The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study.

IF 3.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-09-29 DOI:10.1186/s12937-025-01120-w

Dan Liu, Yingying Niu, Haoyu Yan, Chengping Li, Lianhong Chen, Chenglian Li, Kui Dong, Zhihao Li, Jian Zhang, Zhuoqun Wang, Pengkun Song, Yanfang Zhao, Yi Zhai, Mei Zhang, Shaojie Pang, Shengquan Mi, Xiaofeng Liang, Shuang Song, Zhaoxue Yin, Wenhua Zhao

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引用次数: 0

Abstract

Objectives: We aimed to investigate the associations between dietary choline, its subtypes, and cognitive function in older adults from underdeveloped regions of China, using data from the Nutrition and Chronic Disease Family Cohort (NCDFaC) study.

Methods: This cross-sectional study included 1 522 older adults aged 60 and over. Dietary choline intakes were assessed using a food frequency questionnaire, and cognitive function was evaluated with the Mini-Mental State Examination (MMSE). The associations between choline intake and mild cognitive impairment (MCI) were analyzed using logistic regression models, restricted cubic splines and propensity score matching (PSM).

Result: Among the 1 522 participants, 292 (19.2%) were diagnosed with MCI. Compared to those in the lowest quartile of total choline intake, participants in the 2nd quartile (169.0 mg/[1000 kcal*d]) had lower odds of MCI, with an OR (95% CI) of 0.63 (0.42, 0.94). Similarly, participants in the 2nd (116.0 mg/[1000 kcal*d]) and 3rd (148.0 mg/[1000 kcal*d]) quartiles of phosphatidylcholine intake had reduced odds of MCI, with ORs (95% CI) of 0.59 (0.39, 0.88) and 0.60 (0.40, 0.91), respectively. For free choline intake, the highest quartile (74.2 mg/[1000 kcal*d]) was associated with an OR (95% CI) of 0.55 (0.35, 0.86). After PSM, higher intakes of total choline and phosphatidylcholine remained associated with lower odds of MCI.

Conclusion: Moderate to high dietary intakes of total choline, phosphatidylcholine, and free choline may be associated with lower odds of MCI among older adults in underdeveloped regions.

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不发达地区老年人饮食胆碱摄入量与认知功能的关系：来自NCDFaC研究的结果。

目的：利用营养与慢性疾病家族队列（NCDFaC）研究的数据，研究中国欠发达地区老年人膳食胆碱及其亚型与认知功能之间的关系。方法：本横断面研究纳入1522名60岁及以上的老年人。使用食物频率问卷评估饮食胆碱摄入量，并使用简易精神状态检查（MMSE）评估认知功能。采用logistic回归模型、限制性三次样条和倾向评分匹配（PSM）分析胆碱摄入量与轻度认知障碍（MCI）的关系。结果：1522名参与者中，292名（19.2%）被诊断为轻度认知障碍。与总胆碱摄入量最低四分位数的参与者相比，第二四分位数（169.0 mg/[1000 kcal*d]）的参与者患MCI的几率较低，OR （95% CI）为0.63（0.42,0.94）。同样，磷脂酰胆碱摄入量第二组（116.0 mg/[1000 kcal*d]）和第三组（148.0 mg/[1000 kcal*d]）四分位数的参与者患MCI的几率降低，or （95% CI）分别为0.59（0.39,0.88）和0.60（0.40,0.91）。对于游离胆碱摄入量，最高四分位数（74.2 mg/[1000 kcal*d]）的OR （95% CI）为0.55（0.35,0.86）。PSM后，总胆碱和磷脂酰胆碱的高摄入量仍然与MCI的低几率相关。结论：在不发达地区的老年人中，饮食中摄入适量的总胆碱、磷脂酰胆碱和游离胆碱可能与MCI的发生率较低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.