Nutrition Journal最新文献

{"title":"Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study.","authors":"Rui Qin, Liya Pang, Haiting Hu, Yangqian Jiang, Hong Lv, Kan Ye, Cong Liu, Xin Xu, Xiaoyu Liu, Kun Zhou, Tao Jiang, Jiangbo Du, Lingmin Hu, Zhibin Hu, Zhonghua Shi, Yuan Lin","doi":"10.1186/s12937-025-01197-3","DOIUrl":"https://doi.org/10.1186/s12937-025-01197-3","url":null,"abstract":"<p><strong>Background: </strong>Iron, an essential micronutrient, plays a critical role in fetal neurodevelopment. Animal studies have demonstrated that maternal iron-deficient diets during pregnancy induce permanent structural and functional alterations in offspring brains. Dietary iron exists in two forms: heme iron (found in animal-derived foods), which exhibits high bioavailability (15-35%), and non-heme iron (predominantly from plant-based sources), with lower bioavailability (1-20%). Existing epidemiological studies have reported inconsistent findings regarding maternal iron intake and offspring neurodevelopment, and few have examined the effects of different iron forms.</p><p><strong>Methods: </strong>This study was conducted in the Jiangsu Birth Cohort, a prospective cohort tracking pregnant women throughout gestation and following up their children. Dietary intake, including heme and non-heme iron, was assessed via a semi-quantitative food frequency questionnaire in early, middle and late pregnancy. The total iron intake was defined as the sum of iron intake from diet and supplements (specific iron supplements and multivitamin/ mineral supplements). Infant neurodevelopment was evaluated at 12 months of age using the Bayley Scales of Infant and Toddler Development, Third Edition screening test. This assessment covered cognitive, receptive communication, expressive communication, fine motor, and gross motor domains. Each domain was scored according to standardized criteria and categorized as \"non-optimal\" or \"optimal\" based on age-specific cut-off points. Poisson regression and generalized estimating equations were employed to analyze the associations between maternal iron intake and neurodevelopment of offspring. Furthermore, maternal (demographic, lifestyle, and clinical) and infant (birth and feeding) characteristics that might confound the associations were adjusted in the analysis.</p><p><strong>Results: </strong>The final analytical cohort comprised 3,750 pregnant women and their offspring. Null associations were observed between total iron intake through pregnancy and infant neurodevelopment. Following log-transformation and energy adjustment, each one-unit increase in maternal heme iron intake was associated with a 35% reduced risk of non-optimal cognitive development in infants after the adjustment for potential confounders (RR = 0.65, 95% CI 0.45-0.93). Particularly, trimester-specific analysis demonstrated that maternal heme iron intake in the third trimester was significantly associated with non-optimal cognition development (RR = 0.67, 95% CI 0.52-0.85). Infants of mothers in the highest tertile of heme iron intake (> 3.29 mg/d) during late pregnancy exhibited a 28% lower risk of non-optimal cognition compared to those in the lowest tertile (< 2.22 mg/d) (RR = 0.72, 95% CI 0.56-0.93). While no association was observed for non-heme iron or iron supplements.</p><p><strong>Conclusions: </strong>Maternal heme iron intake, particul","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"131"},"PeriodicalIF":3.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a multimodal model integrating gut microbiota and metabolite for identifying sarcopenia in patients with MASLD: a study from two centers in China.","authors":"Sizhe Wan, Mingkai Li, Wanjun Li, Yuexiang Ren, Yuankai Wu, Qingtian Luo, Wei Gong","doi":"10.1186/s12937-025-01198-2","DOIUrl":"https://doi.org/10.1186/s12937-025-01198-2","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"129"},"PeriodicalIF":3.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Development of empirical anti-inflammatory diet index: a cross-sectional study.","authors":"Joanna Kaluza, Lisa Hellerström, Daniel Kaluza, Abbas Chabok, Agneta Åkesson, Karl Michaëlsson, Alicja Wolk","doi":"10.1186/s12937-025-01208-3","DOIUrl":"https://doi.org/10.1186/s12937-025-01208-3","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"130"},"PeriodicalIF":3.