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The effects of Mixodin supplementation on migraine headache characteristics, oxidative stress and inflammatory biomarkers in patients with migraine: a double-blind, placebo-controlled, randomized trial. 补充米沙定对偏头痛患者偏头痛特征、氧化应激和炎症生物标志物的影响:一项双盲、安慰剂对照、随机试验
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-23 DOI: 10.1186/s12937-026-01308-8
Mohammad Ali Askari, Sahar Golpour-Hamedani, Fariborz Khorvash, Afsaneh Yegdaneh, Mahdi Vajdi
{"title":"The effects of Mixodin supplementation on migraine headache characteristics, oxidative stress and inflammatory biomarkers in patients with migraine: a double-blind, placebo-controlled, randomized trial.","authors":"Mohammad Ali Askari, Sahar Golpour-Hamedani, Fariborz Khorvash, Afsaneh Yegdaneh, Mahdi Vajdi","doi":"10.1186/s12937-026-01308-8","DOIUrl":"10.1186/s12937-026-01308-8","url":null,"abstract":"<p><p>BACKGROUND: Migraine is a prevalent neurological disorder closely linked to oxidative stress and neurogenic inflammation. Curcumin, gingerol, and piperine are natural compounds with well-established anti-inflammatory and antioxidant properties; however, clinical evidence on their combined effects in migraine remains limited. AIM: This study aimed to evaluate the effects of eight weeks of Mixodin supplementation on inflammatory and oxidative stress biomarkers, and clinical migraine characteristics, in patients with migraine. METHODS: This randomized, double-blind, placebo-controlled trial enrolled 60 patients with migraine, who were randomly assigned to receive two Mixodin capsules daily (each containing 300 mg curcumin, 7.5 mg gingerol, and 3.75 mg piperine) or placebo for eight weeks. Serum hs-CRP, NO, MDA, TOS, TAC, and SOD were measured before and after the intervention. Headache severity, frequency, and duration were recorded using VAS and a headache diary. RESULTS: Mixodin supplementation significantly reduced serum Hs-CRP (− 0.87 ± 0.19 vs. − 0.16 ± 0.09 mg/L; P = 0.001) and NO levels (− 5.53 ± 1.53 vs. + 3.51 ± 1.79 µmol/L; P = 0.042) compared with placebo. Additionally, eight weeks of Mixodin supplementation resulted in a trend toward increased SOD activity and TAC, and a trend toward decreased TOS; however, these changes did not reach statistical significance when compared with the control group (all P > 0.05). No significant change was observed in MDA levels. Mixodin supplementation significantly reduced headache severity (-1.93 ± 0.30vs. -0.36 ± 0.21; P = 0.001) compared with placebo, whereas frequency and duration did not differ significantly between groups (P = 0.737 and P = 0.873, respectively). CONCLUSION: Eight weeks of Mixodin supplementation significantly improved hs-CRP, NO levels, and headache severity among migraine patients, suggesting a promising role for this combination as an adjunctive therapeutic approach in migraine management. Further large-scale trials with longer follow-up are needed. TRIAL REGISTRATION: Iranian Registry of Clinical Trials ( www.irct.ir ) (ID: IRCT20241009063312N1). </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between methyl donor nutrients intake with sleep duration, sleep quality and biomarkers of oxidative stress and inflammation among adults. 成人甲基供体营养素摄入与睡眠时间、睡眠质量、氧化应激和炎症生物标志物之间的关系
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-21 DOI: 10.1186/s12937-026-01301-1
Donya Poursalehi, Maryam Foroughi, Zahra Moradmand, Farnaz Shahdadian, Parvane Saneei
