Nutrition Journal最新文献

{"title":"The cost-effectiveness of placement restrictions of unhealthy food and drinks at end of aisles and checkouts in Australian supermarkets.","authors":"Bisola Osifowora, Huong Tran, Emma Frew, Jaithri Ananthapavan","doi":"10.1186/s12937-026-01307-9","DOIUrl":"10.1186/s12937-026-01307-9","url":null,"abstract":"<p><p>BACKGROUND: Obesity is a significant contributor to global morbidity and mortality, driven by rising consumption of unhealthy energy dense foods high in salt, sugar and fat (HFSS). Supermarkets, pivotal in food distribution, influence consumer choices through marketing strategies that regularly promote the purchase of unhealthy foods. Restricting the placement of unhealthy food and beverages in prominent supermarket locations is a promising intervention to reduce the purchase of unhealthy products. This study assesses the cost-effectiveness of a potential policy to restrict the placement of unhealthy foods at prominent locations in supermarkets like checkouts, end-of-aisles, and store entrances compared to the status quo (no policy). METHODS: The impact of the proposed policy to restrict the placement of unhealthy foods on the distribution of Body Mass Index (BMI) in the 2024 Australian population was estimated. A previously validated multiple cohort Markov model (Assessing Cost Effectiveness-Obesity Policy model) was used to estimate the impact of the change in BMI on the epidemiology of nine obesity related diseases resulting in changes in long-term health outcomes quantified as health-adjusted life years (HALYs), and healthcare costs. Policy implementation and monitoring costs to government and retailers were estimated. The analyses were undertaken over the lifetime of the modelled population (100 years), adopting a limited societal perspective with results presented in 2024 values. Deterministic and probabilistic sensitivity analyses were performed to evaluate the robustness of the results. RESULTS: The placement restriction policy was estimated to result in a mean BMI reduction of 0.26 kg/m² for males and 0.21 kg/m² for females, corresponding to 0.37 million HALYs gained and reduced healthcare costs of A$4.45 billion over the lifetime of the population. The total cost of the policy was A$20 million. Sensitivity analyses confirmed the intervention’s cost-effectiveness across various scenarios. CONCLUSION: A policy to restrict retail marketing of unhealthy foods in supermarkets represents a potentially cost-effective intervention, estimated to produce long-term health gains and save costs. These findings support policy action to create healthier food retail environments. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in plasma fatty acid composition in females with lipedema following low-carbohydrate vs low-fat diets and associations with pain reduction.","authors":"Julianne Lundanes, Vilde Fiske Nes, Patrik Hansson, Rikard Fristedt, Rikard Landberg, Catia Martins, Siren Nymo","doi":"10.1186/s12937-026-01304-y","DOIUrl":"10.1186/s12937-026-01304-y","url":null,"abstract":"<p><p>BACKGROUND: Lipedema is a chronic female disease characterized by a painful accumulation of adipose tissue in the limbs. Plasma fatty acid (FA) composition has been proposed as a potential modulator of pain. However, the pathophysiology behind lipedema pain remains uncertain. The primary objective of this secondary analysis was to compare changes in plasma concentrations of FAs between low-energy diets either low in carbohydrates or low in fat, in females with lipedema and obesity. A secondary objective was to investigate potential associations between changes in pain and changes in the concentration of several FAs. METHODS: Females with lipedema and obesity (BMI 30–45 kg/m2) were randomized to isocaloric low-energy diets, either low-carbohydrate diet (LCD) or low-fat diet for 8 weeks. Plasma concentrations of FAs were quantified using gas chromatography and subjective pain using the Brief Pain Inventory, before and after the intervention. RESULTS: 70 females were included in the analyses, with a mean BMI of 37 ± 5 kg/m2 and mean age of 47 ± 11 years. Significant decreases in the concentration of the saturated FAs (SFAs) myristic, stearic, and behenic acids, and the polyunsaturated FAs (PUFA) gamma-linolenic (GLA), dihomo-gamma-linolenic (DGLA), alpha-linolenic (ALA), eicosapentaenoic (EPA), and docosapentaenoic acids (DPA) were seen in both groups. A reduction in the SFA arachidic acid, and the monounsaturated FAs (MUFA) palmitoleic and oleic acids was seen in the LCD group only, while an increase in the SFA lignoceric acid and a decrease in the PUFA linoleic acid was seen only the low-fat diet group. Changes in myristic and palmitic acids (SFAs) were positively associated with changes in pain. CONCLUSION: A reduction in most FAs was found after energy restricted LCD and low-fat diets in females