Nutrition Journal最新文献

{"title":"Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial.","authors":"Yuyang Zhao, Xiaokang Niu, Yong Zhang, Liang Zhao, Liwei Zhang, Jingjing He, Qi Zhang, Yuejian Mao, Fuqing Wang, Xiaohui Zhao, Ran Wang","doi":"10.1186/s12937-025-01124-6","DOIUrl":"10.1186/s12937-025-01124-6","url":null,"abstract":"<p><strong>Background: </strong>The effect of probiotics on Helicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role of Limosilactobacillus fermentum MN-LF23 (MN-LF23) in Hp-infected populations.</p><p><strong>Methods: </strong>A total of 94 adult patients with confirmed Hp infection were enrolled in this study and randomly allocated to the placebo or MN-LF23 group. Patients initially received either placebo or probiotics along with standard quadruple therapy for 2 weeks, followed by continued administration of either placebo or probiotics for an additional 4 weeks. The eradication of Hp, serum levels of inflammatory factors, and alterations in gastrointestinal symptoms were assessed at weeks 0, 2, and 6, while fecal samples were collected for metagenomic sequencing.</p><p><strong>Results: </strong>The results showed no significant difference (P = 1) in the eradication rate between the placebo group (85.11%) and the probiotic group (82.98%). Following treatment, the incidence of constipation, dyspepsia, and Gastrointestinal Symptom Rating Scale (GSRS) scores in the probiotic group were markedly lower (P < 0.05) compared to those observed in the placebo group. Throughout the treatment process, there were no significant differences in TNF-α and IL-1β levels between the two groups. Compared to the placebo group, the probiotic group exhibited a significant increase in beneficial bacteria such as Limosilactobacillus fermentum, Lactiplantibacillus plantarum, Bifidobacterium longum, Coprococcus caltus, and Clostridium butyricum.</p><p><strong>Conclusion: </strong>MN-LF23 supplementation did not improve the eradication rate of standard quadruple therapy. However, it significantly reduced the overall GSRS score, improved digestive and constipation symptoms, and promoted the proliferation of beneficial bacteria in the intestine.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"106"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches.","authors":"Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu","doi":"10.1186/s12937-025-01175-9","DOIUrl":"10.1186/s12937-025-01175-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.</p><p><strong>Methods: </strong>Data of 7,918 participants were derived from the National Health and Nutrition Examination Survey 2005-2018. Cross-sectional analyses using multivariable logistic regression were conducted to evaluate the relationship between DII and CKM staging. Cox proportional hazards models were employed to assess the impact of DII on mortality in CKM patients. Mediation analyses were performed to determine whether biological aging mediated DII-staging and DII-mortality association. Machine learning models were developed to classify CKM stages 3/4 and predict all-cause mortality, with SHapley Additive exPlanations (SHAP) used to interpret the contribution of DII components.</p><p><strong>Results: </strong>Over a median follow-up of 9.3 years, 819 deaths were recorded. Higher DII were associated with an increased risk of advanced CKM stages [OR (95% CI): tertile 2, 1.39 (1.17, 1.65); tertile 3, 1.85 (1.56, 2.20)], and all-cause mortality [(HR (95% CI): tertile 2, 1.20 (1.01-1.43); tertile 3: 1.45 (1.21-1.73)]. The optimal risk stratification threshold for DII to predict all-cause mortality was 1.93. Mediation analyses revealed that biological aging accounted for 23% (95% CI: 18-28%) of the effect of DII on advanced CKM stages and 13% (95% CI: 8-22%) of the effect of DII on all-cause mortality. Furthermore, the Light Gradient Boosting Machine model showed strong performance in predicting advanced CKM staging (AUC: 0.896, 95% CI: 0.882-0.911), while Logistic regression performed better in predicting all-cause mortality (AUC: 0.857, 95% CI: 0.831-0.884). SHAP analysis revealed that intake of magnesium and n-3 fatty acid were associated with reduced risk of both advanced CKM stages and all-cause mortality.</p><p><strong>Conclusion: </strong>DII, a marker of pro-inflammatory dietary patterns, was significantly linked to CKM syndrome progression and mortality, partly by influencing biological aging. This underscores the importance of diet quality in managing CKM staging and mortality risk.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"105"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort.","authors":"Xiao-Ying Li, Dong-Hui Huang, Xin Xu, Xi-Meng Zhang, Jia-Le Lv, Yu-Xin Nan, Fan Cao, Qi-Jun Wu, Yu-Hong Zhao","doi":"10.1186/s12937-025-01174-w","DOIUrl":"10.1186/s12937-025-01174-w","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"107"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sulfur microbial diet and the risk of dementia: a large-scale prospective cohort study.","authors":"Jigen Na, Celi Yang, Muzi Na, Xiaona Na, Yuefeng Tan, Xiaojin Shi, Zhihui Li, John S Ji, Ai Zhao","doi":"10.1186/s12937-025-01172-y","DOIUrl":"10.1186/s12937-025-01172-y","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"104"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between vitamin D intake and the prevalence and mortality of asthma in the US adults.","authors":"Yu Lei, Yu Luo, Yi Wang, Caiyang Liu, Lei Luo, Ji Li","doi":"10.1186/s12937-025-01171-z","DOIUrl":"10.1186/s12937-025-01171-z","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"103"},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between urinary and dietary potassium and diabetic microvascular complications: insights from UK Biobank data.","authors":"Chao Li, Jingjing Zeng, Xufang Huang, Ying Li, Aaron M Lett, Yucen Wu, Qiqi You, Wan Fu, Shaoyong Xu","doi":"10.1186/s12937-025-01161-1","DOIUrl":"10.1186/s12937-025-01161-1","url":null,"abstract":"<p><strong>Background: </strong>Potassium plays an important role in glucose metabolism and blood vessel. However, there is a lack of systematic research on the intake of potassium and diabetic microvascular complications. The aim of this study was to explore whether inadequate potassium intake increases the risk of developing diabetic microvascular complications, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy using the UK Biobank database.