Vitamin D status, vitamin D receptor polymorphisms, and risk of cardiometabolic multimorbidity.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-05-11 DOI:10.1186/s12937-025-01139-z

Jianhua Ma, Pingan Li, Jinqi Wang, Haiping Zhang, Zhiwei Li, Lixin Tao, Xinghua Yang, Yanxia Luo, Xiuhua Guo, Bo Gao

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引用次数: 0

Abstract

Background: The prevalence of cardiometabolic multimorbidity (CMM) has increased substantially in recent years. Previous studies have established the associations between vitamin D, vitamin D receptor (VDR) polymorphisms, and the risk of individual cardiometabolic disease (CMD). However, the role of these factors in the progression of CMD to CMM or mortality remains unclear. This study aimed to investigate the associations between vitamin D, VDR polymorphisms, and the dynamic progression of CMM, as well as to explore the potential modification effect of VDR polymorphisms.

Methods: Data for this cohort study were extracted from the UK Biobank. CMM was defined as the coexistence of at least two CMDs, including type 2 diabetes (T2D), coronary heart disease (CHD), and stroke. A multi-state model was used to analyze associations between serum 25(OH)D, VDR polymorphisms and the dynamic progression of CMM.

Results: The sample included 396,192 participants. Over a median follow-up of 13.8 years, 55,772 individuals experienced at least one CMD and 28,624 died. Compared to participants with 25(OH)D < 25 nmol/L, those with 25(OH)D ≥ 75 nmol/L had HRs of 0.70 (95% CI, 0.67, 0.72) for baseline to first CMD (FCMD), 0.74 (95% CI, 0.67, 0.82) for FCMD to CMM, 0.66 (95% CI, 0.62, 0.70) for baseline to death, 0.84 (95% CI, 0.77, 0.92) for FCMD to death, and 0.85 (95% CI, 0.70, 1.03) for CMM to death. L-shaped relationships of these associations were noted, with a threshold around 45 nmol/L. The rs1544410 (BsmI) T alleles may have a detrimental effect, while the rs11568820 (Cdx2) T alleles may exert a protective effect in the early stages of CMM progression. Additionally, VDR polymorphisms significantly modified the association between serum 25(OH)D and certain stages of CMM progression.

Conclusions: Maintaining adequate vitamin D levels, as a readily implementable intervention strategy, not only reduces the risk of initial CMD but also delays the progression to CMM or death. Risk stratification based on VDR polymorphisms provides further insights for developing personalized prevention strategies.

查看原文本刊更多论文

维生素D状态、维生素D受体多态性和心脏代谢多病的风险。

背景：近年来，心脏代谢多病（CMM）的患病率大幅上升。先前的研究已经确立了维生素D、维生素D受体（VDR）多态性与个体心脏代谢疾病（CMD）风险之间的关联。然而，这些因素在CMD发展为CMM或死亡率中的作用尚不清楚。本研究旨在探讨维生素D、VDR多态性与CMM动态进展之间的关系，并探讨VDR多态性的潜在修饰作用。方法：本队列研究的数据来自英国生物银行。CMM被定义为共存至少两种CMDs，包括2型糖尿病（T2D）、冠心病（CHD）和脑卒中。采用多状态模型分析血清25(OH)D、VDR多态性与CMM动态进展之间的关系。结果：样本包括396192名参与者。在中位13.8年的随访中，55,772人至少经历了一次CMD， 28,624人死亡。结论：维持足够的维生素D水平，作为一种易于实施的干预策略，不仅可以降低初始CMD的风险，还可以延缓进展为CMM或死亡。基于VDR多态性的风险分层为制定个性化预防策略提供了进一步的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.