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics and nutrient intake reveal metabolite-nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study.","authors":"Minyeong Kim, Suyeon Lee, Junguk Hur, Dayeon Shin","doi":"10.1186/s12937-025-01189-3","DOIUrl":"10.1186/s12937-025-01189-3","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in metabolomics, the complex relationship between metabolites and nutrient intake in metabolic syndrome (MetS) remains poorly understood in the Korean population.</p><p><strong>Objective: </strong>This study aimed to characterize the metabolomic profiles and nutrient intake associated with MetS and to examine their relationships in the Ansan-Ansung cohort of the Korean Genome and Epidemiology Study (KoGES).</p><p><strong>Methods: </strong>Data from 2,306 middle-aged adults (1,109 men and 1,197 women) in the KoGES Ansan-Ansung cohort were analyzed. Plasma metabolites were measured using liquid chromatography-mass spectrometry, identifying 135 metabolites. Nutrient intake was assessed using a validated semi-quantitative food frequency questionnaire covering 23 nutrients. MetS-associated metabolites and nutrients were identified using the Wilcoxon rank-sum test, logistic regression, partial least squares-discriminant analysis, and group least absolute shrinkage and selection operator analysis. Pathway enrichment analysis identified key metabolic pathways, and fixed-effects models were applied to assess metabolite-nutrient relationships based on MetS status.</p><p><strong>Results: </strong>Eleven metabolites, including hexose (FC = 0.95, P = 7.04 × 10<sup>-54</sup>), alanine, and branched-chain amino acids, and three nutrients including fat, retinol, and cholesterol, were significantly associated with MetS (FC range = 0.87-0.93; all P < 0.05). Pathway analysis highlighted disruptions in arginine biosynthesis and arginine-proline metabolism. The MetS group exhibited six unique metabolite-nutrient pairs that were not observed in the non-MetS group, including 'isoleucine-fat,' 'isoleucine-P,' 'proline-fat,' 'leucine-fat,' 'leucine-P,' and 'valerylcarnitine-niacin.' Notably, dysregulated metabolism of branched-chain amino acids, such as isoleucine and leucine, has been implicated in oxidative stress. Importantly, the stochastic gradient descent classifier achieved the best predictive performance among the eight machine learning models (area under the curve, AUC = 0.84), highlighting the robustness of classification based on metabolite data. However, the absence of external validation limits the generalizability of these findings.</p><p><strong>Conclusions: </strong>This comprehensive metabolomic analysis of the KoGES Ansan-Ansung cohort revealed distinct metabolic profiles and nutrient intake patterns associated with MetS, highlighting altered metabolite-nutrient relationships and disrupted metabolic pathways. These findings provide new insights into potential associations between metabolic phenotypes and dietary intake, which may help inform individualized dietary approaches related to MetS, such as branched-chain amino acids-restricted diets (valine, isoleucine, leucine), reduced intake of hexose-rich carbohydrates, and modulation of niacin-rich protein sources according to individual metabolic profiles.","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"128"},"PeriodicalIF":3.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of carbohydrate quality on the association between low-carbohydrate diet scores and longitudinal changes of cardiometabolic risk factors.","authors":"Ghaida F Aloraini, Nicola M McKeown, Gail T Rogers, Sai Krupa Das, Alice H Lichtenstein, Paul F Jacques","doi":"10.1186/s12937-025-01194-6","DOIUrl":"10.1186/s12937-025-01194-6","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"127"},"PeriodicalIF":3.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating metabolic biomarkers predict incident sepsis: a large-scale population study in the UK Biobank.","authors":"Hao Bai, Yihui Li, Miaomiao Fan, Mingmin Pang, Yanan Li, Shaohua Zhao, Tingyu Meng, Hao Chen, Ming Lu, Hao Wang","doi":"10.1186/s12937-025-01191-9","DOIUrl":"10.1186/s12937-025-01191-9","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is an absence of large-scale research focusing on the metabolome profiles of individuals prior to the development of sepsis. This study aimed to evaluate the associations of circulating Nuclear Magnetic Resonance (NMR) metabolic biomarkers with the risk of incident sepsis and the predictive ability of these metabolites for sepsis.