{"title":"Association between methyl donor nutrients intake with sleep duration, sleep quality and biomarkers of oxidative stress and inflammation among adults.","authors":"Donya Poursalehi, Maryam Foroughi, Zahra Moradmand, Farnaz Shahdadian, Parvane Saneei","doi":"10.1186/s12937-026-01301-1","DOIUrl":"10.1186/s12937-026-01301-1","url":null,"abstract":"<p><p>OBJECTIVE: Sleep disorders could negatively affect physical and mental health status of adults. These consequences might occur through increased levels of oxidative stress and inflammation. This study was aimed to assess dietary intake of methyl donor nutrients with sleep quantity and quality, concentrations of oxidative stress and inflammation among adults. METHODS: This study was conducted with a cross-sectional design on 535 adults aged 20–65 years. A multilevel cluster random-sampling approach was applied to choose participants. Methyl donor nutrients intake was assessed using a validated food frequency questionnaire. Quantity and quality of sleep were evaluated through the validated Pittsburgh Sleep Quality Index questionnaire. Fasting blood samples of subjects were gathered to determine serum levels of oxidative stress and inflammatory biomarkers. RESULTS: Prevalence of short sleeping and poor sleep quality among participants were 70.1% and 28.6%, respectively. High methyl donor nutrients score (MDNS) was inversely related to short sleeping in fully-adjusted model (OR = 0.42; 95% CI: 0.19–0.91). However, no significant association was observed in terms of poor sleep quality (OR = 0.70; 95% CI: 0.34–1.47). In addition, no significant associations were seen between MDNS with levels of glutathione peroxidase, malondialdehyde, superoxide dismutase and high-sensitivity C-reactive protein. CONCLUSIONS: Dietary intake of methyl donor nutrients was inversely associated with short sleeping, but not related to poor sleep quality. Further prospective studies are needed to confirm this finding. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body mass index, prebiotic supplementation during pregnancy and gestational diabetes mellitus risk: an effect modification analysis from a randomised controlled trial. 体重指数、孕期补充益生元与妊娠期糖尿病风险:一项随机对照试验的效应修正分析。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-16 DOI: 10.1186/s12937-026-01323-9
Rachelle A Pretorius, Thomas R Sullivan, Summer V M Walker, Johan Garssen, Jeffrey A Keelan, Desiree Silva, Susan L Prescott, Debra J Palmer
{"title":"Body mass index, prebiotic supplementation during pregnancy and gestational diabetes mellitus risk: an effect modification analysis from a randomised controlled trial.","authors":"Rachelle A Pretorius, Thomas R Sullivan, Summer V M Walker, Johan Garssen, Jeffrey A Keelan, Desiree Silva, Susan L Prescott, Debra J Palmer","doi":"10.1186/s12937-026-01323-9","DOIUrl":"10.1186/s12937-026-01323-9","url":null,"abstract":"<p><p>BACKGROUND: Prebiotic dietary supplementation has been shown to improve glucose homeostasis in type 2 diabetes patients. The aim of this analysis was to determine whether pre-pregnancy body mass index (BMI) modifies the effect of prebiotic supplementation from mid-pregnancy on reducing the risk of gestational diabetes mellitus (GDM). METHODS: In a double-blinded, randomised controlled trial, pregnant women < 21 gestational weeks were randomly assigned (1:1) to consume daily prebiotics (14.2 g galacto-oligosaccharides and fructo-oligosaccharides) or placebo (8.7 g maltodextrin) powder. An effect modification analysis was performed to assess the heterogeneity of the effect of prebiotic supplementation in relation to pre-pregnancy BMI on GDM diagnosis. RESULTS: Between June 2016 and November 2021, 329 women were assigned to the prebiotic group (50.4%), and 323 (49.5%) were assigned to the placebo group. Overall, 288 of 652 women (44.2%) were classified as overweight/obese prior to pregnancy (BMI ≥ 25 kg/m2). The distribution was balanced, with 146/329 (44.4%) randomised to the prebiotics group and 142/323 (44.0%) in the placebo group. Pre-pregnancy BMI modified the effect of prebiotic supplementation, with the intervention reducing GDM rates in women with a BMI ≥ 25 kg/m2 (prebiotic group 11.0% vs. control group 21.8%; adjusted relative risk 0.50; 95% confidence interval (CI) 0.28 to 0.89) but not in women with a pre-pregnancy BMI < 25 kg/m2 (7.7–7% vs. 4.4%; adjusted relative risk 1.72; 95% CI 0.70 to 4.19; interaction p = 0.02). CONCLUSION: Pre-pregnancy BMI was found to modify the effect of prebiotic supplementation on GDM rates, with benefits observed in overweight and obese women. Our results highlight a target population for future randomised controlled trials to further investigate the effects of prebiotic supplementation during pregnancy on reducing the risk of GDM.  