Nutrition Journal最新文献

{"title":"Associations of a healthy beverage pattern with all-cause and cause-specific mortality among US adults: a nationwide cohort study.","authors":"Yu Feng, Haoming Wang, Kang Wang, Ziyue Li, Bohao Tan, Qirui Li, Fan Ouyang, Zhangling Chen","doi":"10.1186/s12937-025-01179-5","DOIUrl":"10.1186/s12937-025-01179-5","url":null,"abstract":"<p><strong>Background: </strong>Not all beverage items are necessarily beneficial for health, but the potential impact of an overall beverage pattern on health remains unknown. We aimed to examine associations of adherence to an overall healthy beverage pattern with all-cause and cause-specific mortality in a prospective cohort of US populations.</p><p><strong>Methods: </strong>We included 8,894 adults from the National Health and Nutrition Examination Survey (2001-2019), a nationally representative cohort of US populations. Dietary data were collected at baseline based on the 24-h recall dietary interview. Using the data, we calculated a healthy beverage score (HBS), where coffee, tea, and low-fat milk received positive scores, while alcohol, fruit juice, artificially sweetened beverages, sugar-sweetened beverages, and whole-fat milk received reverse scores. A higher HBS reflected a healthier beverage pattern. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of HBS with mortality, adjusting for demographics, dietary and lifestyle factors, and medical history.</p><p><strong>Results: </strong>During a mean follow-up of 15.5 years, we recorded 2,363 all-cause deaths, including 761 cardiovascular disease (CVD) deaths, 511 cancer deaths, and 1,091 other deaths. Compared with the lowest quartile of HBS, the HRs and 95%CIs of the highest quartile of HBS were 0.79 (0.68, 0.92) for all-cause mortality, 0.75 (0.60, 0.95) for CVD mortality, 0.92 (0.70, 1.22) for cancer mortality, and 0.75 (0.58, 0.98) for other mortality. Inverse linear relationships of HBS with all-cause, and CVD mortality were observed using restricted cubic splines (P_{non-linearity} >0.05). These results were consistent across subgroups predefined by age, sex, smoking status, dietary fiber consumption, hypertension, hyperlipidemia, daily energy intake, and Healthy Eating Index-2015. Results were robust in several sensitivity analyses.</p><p><strong>Conclusions: </strong>Greater adherence to HBS was associated with a substantially lower risk of all-cause, CVD and other mortality. These findings suggest that greater adherence to a healthy beverage pattern could benefit prevention of premature mortality.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"118"},"PeriodicalIF":3.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of behavioural change communication through women development army on optimal complementary feeding practice among children aged 6-23 months in Southwest Ethiopia: a cluster randomized controlled trial.","authors":"Meseret Tamrat Gebretsadik, Dessalegn Tamiru, Assefa Legesse Sisay, Tefera Belachew","doi":"10.1186/s12937-025-01123-7","DOIUrl":"10.1186/s12937-025-01123-7","url":null,"abstract":"<p><strong>Background: </strong>Optimal development and growth in children are primarily determined by dietary practice during the first 24 months of life. However, in low-income countries, especially in sub-Saharan Africa, ensuring adequate nutrition and maternal nutritional knowledge are challenging. As a result, it is a major public health issue in Ethiopia. Therefore, it is essential to address feeding practices and knowledge gaps through behavior change communication. This study assessed the effect of behaviour change communication through the women's development army on complementary feeding practices among children aged 6-23 months in Jimma Zone, Ethiopia.</p><p><strong>Methods: </strong>A cluster randomized controlled trial was conducted from December 2021 to November 2022 in rural Ethiopia. The study used two-stage cluster sampling to allocate villages into control and intervention groups and systematic random sampling methods to select participants. Fourteen villages were randomly chosen from 21 eligible ones, with seven clusters (villages) in each group. Initially, 438 mother-child pairs participated, and 404 pairs remained at the endline data collection. The intervention group, consisting of 219 pairs, received food-based BCC from the WDA, while the control group, also with 219 mother-child pairs, received routine health education by Health Extension workers. Data were collected through structured questionnaires and 24-hour dietary recall. The primary objective for this study was optimal complementary feeding practices. The chi-square statistic assessed sociodemographic differences, and the difference-in-differences method evaluated the intervention's effect. Generalized estimating equations were used to analyze BCC's impact and identify predictors.