</p><p><strong>Methods: </strong>The analysis utilized plasma metabolomic data measuring through NMR from the UK Biobank, which involved baseline plasma samples of 106,533 participants. The multivariable-adjusted Cox proportional hazard models were used to assess the associations of each circulating NMR metabolite biomarker with risk of incident sepsis. The full cohort was randomly assigned to a training set (n = 53,267) and a test set (n = 53,266) to develop and validate the sepsis risk prediction model. In training set, the least absolute shrinkage and selection operator (LASSO) and stepwise Cox regression analyses were used to develop the prediction model. In test set, the predictive ability of conventional risk factors-based and combined metabolic biomarkers prediction model was assessed by Harrell's C-index. The incremental predictive power of the metabolic biomarkers was evaluated with continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI).</p><p><strong>Results: </strong>A total of 90 circulating metabolic biomarkers were significantly associated with risk of incident sepsis (all FDR adjusted P value < 0.05). Of these, triglycerides related lipid sub-classes, glycolysis, ketone bodies, and inflammation related metabolite biomarkers, creatinine, and phenylalanine were positively associated with risk of incident sepsis, while most of other lipid sub-classes, albumin, histidine, fatty acid and cholines related metabolic biomarkers were negatively associated with risk of sepsis. The Harrell's C-index of the conventional prediction model was 0.733 (95% CI: 0.722, 0.745) for incident sepsis; after adding the circulating NMR metabolic biomarkers to the conventional prediction model, the Harrell's C-index increased to 0.741 (95% CI: 0.730, 0.753) for incident sepsis. In addition, the continuous NRI and IDI were 0.022 (95% CI: 0.015, 0.043, P < 0.05) and 0.009 (95% CI: 0.006, 0.014, P < 0.05).</p><p><strong>Conclusion: </strong>This study identified multiple plasma metabolic biomarkers were associated with risk of incident sepsis. The addition of these metabolic biomarkers to the conventional risk factors-based model significantly improved the prediction precision.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"126"},"PeriodicalIF":3.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary effectiveness of VR-enhanced nutrition education for promoting healthy diets among college students.","authors":"Li-Ling Liao, Chia-Kuei Lee, I-Ju Lai, Li-Chun Chang","doi":"10.1186/s12937-025-01192-8","DOIUrl":"10.1186/s12937-025-01192-8","url":null,"abstract":"<p><strong>Background: </strong>College students are at a critical stage for forming long-term dietary habits. Nutrition literacy (NL) plays a key role in enabling informed food choices and supporting overall health. Virtual reality (VR) offers emerging opportunities for nutrition education by providing immersive and interactive learning experiences that may enhance engagement and behavior change. This pilot randomized controlled trial examined the preliminary effectiveness of a VR-enhanced nutrition education program in improving NL, self-efficacy, and dietary behaviors among college students, by comparing outcomes between app-based interventions with and without VR components.</p><p><strong>Methods: </strong>This pilot randomized controlled trial was conducted from March to June 2023 and approved by the institutional review board (IRB No. NCKU HREC-E-111-022-2). Participants were recruited from a private university in Southern Taiwan and randomly assigned to one of three groups: Control (n = 51), App (n = 48), and App + VR (n = 52). The App group received a 5-week mobile app-based NL program, while the App + VR group received the same program plus three additional VR-based challenge tasks. NL, self-efficacy, and dietary behaviors were assessed at baseline, post-intervention, and one-month follow-up. Group-by-time effects were analyzed using generalized estimating equations.