TRIAL REGISTRATION: Primary and secondary infant allergic disease outcomes of this randomised controlled trial have been previously published. The trial was registered with the Australian New Zealand Clinical Trial Registry: ACTRN12615001075572, https://www.anzctr.org.au/on13/10/2015 . </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13195933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials. 补充白藜芦醇对多种健康结果的影响:对随机对照试验的系统评价和荟萃分析的综合评价。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-15 DOI: 10.1186/s12937-026-01319-5
Jia-Nan Sun, Rui Yang, Li Fang, Yun-Jia Li, Wei-Yi Xing, Ming-Li Sun, Lang Wu, Qi-Jun Wu, Ting-Ting Gong
{"title":"Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.","authors":"Jia-Nan Sun, Rui Yang, Li Fang, Yun-Jia Li, Wei-Yi Xing, Ming-Li Sun, Lang Wu, Qi-Jun Wu, Ting-Ting Gong","doi":"10.1186/s12937-026-01319-5","DOIUrl":"10.1186/s12937-026-01319-5","url":null,"abstract":"<p><p>BACKGROUND: Resveratrol has shown health benefits like anti-obesity, antioxidant, and anti-inflammatory effects. OBJECTIVES: To resolve conflicting findings and clarify its impact, our study summarizes resveratrol supplementation’s effects and evaluates its effectiveness across populations. METHODS: We conducted the search through PubMed, Embase, and Web of Science databases from inception to April 30th, 2025, to identify meta-analyses of randomized controlled trials examining the effects of resveratrol supplementation on human health. The quality of included studies was evaluated using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) tool, and the credibility of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. This study was registered in PROSPERO (CRD 42024554480). RESULTS: Forty-five systematic reviews with 129 associations between resveratrol supplementation and human health were included, which consists of 68 outcomes. Using the AMSTAR measurement tool, all articles were categorized as moderate-to-high quality. Among 35 significant associations, four were supported by high-certainty evidence according to GRADE, including positive effects of resveratrol supplementation on reducing waist circumference (mean difference [MD] = -0.80 cm, 95% CI = -1.40, -0.20), total cholesterol among overweight adults (MD = -0.19 mmol/L, 95% CI = -0.32, -0.06), diastolic blood pressure (MD = -3.55 mmHg, 95% CI = -5.18, -1.93) and systolic blood pressure (MD = -7.97 mmHg, 95% CI = -10.63, -5.31) among patients with type 2 diabetes. Moreover, moderate-certainty evidence indicated that resveratrol supplementation may promote glucose metabolism, improve renal function, protect endothelial health, enhance working memory, improve hepatic steatosis, lower hormones, and reduce inflammation. CONCLUSIONS: High certainty of evidence suggested that resveratrol supplementation could decline waist circumference, lower blood pressure among patients with type 2 diabetes, and reduce total cholesterol among overweight adults. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tea intake as a dietary factor for cardiovascular health: global estimates of potentially preventable ischemic heart disease. 茶摄入量作为心血管健康的饮食因素:潜在可预防的缺血性心脏病的全球估计。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-14 DOI: 10.1186/s12937-026-01322-w
Longkun Liu, Mengmeng Zhu, Yiwen Li, Qian Xu, Yajie Cai, Xi Cheng, Yanfei Liu, Yue Liu
