TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-04-07 DOI:10.1186/s12937-025-01089-6

Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro

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引用次数: 0

Abstract

Background: The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing the gut microbiota, nutritional interventions targeting RA activity are currently being explored. This study aims to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet +) can impact the gut microbiota, intestinal permeability, and RA-related outcomes.

Methods: One hundred RA patients are being recruited at Unidade Local de Saúde (ULS) Santa Maria in Lisbon, Portugal, and randomly assigned to either the intervention (MedDiet +) or the control group. The 12-week nutritional intervention includes a personalised dietary plan following the MedDiet + pattern, along with educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. The control group receives standardised general healthy diet recommendations at baseline. The intervention's effects will be assessed by evaluating disease activity, functional status, quality of life, intestinal permeability, endotoxemia, inflammatory biomarkers, intestinal and oral microbiota, serum proteomics, and serum glycome profile characterisation.

Discussion: We anticipate obtaining integrative insights into the interplay between diet, the gut, and RA, while also exploring the underlying mechanisms driving these changes. This study, conducted by a multidisciplinary research team of registered dietitians, rheumatologists, biologists, and immunologists, aims to bridge the current gap between nutrition-related knowledge and RA.

Trial registration: Registered in ClinicalTrials.gov (NCT06758817; date of registry: January 6th 2025).

查看原文本刊更多论文

TASTY试验：营养、肠道微生物群和类风湿关节炎三合一研究的方案。

背景：肠道微生物群与类风湿关节炎（RA）的发病和进展有关。有人提出，肠道生态失调会损害肠道屏障功能，导致粘膜完整性和免疫力的改变。这种破坏使细菌易位，有助于炎症过程的延续。由于饮食被认为是影响肠道微生物群的关键环境因素，目前正在探索针对类风湿性关节炎活性的营养干预措施。本研究旨在探讨以富含发酵食品的典型地中海饮食（MedDiet +）为基础的饮食干预是否会影响肠道微生物群、肠道通透性和ra相关结局。方法：在葡萄牙里斯本的Unidade Local de Saúde (ULS) Santa Maria招募了100名RA患者，并随机分配到干预组（MedDiet +）和对照组。为期12周的营养干预包括遵循MedDiet +模式的个性化饮食计划，以及教育资源、食品篮交付和临床烹饪研讨会，所有这些都由注册营养师每周开发和监测。对照组在基线时接受标准化的一般健康饮食建议。干预的效果将通过评估疾病活动性、功能状态、生活质量、肠道通透性、内毒素血症、炎症生物标志物、肠道和口腔微生物群、血清蛋白质组学和血清糖谱特征来评估。讨论：我们期望获得饮食、肠道和类风湿性关节炎之间相互作用的综合见解，同时也探索驱动这些变化的潜在机制。这项研究由注册营养师、风湿病学家、生物学家和免疫学家组成的多学科研究团队进行，旨在弥合目前营养相关知识与类风湿性关节炎之间的差距。试验注册：ClinicalTrials.gov注册(NCT06758817；注册日期：2025年1月6日)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.