Nutrition Journal最新文献

{"title":"The association of dietary fat and fatty acid intake with ovarian cancer survival: findings from the OOPS, a prospective cohort study.","authors":"Yi-Fan Wei, Yi-Lin Xu, Yi-Zi Li, Shu-Hong Huang, Xue Qin, Shi Yan, Jin Xu, Fang-Hua Liu, Song Gao, Meng Luan, Ting-Ting Gong, Qi-Jun Wu","doi":"10.1186/s12937-025-01135-3","DOIUrl":"https://doi.org/10.1186/s12937-025-01135-3","url":null,"abstract":"<p><strong>Background: </strong>Dietary fat and fatty acid intakes impact the occurrence and development of several cancers. However, the evidence regarding fat and fatty acid intake and ovarian cancer (OC) survival is limited.</p><p><strong>Methods: </strong>The Ovarian Cancer Follow-Up Study (OOPS), a prospective cohort study, analyzed data collected from 703 OC patients. Deaths were ascertained via medical records and active follow-up. Dietary intake was derived from a validated food frequency questionnaire. Cox proportional hazard models were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for association evaluation. Furthermore, several subgroup and sensitivity analyses were also performed.</p><p><strong>Results: </strong>A total of 130 patients died during a median follow-up of 37.17 (interquartile: 24.73-50.17) months. Relative to the lowest tertile of intake, patients with the highest tertile of total fat (HR = 1.87, 95% CI = 1.01-3.49), total fatty acid (HR = 2.20, 95% CI = 1.27-3.80), total saturated fatty acid (SFA) (HR = 2.02, 95% CI = 1.22-3.34), shorter-chain SFA (HR = 1.59, 95% CI = 1.03-2.47), long-chain SFA (HR = 1.69, 95% CI = 1.03-2.77), total monounsaturated fatty acid (MUFA) (HR = 1.77, 95% CI = 1.02-3.05), and animal-based MUFA (HR = 2.05, 95% CI = 1.17-3.58) intake had higher all-cause mortality risk. In contrast, individuals in the highest tertile of egg fat (HR = 0.57, 95% CI = 0.35-0.92) and fruit and vegetable fat (HR = 0.48, 95% CI = 0.31-0.75) intake exhibited a reduced risk of all-cause mortality. Additionally, significant positive associations with all-cause mortality were identified for the consumption of several common fatty acids, including capric acid (HR = 1.92, 95% CI = 1.23-3.00), myristic acid (HR = 1.86, 95% CI = 1.15-3.02), palmitic acid (HR = 1.72, 95% CI = 1.07-2.76), stearic acid (HR = 1.93, 95% CI = 1.12-3.31), and oleic acid (HR = 1.96, 95% CI = 1.13-3.40), when comparing the highest to the lowest tertile of intake.</p><p><strong>Conclusions: </strong>We identified a linkage of higher intake of total fats, total fatty acids, SFAs, shorter-chain SFAs, long-chain SFAs, total MUFAs, and animal-based MUFAs with increased all-cause mortality of OC patients. Conversely, consumption of egg fats and fruit and vegetable fats demonstrated inverse associations with all-cause mortality.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"70"},"PeriodicalIF":4.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between the dietary omega-6 to omega-3 fatty acid ratio and age-related macular degeneration in Korean adults.","authors":"Won Jang, Yuna Kim, Hyesook Kim","doi":"10.1186/s12937-025-01140-6","DOIUrl":"https://doi.org/10.1186/s12937-025-01140-6","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"68"},"PeriodicalIF":4.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chrononutrition behaviors in relation to diet quality and obesity: do dietary assessment methods and energy intake misreporting matter?","authors":"Kentaro Murakami, Nana Shinozaki, M Barbara E Livingstone, Tracy A McCaffrey, Shizuko Masayasu, Satoshi Sasaki","doi":"10.1186/s12937-025-01129-1","DOIUrl":"https://doi.org/10.1186/s12937-025-01129-1","url":null,"abstract":"<p><strong>Background: </strong>Inconsistent epidemiologic findings on the associations of chrononutrition behaviors with diet quality and adiposity measures may be due to the use of different dietary assessment methodologies and a lack of consideration of dietary misreporting. We aimed to investigate the associations by using questionnaires and diaries, with adjustment for energy intake (EI) misreporting.</p><p><strong>Methods: </strong>This cross-sectional study included 1047 Japanese adults aged 20-69 years. We used the Chrono-Nutrition Behavior Questionnaire (CNBQ) or 11-day diaries to assess chrononutrition behaviors (meal frequency, snack frequency, total eating frequency, timing of first eating occasion, timing of last eating occasion, duration of eating window, and eating midpoint) for workdays and non-workdays separately. Eating jetlag was defined as the eating midpoint difference between workdays and non-workdays. Diet quality was assessed using the Healthy Eating Index-2020, based on the Meal-based Diet History Questionnaire (MDHQ) or 4-day weighed food diaries. EI misreporting was evaluated using the Goldberg cut-off principle.