</p><p><strong>Results: </strong>Compared to baseline, both the App group and App + VR group demonstrated significant improvements in NL, self-rated NL, self-efficacy, and dietary behaviors, whereas no significant changes were observed in the Control group. At post-intervention, both intervention groups outperformed the Control group in self-rated NL and dietary behaviors. The App group showed significant gains in NL test scores, while the App + VR group exhibited greater improvements in self-efficacy. At one-month follow-up, both intervention groups sustained improvements in dietary behaviors. The App group maintained significant gains in NL test scores, whereas the App + VR group sustained improvements in self-efficacy. No statistically significant differences were found between the two intervention groups on any outcome measures at either post-test or follow-up.</p><p><strong>Conclusion: </strong>These findings suggest that different digital formats may support distinct learning outcomes, with immersive technologies like VR potentially contributing to the reinforcement of self-efficacy. Future research is needed to evaluate the long-term impact and cost-effectiveness of VR-based nutrition education across broader populations.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"125"},"PeriodicalIF":3.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EAT-Lancet diet in relation nutrient intake among older adults: insights from the Gothenburg H70 birth cohort study.","authors":"Anna Stubbendorff, Silke Kern, Lina Rydén, Ingmar Skoog, Jessica Samuelsson","doi":"10.1186/s12937-025-01193-7","DOIUrl":"10.1186/s12937-025-01193-7","url":null,"abstract":"<p><strong>Background: </strong>The EAT-Lancet Commission has proposed a global reference diet aimed at promoting both human health and environmental sustainability. While adherence to this dietary pattern has been associated with reduced risks of chronic disease and lower environmental impact, concerns remain about its ability to meet nutritional requirements - particularly among older adults. The aim was to explore the association between adherence to the EAT-Lancet diet and nutrient intake and adequacy among 70-year-old adults in Gothenburg, Sweden.</p><p><strong>Methods: </strong>This cross-sectional study included 861 participants from the Swedish population-based Gothenburg H70 Birth Cohort Study (mean age 70.5 years, 55% women). Dietary intake was assessed using a validated diet history interview, and adherence to the EAT-Lancet diet was scored based on 14 food components. Nutrient intake was evaluated against age- and sex-specific recommended intake (RI) levels. Cardiometabolic risk markers and biomarkers of nutritional status, including homocysteine and haemoglobin, were measured. Linear and logistic regression models were used to examine trends across sex-specific tertiles of diet adherence, with sensitivity analyses adjusting for energy intake and comparing adequacy based on average requirement (AR) thresholds.</p><p><strong>Results: </strong>Higher adherence to the EAT-Lancet diet was linked to higher intake of fibre and polyunsaturated fats, and lower intake of saturated fat and alcohol. Mean protein intake per kilogram body weight/day was similar across adherence tertiles. Intake of beta-carotene, folate, vitamin C, magnesium, potassium, and iron was higher with greater adherence, while retinol equivalents, vitamin B12, niacin equivalents was lower- patterns that remained consistent after energy adjustment. Despite lower B12 intake, homocysteine levels were lowest in the group with highest adherence, and anaemia prevalence did not differ. Micronutrient adequacy improved with higher adherence for vitamin E, folate, vitamin C, magnesium, potassium, and iron. Similar results were observed using average requirement (AR) thresholds in sensitivity analyses.</p><p><strong>Conclusions: </strong>Adherence to the EAT-Lancet diet was associated with a more favourable nutrient profile in this cohort of older adults, without evidence of widespread micronutrient inadequacy. These findings suggest that environmentally sustainable diets can support adequate nutrition when well-balanced, even in nutritionally vulnerable populations such as older adults.