{"title":"Tea intake as a dietary factor for cardiovascular health: global estimates of potentially preventable ischemic heart disease.","authors":"Longkun Liu, Mengmeng Zhu, Yiwen Li, Qian Xu, Yajie Cai, Xi Cheng, Yanfei Liu, Yue Liu","doi":"10.1186/s12937-026-01322-w","DOIUrl":"10.1186/s12937-026-01322-w","url":null,"abstract":"<p><p>BACKGROUND: Tea intake (TI) has been associated with a reduced risk of ischemic heart disease (IHD) through antioxidant, anti-inflammatory, and metabolic regulatory biological mechanisms, but a comprehensive global assessment of the IHD burden reduction potentially associated with TI is lacking. This study aimed to quantify the reductions in global IHD incidence and mortality associated with TI from 1990 to 2021, and explore heterogeneity in these associations across demographic subgroups and regions. METHODS: We conducted a comparative risk assessment analysis integrating data from the Global Dietary Database (GDD), IHD burden estimates from the Global Burden of Disease (GBD) study, and BMI-stratified population distributions from the NCD Risk Factor Collaboration (NCD-RisC) across 180 countries and regions. TI distributions were modeled using gamma distributions, and BMI-stratified relative risks derived from dose-response meta-analyses were applied to estimate population attributable fractions. The analysis was stratified by sex, age, education level, and urbanicity. Proportional and absolute burden reductions (cases per million adults) were estimated, with uncertainty propagated through Monte Carlo simulation. RESULTS: Globally in 2021, approximately 28.66 million (95% UI: 18.76–44.79) IHD incident cases and 4.42 (95% UI: 2.94–6.72) million IHD deaths were potentially attributable to TI, accounting for 15.49% (95% UI: 7.03%–36.85%) and 8.32% (95% UI: 4.60%–15.70%) of total cases and deaths, respectively. The beneficial association was greater in men and middle-aged/older adults, with no significant difference by education level or urbanicity. Regionally, the Middle East and North Africa showed the highest proportional reductions (incidence: 22.04%; mortality: 11.72%), followed by Southeast and East Asia. From 1990 to 2021, Southeast and East Asia and Sub-Saharan Africa saw the largest increases in preventable IHD case proportions. At the national level, countries like Iran, Japan, and Kenya had the highest estimated proportional reductions, while China and Japan contributed the largest absolute reductions in preventable cases per million adults. CONCLUSION: TI is potentially associated with the reduced global burden of IHD, with benefits varying by region and demographic characteristics. These findings underscore the potential of TI as a dietary strategy for cardiovascular disease prevention and can inform targeted policies worldwide. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Night shift work and dietary behaviors: a comparative analysis of European night shift and day workers from the SHIFT2HEALTH online survey. 夜班工作和饮食行为:SHIFT2HEALTH在线调查对欧洲夜班和白班工人的比较分析。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-07 DOI: 10.1186/s12937-026-01320-y
Urte Klink, Edith J M Feskens, Desiree A Lucassen, Monique H Vingerhoeds, Sandra Haider, Kyriaki Papantoniou, Imke Matullat, Catalina Cuparencu, Anna Lena Aufschnaiter, Bianca Fuchs-Neuhold, Christina Höfler, Marlies Wallner, Katarzyna W Binder-Olibrowska, Magdalena Agnieszka Wrzesińska, Heidi M Lammers-van der Holst, Isabel Santonja, Katrin Scionti, Vanessa Schoissengeier, Karl-Heinz Wagner, Maria Wakolbinger, Eva Winzer, Meeke Ummels, Hannah Jilani
{"title":"Night shift work and dietary behaviors: a comparative analysis of European night shift and day workers from the SHIFT2HEALTH online survey.","authors":"Urte Klink, Edith J M Feskens, Desiree A Lucassen, Monique H Vingerhoeds, Sandra Haider, Kyriaki Papantoniou, Imke Matullat, Catalina Cuparencu, Anna Lena Aufschnaiter, Bianca Fuchs-Neuhold, Christina Höfler, Marlies Wallner, Katarzyna W Binder-Olibrowska, Magdalena Agnieszka Wrzesińska, Heidi M Lammers-van der Holst, Isabel Santonja, Katrin Scionti, Vanessa Schoissengeier, Karl-Heinz Wagner, Maria Wakolbinger, Eva Winzer, Meeke Ummels, Hannah