Mengying Wang, Yinxi Tan, Huangda Guo, Hexiang Peng, Siyue Wang, Yi Zheng, Tianjiao Hou, Chenghua Gao, Wenyan Xian, Jie Huang, Tao Wu
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引用次数: 0
Abstract
Objective: To investigate the sex-specific association between irritable bowel syndrome (IBS) and type 2 diabetes (T2D), and further explore whether sex-hormone binding globulin (SHBG) was an associated factor of the sex-specific association.
Methods: The study was a prospective analysis based on the UK biobank (UKB) data. We included 359 503 participants, all of whom were without diabetes diagnosis and had complete SHBG information at baseline. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using non-IBS group as the reference, further stratified by sex and SHBG levels in multivariable-adjusted models, including demographics, lifestyle factors, and disease history.
Results: During a median follow-up of 10.4 years, 14 317 incident T2D cases had been documented. A statistically significant increased risk of T2D with IBS compared to those without IBS was observed in all multivariable-adjusted models (HR = 1.32, 95% CI = 1.23-1.42, P < 0.001). Additionally, a sex-specific association between IBS and T2D was found (Pinteraction = 0.004), with the risk in women (HR = 1.43, 95% CI = 1.31-1.57) being higher than in men (HR = 1.14, 95% CI = 1.01-1.29). A significant effect modification of SHBG was also observed in the association between IBS and T2D (Pinteraction = 0.001). The risk of incident T2D was higher in participants with higher SHBG levels (HR = 1.42, 95% CI = 1.25-1.63) than in those with lower SHBG levels (HR = 1.26, 95% CI = 1.16-1.37).
Conclusions: A sex-specific association between prevalent IBS and T2D incidence was found, and SHBG level might modify the association.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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