{"title":"老年社区获得性肺炎危重患者的老年营养风险指数与全因死亡率之间的关系","authors":"Lei Zhang, Minye Li, Jianfei Liu, Hui Ma","doi":"10.1186/s12937-025-01216-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to explore the association between the geriatric nutritional risk index (GNRI) and the risk of mortality in critically ill older patients with community-acquired pneumonia (CAP).</p><p><strong>Methods: </strong>This retrospective study included 1924 critically ill patients with CAP from the Medical Information Mart for Intensive Care-IV3.1 (MIMIC-IV3.1) database. The participants were grouped into four groups based on GNRI levels. The clinical outcome was 30-day, 90-day, 180-day, and 1-year mortality. Cox proportional hazards regression analysis and restricted cubic spline regression were used to evaluate the association between the GNRI and clinical outcomes in critically ill older patients with CAP.</p><p><strong>Results: </strong>A total of 1924 patients (56.9% male) were included in the study. The 30-day, 90-day, 180-day, and 1-year mortality were 37.7%, 47.7%, 54.0% and 59.1%, respectively. Multivariate Cox proportional hazards analysis showed that the GNRI was independently associated with all-cause mortality. After adjusting for confounders, GNRI remained significantly associated with both short- and long-term mortality. Restricted cubic splines revealed a linear association between GNRI and all-cause mortality in CAP patients.</p><p><strong>Conclusion: </strong>Our study indicates that the GNRI has a significant association with all-cause mortality in critically ill older patients with CAP. However, further confirmation of these findings requires larger prospective studies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":"24 1","pages":"149"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482389/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between the geriatric nutritional risk index and all-cause mortality in older critically ill patients with community-acquired pneumonia.\",\"authors\":\"Lei Zhang, Minye Li, Jianfei Liu, Hui Ma\",\"doi\":\"10.1186/s12937-025-01216-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>This study aimed to explore the association between the geriatric nutritional risk index (GNRI) and the risk of mortality in critically ill older patients with community-acquired pneumonia (CAP).</p><p><strong>Methods: </strong>This retrospective study included 1924 critically ill patients with CAP from the Medical Information Mart for Intensive Care-IV3.1 (MIMIC-IV3.1) database. The participants were grouped into four groups based on GNRI levels. The clinical outcome was 30-day, 90-day, 180-day, and 1-year mortality. Cox proportional hazards regression analysis and restricted cubic spline regression were used to evaluate the association between the GNRI and clinical outcomes in critically ill older patients with CAP.</p><p><strong>Results: </strong>A total of 1924 patients (56.9% male) were included in the study. The 30-day, 90-day, 180-day, and 1-year mortality were 37.7%, 47.7%, 54.0% and 59.1%, respectively. Multivariate Cox proportional hazards analysis showed that the GNRI was independently associated with all-cause mortality. After adjusting for confounders, GNRI remained significantly associated with both short- and long-term mortality. Restricted cubic splines revealed a linear association between GNRI and all-cause mortality in CAP patients.</p><p><strong>Conclusion: </strong>Our study indicates that the GNRI has a significant association with all-cause mortality in critically ill older patients with CAP. However, further confirmation of these findings requires larger prospective studies.</p>\",\"PeriodicalId\":19203,\"journal\":{\"name\":\"Nutrition Journal\",\"volume\":\"24 1\",\"pages\":\"149\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482389/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12937-025-01216-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12937-025-01216-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Association between the geriatric nutritional risk index and all-cause mortality in older critically ill patients with community-acquired pneumonia.
Aim: This study aimed to explore the association between the geriatric nutritional risk index (GNRI) and the risk of mortality in critically ill older patients with community-acquired pneumonia (CAP).
Methods: This retrospective study included 1924 critically ill patients with CAP from the Medical Information Mart for Intensive Care-IV3.1 (MIMIC-IV3.1) database. The participants were grouped into four groups based on GNRI levels. The clinical outcome was 30-day, 90-day, 180-day, and 1-year mortality. Cox proportional hazards regression analysis and restricted cubic spline regression were used to evaluate the association between the GNRI and clinical outcomes in critically ill older patients with CAP.
Results: A total of 1924 patients (56.9% male) were included in the study. The 30-day, 90-day, 180-day, and 1-year mortality were 37.7%, 47.7%, 54.0% and 59.1%, respectively. Multivariate Cox proportional hazards analysis showed that the GNRI was independently associated with all-cause mortality. After adjusting for confounders, GNRI remained significantly associated with both short- and long-term mortality. Restricted cubic splines revealed a linear association between GNRI and all-cause mortality in CAP patients.
Conclusion: Our study indicates that the GNRI has a significant association with all-cause mortality in critically ill older patients with CAP. However, further confirmation of these findings requires larger prospective studies.
期刊介绍：
Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered.
Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies.
In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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