</p><p><strong>Results: </strong>Using questionnaire data (CNBQ and MDHQ), we found inverse associations of snack and total eating frequencies, timing of last eating occasion, eating midpoint, and eating jetlag with diet quality (P < 0.05), irrespective of adjustment for EI misreporting. Also, we found positive associations of meal, snack, and total eating frequencies and duration of eating window with the prevalence of general obesity (body mass index ≥ 25 kg/m²), abdominal obesity (waist circumference ≥ 90 cm for males; ≥ 80 cm for females), or both; many of these associations were only evident (P < 0.05) after adjustment for EI misreporting. In contrast, using diary data, we found no associations between chrononutrition behaviors and diet quality, general obesity, or abdominal obesity, regardless of adjustment for EI misreporting (except for inverse associations of timings of first and last eating occasions and eating midpoint on workdays with diet quality).</p><p><strong>Conclusions: </strong>The associations of chrononutrition behaviors with diet quality and obesity were dependent on the methodology used to assess these behaviors. Adjustment for EI misreporting radically changed only the associations with obesity in the questionnaire-based analysis. These findings suggest the importance of careful consideration of dietary assessment method selection and EI misreporting in chrononutrition research.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"67"},"PeriodicalIF":4.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of structured exercise and oat supplementation for treating non-alcoholic fatty liver disease: protocol of a randomized controlled trial.","authors":"Jiahui Yin, Lianying Wang, Ran Li, Xiaoguang Cheng, Haibo Wang, Yufeng Li","doi":"10.1186/s12937-025-01128-2","DOIUrl":"https://doi.org/10.1186/s12937-025-01128-2","url":null,"abstract":"<p><strong>Background: </strong>Lifestyle modifications, including nutritional therapy and physical activity, are recommended as a first-line treatment for non-alcoholic fatty liver disease (NAFLD). However, both the best dietary approach and the optimal exercise pattern remain controversial. We will assess the efficacy of structured exercise and oats supplementation in NAFLD patients.</p><p><strong>Methods/design: </strong>Participants aged 18-65 years with intrahepatic lipid content ≥5% according to quantitative computed tomography (QCT) (N = 180) will be included in this randomized controlled 24-week structured exercise and dietary intervention study. Eligible participants will be randomly assigned (1:1:1:1) to the structured exercise group (aerobic exercise and resistance training), diet intervention group (80 g oats/daily supplementation), combined group (structured exercise + diet intervention) or control group. All participants will receive routine lifestyle education based on their daily caloric intake. The primary outcome was the change in the intrahepatic lipid content in the four groups. Body composition, muscle strength, and 72-hour dietary records will be assessed, and blood, urine and faeces tissue samples at baseline and at 12 and 24 weeks will be collected. Data will be analysed using t tests or Wilcoxon rank sum tests to compare the changes in the outcome measures among the different groups.</p><p><strong>Discussion: </strong>There are limited data on the efficiency of structured exercise and oat supplementation for NAFLD treatment. The findings of this study will provide evidence-based data to health providers on lifestyle interventions aimed at alleviating the current NAFLD epidemic.</p><p><strong>Trial registration: </strong>The study was registered with the Chinese Clinical Trial Registry (ChiCTR2100048042) on June 28, 2021.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"66"},"PeriodicalIF":4.4,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meat and fish consumption, genetic risk and risk of severe metabolic-associated fatty liver disease: a prospective cohort of 487,875 individuals.","authors":"Jianjin Wang, Jianshu Mo, Xuzhi Wan, Yilei Fan, Pan Zhuang","doi":"10.1186/s12937-025-01134-4","DOIUrl":"https://doi.org/10.1186/s12937-025-01134-4","url":null,"abstract":"<p><strong>Background: </strong>Diet, specifically meat consumption, has been implicated as a modifiable risk factor in the development of metabolic-associated fatty liver disease (MAFLD). This study aimed to investigate the associations between various types of meat intake and the risk of severe MAFLD and to examine whether genetic risk influences these associations.</p><p><strong>Methods: </strong>This research utilized data from the UK Biobank, which initially enrolled over 500,000 participants between 2006 and 2010, of whom 487,875 were eligible for our analyses. Meat intake, including unprocessed red meat, processed meat, poultry, and fish, was evaluated through a validated touchscreen questionnaire. Cox proportional hazards models were used to analyze the relationship between meat consumption and severe MAFLD risk, adjusting for potential confounders. Genetic risk scores (GRS) were calculated using five MAFLD-associated SNPs, allowing for analyses of gene-diet interactions.