Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu
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Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.</p><p><strong>Results: </strong>A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose C<sub>max</sub> (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.</p><p><strong>Conclusion: </strong>Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. Future studies should explore the long-term effects of chickpea consumption, investigate the impact of processing methods, and include metabolically unhealthy populations to enhance generalizability.</p><p><strong>Registration: </strong>This review was registered on PROSPERO (CRD42022365074).</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"111"},"PeriodicalIF":4.4000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261582/pdf/","citationCount":"0","resultStr":"{\"title\":\"Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis.\",\"authors\":\"Eunice Mah, Cassi N Uffelman, Traci M Blonquist, Ding Ding Wang, Colin D Rehm, Shellen R Goltz, YiFang Chu\",\"doi\":\"10.1186/s12937-025-01176-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials.</p><p><strong>Methods: </strong>We screened PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from inception through March 21, 2024 for acute, controlled, experimental (randomized or non-randomized) trials comparing chickpea consumption with carbohydrate-matched controls that reported on postprandial glucose and insulin responses (iAUC and C<sub>max</sub>). Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.</p><p><strong>Results: </strong>A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose C<sub>max</sub> (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.</p><p><strong>Conclusion: </strong>Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. 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引用次数: 0
摘要
背景：鹰嘴豆是一种豆类，可能有助于改善血糖控制，但其对餐后血糖和胰岛素反应的急性影响尚不清楚。本系统综述和荟萃分析旨在评估急性鹰嘴豆摄入对对照交叉试验中这些结果的影响。方法：我们筛选PubMed、Cochrane中央对照试验登记册（Central）和Embase从成立到2024年3月21日的急性、对照、实验性（随机或非随机）试验，比较鹰嘴豆食用与碳水化合物匹配的对照组报告的餐后血糖和胰岛素反应（iAUC和Cmax）。两名审稿人提取数据并评估偏倚风险（RoB 2）和证据确定性（GRADE）。采用随机效应通用反方差模型对数据进行分析。结果：共确定了28项符合条件的研究（40项比较）。与碳水化合物匹配的对照组相比，鹰嘴豆摄入显著降低餐后葡萄糖iAUC (MD: -47.89, 95% CI: -64.20, -31.58, p max （MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207）或胰岛素iAUC （MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795）。GRADE评估显示，由于异质性，葡萄糖iAUC的确定性非常低。结论：对照试验的荟萃分析表明，急性鹰嘴豆食用可降低餐后血糖iAUC，尽管证据的确定性较低。虽然没有观察到对血糖峰值或胰岛素反应的显著影响，但研究结果与之前关于脉冲和血糖控制的研究一致。需要进一步的高质量研究来证实这些发现，因为目前的证据的确定性很低或非常低。未来的研究应探讨鹰嘴豆食用的长期影响，调查加工方法的影响，并包括代谢不健康的人群，以提高普遍性。注册：本综述在PROSPERO注册（CRD42022365074）。
Chickpea attenuates postprandial blood glucose responses: a systematic review and meta-analysis.
Background: Chickpeas are a legume that may help improve glycemic control, but their acute effects on postprandial glucose and insulin responses are unclear. This systematic review and meta-analysis aimed to assess the impact of acute chickpea consumption on these outcomes in controlled, crossover trials.
Methods: We screened PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from inception through March 21, 2024 for acute, controlled, experimental (randomized or non-randomized) trials comparing chickpea consumption with carbohydrate-matched controls that reported on postprandial glucose and insulin responses (iAUC and Cmax). Two reviewers extracted the data and assessed risk-of-bias (RoB 2) and certainty-of-evidence (GRADE). Data were analyzed using generic inverse-variance with random-effects model.
Results: A total of 28 eligible studies (40 comparisons) were identified. Chickpea consumption significantly reduced postprandial glucose iAUC compared to carbohydrate-matched controls (MD: -47.89, 95% CI: -64.20, -31.58, p < 0.0001). No significant effects were observed on glucose Cmax (MD: -0.23, 95% CI: -1.48, 1.02, p = 0.7207) or insulin iAUC (MD: 50.06, 95% CI: -3771.14, 3871.26, p = 0.9795). The GRADE assessment indicated very low certainty for glucose iAUC due to heterogeneity.
Conclusion: Meta-analysis of controlled trials suggest that acute chickpea consumption lowers postprandial glucose iAUC, albeit with low certainty of evidence. While no significant effects were observed on glucose peak or insulin response, the findings align with previous research on pulses and glycemic control. Further high-quality studies are needed to confirm these findings, as the current evidence is of low to very low certainty. Future studies should explore the long-term effects of chickpea consumption, investigate the impact of processing methods, and include metabolically unhealthy populations to enhance generalizability.
Registration: This review was registered on PROSPERO (CRD42022365074).
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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