</p><p><strong>Methods: </strong>This study included 22,395 subjects with type 2 diabetes mellitus at baseline. Urinary potassium and creatinine were measured by potentiometry and photometric assay respectively. Dietary potassium intake was measured using the 24-hour dietary recall method. The occurrence of microvascular complications was determined using ICD-10 codes from cumulative hospitalization records and death records in the national death registry. Cox proportional hazards models were used to explore the relationship between urinary potassium-to-creatinine ratio, dietary potassium, and overall and individual microvascular complications, generating hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Compared with the minimum potassium-to-creatinine ratio group, the highest potassium-to-creatinine ratio group had a significantly lower risk of diabetic microvascular complications (HR, 0.70 [95% CI 0.63-0.78]; P for trend < 0.001) and diabetic nephropathy (HR, 0.54 [95% CI 0.47-0.61]; P for trend < 0.001). The group with the highest dietary potassium had a significantly lower risk of diabetic nephropathy (HR, 0.48 [95% CI 0.29-0.80], P for trend = 0.005) than the minimum dietary potassium group. The restricted cubic spline results showed a non-linear relationship between urinary potassium-to-creatinine ratio and overall microvascular complications and diabetic nephropathy, with nonlinear P values of 0.009 and < 0.001, respectively, and a generally declining trend.</p><p><strong>Conclusions: </strong>The urinary potassium-to-creatinine ratio was significantly negatively associated with overall diabetic microvascular complications and diabetic nephropathy.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"101"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men.","authors":"Harpa Oskarsdottir, Arnar Palsson, Erla B Olafsdottir, Vilmantas Giedraitis, Salahuddin Mohammad, Ulf Risérus, Helgi B Schiöth, Gudrun V Skuladottir, Jessica Mwinyi","doi":"10.1186/s12937-025-01168-8","DOIUrl":"10.1186/s12937-025-01168-8","url":null,"abstract":"<p><strong>Background: </strong>Genetic risk variants for obesity and metabolic syndrome (MetS) have been identified, but their link to relevant metabolic health parameters warrants further attention. This study aimed to investigate the extent to which single-nucleotide polymorphisms (SNPs) associated with obesity are linked to changes in fatty acid (FA) profiles in serum cholesteryl esters, lipid metabolism, and MetS risk.</p><p><strong>Method: </strong>Data from the Uppsala Longitudinal Study of Adult Men (ULSAM), conducted in men at age 50 (N = 1973) and age 70 (N = 982), were used to investigate SNPs associated with body mass index (BMI) in genome-wide association studies with metabolic parameters at age 50. The significant SNPs and associated lipid parameters were then used as predictors of MetS over a 20-year follow-up period, at age 70 in binary regression models.</p><p><strong>Results: </strong>The two genes, the brain-derived neurotrophic factor gene (BDNF) (rs7103411) and the fat mass and obesity-associated gene (FTO) (rs1558902), together with delta-5-desaturase (D5D) activity, 20:5n-3 in serum cholesteryl esters (CE), fasting blood glucose, abdominal skinfold thickness, apolipoprotein-B, and high-density lipoprotein cholesterol (HDL-C) at age 50, significantly predicted the risk of MetS at age 70.</p><p><strong>Conclusion: </strong>The findings suggest a considerable contribution of the SNPs BDNF rs7103411, FTO rs1558902, and ETV5 rs9816226, along with low D5D activities and serum levels of HDL-C in men at age 50, to the risk for MetS 20 years later.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"99"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis.","authors":"Jinrui Li, Kai Yu, Fan Bu, Peng Li, Lei Hao","doi":"10.1186/s12937-025-01173-x","DOIUrl":"10.1186/s12937-025-01173-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of coffee consumption and caffeine intake on cognitive performance in older adults, with a particular focus on the potential mediating role of alkaline phosphatase(ALP).</p><p><strong>Methods: </strong>We analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014, involving 2,254 participants aged 60 and older. Cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). To establish causal relationships between coffee consumption, caffeine intake, ALP levels, and cognitive performance, we employed methodologies such as Mendelian randomization, protein quantitative trait locus analysis, and protein-protein interaction networks.