.1186/s12937-025-01171-z","DOIUrl":"10.1186/s12937-025-01171-z","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"103"},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between urinary and dietary potassium and diabetic microvascular complications: insights from UK Biobank data. 尿钾和膳食钾与糖尿病微血管并发症之间的关系:来自英国生物银行数据的见解。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-01 DOI: 10.1186/s12937-025-01161-1
Chao Li, Jingjing Zeng, Xufang Huang, Ying Li, Aaron M Lett, Yucen Wu, Qiqi You, Wan Fu, Shaoyong Xu
{"title":"The association between urinary and dietary potassium and diabetic microvascular complications: insights from UK Biobank data.","authors":"Chao Li, Jingjing Zeng, Xufang Huang, Ying Li, Aaron M Lett, Yucen Wu, Qiqi You, Wan Fu, Shaoyong Xu","doi":"10.1186/s12937-025-01161-1","DOIUrl":"10.1186/s12937-025-01161-1","url":null,"abstract":"<p><strong>Background: </strong>Potassium plays an important role in glucose metabolism and blood vessel. However, there is a lack of systematic research on the intake of potassium and diabetic microvascular complications. The aim of this study was to explore whether inadequate potassium intake increases the risk of developing diabetic microvascular complications, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy using the UK Biobank database.</p><p><strong>Methods: </strong>This study included 22,395 subjects with type 2 diabetes mellitus at baseline. Urinary potassium and creatinine were measured by potentiometry and photometric assay respectively. Dietary potassium intake was measured using the 24-hour dietary recall method. The occurrence of microvascular complications was determined using ICD-10 codes from cumulative hospitalization records and death records in the national death registry. Cox proportional hazards models were used to explore the relationship between urinary potassium-to-creatinine ratio, dietary potassium, and overall and individual microvascular complications, generating hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Compared with the minimum potassium-to-creatinine ratio group, the highest potassium-to-creatinine ratio group had a significantly lower risk of diabetic microvascular complications (HR, 0.70 [95% CI 0.63-0.78]; P for trend < 0.001) and diabetic nephropathy (HR, 0.54 [95% CI 0.47-0.61]; P for trend < 0.001). The group with the highest dietary potassium had a significantly lower risk of diabetic nephropathy (HR, 0.48 [95% CI 0.29-0.80], P for trend = 0.005) than the minimum dietary potassium group. The restricted cubic spline results showed a non-linear relationship between urinary potassium-to-creatinine ratio and overall microvascular complications and diabetic nephropathy, with nonlinear P values of 0.009 and < 0.001, respectively, and a generally declining trend.</p><p><strong>Conclusions: </strong>The urinary potassium-to-creatinine ratio was significantly negatively associated with overall diabetic microvascular complications and diabetic nephropathy.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"101"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men. 遗传学和脂肪酸代谢的相互作用:探索它们对瑞典男性代谢综合征的影响。
IF 4.4 2区 医学
Nutrition Journal Pub Date : 2025-07-01 DOI: 10.1186/s12937-025-01168-8
Harpa Oskarsdottir, Arnar Palsson, Erla B Olafsdottir, Vilmantas Giedraitis, Salahuddin Mohammad, Ulf Risérus, Helgi B Schiöth, Gudrun V Skuladottir, Jessica Mwinyi
{"title":"The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men.","authors":"Harpa Oskarsdottir, Arnar Palsson, Erla B Olafsdottir, Vilmantas Giedraitis, Salahuddin Mohammad, Ulf Risérus, Helgi B Schiöth, Gudrun V Skuladottir, Jessica Mwinyi","doi":"10.1186/s12937-025-01168-8","DOIUrl":"10.1186/s12937-025-01168-8","url":null,"abstract":"<p><strong>Background: </strong>Genetic risk variants for obesity and metabolic syndrome (MetS) have been identified, but their link to relevant metabolic health parameters warrants further attention. This study aimed to investigate the extent to which single-nucleotide polymorphisms (SNPs) associated with obesity are linked to changes in fatty acid (FA) profiles in serum cholesteryl esters, lipid metabolism, and MetS risk.</p><p><strong>Method: </strong>Data from the Uppsala Longitudinal Study of Adult Men (ULSAM), conducted in men at age 50 (N = 1973) and age 70 (N = 982), were used to investigate SNPs associated with body mass index (BMI) in genome-wide association studies with metabolic parameters at age 50. The significant SNPs and associated lipid parameters were then used as predictors of MetS over a 20-year follow-up period, at age 70 in binary regression models.</p><p><strong>Results: </strong>The two genes, the brain-derived neurotrophic factor gene (BDNF) (rs7103411) and the fat mass and obesity-associated gene (FTO) (rs1558902), together with delta-5-desaturase (D5D) activity, 20:5n-3 in serum cholesteryl esters (CE), fasting blood glucose, abdominal skinfold thickness, apolipoprotein-B, and high-density lipoprotein cholesterol (HDL-C) at age 50, significantly predicted the risk of MetS at age 70.</p><p><strong>Conclusion: </strong>The findings suggest a considerable contribution of the SNPs BDNF rs7103411, FTO rs1558902, and ETV5 rs9816226, along with low D5D activities and serum levels of HDL-C in men at age 50, to the risk for MetS 20 years later.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"99"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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