</p><p><strong>Results: </strong>The intervention group showed a 28.4% (DID: 28.4%, 95% CI: 18.1 to 38.6) improvement in optimal complementary feeding practices compared to the control group (p < 0.001). Factors associated with optimal complementary feeding practices included BCC (AOR = 5.00, 95% CI: 1.78-14.05), maternal education (AOR = 2.00, 95% CI: 1.33-3.01), not using traditional food processing methods (AOR = 0.34, 95% CI: 0.21-0.54), and maternal knowledge (AOR = 0.65, 95% CI: 0.43-0.99).</p><p><strong>Conclusion: </strong>BCC, through the WDA, significantly improved complementary feeding knowledge and practices. Policymakers should support long-term BCC interventions and adopt a multi-sectoral approach to address the factors influencing child feeding practices. The study is registered retrospectively in the Pan African Clinical Trials Registry with number PACTR202106621156513 on 21/06/2021.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"116"},"PeriodicalIF":4.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness and safety of nanocurcumin supplementation for diabetic peripheral neuropathy in patients with type 2 diabetes: a randomized double-blind clinical trial.","authors":"Asieh Mansour, Hamid Reza Rahimi, Hadis Gerami, Atie Sadat Khorasanian, Amir Hossein Esmaeili, Atefeh Amrollahi Bioky, Mohammad Reza Mohajeri-Tehrani, Hamid Reza Fateh, Sayed Mahmoud Sajjadi-Jazi","doi":"10.1186/s12937-025-01184-8","DOIUrl":"10.1186/s12937-025-01184-8","url":null,"abstract":"<p><strong>Background: </strong>Diabetic neuropathy is the most prevalent complication of diabetes mellitus, affecting up to 50% of patients with type 2 diabetes mellitus (T2DM). Among the various types of diabetic neuropathy, diabetic peripheral neuropathy (DPN) is the most common. Numerous animal studies have highlighted a strong association between the improvement of DPN and curcumin supplementation, particularly due to curcumin's anti-inflammatory and antioxidant properties. However, the effects of curcumin on DPN have been evaluated in only one randomized controlled trial. In our study, we assessed the efficacy and safety of a 16-week supplementation with nanocurcumin in T2DM patients suffering from DPN.</p><p><strong>Methods: </strong>This randomized, double-blind, placebo-controlled trial was conducted at a diabetes clinic within the Endocrinology and Metabolism Research Center in Tehran, Iran. The study aimed to evaluate the effects of nanocurcumin (40 mg taken twice daily) compared to a placebo in patients with DPN over a 16-week period. The primary endpoint of the study was the reduction of pain severity, measured by the Numerical Rating Scale (NRS). Additionally, we assessed neuropathic outcomes by monitoring changes in the Michigan Neuropathy Screening Instrument examination (MNSIE) and the Neuropathy Disability Score (NDS). Secondary endpoints included improvements in metabolic and cardiovascular parameters from baseline to the end of the treatment.</p><p><strong>Results: </strong>Ninety-seven patients were randomized, with 41 in the nanocurcumin group and 45 in the placebo group completing the study. No significant differences were found between the groups in terms of NRS (P = 0.787), NDS (P = 0.576), or MNSIE (P = 0.405) after 16 weeks. Nanocurcumin supplementation did not alter the metabolic profile or cardiovascular parameters and was well-tolerated, without major adverse events.</p><p><strong>Conclusion: </strong>Nanocurcumin supplementation over 16 weeks did not improve pain, neuropathic outcomes, or metabolic/cardiovascular parameters in patients with T2DM suffering from DPN.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"115"},"PeriodicalIF":4.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for a randomized trial comparing a synbiotic-enriched goat milk-based infant formula with a commercially available cow milk-based formula: effects on gastrointestinal symptoms, quality of life, and growth in infants with cow milk-related symptoms.","authors":"Mateusz Jankiewicz, Hania Szajewska","doi":"10.1186/s12937-025-01183-9","DOIUrl":"10.1186/s12937-025-01183-9","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"114"},"PeriodicalIF":4.