Efficacy of structured exercise and oat supplementation for treating non-alcoholic fatty liver disease: protocol of a randomized controlled trial.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-04-26 DOI:10.1186/s12937-025-01128-2

Jiahui Yin, Lianying Wang, Ran Li, Xiaoguang Cheng, Haibo Wang, Yufeng Li

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引用次数: 0

Abstract

Background: Lifestyle modifications, including nutritional therapy and physical activity, are recommended as a first-line treatment for non-alcoholic fatty liver disease (NAFLD). However, both the best dietary approach and the optimal exercise pattern remain controversial. We will assess the efficacy of structured exercise and oats supplementation in NAFLD patients.

Methods/design: Participants aged 18-65 years with intrahepatic lipid content ≥5% according to quantitative computed tomography (QCT) (N = 180) will be included in this randomized controlled 24-week structured exercise and dietary intervention study. Eligible participants will be randomly assigned (1:1:1:1) to the structured exercise group (aerobic exercise and resistance training), diet intervention group (80 g oats/daily supplementation), combined group (structured exercise + diet intervention) or control group. All participants will receive routine lifestyle education based on their daily caloric intake. The primary outcome was the change in the intrahepatic lipid content in the four groups. Body composition, muscle strength, and 72-hour dietary records will be assessed, and blood, urine and faeces tissue samples at baseline and at 12 and 24 weeks will be collected. Data will be analysed using t tests or Wilcoxon rank sum tests to compare the changes in the outcome measures among the different groups.

Discussion: There are limited data on the efficiency of structured exercise and oat supplementation for NAFLD treatment. The findings of this study will provide evidence-based data to health providers on lifestyle interventions aimed at alleviating the current NAFLD epidemic.

Trial registration: The study was registered with the Chinese Clinical Trial Registry (ChiCTR2100048042) on June 28, 2021.

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有组织的运动和燕麦补充剂治疗非酒精性脂肪性肝病的疗效：一项随机对照试验的方案。

背景：生活方式的改变，包括营养治疗和身体活动，被推荐作为非酒精性脂肪性肝病（NAFLD）的一线治疗方法。然而，最佳饮食方法和最佳运动模式仍然存在争议。我们将评估有组织的运动和燕麦补充剂对NAFLD患者的疗效。方法/设计：根据定量计算机断层扫描（QCT），年龄在18-65岁、肝内脂质含量≥5%的参与者（N = 180）将被纳入这项为期24周的随机对照结构化运动和饮食干预研究。符合条件的参与者将按1:1:1:1的比例随机分配到结构化运动组（有氧运动加抗阻训练）、饮食干预组（每天补充80 g燕麦）、组合组（结构化运动+饮食干预）或对照组。所有参与者将根据他们每天的卡路里摄入量接受日常生活方式教育。主要观察结果是四组患者肝内脂质含量的变化。评估身体组成、肌肉力量和72小时饮食记录，并收集基线、12周和24周时的血液、尿液和粪便组织样本。将使用t检验或Wilcoxon秩和检验对数据进行分析，以比较不同组间结果测量值的变化。讨论：关于有组织的运动和燕麦补充剂对NAFLD治疗的有效性的数据有限。本研究的结果将为卫生保健提供者提供旨在减轻当前NAFLD流行的生活方式干预的循证数据。试验注册：该研究已于2021年6月28日在中国临床试验注册中心注册（ChiCTR2100048042）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.