Jilani","doi":"10.1186/s12937-026-01320-y","DOIUrl":"10.1186/s12937-026-01320-y","url":null,"abstract":"<p><p>BACKGROUND: Night shift workers are more likely to exhibit unfavorable dietary behaviors than day workers. However, these differences remain insufficiently explored within the European workforce. This study aims to examine differences in dietary behaviors (food intake frequency, eating frequency) by night shift exposure (history, frequency, duration) to investigate eating frequency, meal timing, and food choice determinants during night shifts, and to explore gender differences across Europe. METHODS: Data were collected via an online survey (May 2024-January 2025) in eight countries (Austria, Germany, Denmark, Greece, Italy, the Netherlands, Poland, Spain). Participants self-reported sociodemographics, occupational sector, current work schedules, shift work history, lifestyle characteristics, and dietary behaviors. A shortened Food Frequency Questionnaire (FFQ) assessed dietary intake, alongside questions on eating rate and frequency on work and non-work-days. Current night shift workers additionally reported eating frequency, timing, and food choice determinants during night shifts. Analyses compared dietary behaviors by night shift exposure (current, former, vs. day worker). Among current night shift workers, associations with night shift frequency (nights/month) and duration (years) were examined. Secondary analyses were stratified by gender. RESULTS: A total of 6,260 individuals were included (mean age 40.7, SD 10.7; 50.5% female). Overall, 60.4% were current night shift workers, 19.6% former night shift workers, and 20% day workers. Compared to day workers, current night shift workers reported significantly faster eating rates (OR = 1.21, 95% CI: 1.06–1.37), more frequent intake of sugar-sweetened (OR = 1.30, 95% CI: 1.14–1.48) and caffeinated beverages (OR = 1.14, 95% CI: 1.01–1.30), and lower fruit intake (OR = 0.87, 95% CI: 0.77–0.98). Higher monthly night shift load and longer duration of night work were associated with less favorable dietary patterns. Most current night shift workers reported one to two eating occasions per night, typically at the beginning or middle of their shift. Food choices were primarily driven by appetite, time, and food availability. Gender differences were observed only in food choice determinants. CONCLUSIONS: Night shift and day workers in Europe showed differences in dietary behaviors, particularly in sugar-sweetened beverage intake and eating rate. These findings highlight the need for targeted interventions to promote healthy eating among shift working populations. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High proportion of young children are vitamin D sufficient after expansion of Sweden's mandatory fortification but dairy products also contribute to a high climate impact. 在瑞典扩大了强制性强化维生素D后,很大比例的幼儿摄入了充足的维生素D,但乳制品也对气候产生了很大影响。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-04-01 DOI: 10.1186/s12937-026-01318-6
André Hesselink, Anna Winkvist, Anna Karin Lindroos, Lotta Moraeus, Helena Bjermo, Sanna Lignell, Linnea Bärebring, Elinor Hallström, Hanna Augustin
{"title":"High proportion of young children are vitamin D sufficient after expansion of Sweden's mandatory fortification but dairy products also contribute to a high climate impact.","authors":"André Hesselink, Anna Winkvist, Anna Karin Lindroos, Lotta Moraeus, Helena Bjermo, Sanna Lignell, Linnea Bärebring, Elinor Hallström, Hanna Augustin","doi":"10.1186/s12937-026-01318-6","DOIUrl":"10.1186/s12937-026-01318-6","url":null,"abstract":"<p><p>BACKGROUND: Sweden expanded its mandatory vitamin D fortification program in 2018 addressing high rates of insufficient vitamin D status and low intake. This study aimed to assess vitamin D status among young children post-expansion, evaluate its determinants, and identify main vitamin D sources and their climate impact. METHODS: Dietary intake among 