Higher dietary insulinemic potential is associated with kidney stones: a nationally representative cross-sectional study.

IF 3.8 2区 医学 Q1 NUTRITION & DIETETICS
Bao Zhang, Mengsha Tang, Xiude Li
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引用次数: 0

Abstract

Background: Insulin response may significantly contribute to the formation of kidney stones. Diets can modulate the insulin response and we hypothesize that high insulinemic potential diets may increase the kidney stones risk.

Methods: Data were from the US National Health and Nutrition Examination Survey. Diets were assessed by 24-hour dietary recall. Two empirical dietary indices for insulin resistance (EDIR) and hyperinsulinemia (EDIH) were used to reflect the dietary insulinemic potential. Diagnosis of kidney stones was based on self-report. Logistic regression was employed to calculate ORs and 95% CIs while adjusting for variables identified through a directed acyclic graph (DAG).

Results: Higher EDIR [ORTertile 3 vs. Tertile 1 = 1.31 (95% CI: 1.13-1.53); ORPer-standard deviation increase= 1.11 (95% CI: 1.05-1.18); ptrend = 0.001] and EDIH [ORTertile 3 vs. Tertile 1 = 1.26 (95% CI: 1.08-1.47); ORPer-standard deviation increase= 1.10 (95% CI: 1.04-1.16); ptrend = 0.001] scores were both positively associated with kidney stones. The conclusion remains unchanged in the sensitivity analysis after adjusting for potential mediating factors that were identified from the DAG, including BMI, hypertension, and diabetes. Subgroup analysis showed that results in most subgroups were consistent with the main analysis.

Conclusions: This study indicates that the insulinemic potential of diet may partly underlie the influence of dietary patterns on kidney stones, emphasizing the importance of avoiding dietary patterns with insulinemic potential.

Clinical trial number: Not applicable.

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较高的饮食胰岛素潜能与肾结石相关:一项具有全国代表性的横断面研究。
背景:胰岛素反应可能显著促进肾结石的形成。饮食可以调节胰岛素反应,我们假设高胰岛素潜力的饮食可能会增加肾结石的风险。方法:数据来自美国国家健康与营养检查调查。通过24小时饮食回忆法评估饮食。采用胰岛素抵抗(EDIR)和高胰岛素血症(EDIH)两项经验饮食指标来反映饮食中的胰岛素潜能。肾结石的诊断是基于自我报告。采用Logistic回归计算or和95% ci,同时调整通过有向无环图(DAG)识别的变量。结果:较高的EDIR [Tertile 3 vs. Tertile 1 = 1.31 (95% CI: 1.13-1.53);orper标准偏差增加= 1.11 (95% CI: 1.05-1.18);ptrend = 0.001]和EDIH [Tertile 3 vs. Tertile 1 = 1.26 (95% CI: 1.08-1.47);orper标准偏差增加= 1.10 (95% CI: 1.04-1.16);Ptrend = 0.001]评分均与肾结石呈正相关。在调整了从DAG中确定的潜在中介因素(包括BMI、高血压和糖尿病)后,敏感性分析的结论保持不变。亚组分析显示大部分亚组结果与主分析一致。结论:本研究表明,饮食的胰岛素潜能可能在一定程度上影响了饮食模式对肾结石的影响,强调避免有胰岛素潜能的饮食模式的重要性。临床试验号:不适用。
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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