Nutrition Journal最新文献

{"title":"Predictive effects of advanced lung cancer inflammation index and serum vitamin D on mortality in patients with asthma.","authors":"Ting Li, Qi Wang, Yuhan Li, Wenyong Zhang, Manyu Chen, Bihua Deng, Lin Liang, Weixian Lin, Yuying Lin, Ying Meng","doi":"10.1186/s12937-024-01065-6","DOIUrl":"10.1186/s12937-024-01065-6","url":null,"abstract":"<p><strong>Background: </strong>Changes in systemic inflammation, nutritional status and serum vitamin D level are important characteristics of asthma. However, role and importance of nutritional inflammatory indicators or serum vitamin D concentrations in predicting the prognosis of asthma remain unclear. The advanced lung cancer inflammation index (ALI), based on body mass index (BMI), serum albumin and neutrophil-lymphocyte ratio (NLR), is a comprehensive index to assess systemic inflammation and nutrition. This study aimed to evaluate their independent and combined predictive value of mortality in asthma patients.</p><p><strong>Methods: </strong>This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2001-2018. Cox regression analysis was used to assess the independent or joint effect of ALI and serum vitamin D on mortality risks of asthma. Receiver operator characteristic curve analysis was used to compare the prognostic ability of ALI with its component factors, including NLR, albumin, neutrophil, lymphocyte and BMI.</p><p><strong>Results: </strong>A total of 2870 eligible asthma patients were included. After adjustment, higher ALI correlated significantly with reduced all-cause and respiratory disease mortality (adjusted hazard ratio [aHR] = 0.64 and 0.34; P < 0.05). Meanwhile, vitamin D deficiency correlated significantly with increased all-cause and respiratory disease mortality (aHR = 2.06 and 2.73; P < 0.05). The area under the curve of ALI in predicting 1-year, 5-year or 10-year all-cause mortality surpassed that of its five component indices. Joint analyses showed that individuals with higher levels of ALI and vitamin D had the lowest risks of all-cause and respiratory disease mortality (aHR = 0.31 and 0.17; P < 0.05).</p><p><strong>Conclusions: </strong>ALI and serum vitamin D are robust independent and combined predictors of mortality in asthma patients. ALI offers superior predictive capability over its components, and sufficient vitamin D levels are beneficial for survival outcomes. The synergistic effect of high ALI and adequate vitamin D highlights the benefit of integrating both metrics into clinical practice for enhanced prognostic accuracy.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"26"},"PeriodicalIF":4.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum carotenoids and osteoarthritis or degenerative arthritis: A cross-sectional study using the National Health and Nutrition Examination Survey.","authors":"Bowen Zhu, Guochun Li, Kaiwen Wu, Qian Luo, Xie Wu","doi":"10.1186/s12937-025-01087-8","DOIUrl":"10.1186/s12937-025-01087-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Carotenoids possess essential antioxidant and anti-inflammatory properties; however, the relationships between carotenoids and osteoarthritis or degenerative arthritis (OA) remain inadequately understood. This study aimed to investigate the correlation between diverse serum carotenoid concentrations and OA in a large American cohort and to examine the influence of various factors on the association between carotenoids and OA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data from the 2001-2006 and 2017-2018 National Health and Nutrition Examination Surveys were utilized. In our analysis, we utilized a directed acyclic graph to identify potential confounding variables. The associations between serum carotenoids (including total carotenoid, trans-lycopene, β-cryptoxanthin, lutein/zeaxanthin, α-carotene, and β-carotene) and OA were comprehensively evaluated via a weighted generalized linear model (GLM) and restricted cubic spline models. Threshold effect analyses were used to identify potential cutoff points, subgroup analyses were used to explore heterogeneity, interaction analyses were used to examine potential modifiers, and sensitivity analyses were used to validate the robustness of the findings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The weighted GLM results revealed that, overall, the concentrations of various serum carotenoids did not exhibit a significant linear correlation with the probability of OA. Dose‒response curves and threshold effect analysis revealed a significant nonlinear relationship (P &lt;sub&gt;for overall&lt;/sub&gt; = 0.027; P &lt;sub&gt;for nonlinearity&lt;/sub&gt; = 0.019; P &lt;sub&gt;for likelihood ratio&lt;/sub&gt; = 0.0128) between trans-lycopene (threshold effect) and