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"124"},"PeriodicalIF":3.8,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy intake and physical activity over the course of pregnancy and gestational weight gain: a systematic review and dose-response meta-analysis of data from randomized controlled lifestyle intervention trials.","authors":"Yixin Chen, Sasithorn Sarnthiyakul, Sophie K F Michel, Chuyue Wu, Hans Hauner, Ondine S von Ehrenstein, Jihong Liu, Liwei Chen","doi":"10.1186/s12937-025-01182-w","DOIUrl":"10.1186/s12937-025-01182-w","url":null,"abstract":"<p><strong>Background: </strong>This systematic review and meta-analysis aimed to quantify the relationship between energy intake (EI) and physical activity (PA) during pregnancy and gestational weight gain (GWG) in randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>RCTs measuring EI and PA at least twice and total GWG during pregnancy were eligible. To synthesize PA measures reported on different scales, standardized mean change per day (SMC/day) were obtained by dividing the change in PA by the standard deviation of the change. We estimated mean changes in EI, PA, and mean total GWG across studies, accounting for clustering within studies. One-stage dose-response meta-analyses (DRMA) quantified the additional GWG associated with changes in EI and PA during pregnancy.</p><p><strong>Results: </strong>A total of 21 RCTs with 7,705 participants were included. The mean total GWG was 11.99 kg (95% CI: 11.05 kg to 12.94 kg). The mean baseline EI was 1977 kcal/day across studies (range: 1652 to 2777 kcal/day) and the mean increase in EI throughout pregnancy was 132 kcal/day (95% CI: 54 to 209 kcal/day). The average change in PA during pregnancy was - 0.11 SMC/day (95% CI: -0.33 to 0.12 SMC/day). DRMA indicated 0.30 kg additional weight gain per 100 kcal/day increase in EI (95% CI: -0.01 kg to 0.60 kg, P = 0.06). The effect size was greater in studies with low risk of bias vs. high risk of bias (0.57 vs. -0.20 kg, P for difference = 0.02). DRMA showed 0.24 kg less weight gain per 0.25 SMC/day increase in PA (-0.50 to 0.02 kg, P = 0.07).</p><p><strong>Conclusions: </strong>Average GWG often exceeds recommendations of current guidelines, particularly among women with overweight/obesity (OWOB), while average increases in EI were below current recommendations, and PA levels were frequently observed to decrease. DRMA further suggests that GWG may be modifiable through changes in EI and PA with greater EI increases or PA reductions linked to greater GWG, especially among women with OW/OB. Despite challenges in precisely quantifying these associations, integrated findings from this comprehensive systematic review and subgroup/sensitivity analyses highlight the need for more individualized nutrition and exercise recommendations and may warrant revisiting current guidelines.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"123"},"PeriodicalIF":3.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study.","authors":"Dong-Hui Huang, Lei Wang, Xiao-Ying Li, Ying Qin, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Fan Cao, Lang Wu, Yi-Fan Wei, Song Gao, Ting-Ting Gong, Yu-Hong Zhao, Qi-Jun Wu","doi":"10.1186/s12937-025-01185-7","DOIUrl":"10.1186/s12937-025-01185-7","url":null,"abstract":"<p><strong>Background: </strong>The current study aims to investigate the association between dietary total antioxidant capacity (DTAC) and overall survival (OS) in patients with ovarian cancer (OC).</p><p><strong>Methods: </strong>A validated 111-item food frequency questionnaire was used to assess their pre- and post-diagnosis dietary intake. DTAC is represented by ferric-reducing ability of plasma (FRAP), total oxygen radical absorbance capacity (TORAC), hydrophilic oxygen radical absorbance capacity (HORAC), lipophilic oxygen radical absorbance capacity (LORAC), and total phenolics (TP). The OS was determined by both passive and active follow-up.</p><p><strong>Results: </strong>A total of 531 patients with OC was involved in this study. High post-diagnosis FRAP (HR_{T3 vs. T1}=0.65, 95%CI = 0.42-0.99), post-diagnosis TORAC (HR_{T3 vs. T1}=0.68, 95%CI = 0.47-0.98), and pre-diagnosis LORAC (HR_{T3 vs. T1}=0.62, 95%CI = 0.43-0.89) had statistically significant association with an improved OS. Additionally, increased DTAC consumption (FRAP: HR _Low-Medium=0.53, 95%CI = 0.30-0.95; FRAP: HR _Low-High=0.46, 95%CI = 0.23-0.93; LORAC: HR _Medium-High=0.50, 95%CI = 0.27-0.91), as well as maintaining high or medium DTAC consumption (TORAC: HR _{Medium-Medium}=0.46, 95%CI = 0.26-0.83; TORAC: HR _High-High=0.57, 95%CI = 0.34-0.96; LORAC: HR _High-Medium=0.43, 95%CI = 0.23-0.82), improved the OS in patients with OC.</p><p><strong>Conclusions: </strong>Increased pre- and post-diagnosis DTAC intake, and maintaining moderate or high DTAC intake after diagnosis, may be associated with enhanced OS in patients with OC.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"122"},"PeriodicalIF":3.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}