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino acid intake, plasma metabolites, and incident type 2 diabetes risk: a systematic approach in prospective cohort studies.","authors":"Siyue Wang, Yanping Li, Molin Wang, Jeffrey Yuan, Oana A Zeleznik, A Heather Eliassen, Andrew T Chan, Frank B Hu, Yang Hu, Qi Sun","doi":"10.1186/s12937-025-01157-x","DOIUrl":"10.1186/s12937-025-01157-x","url":null,"abstract":"<p><strong>Background: </strong>Amino acid (AA) intake is thought to be closely related to the etiology of type 2 diabetes (T2D), although few prospective human studies have examined the association. The study prospectively examined inter-relationships among the intake of all 20 AAs, blood metabolome, and T2D incidence.</p><p><strong>Methods: </strong>Prospective associations between 20 individual AA intake and T2D were examined among 201,113 participants from the Health Professionals Follow-up Study (HPFS), Nurses' Health Study (NHS), and NHSII who did not have T2D, cardiovascular disease, or cancer at baseline. Next, a multi-metabolite signature responsive to AA intake was derived through two sets of 7-day diet record (7DDR) assessments, and subsequently replicated in multiple cohorts. Finally, Cox regression models were used to determine and confirm the prospective associations of AA intake, plasma metabolite signatures, with T2D incidence.</p><p><strong>Results: </strong>During 5,037,848 person-years of follow-up, 20,619 T2D cases were documented. Sulfur AAs (SAAs) and aromatic amino acids were significantly associated with higher T2D risk independent of other AAs. Comparing the highest with lowest quintiles of intake, the multivariable adjusted pooled hazard ratios (HRs) for T2D were 1.20 (95% CI: 1.13-1.27) for total SAA (P _{for trend} < 0.0001) and 1.14 (95% CI: 1.08-1.21) for total aromatic AAs (P _{for trend} < 0.0001). A total of 73 plasma metabolites were identified as responsive markers for total SAA intake, and 87 metabolites for total aromatic AA intake. Approximately 75% of these metabolites were commonly responsive within the individual AAs within the same class. The multi-metabolite signatures for SAAs and aromatic AAs intakes were replicated in an independent study [β = 0.30 or 0.31 per SD increase of SAA and aromatic AA intake, respectively, P < 0.0001 for both associations). Moreover, the signatures were associated with T2D incidence: the HRs for per SD change were 1.14 (95%CI: 1.08-1.20, P < 0.00001) for SAA signature and 1.18 (95%CI: 1.12-1.24, P < 0.00001) for aromatic AA signature. Mediation analysis showed that the metabolite signatures explained various degree (% ranging from 10.5(95%CI: 3.8-26.1) to 29.9(95%CI: 13.5-53.9)) for the associations between dietary SAAs/aromatic AAs and T2D incidence risk.</p><p><strong>Conclusions: </strong>This study provides novel evidence that higher intake of sulfur and aromatic AAs is independently associated with an increased risk of T2D. Multiple plasma metabolites are responsive to these dietary AAs, potentially serving as objective markers for AA intake. Collectively, the metabolite signatures significantly predict a higher T2D risk, and mediate the positive associations to various degrees, corroborating findings from long-term dietary assessments.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"112"},"PeriodicalIF":4.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycemic response to SSBs and ASBs: the role of mixed meals and individual variability.","authors":"Sejin Kim, YoonJu Song","doi":"10.1186/s12937-025-01181-x","DOIUrl":"10.1186/s12937-025-01181-x","url":null,"abstract":"<p><strong>Background: </strong>While artificially sweetened beverages (ASBs) are widely reported to have minimal glycemic impact compared to sugar-sweetened beverages (SSBs), their effects in mixed meal conditions and individual variability in response remain poorly understood. This study aimed to evaluate postprandial glycemic response (PPGR) and individual variability in response to an SSB (regular cola) and an ASB (zero cola), both in single and mixed conditions, using continuous glucose monitoring (CGM).