</p><p><strong>Results: </strong>During a follow-up period totaling 6,036,554 person-years (mean duration: 12.1 years), 5,731 new cases of severe MAFLD were identified. High intakes of total meat, processed meat, unprocessed red meat and poultry were associated with increased MAFLD risk, with adjusted hazard ratios (HR) of 1.76 (95% CI: 1.33-2.33), 1.19 (1.02-1.40), 1.34 (1.17-1.53), and 1.21 (0.98-1.49), respectively, for the highest versus lowest intake categories. In contrast, oily fish intake showed a protective association (HR: 0.72; 95% CI: 0.53-0.97). No significant interaction was observed between meat intake and GRS for any meat subtype, suggesting that the associations were independent of genetic predisposition.</p><p><strong>Conclusions: </strong>High consumption of red and processed meat was associated with an increased risk of severe MAFLD, while oily fish intake showed an inverse association with the risk of MAFLD. These effects were consistent across genetic risk levels for MAFLD. Our findings reinforce dietary recommendations to limit red and processed meat and encourage oily fish intake for MAFLD prevention, irrespective of individual genetic risk.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"65"},"PeriodicalIF":4.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Spirulina (Arthrospira) platensis supplementation on intestinal permeability, antioxidant and inflammatory markers, quality of life and disease severity in patients with constipated-predominant irritable bowel syndrome: a randomized double‑blind, placebo‑controlled trial.","authors":"Saeede Jafari Nasab, Awat Feizi, Parisa Hajihashemi, Mohammad-Hassan Entezari, Manoj Sharma, Peyman Adibi, Mohammad Bagherniya","doi":"10.1186/s12937-025-01132-6","DOIUrl":"10.1186/s12937-025-01132-6","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) is a chronic, functional gastrointestinal disorder (FGID) which is characterized by chronic pain related to defecation and alteration in GI motility. Recent findings indicated that intestinal barrier dysfunction, hyperpermeability, oxidative stress, and inflammation play a role in IBS pathogenesis. Considering the antioxidant properties of Spirulina (Arthrospira) platensis (SP), this study aimed to investigate the effect of SP supplementation on Quality of life (QoL), disease severity, antioxidant capacity, oxidative stress index and intestinal permeability in constipation-dominant IBS (IBS-C) patients.</p><p><strong>Methods: </strong>This study was a parallel randomized, double-blind, placebo-controlled clinical trial involving 60 IBS-C patients aged 18-50 years. The patients were given either 1 g SP (two capsules/day; each capsule contained 500 mg of SP) or placebo for 12 weeks. IBS-QoL, IBS-Severity system score (IBS-SSS), plasma total antioxidant capacity (TAC), malondialdehyde (MDA), and zonulin levels were measured at baseline and the end of the intervention. Univariate comparison and intention-to-treat (ITT) were used for analysis.</p><p><strong>Results: </strong>SP supplementation compared to placebo resulted in a significant increase in QoL score (7.05 ± 2.02 vs. - 1.57 ± 2.49; p = 0.008), TAC (145.27 ± 30.77 vs. -54.90 ± 45.72; p < 0.001) and decrease in IBS-SSS (-32.17 ± 8.96 vs. 1.07 ± 8.49; p = 0.002), MDA level (- 11.61 ± 2.57 vs. - 2.00 ± 2.24; p < 0.001) and zonulin level (- 0.22 ± 0.05 vs. 0.12 ± 0.07; p = 0.001). These results remained significant after adjusting for baseline values.</p><p><strong>Conclusions: </strong>SP supplementation demonstrated a promising effect in the management of IBS. However, larger trials with a dose-dependent approach in IBS-C and other subtypes of IBS are warranted.</p><p><strong>Trial registration: </strong>The study protocol was approved by the ethical committee at the Isfahan University of Medical Sciences (Registration No. IR.MUI.</p><p><strong>Research: </strong>REC.1401.370) and registered online at http://www.IRCT.ir (code: IRCT20140208016529N8, approved date 25.04.2023).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"64"},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How animal and plant-based proteins affect energy metabolism during the postprandial phase in overweight and obese men: a cross-over design study.","authors":"Zahra Dehnavi, Shima Sabbaghi, Ali Jafarzadeh Esfehani, Mahnaz Namazi, Fahimeh Hoseinzadeh, Hanieh Barghchi, Monireh Dahri, Reza Rezvani, Mahdi Shadnoush, Mohammad Safarian","doi":"10.1186/s12937-025-01106-8","DOIUrl":"https://doi.org/10.1186/s12937-025-01106-8","url":null,"abstract":"<p><strong>Background: </strong>Animal proteins (APs) and plant proteins (PPs) seem to exhibit different thermic and metabolic effects, which may be attributed to differences in amino acid profiles, bioavailability, and digestibility.