OA, with an inflection point at 19.49 µg/dl. Further subgroup weighted linear regression analysis indicated that when the serum trans-lycopene concentration exceeded 19.49 µg/dl, there was a significant association [odds ratio (OR) = 0.89 (0.80-0.99); P = 0.027] between the per standard deviation trans-lycopene increase and a lower probability of OA after adjusting for other variables. Moreover, individuals with elevated trans-lycopene [0.70 (0.52-0.94); P = 0.018] in the fifth quintile had notably reduced odds of OA compared with those in the first quintile. When the trans-lycopene level is less than 19.49 µg/dl, no correlation exists between the two variables. Linear subgroup and interaction analyses revealed that when the concentration of carotenoids exceeded 19.49 µg/dl, various categorical factors did not significantly influence the relationship between trans-lycopene and OA overall. However, pairwise comparisons revealed that lower serum trans-lycopene concentrations are more closely associated with a greater probability of OA in elderly individuals [OR (95% CI) = 0.270 (0.112-0.654); P = 0.005; P &lt;sub&gt;for trend&lt;/sub&gt; = 0.003] than in younger individuals [0.973 (0.385-2.463); P = 0.954; P &lt;sub&gt;for trend&lt;/sub&gt; = 0.61] (P &lt;sub&gt;for interaction&lt;/sub&gt; = 0.007).&lt;/p&gt;&lt;p&gt;&lt;strong","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"25"},"PeriodicalIF":4.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of diseases attributable to excess body weight in 204 countries and territories, 1990-2019.","authors":"Saeid Safiri, Jessica A Grieger, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Asra Fazlollahi, Mark J M Sullman, Nahid Karamzad, Fikrettin Sahin, Kuljit Singh, Gary S Collins, Ali-Asghar Kolahi","doi":"10.1186/s12937-025-01082-z","DOIUrl":"10.1186/s12937-025-01082-z","url":null,"abstract":"<p><strong>Background: </strong>To investigate the global, regional, and national burden of the diseases attributable to excess body weight (EBW) from 1990 to 2019, stratified by age, sex, underlying cause, and sociodemographic index (SDI).</p><p><strong>Methods: </strong>Using the Comparative Risk Assessment approach of the Global Burden of Disease (GBD) study 2019, the burden of diseases attributable to EBW was reported for the period from 1990 to 2019. For adults, EBW was defined as a body mass index (BMI) exceeding 25 kg/m², while for children aged 1 to 19 years, EBW was determined according to the standards set by the International Obesity Taskforce. The burden was reported in terms of numbers, proportions, and age-standardised rates per 100,000, accompanied by corresponding 95% uncertainty intervals (UIs).</p><p><strong>Results: </strong>In 2019, there were an estimated 5.0 million deaths (95% UI: 3.2-7.1) and 160.3 million DALYs (106.0-218.9) attributable to EBW worldwide. The age-standardised DALY rate attributable to EBW increased by 18.0% (2.2-42.3) from 1990 to 2019, with notable regional variations. Southeast Asia and South Asia exhibited the highest age-standardised DALY rates. Conversely, the age-standardised death rate due to EBW showed no significant change, with an increase of 4.9% (-7.3 to 24.6) over the same period. Significant regional variations were again observed, particularly in Southeast Asia and South Asia, which recorded the highest age-standardised death rates. Moreover, a non-linear association was observed between the SDI and the regional age-standardised DALY rate of diseases attributable to EBW.</p><p><strong>Conclusions: </strong>The global burden of EBW has increased over the past three decades. This trend aligns with socio-demographic indices and is influenced by the physical activity levels and dietary habits of these populations.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"23"},"PeriodicalIF":4.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials.","authors":"Mitra Hariri, Masoudreza Sohrabi, Ali Gholami","doi":"10.1186/s12937-025-01085-w","DOIUrl":"10.1186/s12937-025-01085-w","url":null,"abstract":"<p><strong>Background: </strong>Some evidence suggests magnesium might reduce serum levels of lipid profile. Due to the significance of this matter on hand, we centralized our aim to conduct a systematic review and meta-analysis to interrogate the effect of magnesium supplementation on serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) in the general population aged ≥ 18 years.</p><p><strong>Methods: </strong>In line with conducting this study first, relevant articles were found through searching databases, including five databases: Cochrane Library, ClinicalTrials.gov, ISI Web of Science, Scopus, and PubMed until January 2024. Following fulfilling the first aim, their mean differences and standard deviations were calculated to conduct the meta-analysis. Ultimately, an assessment of the statistical heterogeneity of intervention effects was performed using I-squared statistics and Cochran's Q test.