Xiaoyi Lin, Boheng Liang, Tai Hing Lam, Kar Keung Cheng, Weisen Zhang, Lin Xu
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引用次数: 0
Abstract
Background: Breast cancer (BC) is the most common malignancy in women, yet the role of beverage consumption in BC risk remains unclear. Additionally, the contribution of anthropo-metabolic biomarkers as mediators is unknown, limiting the development of effective prevention strategies.
Methods: This study included 13,567 participants from the Guangzhou Biobank Cohort Study (GBCS), where beverage consumption was assessed at baseline using a food frequency questionnaire. BC cases were identified through cancer registry linkage over a mean follow-up of 14.8 years. Mendelian randomization (MR) analyses were performed to evaluate the causal effects of beverage consumption on BC risk, with a two-step MR approach used to estimate mediation effects.
Results: During follow-up, 243 BC cases were identified. Weekly consumption of ≥ 1 portion of sugar sweetened beverages (SSB), versus < 1 portion, was significantly associated with a higher risk of BC (hazard ratio [HR] 1.58, 95% confidence interval [CI] 1.12-2.23). This association was partly mediated by body mass index (proportion mediated [PM] 4.2%, 95% CI 0.9-17.1%) and uric acid (PM 18.8%, 95% CI 1.5-77.5%). Weekly consumption of > 6 portions of dairy-based milk was associated with a non-significantly higher BC risk (HR 1.41, 95% CI 0.99-2.03), while 3-6 portions of soy milk were associated with a lower BC risk (HR 0.31, 95% CI 0.10-0.98). No significant associations were found for pure fruit juice, coffee, tea, or alcoholic drinks. MR analyses supported the detrimental effect of SSB on BC risk, with high-density lipoprotein cholesterol, polyunsaturated fatty acids to total fatty acids (TFAs) ratio, and omega-6 fatty acids to TFAs ratio mediating 2.44%, 2.73%, and 3.53% of the association, respectively.
Conclusion: This study suggested that SSB consumption was a risk factor for BC and identified key anthropo-metabolic biomarkers mediating this relationship. Reducing SSB consumption and addressing associated metabolic pathways may offer effective strategies for BC prevention.
背景：乳腺癌（BC）是女性中最常见的恶性肿瘤，然而饮料消费在BC风险中的作用尚不清楚。此外，人类代谢生物标志物作为介质的作用尚不清楚，限制了有效预防策略的发展。方法：本研究包括来自广州生物库队列研究（GBCS）的13567名参与者，在基线时使用食物频率问卷评估饮料消费。通过癌症登记联系确定BC病例，平均随访14.8年。采用孟德尔随机化（MR）分析来评估饮料消费对BC风险的因果关系，并采用两步MR方法来估计中介效应。结果：在随访中，发现243例BC病例。每周饮用≥1份含糖饮料（SSB）与6份乳基牛奶相比，BC风险无显著性升高（HR 1.41, 95% CI 0.99-2.03），而3-6份豆浆与较低的BC风险相关（HR 0.31, 95% CI 0.10-0.98）。纯果汁、咖啡、茶或酒精饮料没有发现明显的关联。MR分析支持SSB对BC风险的有害影响，高密度脂蛋白胆固醇、多不饱和脂肪酸与总脂肪酸（tfa）比率和omega-6脂肪酸与总脂肪酸比率分别介导2.44%、2.73%和3.53%的关联。结论：本研究提示SSB摄入是BC的一个危险因素，并确定了介导这一关系的关键人类代谢生物标志物。减少SSB的消耗和解决相关的代谢途径可能为BC预防提供有效的策略。
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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