Serum 25-hydroxyvitamin D levels and risk of overall and site-specific cancers in Korean adults: results from two prospective cohort studies.

IF 3.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-05-22 DOI:10.1186/s12937-025-01146-0

Sihan Song, Hae Dong Woo, Jieun Lyu, Bo Mi Song, Joong-Yeon Lim, Hyun-Young Park

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引用次数: 0

Abstract

Background: The link between vitamin D and cancer remains inconclusive. In this study, we aimed to explore the relationship between circulating vitamin D levels and overall and site-specific cancers in Korean adults using data from two large prospective cohort studies.

Methods: Baseline serum 25-hydroxyvitamin D [25(OH)D] levels were measured in a subset of participants from the Cardiovascular Disease Association Study (2005-2012) and the Health Examinees Study (2009-2013). We followed 46,514 adults aged ≥ 40 years who consented to linkage with national cancer registry data. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for cancer incidence according to quartiles of season-standardized 25(OH)D levels.

Results: The median season-standardized 25(OH)D level was 45.6 nmol/L (interquartile range: 33.6-59.7 nmol/L). During the median follow-up of 10.6 years, 3,529 incident cancer cases were recorded. Compared with the first quartile, the upper quartiles of serum 25(OH)D were associated with a lower risk of overall cancer [HR (95% CI): 0.86 (0.77-0.95), 0.84 (0.75-0.93), and 0.80 (0.72-0.89), respectively; P for trend < 0.001]. For site-specific cancers, the HRs (95% CIs) for the comparison of extreme quartiles of serum 25(OH)D were 0.72 (0.52-0.99) for colorectal cancer, 0.32 (0.21-0.50) for liver cancer, and 0.75 (0.55-1.04) for lung cancer. Upon categorization of serum 25(OH)D levels based on absolute cut-off points, participants with levels ≥ 75 nmol/L had significantly lower risks of overall, liver, and lung cancers compared with those with levels < 30 nmol/L.

Conclusions: These findings suggest that higher 25(OH)D levels are associated with a lower risk of overall and some site-specific cancers in the Korean population.

Clinical trial number: Not applicable.

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韩国成人血清25-羟基维生素D水平与整体和部位特异性癌症的风险：两项前瞻性队列研究的结果

背景：维生素D和癌症之间的联系仍然没有定论。在这项研究中，我们旨在利用两项大型前瞻性队列研究的数据，探讨韩国成年人循环维生素D水平与整体和部位特异性癌症之间的关系。方法：在心血管疾病关联研究（2005-2012）和健康体检者研究（2009-2013）的一部分参与者中测量基线血清25-羟基维生素D [25(OH)D]水平。我们随访了46,514名年龄≥40岁的成年人，他们同意与国家癌症登记数据相关联。采用Cox比例风险回归，根据季节标准化25(OH)D水平的四分位数估计癌症发病率的风险比（hr）和95%置信区间（CIs）。结果：季节标准化25(OH)D水平中位数为45.6 nmol/L（四分位数范围为33.6-59.7 nmol/L）。在中位随访10.6年期间，记录了3529例癌症病例。与第一个四分位数相比，血清25(OH)D的上四分位数与总体癌症风险较低相关[HR （95% CI）分别为0.86（0.77-0.95）、0.84（0.75-0.93）和0.80 (0.72-0.89)；结论：这些发现表明，在韩国人群中，较高的25(OH)D水平与总体和某些特定部位癌症的较低风险相关。临床试验号：不适用。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.