</p><p><strong>Results: </strong>Regarding serum levels of TC, TG, LDL-C, and HDL-C, twenty-one, twenty-three, twenty, and twenty-five studies were included in the meta-analysis. The pooled estimates showed no significant differences in serum levels of TC, TG, and LDL-C between the magnesium group and comparison group (weighted mean difference (WMD) = 0.34 mg/dl, 95% confidence interval (CI): -1.75 to 2.43, P = 0.749, I² = 99.1%; WMD=-2.06 mg/dl, 95% CI: -6.35 to 2.23, P = 0.346, I² = 99.1; WMD = 1.71 mg/dl, 95% CI: -0.81 to 4.24, P = 0.183, I² = 99.4, respectively). However, magnesium significantly increased HDL-C (WMD = 1.21 mg/dl, 95% CI: 0.58 to 1.85, P < 0.001, I² = 99.5).</p><p><strong>Conclusion: </strong>In conclusion, our study showed that magnesium significantly increased HDL-C levels. However, due to high heterogeneity, we must note that more research is needed to make robust recommendations regarding magnesium supplementation in clinical practice.</p><p><strong>Registry number: </strong>This study was registered in PROSPERO under the protocol number CRD42024505142.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"24"},"PeriodicalIF":4.4,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of serum creatine kinase as a prognostic marker for patients with resectable pancreatic cancer: looking into the relationship with body composition.","authors":"Cong Chen, Xin Luo, Xianchao Lin, Ronggui Lin, Yuanyuan Yang, Congfei Wang, Haizong Fang, Tianhong Teng, Heguang Huang, Fengchun Lu","doi":"10.1186/s12937-025-01084-x","DOIUrl":"10.1186/s12937-025-01084-x","url":null,"abstract":"<p><strong>Background: </strong>Among cancer patients, pancreatic cancer patients have the highest rate of sarcopenia, which is a critical prognostic factor. Serum creatine kinase (CK) is closely related to skeletal muscle mass and has been reported to decline with the progression of cancer. This study investigated whether preoperative serum CK is associated with the survival of patients with pancreatic cancer.</p><p><strong>Methods: </strong>Data were obtained from patients with pathologically confirmed pancreatic cancer between June 2016 and March 2022. The prognostic significance of CK was analyzed based on sex-stratified groups. The Kaplan-Meier method was used to compare overall survival (OS) and disease-free survival (DFS). Multivariate Cox proportional hazards models were used to determine prognostic factors. Body composition was analyzed based on preoperative abdominal CT images to explore the sex-specific associations between skeletal muscle area (SMA) and serum CK levels.</p><p><strong>Results: </strong>A total of 166 patients were included in this study. Sarcopenia was presented in 70 patients (42.2%). A low serum CK level showed a significant correlation with the diagnosis of sarcopenia in male patients (P = 0.026). The levels of CK did not predict the outcome in female patients, while a low preoperative CK was notably linked to shorter OS in male patients (median OS: 15 months vs. 33 months, P = 0.011; median DFS: 5 months vs. 14 months, P = 0.007). Multivariate analyses further confirmed the effect of CK in predicting OS (CK>44 IU/L, HR:0.226, 95% CI:0.107-0.478, P < 0.001) and DFS (CK>44 IU/L, HR:0.272, 95% CI:0.139-0.529, P < 0.001) of male patients. Correlation analysis revealed a significant association between SMA and CK levels in male patients (r = 0.225, P = 0.025), and such a correlation was not observed in female patients (r = 0.088, P = 0.478).</p><p><strong>Conclusion: </strong>The pretherapeutic CK may represent a simple marker for predicting poor survival in male patients with resectable pancreatic cancer, thereby aiding in the selection of therapeutic strategies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"22"},"PeriodicalIF":4.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study.","authors":"Natalia Ortega, Nick J Mueller, Abbas Dehghan, Tosca O E de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O Chocano-Bedoya","doi":"10.1186/s12937-025-01083-y","DOIUrl":"10.1186/s12937-025-01083-y","url":null,"abstract":"<p><strong>Background: </strong>Meta-analyses of observational studies on the effect of dairy on cognitive function have yielded inconclusive results, potentially due to unmeasured confounding. To avoid the no-unmeasured confounding assumption, we used lactase persistence genetic variant as an instrumental variable, for which the CC genotype is associated with lower lactase production and, consequently, lower dairy consumption. We used it to assess the effect of long-term consumption of total and non-fermented dairy on cognitive function.