with lipedema and obesity. Notably, reductions in SFAs seem to be associated with the reduction in pain seen in the LCD group, especially myristic acid. These findings suggest that FA composition may play a role in pain reduction in females with lipedema. TRIAL REGISTRATION: NCT04632810, Effect of Ketosis on Pain and Quality of Life in Patients With Lipedema (Lipodiet). </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study.","authors":"Ingrid Möller, Kirsten Martínez, Andrea Terradillos-Guillén, Ester Costa-Larrión, Daniel Martínez-Puig, Javier Velasco-Álvarez","doi":"10.1186/s12937-026-01302-0","DOIUrl":"10.1186/s12937-026-01302-0","url":null,"abstract":"<p><p>BACKGROUND: In non-osteoarthritic individuals, the appearance of joint discomfort with physical activity is a potential indicator of initial joint degeneration. The present study aimed to evaluate the efficacy and tolerability of native (undenatured) type-II collagen in the joint function of healthy volunteers who experienced joint discomfort as a result of physical activity. METHODS: This prospective, randomized, double-blind, placebo-controlled-study, included seventy-four healthy subjects with joint discomfort during physical activity. Participants were randomized to receive placebo (PBO) or native (undenatured) type-II collagen (CN2) at 40 mg/d for 180 days. Joint function and time to recover from knee discomfort after a standardized exercise protocol were evaluated. CTX-II was analyzed as biomarker of cartilage degradation. RESULTS: In both groups a significant improvement in joint function measured with the KOOS score was detected at 180 days, but improvements from baseline were detected earlier in the CN2 as compared to PBO group for KOOS pain, Symptoms and Quality of Life. In the subgroups of subjects with milder basal joint discomfort during activity (VAS≤40 mm) differences between groups in improvement from baseline were detected at 180 days for KOOS pain and Quality of Life subscales. Between-group differences were also detected in time to recover after cycling in the air test. In the subgroups of subjects with higher basal joint discomfort during activity (VAS>40 mm) between-group differences were detected on the progression of CTX-II concentration from baseline, which decreased in CN2 and increased in PBO group. CONCLUSIONS: This study found that supplementation with CN2, containing native (undenatured) type II collagen supports certain aspects of joint health in people who experience joint discomfort after exercise, including improvements in joint function, discomfort and their impact on quality of life. TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov (NCT05282992) on March 16, 2022. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal intervention for sarcopenia in nasopharyngeal carcinoma patients undergoing definitive treatment: a pilot randomized controlled trial protocol.","authors":"Lijuan Xia, Zhifang Ma, Sujuan Chen, Sha Liu, Bin Yan, Jia Min, Zhihua Yang, Weihong Wang, Qiang Liu, Yuke Xia, Naoko Hayashi","doi":"10.1186/s12937-026-01296-9","DOIUrl":"10.1186/s12937-026-01296-9","url":null,"abstract":"<p><p>BACKGROUND: This protocol describes a pilot randomized controlled trial (RCT) designed to assess the feasibility of a multidisciplinary, multimodal intervention for sarcopenia prevention in patients with nasopharyngeal carcinoma (NPC) undergoing concurrent chemoradiotherapy (CCRT). The intervention was developed using the Medical Research Council (MRC) framework and incorporates personalized immunonutrition, structured exercise, side effect management, behavior monitoring, and guidance. This pilot trial aims to evaluate the feasibility of implementing a multimodal intervention model in this patient population. METHODS: This study will be a single-site RCT including 30 patients with NPC undergoing definitive treatment. The trial will be conducted from September 2025 to May 2026 in Ningxia, China. Patients will be randomly assigned to either the intervention or control group. The intervention integrates head and neck and gastrointestinal cluster symptom management, immunonutrition management, and exercise based on the Theory of Planned Behavior. The primary outcome is feasibility, assessed through acceptability, demand, fidelity, and practicality. Secondary outcomes include changes in skeletal muscle index, sarcopenia prevalence, body composition, composite biomarkers (Global Immune-Nutrition-Inflammation Index [GINI], Hemoglobin–Albumin–Lymphocyte–Platelet Score [HALP], and Prognostic Nutritional Index [PNI]), symptom burden (Head and Neck Symptom Checklist), nutritional status (Patient-Generated Subjective Global Assessment [PG-SGA]), and adherence to exercise and dietary interventions. Exploratory outcomes include behavior change mechanisms assessed using a Theory of Planned Behavior–based questionnaire. DISCUSSION: This pilot study is designed to evaluate the feasibility of implementing a comprehensive multimodal intervention for sarcopenia in NPC patients undergoing CCRT. The outcomes will provide preliminary evidence to guide the design of future large-scale RCTs and advance multidisciplinary care models for sarcopenia management in oncology. TRIAL REGISTRATION: UMIN Clinical Trials Registry, UMIN000059146. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of resistant dextrin on glycemic traits: a systematic review and meta-analysis of randomized controlled trials.","authors":"Shanbin Chen, Linjing Zhang, Aizhen Zong, Zhaobo Gan, Xingjing Zhang, Fangling Du, He Liu, Tongcheng Xu","doi":"10.1186/s12937-026-01292-z","DOIUrl":"10.1186/s12937-026-01292-z","url":null,"abstract":"<p><p>BACKGROUND: Chronic hyperglycemia has affected billions of people currently and has emerged as an alarming public health concern for decades. Resistant dextrin (RD), an indigestible glucan with various applications in the food industry, has been reported to improve insulin sensitivity and help blood glucose control. However, the effect of RD on glucose metabolism was not systematically and comprehensively reviewed. The present study aimed to investigate the effect of RD on glycemic markers, including fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR). METHODS: PubMed, Embase, Web of Science, Scopus, Cochrane library databases, and other additional records were systematically retrieved for randomized controlled trials (RCTs) on the effect of resistant dextrin intervention on FBG, FBI, HbA1c, HOMA-IR up to October 2024. Data were pooled using weighted mean difference (WMD) and 95% confidence intervals (95%CI), with P value ≤ 0.05 as statistical significance. Risk of bias was assessed with the Cochrane tool. Certainty of evidence was assessed with Grading of Recommendations Assessment, Development and Evaluation approach. RESULTS: A total of 13 RCTs were eligible. RD significantly reduced FBG (WMD: -0.15 mmol/L, 95%CI: -0.30 to -0.00 mmol/L; P = 0.049; I2 = 77.5%; 13 trials; 952 participants) and HOMA-IR (WMD: -0.51; 95% CI: -0.93 to -0.09; P = 0.02; I2 = 25.2%; 7 trials;332 participants), while modestly improved HbA1c (WMD: -0.18%; 95%CI: -0.39 to 0.02%; P = 0.07; I2 = 62.0%; 10 trials; 788 participants). The effect of RD on FBI was not significant (WMD: -4.26 pmol/L; 95%CI: -13.05 to 4.53 pmol/L; P = 0.29; I2 = 65.0%; 8 trials; 625 participants). Subgroup analysis revealed that RD was more beneficial to overweight/obese or diabetic patients than the non-obese and non-diabetic. A dosage of 10 g per day was the most frequently used dose that showed efficacy. CONCLUSION: This study is so far the most extensive systematic review to evaluate the role of RD on markers of glycemic control. RD interventions can exert beneficial effects on FBG and HOMA-IR. Further high-quality and long-term studies are needed to strengthen its credibility. TRIAL REGISTRATION: This systematic review was registered on PROSPERO (international prospective register of systematic reviews) as CRD42023429881. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota supportive dietary pattern associated with reduced MASLD risk mediated by metabolomic profiles: a prospective cohort study.","authors":"Dong-Run Li, Ke-Ru Li, Ying Wang, Jia-Qi Zheng, Wen-Rui Zheng, Bang-Quan Liu, Jia-Cheng Liu, Rui-Han Bao, Ting-Ting Gong, Qiu-Ju Sheng, Shan-Yan Gao, Qi-Jun Wu","doi":"10.1186/s12937-026-01297-8","DOIUrl":"10.1186/s12937-026-01297-8","url":null,"abstract":"<p><p>BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 38% of adults worldwide. While diet influences MASLD development through multiple pathways, the role of gut microbiota-targeted dietary patterns remains unclear. We aimed to investigate the association between Dietary Index for Gut Microbiota (DI-GM) and incident MASLD risk, and to identify metabolomic signatures that may mediate this relationship. METHODS: We analyzed data from 100,953 UK Biobank participants with detailed dietary and metabolomic information. The DI-GM was calculated based on 14 food components with established effects on gut microbiota. Plasma metabolomic profiling was performed using NMR spectroscopy. A metabolic signature was derived through LASSO regression with cross-validation. Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MASLD. RESULTS: During a median follow-up of 13.46 years, 1,221 cases of MASLD were documented. Each one-point increase in DI-GM was associated with a 15% reduction in MASLD risk (HR: 0.85, 95% CI: 0.80–0.90). Participants in the highest DI-GM (≥ 7) had a HR of 0.68 (95% CI: 0.58–0.80) compared to the lowest (≤ 4). The metabolomic analysis identified a signature of 92 metabolites strongly correlated with DI-GM (r = 0.30, P < 0.001). This signature was associated with a 26% reduction in MASLD risk per standard deviation increase (HR: 0.74, 95% CI: 0.69–0.79). Mediation analysis revealed that the metabolic signature explained 34.2% (95% CI: 19.3%–60.6%) of the association between DI-GM and MASLD risk. CONCLUSIONS: Higher adherence to a gut microbiota supportive dietary pattern is associated with reduced risk of MASLD. The association is partially mediated through favorable alterations in metabolism. These findings support the implementation of gut microbiota-focused dietary strategies for chronic liver disease prevention. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption of coffee and tea and the risk of developing neurodegenerative diseases: a cohort study in the UK biobank.","authors":"Yixiang Lin, Yisen Shi, Lina Chen, Zhuoli Chen, Huilin Zhong, Yuxuan Zhong, Ruitian Zeng, Xinyan Chen, Fabin Lin, Guoen Cai","doi":"10.1186/s12937-026-01291-0","DOIUrl":"10.1186/s12937-026-01291-0","url":null,"abstract":"<p><strong>Background: </strong>Coffee and tea are among the most consumed drinks worldwide. Increasing evidence indicates an association between coffee or tea intake and neurodegenerative diseases. However, most studies have focused on the association of coffee or tea alone; studies on the interactive associations between coffee and tea and neurodegenerative diseases are few. Therefore, this study aimed to explore the individual or interactive associations between coffee and tea intake and neurodegenerative diseases and their various subtypes.</p><p><strong>Methods: </strong>This study included 134,425 participants without neurodegenerative diseases at baseline in UK Biobank. A total of 6483 participants developed neurodegenerative diseases during a median follow-up time of 13.5 years. The median daily coffee intake was two cups, and the median daily tea intake was three cups. A restricted cubic spline was used to explore the nonlinear associations between coffee or tea intake and neurodegenerative diseases. The individual or interactive associations between coffee and tea intake and neurodegenerative diseases were assessed using the Cox proportional-hazards model.</p><p><strong>Results: </strong>An individual association was noted between coffee or tea intake and neurodegenerative diseases. A significant J-shaped association was found between coffee intake and all-cause neurodegenerative diseases (Pnonlinear = 0.004) and vascular neurodegenerative diseases (Pnonlinear = 0.023), with increased risk at higher consumption. Moreover, a nonlinear association was observed between tea intake and all-cause neurodegenerative diseases (Pnonlinear = 0.004), vascular neurodegenerative diseases (Pnonlinear = 0.031), other neurodegenerative diseases (Pnonlinear = 0.002), and vascular dementia (VD) (Pnonlinear = 0.026). Furthermore, a significant interactive association was noted between coffee and tea intake among all-cause neurodegenerative diseases (Pinteraction = 0.004); Further, this interaction was also observed in Alzheimer's disease (AD) (Pinteraction = 0.006).</p><p><strong>Conclusions: </strong>Excessive coffee consumption was significantly associated with an increased risk of all-cause neurodegenerative diseases and vascular neurodegenerative diseases. The results also showed that tea intake was associated with a reduced risk of all-cause neurodegenerative disease, vascular neurodegenerative disease, other neurodegenerative diseases, and VD. Moreover, coffee and tea had an interactive relationship with all-cause neurodegenerative diseases and AD, with specific combinations significantly associated with reduced risk of disease onset.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the EAT-Lancet diet and risk of chronic kidney disease among middle-aged and older adults: insights from two nationwide cohort studies.","authors":"Zenghui Zhang, Shaojie Han, Xunda Ye, Huimin Zhu, Zegui Huang, Yangbo Xi, Chuxian Guo, Zhaoyu Liu, Jun Guo","doi":"10.1186/s12937-025-01236-z","DOIUrl":"10.1186/s12937-025-01236-z","url":null,"abstract":"<p><p>BACKGROUND: Adherence to the EAT-Lancet diet has been associated with a lower risk of adverse health outcomes. However, its relationship with chronic kidney disease (CKD) risk remains unclear. We aimed to investigate the association between adherence to the EAT-Lancet diet and CKD risk among middle-aged and older adults. METHODS: This study included 19,991 participants from the US NHANES cohort for cross-sectional analysis and 119,820 participants from the UK Biobank cohort for longitudinal analysis, all aged 40 years or older. Dietary data were collected using 24-hour dietary recall questionnaires, and a modified EAT-Lancet diet index was constructed based on the EAT-Lancet reference diet. Multivariable poisson regression models and Cox proportional hazards regression models were employed to examine the associations between the EAT-Lancet diet index and CKD risk. RESULTS: In the US NHANES cohort, 