</p><p><strong>Objectives: </strong>In this study, we aimed to investigate and compare the postprandial effects of AP and PP meals on energy metabolism parameters, including resting energy expenditure (REE) and substrate oxidation (SO), in overweight and obese men.</p><p><strong>Methods: </strong>This acute randomized crossover clinical trial involved forty-eight overweight and obese men, with a mean age of 33.48 ± 8.35 years and an average BMI of 29.15 ± 2.33 kg/m². Participants consumed two high-protein test meals with different protein sources (AP and PP) on separate days, with a washout period of 7 to 10 days between them. On each test day, energy metabolism parameters were measured in both the fasting state and postprandial phase using indirect calorimetry. Statistical analysis was conducted using SPSS version 25 and R programs, evaluating the effects of carry-over, treatment, time, and treatment × time interaction through generalized estimating equations (GEE) analysis.</p><p><strong>Results: </strong>After controlling for baseline values, there was a significant effect of time (P < 0.05), protein source (P < 0.05), and protein source × time (P < 0.05) on REE, TEF, and carbohydrate oxidation. REE showed an increase following the consumption of both meals; however, the rise observed after AP (14.2%) was greater than that of PP (9.55%). The trends in TEF changes were similar to those of REE. The mean carbohydrate oxidation after consuming PP remained relatively stable throughout the test, whereas the AP meal gradually increased, reaching its peak at the 180th minute. The decline in carbohydrate oxidation was more pronounced following the AP meal than the PP meal by the end of the test.</p><p><strong>Conclusion: </strong>This clinical trial demonstrates that animal-based protein results in higher energy expenditure and carbohydrate oxidation than plant-based protein.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"63"},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between ultra-processed food consumption, fecal microbiota, and metabolomic profiles in older mediterranean adults at high cardiovascular risk.","authors":"Alessandro Atzeni, Adrián Hernández-Cacho, Nadine Khoury, Nancy Babio, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Clary Clish, Josep Vidal, Prokopis Konstanti, Sandra Gonzales-Palacios, Oscar Coltell, Albert Goday, Isabel Moreno Indias, Silvia Carlos Chillerón, Miguel Ruiz-Canela, Francisco J Tinahones, Frank B Hu, Jordi Salas-Salvadó","doi":"10.1186/s12937-025-01125-5","DOIUrl":"https://doi.org/10.1186/s12937-025-01125-5","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed food (UPF) consumption has been linked to adverse metabolic outcomes, potentially mediated by alterations in gut microbiota and metabolite production.</p><p><strong>Objective: </strong>This study aims to explore the cross-sectional and longitudinal associations between NOVA-classified UPF consumption, fecal microbiota, and fecal metabolome in a population of Mediterranean older adults at high cardiovascular risk.</p><p><strong>Methods: </strong>A total of 385 individuals, aged between 55 and 75 years, were included in the study. Dietary and lifestyle information, anthropometric measurements, and stool samples were collected at baseline and after 1-year follow-up. Fecal microbiota and metabolome were assessed using 16 S rRNA sequencing and liquid chromatography-tandem mass spectrometry, respectively.</p><p><strong>Results: </strong>At baseline, higher UPF consumption was associated with lower abundance of Ruminococcaceae incertae sedis (β = - 0.275, P = 0.047) and lower concentrations of the metabolites propionylcarnitine (β = - 0.0003, P = 0.013) and pipecolic acid (β = - 0.0003, P = 0.040) in feces. Longitudinally, increased UPF consumption was linked to reduced abundance of Parabacteroides spp. after a 1-year follow-up (β = - 0.278, P = 0.002).</p><p><strong>Conclusions: </strong>High UPF consumption was associated with less favorable gut microbiota and metabolite profiles, suggesting a possible link to reduced short-chain fatty acid (SCFA) production, altered mitochondrial energy metabolism, and impaired amino acid metabolism. These findings support the reduction of UPF consumption and the promotion of dietary patterns rich in fiber for better gut health. Further research is needed to confirm these associations and clarify the underlying mechanisms.</p><p><strong>Trial registration: </strong>ISRCTN89898870 ( https://doi.org/10.1186/ISRCTN89898870 ).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"62"},"PeriodicalIF":4.