</p><p><strong>Methods: </strong>We included 43,836 individuals over 55 years old with genotyping, dietary data, and cognitive function measurements from three population-based studies: CoLaus|PsyCoLaus (Switzerland), the Rotterdam Study (the Netherlands) and the Canadian Longitudinal Study on Aging (CLSA - Canada). We performed a one-sample Mendelian randomization using two-stage least-squares regression. First, we estimated total and non-fermented dairy consumption by T-allele frequency. Second, we used the estimated dairy consumption in linear regression models on general cognition, assessed by the Mini-Mental State Examination (MMSE) and the Mental Alternation Test, executive function, verbal fluency, verbal learning, and memory.</p><p><strong>Results: </strong>Per T-allele, total dairy intake and non-fermented was 24.8 and 15.3 g/day higher in PsyCoLaus, 57.9 and 49.8 g/day in the Rotterdam Study, and 0.31 and 0.29 times/day in CLSA, respectively. We found no association between the genetically predicted difference and the MMSE in PsyCoLaus and the Rotterdam Study. However, lactase persistent individuals scored 3.4 (95% CI 2.1- 4.7) and 3.5 (95% CI 2.3-4.7) points more in the Mental Alternation Test for total and fermented dairy, respectively, in CLSA. Similarly, lactase persistent participants in CLSA had higher verbal fluency, verbal learning and executive function, but no differences were found in the other cohorts. Such inconsistencies might stem from different FFQs across cohorts and consumption ranges. Nonetheless, the generally small magnitude of effect sizes may suggest that there is no real effect between total or non-fermented dairy intake and cognitive function.</p><p><strong>Conclusion: </strong>The evidence for a causal effect of dairy consumption on general cognitive function is weak, consistent with previous results from classic analysis from observational studies. Interventions targeting dairy are unlikely to have a relevant effect on cognitive function.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"20"},"PeriodicalIF":4.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ultra-processed food-related metabolites with selected biochemical markers in the UK Biobank.","authors":"Anthony Kityo, Byeonggeun Choi, Jung-Eun Lee, Chulho Kim, Sang-Ah Lee","doi":"10.1186/s12937-025-01077-w","DOIUrl":"10.1186/s12937-025-01077-w","url":null,"abstract":"<p><strong>Background: </strong>Ultra-processed food (UPF) intake is positively associated with multiple adverse health outcomes. However, the underlying biological mechanisms remain unclear. Serum metabolites may elucidate these mechanisms. We investigated serum metabolites correlated with UPF and un/minimally processed food (UNPF) intake and evaluated their association with selected biochemical markers.</p><p><strong>Methods: </strong>Cross-sectional study within the UK biobank, including a total of 72,817 participants with 24-hour recall dietary data and 134 nuclear magnetic resonance metabolites. UPF and UNPF intakes were evaluated using the NOVA classification, and related metabolites were identified using elastic net penalized regression. A UPF metabolomic signature was computed as a weighted sum of UPF-related metabolites, using elastic net coefficients as weights. Associations between UPF and UNPF-related metabolites, and serum C-reactive protein (CRP), insulin-like growth factor-1(IGF-1), sex hormone-binding globulin (SHBG), and testosterone were examined using multiple quantile regression.</p><p><strong>Results: </strong>Elastic net model identified 17 and 15 metabolites uniquely related to UPF and UNPF intake, respectively. Acetoacetate, acetone, high-density lipoprotein (HDL) diameter, docosahexaenoic acid, linoleic acid, ω-3 fatty acids (FA), total lipids in large HDL cholesterol, and valine levels were decreased, but free cholesterol in extremely small very low-density lipoproteins (LDL), glutamine, glycine, glycoprotein acetyls, lactate, saturated FA, sphingomyelins, triglycerides in large LDL, and triglycerides in medium HDL levels were increased with high UPF intake. Opposite relationships were observed for UNPF intake. Heterogeneous associations were observed between UPF-related metabolites and CRP, IGF-1, SHBG, and testosterone levels. A UPF metabolomic signature was positively associated with CRP (regression coefficient per standard deviation, 1.45, 95% confidence interval, 1.385, 1.515) and negatively associated with IGF-1 (-3.16, -4.493, -1.827) and SHBG (-13.878, -15.291, -12.465).