</p><p><strong>Results: </strong>The NHANES study revealed significant findings regarding coffee consumption and cognitive performance. Compared to non-coffee consumers, individuals consuming ≥ 480 g/day of coffee had a significantly lower odds of low CERAD scores, with an adjusted OR of 0.58 (95% CI: 0.41-0.82) in the fully adjusted Model 4. Similarly, those consuming caffeinated coffee 477.9 g/day) had an OR of 0.56 (95% CI: 0.34-0.92). A comparison of the lowest quartile of ALP intake with the highest quartile showed an OR of 1.82 (95% CI: 1.16-2.85), indicating a negative correlation with cognitive performance. Mendelian Randomization (MR) studies suggested that increased coffee intake is associated with cognitive impairment progression, while coffee consumption may protect against Lewy body dementia (OR = 0.2365, 95% CI: 0.0582-0.9610). Additionally, coffee/caffeine intake affected serum ALP (OR = 0.86, 95% CI: 0.79-0.93) and cognitive ability (OR = 0.95, 95% CI: 0.92-0.98), both indicating protective effects. Finally, the IGFLR1 gene exhibited a moderate colocalization with ALP, suggesting potential therapeutic significance.</p><p><strong>Conclusions: </strong>This study provides evidence of a positive correlation between coffee consumption, caffeine intake, and cognitive performance in older adults, with ALP potentially contributing to this relationship. These findings underscore the importance of considering dietary factors in cognitive health management for aging populations, highlighting the need for further research to clarify the specific mechanisms involved.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"102"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models integrating dietary data predict all-cause mortality in U.S. NAFLD patients: an NHANES-based study.","authors":"Pinchu Chen, Yao Li, Chenfenglin Yang, Qifan Zhang","doi":"10.1186/s12937-025-01170-0","DOIUrl":"10.1186/s12937-025-01170-0","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, closely associated with metabolic abnormalities and unhealthy lifestyle habits. Despite the critical role of diet in disease progression, most existing prognostic models for NAFLD fail to incorporate dietary factors. This study aims to integrate demographic, serological, and nutritional data. It focuses on developing machine learning models that predict all-cause mortality risk in NAFLD patients, with a particular emphasis on dietary interventions.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018, comprising 2,589 NAFLD participants, were analyzed. Variables associated with survival outcomes were selected using LASSO-Cox regression. Five machine learning models-Random Survival Forest (RSF), Gradient Boosting Machine (GBM), CoxBoost, and Survival Support Vector Machine (SurvivalSVM), eXtreme Gradient Boosting (XGBoost) -were developed and their performance evaluated through time-dependent AUC, ROC curves, C-index, Brier score and Kaplan-Meier analysis. SHAP values were employed for model interpretability.</p><p><strong>Results: </strong>LASSO-Cox regression identified 13 significant variables, including age, household income, blood glucose, sedentary behavior, dietary fiber intake and so on. The GBM and RSF models demonstrated strong predictive performance with AUC values around 0.8 for both 5- and 10-year survival predictions, and also performed well in terms of C-index and Brier score. SHAP analysis revealed that advanced age, low household income, hyperglycemia, and sedentary behavior were associated with poor prognosis, whereas higher dietary fiber intake was linked to improved survival.</p><p><strong>Conclusions: </strong>This study integrates dietary data into machine learning models, demonstrating the potential for predicting all-cause mortality in NAFLD patients. The models, particularly RSF and GBM, show robust predictive accuracy, with dietary fiber intake consistently exhibiting a protective effect on survival outcomes. These findings suggest that dietary interventions, such as increasing dietary fiber intake, could improve the long-term prognosis of NAFLD patients.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"100"},"PeriodicalIF":4.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the dietary index for gut microbiota and constipation in American adults.","authors":"Chunyan Song, Zhulin Zhang, Shanxiang Zhu, Huacheng Tong","doi":"10.1186/s12937-025-01164-y","DOIUrl":"10.1186/s12937-025-01164-y","url":null,"abstract":"<p><p>Constipation, a common gastrointestinal disorder, significantly impacts quality of life.Its association with gut microbiota has garnered attention.Dietary factors play a crucial role in the development and management of constipation.The recently introduced dietary index for gut microbiota (DI-GM), a measure of gut microbiota diversity, offers insights into this connection.The association between dietary gut microbiota index and constipation is a critical public health issue.This study investigated the association between DI-GM and constipation prevalence in the American population using data from 11,819 individuals from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2010.Constipation was defined using Bristol stool form scale types 1 and 2.Dietary recall information was used to determine the DI-GM score, indicating the dietary influence on the gut microbiome. Multivariate weighted logistic regression, adjusted for confounders, was performed to analyze the association between DI-GM scores and constipation prevalence.Further analyses included a subgroup analysis and restricted cubic splines to explore this association [restricted cubic spline(RCS)].An increased DI-GM index, indicating a healthier gut microbiome, was related to a decreased risk of constipation.A similar association was observed with a more favorable score for beneficial gut microbiota.Non-linear associations between DI-GM scores and constipation were identified through RCS analysis.Subgroup and interaction analyses confirmed the consistency of these findings across strata, suggesting no significant heterogeneity.These findings suggest that dietary adjustments may be an important method for preventing constipation.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"98"},"PeriodicalIF":4.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}