</p><p><strong>Methods: </strong>A total of 66 healthy young adults participated in this 14-day, non-randomized crossover intervention study. Test meals included 75 g oral glucose load as a reference, muffin, regular cola, zero cola, muffin with regular cola (MRC), and muffin with zero cola (MZC). PPGR was evaluated using incremental area under the curve. The glucose dip was assessed as the minimum glucose reduction from baseline. Participants were classified as MZC-High (n = 17) if their glycemic response to MZC was higher than to MRC, and as MZC-Stable (n = 44) if MRC showed the higher response.</p><p><strong>Results: </strong>The 75 g oral glucose load reference exhibited a typical glycemic pattern, peaking at 45 min before steadily declining. The muffin induced a moderate glycemic response, while regular cola led to a rapid glucose rise followed by a sharp decline. When combined with a muffin, MRC exhibited a slightly higher glycemic response (iAUC₁₈₀:161.6 mmol∙min/L), whereas MZC showed a similar response to the muffin alone (113.3 and 111.1 mmol∙min /L, respectively). At 120 min, the glucose dip was most pronounced for regular cola, whereas oral glucose load and muffin showed smaller reductions. These patterns persisted at 180 min, with oral glucose load showing the largest drop. Mixed meals attenuated glucose dips, with MRC and MZC preventing excessive declines. Individual responses analysis revealed that while the overall iAUC was not significantly different between muffin alone and MZC, 26 participants (MZC-High Responders) exhibited a higher iAUC with MZC than with MRC, suggesting variability in glucose regulation. Comparisons between MZC-High Responders and MZC-Stable participants showed no significant differences in age or body composition.</p><p><strong>Conclusion: </strong>While zero cola alone or in combination with a muffin had a minimal overall glycemic impact, some individuals exhibited higher glycemic responses in mixed conditions. These findings suggest that individual variability and mixed condition should be considered when consuming artificially sweetened beverages.</p><p><strong>Trial registration: </strong>Clinical Research Information Service (CRIS, cris.nih.go.kr) No. KCT0009921.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"113"},"PeriodicalIF":4.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of long-term oral nutritional supplementation with dietary counseling on growth, body composition and bone mineralization in children with or at risk for undernutrition: a randomized controlled trial.","authors":"Mandy Y L Ow, Nga Thuy Tran, Yatin Berde, Tu Song Nguyen, Van Khanh Tran, Morgan J Jablonka, Geraldine E Baggs, Dieu T T Huynh","doi":"10.1186/s12937-025-01133-5","DOIUrl":"10.1186/s12937-025-01133-5","url":null,"abstract":"<p><strong>Background: </strong>Impaired growth, accompanied by low lean mass and poor bone mineralization in undernourished children, is linked to adverse short- and long-term health outcomes. Oral nutritional supplements (ONS) promote catch-up growth, but their efficacy in improving lean mass and bone mineralization remains uninvestigated. This study aims to compare the efficacy of long-term ONS with dietary counseling (DC) versus DC alone on growth, body composition, bone mineralization, and health outcomes in children with or at risk of undernutrition.</p><p><strong>Methods: </strong>Children (n = 330) aged 24-60 months with WHO Growth Standard z-scores of weight-for-age < - 1, height-for-age < - 1, and weight-for-height < 0 were randomized in a multisite controlled trial to receive two servings of a complete and balanced ONS formula with DC, or DC-only, for 240 days. Anthropometric measurements, dietary intake, and parent-reported measures of illness-related and other health outcomes were assessed at baseline and days 30, 120, and 240. Dual X-ray absorptiometry-assessed body composition and bone mineralization, and nutritional blood biomarkers were measured at baseline and day 240.</p><p><strong>Results: </strong>ONS supplementation augmented growth in height and weight through day 240, with increasing between-group differences over visits (P < 0.01 for treatment-by-visit interaction in height, weight, height-for-age and weight-for-age z-scores). Energy and protein intake levels were 26% and 22% higher, respectively, in the ONS + DC compared to the DC-group at day 240 (both P < 0.001). The ONS + DC group also had a higher lean mass index of 11.06 (0.05) versus 10.92 (0.05) kg/m2 (P = 0.048) and total body less head bone mineral density of 0.407 (0.003) versus 0.399 (0.003) g/cm2 (P = 0.03) at day 240, with no differences in fat mass index compared to DC. The ONS + DC group also had better serum vitamin D and K status, fewer sick and missed school days, better parent-reported sleep habits, appetite, energy, and physical activity levels versus DC-group (all P < 0.05).