</p><p><strong>Conclusion: </strong>A UPF metabolomic profile, including VLDL free cholesterol, saturated FA, triglycerides, glutamine, glycine, and glycoprotein acetyl was associated with inflammatory, insulin signalling, and reproductive biomarkers. This metabolomic profile should be explored as a potential mediators of UPF-disease associations, and as an objective marker of UPF intake.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"21"},"PeriodicalIF":4.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between early dietary patterns and cardiometabolic health at age 8: a confirmatory analysis of the European Childhood Obesity Project.","authors":"Mariona Gispert-Llauradó, Joaquin Escribano, Natalia Ferré, Veit Grote, Berthold Koletzko, Gina Ambrosini, Elvira Verduci, Dariusz Gruszfeld, Annick Xhonneux, Veronica Luque","doi":"10.1186/s12937-025-01080-1","DOIUrl":"10.1186/s12937-025-01080-1","url":null,"abstract":"<p><strong>Background & aim: </strong>Metabolic and cardiovascular health outcomes are strongly influenced by diet. Dietary habits established in early childhood may persist into adulthood. This study aimed to examine the association between dietary patterns at both 2 and 8 years of age, explaining the maximum variability of high- and low-quality fats, sugars, and fibre, and cardiometabolic markers at age 8 years.</p><p><strong>Methods: </strong>This was a secondary analysis of the European Childhood Obesity Project, formerly a randomized clinical trial across five European countries performed in healthy term newborns. Children in the study were categorized at ages 2 and 8 years into two groups based on cluster analysis of dietary patterns (DP) derived from Reduction Rank Regression (RRR). A cross-sectional and prospective analysis was conducted to evaluate the associations between these DPs and cardiometabolic outcomes, including body mass index (BMI), blood pressure (BP), and biochemical markers. Triglycerides, HDL cholesterol and insulin resistance index (HOMA-IR) were also categorized as altered versus normal values. Asociations between dietary patterns and health outcomes were assessed using linear and logistic regression models, adjusting for covariates based on a step-wise approach.</p><p><strong>Results: </strong>A total of 336 children were classified based on quality of nutrient intakes into either a \"Poor-Quality dietary pattern\" (PQ-DP) (48% and 66% of infants at 2 and 8 years, respectively) or the \"Health-Conscious dietary pattern\" (HC-DP) (52% and 34% of infants at 2 and 8 years, respectively). Following a PQ-DP at both ages 2 and 8 was associated with higher triglycerides (β = 0.061, p = 0.049), systolic and diastolic BP (β = 13.019, p < 0.001 & β = 7.612, p = 0.014, respectively) and altered levels of HOMA-IR (OR = 3.1, p = 0.037, 95% CI = 1.1-9.1) at 8 years, compared to children with an HC-DP at both ages, after adjusting for confounders.</p><p><strong>Conclusion: </strong>Adherence to a dietary pattern with a poorer nutritional profile in early childhood and school age is associated with worse cardiometabolic risk markers at 8 years old.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"18"},"PeriodicalIF":4.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived healthiness of sugary drinks and related social norms among adults in five countries: evidence from the International Food Policy Study.","authors":"Virginie Drolet-Labelle, Christine M White, Jean Adams, Sharon I Kirkpatrick, Alejandra Jáuregui, Lilia S Pedraza, Véronique Provencher, Gary Sacks, James F Thrasher, Gabriela C Armendariz, Simón Barquera, David Hammond, Lana Vanderlee","doi":"10.1186/s12937-024-01063-8","DOIUrl":"10.1186/s12937-024-01063-8","url":null,"abstract":"<p><strong>Background: </strong>A better understanding of correlates of sugary drink consumption is essential to inform public health interventions. This study examined differences in perceived healthiness of sugary drinks and related social norms between countries, over time, and sociodemographic groups and associations with sugary drink intake.</p><p><strong>Methods: </strong>This study used annual cross-sectional data from the International Food Policy Study from 2018 to 2021 in Australia, Canada, the United Kingdom, the United States, and Mexico. Analyses examined perceived healthiness of eight beverage types and two types of perceived social norms (descriptive, injunctive) that discourage sugary drink consumption. The 24-item Beverage Frequency Questionnaire was used to estimate beverage intake in the past 7 days. Logistic regression models examined trends over time in odds of perceiving each beverage type as unhealthy and agreeing with social norms discouraging sugary drink consumption, across countries and sociodemographic characteristics. Negative binomial regressions examined associations between perceived healthiness, social norms and consumption.