18-month-olds (18mo, n = 1074) and 4-year-olds (4yo, n = 746) were obtained from the Swedish national survey Riksmaten Young Children 2021-24 based on two non-consecutive 24-hour food records. Intake of vitamin D from drops (µg/d) was also recorded. Individual vitamin D intakes were adjusted using the Multiple Source Method to reflect habitual intake. Blood concentrations of 25-hydroxyvitamin D (25OHD) were provided for a subset (18mo, n = 281; 4yo, n = 270). Climate impact was expressed as greenhouse gas emissions (GHGEs) in carbon dioxide equivalents (CO₂ eq), using life cycle assessment data from the Research Institutes of Sweden. Associations between 25OHD and plausible determinants were analyzed with linear regression. RESULTS: 16% of 18mo and 61% of 4yo had total vitamin D intakes (including diet and drops) below the average requirement, 7.5 µg/d. None were deficient (25OHD < 30 nmol/l), and 7% of 18mo and 4% of 4yo were insufficient (< 50 nmol/l). 25OHD was positively associated with dietary vitamin D intake and vitamin D from drops, and inversely associated with blood sampling during winter and parents’ birth country (≥ 1 parent born outside Nordics). Main vitamin D sources for 18mo were vitamin D drops and fortified foods: dairy, porridge and cereal drinks; and for 4yo, fortified dairy and fat spreads. Dairy was a large contributor to diet-related GHGEs (18mo: 10%, 4yo: 16%), whereas fortified fat spreads and plant-based dairy alternatives were effective sources of vitamin D, providing the highest vitamin D concentrations per kg CO₂ eq. CONCLUSIONS: A high proportion of young children in Sweden are vitamin D sufficient, with dietary vitamin D intake, vitamin D drops, and blood sampling season being major determinants. Fortified dairy is an important dietary source of vitamin D, but a shift to fortified plant-based alternatives would reduce diet-related climate impact and should be explored in future research. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating function availability and user satisfaction with nutrition apps: user-generated content analysis and text mining study. 评估功能可用性和用户对营养应用的满意度:用户生成内容分析和文本挖掘研究。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-03-31 DOI: 10.1186/s12937-026-01321-x
Songping Li, Qinghua Yao, Feihe Shao, Kejun Yang, Xiao Yu, Lixue Zhou, Junyi Xin
{"title":"Evaluating function availability and user satisfaction with nutrition apps: user-generated content analysis and text mining study.","authors":"Songping Li, Qinghua Yao, Feihe Shao, Kejun Yang, Xiao Yu, Lixue Zhou, Junyi Xin","doi":"10.1186/s12937-026-01321-x","DOIUrl":"10.1186/s12937-026-01321-x","url":null,"abstract":"<p><p>BACKGROUND: Nutrition apps are increasingly used to support dietary self-management and health promotion. However, how app functions align with nutrition-related tasks and user satisfaction with these apps remain unclear. Evidence from cross-country comparisons is limited. OBJECTIVE: This study aimed to compare function availability and user satisfaction of nutrition apps in China and the US and to examine key factors associated with nutrition app satisfaction in different market contexts. METHODS: A large-scale review-based analysis was conducted using nutrition app data from major app stores in China and the US. Task–Technology Fit, Latent Dirichlet Allocation, the Two-Factor Theory, the KANO model, DeepSeek-R1, and the Analytic Hierarchy Process were combined to assess function coverage and satisfaction patterns. A total of 269,300 reviews from China and 455,245 reviews from the US were included. RESULTS: Chinese nutrition apps showed broader coverage in target monitoring (n = 111, 84.73%) and nutrition education (n = 101, 77.10%), while US apps focused more on dietary behavior intervention (n = 364, 89.66%). Both countries showed clear gaps in personalized nutrition services. KANO analysis showed that all identified factors in China were classified as charm