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between dietary protein and amino acid intake and handgrip strength in Korean adults: data from the 2014-2019 Korea National Health and Nutrition Examination Survey.","authors":"Hyunji Ham, Sumin Kim, Kyungho Ha","doi":"10.1186/s12937-025-01131-7","DOIUrl":"https://doi.org/10.1186/s12937-025-01131-7","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia contributes to an increased risk of falls and fractures, and reduced mobility, and mortality. Supplementation with dietary protein and amino acids has been suggested as a potential strategy to slow or prevent the associated loss of muscle mass and strength. However, most previous studies have focused on dietary protein or limited populations, such as older adults. Therefore, this study aimed to investigate the relationship between dietary protein and amino acid intake and handgrip strength (HG) in Korean adults.</p><p><strong>Methods: </strong>This study used data from the 2014-2019 Korea National Health and Nutrition Examination Survey. A total of 18,565 adults who participated in a 1-day 24-hour recall method were included. Protein intake was calculated as a percentage of total energy intake from food sources (animal and plant). Amino acid intake (g/day), including essential amino acids (EAAs), branched-chain amino acids (BCAAs), and non essential amino acids (NEAAs), was assessed using a database expanded based on amino acid composition databases constructed by national institutions. Low HG was diagnosed based on the 2019 guidelines of the Asian Working Group on Sarcopenia.</p><p><strong>Results: </strong>In the fully adjusted model, total and plant protein intakes were positively associated with HG levels (kg) (β = 0.04 and 0.07 per 1% increase, respectively; p < 0.05 for both). Participants aged ≥ 65 years in the highest NEAA intake group had a 42% lower risk of low HG compared to those in the lowest intake group (odds ratio 0.58; 95% confidence interval 0.35-0.97; p for trend = 0.1026). A lower risk of HG was observed in older participants whose plant protein intake ranged from 8 to 10% of energy, compared to those consuming less than 7%. However, no association was found when intake exceeded 10% of energy.</p><p><strong>Conclusions: </strong>These findings suggest that a high intake of NEAAs and a moderately high intake of plant protein may be associated with a lower risk of low HG among Korean older adults. Further prospective studies are needed to explore the effects of protein and amino acid intake on muscle mass and strength.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"61"},"PeriodicalIF":4.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary inflammatory index and cardiovascular-kidney-metabolic syndrome risk: a cross-sectional study.","authors":"Chuanwei Zhao, Mu Lin, Yane Yang, Haijie Yang, Zhengqian Gao, Zijie Yan, Chunxin Liu, Shumeng Yu, Ying Zhang","doi":"10.1186/s12937-025-01127-3","DOIUrl":"https://doi.org/10.1186/s12937-025-01127-3","url":null,"abstract":"<p><strong>Background: </strong>Dietary inflammation has been linked to various diseases. The dietary inflammatory index (DII) is a tool used to assess the inflammatory potential of a diet. The aim of this study was to explore the relationship between the DII and the risk of developing cardiovascular-kidney-metabolic syndrome (CKMS) in a U.S.</p><p><strong>Population: </strong></p><p><strong>Methods: </strong>Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2020, which included 24,071 participants, were analyzed. CKMS was defined as the coexistence of cardiometabolic syndrome (CMS) and chronic kidney disease (CKD). The DII was calculated on the basis of the anti-inflammatory and pro-inflammatory scores of foods and nutrients. Weighted multivariable logistic regression models were used to estimate the associations between the DII and the risk of developing CKMS. Restricted cubic spline (RCS) regression was conducted to test nonlinear relationships. Subgroup analyses were performed by sex, age, race, smoking status, and alcohol consumption status.</p><p><strong>Results: </strong>After adjusting for confounders, compared with those of the lowest quartile of the DII, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for higher DII quartiles were 1.17 (0.93-1.47), 1.43 (1.13-1.81), and 1.76 (1.42-2.18), respectively. Each one-unit increase in the DII was associated with a 12% greater risk of developing CKMS (OR: 1.12, 95% CI: [1.08, 1.18]). RCS regression indicated a significant nonlinear positive association between the DII and the risk of developing CKMS.</p><p><strong>Conclusions: </strong>This study revealed a nonlinear positive association between the DII and the risk of developing CKMS in the U.S.</p><p><strong>Population: </strong>Further longitudinal studies are needed to establish causality and explore the underlying biological mechanisms involved.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"60"},"PeriodicalIF":4.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}