</p><p><strong>Results: </strong>Energy drinks, regular soft drinks, and diet soft drinks were most frequently perceived as unhealthy in all countries, while water and 100% juice were least frequently perceived as unhealthy. Participants in Mexico had higher odds of perceiving 100% juice, chocolate milk, and iced tea as unhealthy in 2021 compared to 2018 (AOR = 1.71 99%CI 1.10-2.64; AOR = 2.69, 99%CI 1.70-4.26; AOR = 1.79, 99%CI 1.15-2.76; respectively), with little change in other countries. Agreement with social norms discouraging consumption of sugary drinks was higher in Mexico than in other countries. Trends in social norms over time were mostly stable, except in Mexico where participants had higher odds of agreeing with both norms in 2020 compared to 2018 (AOR = 1.27, 99%CI 1.09-1.48 for a descriptive norm and AOR = 1.27 99%CI 1.09-1.49 for an injunctive norm). In most countries, perceiving a beverage as unhealthy and agreeing with social norms discouraging consumption of sugary drink were associated with lower sugary drink consumption, with varying strength of associations across countries and beverage types.</p><p><strong>Conclusions: </strong>Shifts over time in social norms and perceived healthiness observed in Mexico and associations with intake of sugary drinks in most countries suggest that targeted interventions to change norms and perceptions could help reduce sugary drink consumption.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"19"},"PeriodicalIF":4.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which dietary shifts to improve nutritional quality while reducing diet cost in the French West Indies?","authors":"Marlène Perignon, Rozenn Gazan, Viola Lamani, Zoé Colombet, Caroline Méjean, Florent Vieux, Nicole Darmon","doi":"10.1186/s12937-024-01068-3","DOIUrl":"10.1186/s12937-024-01068-3","url":null,"abstract":"<p><strong>Background: </strong>The French West Indies are facing increasing rates of obesity and diet-related chronic diseases. Food prices are more than 30% higher compared with mainland France, while a large part of the population is socioeconomically disadvantaged. The affordability of a healthy diet is a key issue.</p><p><strong>Objective: </strong>To identify dietary shifts allowing to achieve nutritional adequacy while reducing the cost of Guadeloupean and Martinican adult diets.</p><p><strong>Methods: </strong>Dietary intakes of 1112 adults (≥ 16y) were obtained from a cross-sectional survey conducted on a representative sample of the Guadeloupean and Martinican populations. Diet cost was based on mean prices of 1357 foods compiled from a Martinican supermarket website. Individual optimized diets respecting all nutritional recommendations with minimized departure from the initial diet were designed under different scenarios of cost constraint: none, not exceeding the initial diet cost (COSTinit), and 10%-step reductions (COST-X%); the initial diet cost referring to the cost of the diet based on initial dietary intakes and mean food prices.</p><p><strong>Results: </strong>Without cost constraint, achieving nutritional adequacy while departing the least from initial diet increased diet cost on average (+ 20%) and for 74% of adults. In COSTinit, achieving nutritional adequacy was possible for 98% of adults and induced an increase in the amount of fruit & vegetables, unrefined starches, dairy products (especially milk), eggs and vegetable fats, and a decrease in sweetened beverages (especially among < 30y), refined cereals, sweetened products, meat and fish. In COST-30% scenario, achieving nutritional adequacy was possible for 93% of adults and induced the same dietary shifts as in COSTinit, but modified their magnitude, notably a smaller increase of vegetables (increase of + 7 g/d in the COST-30% scenario and + 86 g/d in the COSTinit scenario, both relative to initial diet), a larger increase of dairy (+ 90 g/d and + 72 g/d, respectively) and starchy foods (+ 112 g/d and + 54 g/d), and a larger reduction of meat (-48 g/d and -12 g/d). Increases in fruits (~ + 80 g/d) and unrefined starches (+ 127 g/d), and decreases in sweetened beverages (~ -100 g/d) and fish (~ -40 g/d) were maintained.</p><p><strong>Conclusions: </strong>Nutrition prevention programs promoting the affordable and nutritious dietary shifts identified in the present study, i.e. reduction in animal flesh foods (meat, fish) as well as refined cereals and sweet products in favour of an increase in healthy plant-based foods and animal co-products (dairy, eggs), could help improve nutritional adequacy of the Guadeloupean and Martinican populations.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"16"},"PeriodicalIF":4.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}