attributes, whereas in the US both charm and essential attributes were identified. AHP-based results indicated that overall user satisfaction was higher in China (0.8901/1) than in the US (0.8372/1). In the US market, dissatisfaction was primarily associated with issues related to the food database (0.7217/1) and fee (0.6795/1), whereas Chinese users more frequently reported concerns regarding reliability (0.7725/1). CONCLUSIONS: User satisfaction with nutrition apps differs between China and the US in functional focus and expectation structures. Improving system reliability in China and optimizing core functions and pricing in the US, alongside strengthening personalized services in both contexts, are key to enhancing user satisfaction and intervention effectiveness. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13188609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between dietary patterns and diabetes in patients with acute pancreatitis: a cross-sectional analysis from the DREAM study. 急性胰腺炎患者饮食模式与糖尿病之间的关系:DREAM研究的横断面分析
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-03-27 DOI: 10.1186/s12937-026-01294-x
Djibril M Ba, Tian Qiu, Nazia Raja-Khan, Sun Qi, Fred Tabung, Kristen M Roberts, Anna E Phillips, Cemal Yazici, Dhiraj Yadav, Elham Afghani, Venkata S Akshintala, Marina Basina, Melena Bellin, James L Buxbaum, Anna Casu, Kathleen Dungan, Carmella Evans-Molina, Evan L Fogel, Chris E Forsmark, Mark O Goodarzi, Brian T Layden, Sandra Lord, Stephen J Pandol, Georgios I Papachristou, Walter G Park, Richard Pratley, Vikesh K Singh, Cate Speake, Frederico G S Toledo, Guru Trikudanathan, Vernon M Chinchilli, Phil A Hart
{"title":"Associations between dietary patterns and diabetes in patients with acute pancreatitis: a cross-sectional analysis from the DREAM study.","authors":"Djibril M Ba, Tian Qiu, Nazia Raja-Khan, Sun Qi, Fred Tabung, Kristen M Roberts, Anna E Phillips, Cemal Yazici, Dhiraj Yadav, Elham Afghani, Venkata S Akshintala, Marina Basina, Melena Bellin, James L Buxbaum, Anna Casu, Kathleen Dungan, Carmella Evans-Molina, Evan L Fogel, Chris E Forsmark, Mark O Goodarzi, Brian T Layden, Sandra Lord, Stephen J Pandol, Georgios I Papachristou, Walter G Park, Richard Pratley, Vikesh K Singh, Cate Speake, Frederico G S Toledo, Guru Trikudanathan, Vernon M Chinchilli, Phil A Hart","doi":"10.1186/s12937-026-01294-x","DOIUrl":"10.1186/s12937-026-01294-x","url":null,"abstract":"<p><p>BACKGROUND: Dietary patterns have been associated with altered risk of diabetes mellitus (DM) in the general population. These patterns can estimate habitual intake of food groups associated with decreased or increased (e.g., greater intake of red meats) risk of DM. OBJECTIVE: This analysis aimed to examine the underexplored associations of four dietary patterns in patients presenting with an acute pancreatitis (AP) diagnosis based on the presence of pre-existing DM. METHODS: Study participants were selected from the Diabetes RElated to Acute Pancreatitis and its Mechanisms (DREAM) study, an ongoing, multicenter study of adults (18–75 years) with AP in the US. This is a cross-sectional analysis of baseline data collected using the VioScreen computer-administered Food Frequency Questionnaire. We examined four dietary patterns: the Alternate Mediterranean Diet (AMED), the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND), the Healthy Eating Index-2020 (HEI-2020), and the Alternate Healthy Eating Index-2010 (AHEI-2010). Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The study population included 647 individuals with AP (mean (SD) baseline age, 49.1 (14.5) years). Participants in the highest tertile of dietary index scores were more likely to be older, female, non-Hispanic White, and to have higher educational attainment. In multivariable analyses, greater adherence to the AMED and the MIND dietary patterns was associated with lower odds of pre-existing DM. Multivariable ORs for the odds of pre-existing DM comparing the highest to lowest tertile of diet scores were 0.44 (95% CI: 0.23, 0.84; P-trend = 0.01) for AMED, 0.46 (95% CI: 0.26, 0.82; P-trend = 0.01) for MIND, indicating lower odds for participants with a healthier dietary pattern. CONCLUSIONS: In this analysis, greater adherence to selected healthy dietary patterns was associated with lower odds of pre-existing DM at the time of AP presentation. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147531341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agreement between a new web-based and a legacy paper-based food frequency questionnaires in French-speaking Switzerland. 瑞士法语区新的基于网络的和传统的纸质食物频率调查问卷之间的协议。
IF 5.7 2区 医学
Nutrition Journal Pub Date : 2026-03-27 DOI: 10.1186/s12937-026-01309-7
Angeline Chatelan, Elsa Chevillard, Sarah T Pannen, Elaine Hillesheim, Silvia Stringhini, Mayssam Nehme, Idris Guessous, Sabine Rohrmann, Nina Steinemann, Janice Sych, Pedro Marques-Vidal
{"title":"Agreement between a new web-based and a legacy paper-based food frequency questionnaires in French-speaking Switzerland.","authors":"Angeline Chatelan, Elsa Chevillard, Sarah T Pannen, Elaine Hillesheim, Silvia Stringhini, Mayssam Nehme, Idris Guessous, Sabine Rohrmann, Nina Steinemann, Janice Sych, Pedro Marques-Vidal","doi":"10.1186/s12937-026-01309-7","DOIUrl":"10.1186/s12937-026-01309-7","url":null,"abstract":"<p><p>BACKGROUND: Updated and validated tools are crucial for assessing dietary intake. In French-speaking Switzerland, the only validated food frequency questionnaire (FFQ) was a paper-based version developed using data collected in 1990s. A new Swiss electronic FFQ (eFFQ) has recently been developed based on nationally representative dietary data from 2010s. The eFFQ has been recently validated and is intended for adoption in future studies among French-speaking adults living in Switzerland. Both FFQs differ in format (paper vs. electronic), food lists, frequency categories, portion sizes, and food composition databases. We aimed to compare dietary intake estimates from the recently developed eFFQ vs. the paper-based FFQ. METHODS: We recruited 75 volunteers aged 18 to 75 years (54.7% female) who completed both FFQs in random order. Intakes of energy, 10 macronutrients, four micronutrients and 28 food groups were estimated using each FFQ and compared using multiple statistical tests. RESULTS: Group-level estimates of energy and most nutrients showed good agreement between FFQs, with differences in median intakes < 10% for 8 of 14 nutrients, including energy, protein, carbohydrates, total sugars, total fat, and saturated fatty acids (SFAs). Largest differences were observed for alcohol (+ 119% in the eFFQ), fibre (+ 37%), polyunsaturated fatty acids (+ 27%), and cholesterol (+ 26%). Spearman’s correlation coefficients (SCCs) were ≥ 0.50 for 12 of 14 nutrients, and misclassification into opposite tertiles (> 10% of participants) was observed only for SFAs (13%). Bland-Altman analysis confirmed acceptable agreement for energy and macronutrient intakes. At the food group level, the eFFQ yielded significantly higher median intakes for 14 of 28 food groups – most notably plant-based protein-rich foods and cream, fatty sauces & other fats – and lower median intakes for four groups, including vegetables and fish. Ranking agreement was acceptable for most food groups (SCCs = 0.57–0.91) but weaker for water (0.07); vegetable oil (0.42); cream, fatty sauces & other fats (0.33); and mixed dishes & soups (0.47). CONCLUSIONS: The new eFFQ demonstrated good relative agreement with the previous paper-based FFQ, particularly for ranking individuals. These findings provide valuable information for researchers and policy makers comparing results of both FFQs over time and across populations. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147531297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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