</p><p><strong>Conclusion: </strong>Adding ONS to DC for 8 months improved linear catch-up growth and supported quality growth, as evidenced by greater lean mass and bone mineral accretion. These findings, alongside parent-reported improvements in child health, suggest that improved nutrient intake with ONS improves multiple domains of child health and well-being.</p><p><strong>Trial registration: </strong>This clinical trial was registered on ClinicalTrials.gov (registration number: NCT05239208) on 14 February 2022. Video Abstract.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"110"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis.","authors":"Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu","doi":"10.1186/s12937-025-01176-8","DOIUrl":"10.1186/s12937-025-01176-8","url":null,"abstract":"<p><strong>Background: </strong>Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials.</p><p><strong>Methods: </strong>We screened PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from inception through March 21, 2024 for acute, controlled, experimental (randomized or non-randomized) trials comparing chickpea consumption with carbohydrate-matched controls that reported on postprandial glucose and insulin responses (iAUC and C_max). Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.</p><p><strong>Results: </strong>A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose C_max (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.</p><p><strong>Conclusion: </strong>Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. Future studies should explore the long-term effects of chickpea consumption, investigate the impact of processing methods, and include metabolically unhealthy populations to enhance generalizability.</p><p><strong>Registration: </strong>This review was registered on PROSPERO (CRD42022365074).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"111"},"PeriodicalIF":4.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.","authors":"Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park","doi":"10.1186/s12937-025-01177-7","DOIUrl":"10.1186/s12937-025-01177-7","url":null,"abstract":"","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"109"},"PeriodicalIF":4.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study.","authors":"Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu","doi":"10.1186/s12937-025-01155-z","DOIUrl":"10.1186/s12937-025-01155-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the sex-specific association between irritable bowel syndrome (IBS) and type 2 diabetes (T2D), and further explore whether sex-hormone binding globulin (SHBG) was an associated factor of the sex-specific association.</p><p><strong>Methods: </strong>The study was a prospective analysis based on the UK biobank (UKB) data. We included 359 503 participants, all of whom were without diabetes diagnosis and had complete SHBG information at baseline. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using non-IBS group as the reference, further stratified by sex and SHBG levels in multivariable-adjusted models, including demographics, lifestyle factors, and disease history.</p><p><strong>Results: </strong>During a median follow-up of 10.4 years, 14 317 incident T2D cases had been documented. A statistically significant increased risk of T2D with IBS compared to those without IBS was observed in all multivariable-adjusted models (HR = 1.32, 95% CI = 1.23-1.42, P < 0.001). Additionally, a sex-specific association between IBS and T2D was found (P_interaction = 0.004), with the risk in women (HR = 1.43, 95% CI = 1.31-1.57) being higher than in men (HR = 1.14, 95% CI = 1.01-1.29). A significant effect modification of SHBG was also observed in the association between IBS and T2D (P_interaction = 0.001). The risk of incident T2D was higher in participants with higher SHBG levels (HR = 1.42, 95% CI = 1.25-1.63) than in those with lower SHBG levels (HR = 1.26, 95% CI = 1.16-1.37).</p><p><strong>Conclusions: </strong>A sex-specific association between prevalent IBS and T2D incidence was found, and SHBG level might modify the association.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"108"},"PeriodicalIF":4.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}