实证抗炎饮食指数的发展:一项横断面研究。

IF 3.8 2区 医学 Q1 NUTRITION & DIETETICS
Joanna Kaluza, Lisa Hellerström, Daniel Kaluza, Abbas Chabok, Agneta Åkesson, Karl Michaëlsson, Alicja Wolk
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引用次数: 0

摘要

背景:有证据表明,一些食物和饮食模式可能影响低度炎症状态。我们的目标是开发一个用户友好的经验抗炎饮食指数(eADI),预测低级别慢性炎症。方法:在这项来自瑞典男性临床队列的4,432名男性(74±6岁)的横断面研究中,通过高敏c反应蛋白(hsCRP)、白细胞介素6 (IL-6)、肿瘤坏死因子受体1 (TNF-R1)和肿瘤坏死因子受体2 (TNF-R2)评估炎症状态。使用食物频率问卷评估饮食摄入量。eADI是在随机选择的Discovery组(n = 2216)中开发的,使用10倍特征选择和过滤(基于Lasso回归)来选择与炎症生物标志物最相关的食物组。从选定的食物中,根据消费分值的总和(对应于0、0.5和1分)构建eADI。接下来,在复制组(n = 2216)中,使用多变量调整线性回归模型检查eADI与炎症生物标志物的关联。结果:eADI-17分为17个食物组(11个具有抗炎潜能,6个具有促炎潜能)。在复制组中,eADI-17的中位数为9(范围:2-16)分,eADI-17与hsCRP、IL-6、TNF-R1和TNF-R2的Spearman相关系数分别为-0.17、-0.23、-0.28和-0.26。eADI-17 (2 SD)每增加4.5个点,hsCRP浓度降低12%,IL-6浓度降低6%,TNF-R1浓度降低8%,TNF-R2浓度降低9%。复制组获得的这些结果是可靠的,因为它们基本上与发现组的结果相同。结论:eADI-17是一种经过验证的、强大的、用户友好的抗炎饮食指数,用于预测低度慢性炎症。该指数有可能进一步完善未来的饮食指南,并用于个性化营养。然而,其预测有效性有待于在不同人群中进一步评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Development of empirical anti-inflammatory diet index: a cross-sectional study.

Development of empirical anti-inflammatory diet index: a cross-sectional study.

Development of empirical anti-inflammatory diet index: a cross-sectional study.

Background: There is evidence that some foods and dietary patterns may influence low-grade inflammation status. We aimed to develop a user-friendly empirical Anti-inflammatory Diet Index (eADI) that predicts low-grade chronic inflammation.

Methods: In this cross-sectional study of 4,432 men (aged 74 ± 6 years) from the Cohort of Swedish Men-Clinical, inflammatory status was assessed by high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), tumor necrosis factor receptor 1 (TNF-R1), and tumor necrosis factor receptor 2 (TNF-R2). Dietary intake was assessed using a food frequency questionnaire. The eADI was developed in a randomly chosen Discovery group (n = 2,216) using a 10-fold feature selection with filtering (based on Lasso regression) to select food groups most correlated with inflammatory biomarkers. From the selected foods, the eADI was then constructed based on summed scores of the consumption tertiles (corresponding to 0, 0.5, and 1 point). Next, in the Replication group (n = 2,216), the association of eADI with inflammatory biomarkers was examined using multivariable-adjusted linear regression models.

Results: eADI-17 included 17 food groups (11 with anti-inflammatory, 6 with pro-inflammatory potential). In the Replication group, the median of eADI-17 was 9 (range: 2-16) scores and the Spearman correlation coefficients for eADI-17 vs. hsCRP, IL-6, TNF-R1, and TNF-R2 were -0.17, -0.23, -0.28, and -0.26, respectively. Each increment by 4.5-point eADI-17 (2 SD) was associated with concentrations that were 12% lower for hsCRP, 6% lower for IL-6, 8% lower for TNF-R1, and 9% lower for TNF-R2. These results obtained for the Replication group were robust as they were essentially the same as those of the Discovery group.

Conclusions: The eADI-17 is a validated, robust and user-friendly anti-inflammatory diet index developed to predict low-grade chronic inflammation. This index has the potential to further refine future dietary guidelines and to be used in personalized nutrition. However, its predictive validity should be further evaluated in diverse populations.

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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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