4,640 (23.21%) participants were diagnosed with CKD. Within the multivariable model, the relative risk for CKD in the highest adherence group of the EAT-Lancet diet index was 0.78 (95% CI: 0.70, 0.87) compared to those in the lowest adherence group. During a mean follow-up of 13.19 years, 3,658 (3.05%) incident cases of CKD were identified in the UK Biobank cohort. After adjusting for covariates, the Q2, Q3, Q4, and Q5 groups exhibited significantly lower risks for incident CKD compared to the Q1 group, with hazard ratios (95% CI) of 0.94 (0.85, 1.03), 0.85 (0.77, 0.94), 0.82 (0.74, 0.91), and 0.71 (0.64, 0.79), respectively. A clear dose-response relationship between EAT-Lancet diet index and CKD risk was observed in two cohorts. CONCLUSIONS: Adherence to the EAT-Lancet diet is associated with a lower prevalence and risk of CKD in middle-aged and older adults, with a dose-response relationship. These findings highlight the importance of adopting the EAT-Lancet diet to lower the risk burden of CKD. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between plant protein intake and cancer risk: a prospective cohort study.","authors":"Shengtao Hu, Rui Yang, Yujiao Deng, Dixuan Xue, Yucheng Sun, Xia Xiao, Zhuoyang Shen, Yingnan Wang, Qing Wu, Jiayuan Wu, Zhijun Dai","doi":"10.1186/s12937-026-01293-y","DOIUrl":"10.1186/s12937-026-01293-y","url":null,"abstract":"<p><strong>Background: </strong>To examine the association between plant protein intake and the risk of overall and site-specific cancers in a large prospective cohort.</p><p><strong>Methods: </strong>This prospective cohort study included 192,428 participants from the UK Biobank, recruited from 2006 and followed until 2023. Plant protein consumption information was assessed using validated 24-hour dietary recalls. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of plant protein consumption with cancer risk were calculated using Cox proportional risk regression models. Nonlinear associations were tested using restricted cubic spline analysis.</p><p><strong>Results: </strong>During a median follow-up of 11.2 years, 22,779 cancer events were recorded. Compared to participants in the lowest quartile of plant protein intake, those in the highest quartile had HRs for overall cancer, lung cancer, renal cancer, and colorectal cancer of 0.91 (95% CI = 0.88-0.95, P < 0.001), 0.86 (95% CI = 0.73-1.00, P = 0.048), 0.69 (95% CI = 0.55-0.87, P = 0.002), and 0.89 (95% CI = 0.79-1.00, P = 0.046), respectively. Furthermore, each 10% increase in the ratio of plant protein to total daily protein was associated with a 3% lower overall cancer risk (HR = 0.97, 95% CI = 0.95-0.98, P < 0.001). Subgroup analyses suggested that the negative association was more pronounced in male. Among individuals who did not meet the WHO-recommended protein intake, a nonlinear association between plant protein intake and overall cancer risk was observed, characterized by a modest reduction in risk at moderate intake levels with no further risk reduction at higher intake levels (P for nonlinearity = 0.02).</p><p><strong>Conclusion: </strong>This cohort study indicates that higher dietary plant protein intake is significantly associated with a reduced risk of overall and specific cancers, including lung, renal, and colorectal cancer. These findings support the notion that increasing the consumption of plant protein-rich foods is beneficial for health.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13049816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and behaviors toward the planetary health diet in France: a survey among patients, healthcare professionals, and farmers-bakers' customers.","authors":"Florence Carrouel, Rita Nugem, Yohan Fayet, Laurie Fraticelli, Lama Basbous, Jean-Francois Vian, Camille Vindras, Corélie Salque, Claude Dussart, Marie-Thérèse Charreyre, Romain Lan, Audrey Murat-Ringot","doi":"10.1186/s12937-026-01300-2","DOIUrl":"10.1186/s12937-026-01300-2","url":null,"abstract":"<p><p>BACKGROUND: The Planetary Health Diet (PHD), developed by the EAT–Lancet Commission, provides a comprehensive framework to promote human and planetary health through dietary transformation. Despite its benefits, adoption of the PHD remains limited in high-income countries like France. This study aimed to evaluate knowledge, attitudes, and behaviors (KAB) related to the PHD across diverse French populations and identify determinants of inadequate KAB. METHODS: This cross-sectional quantitative study was conducted between April and June 2024 under the BIOQUALIM protocol. Eligible participants were adults (≥ 18 years) fluent in French and included healthcare professionals and patients from the Hospices Civils de Lyon (HCL), as well as farmers-bakers’ customers from the Rhône-Alpes region. A validated 89-item questionnaire was administered via paper and digital formats using a convenience sampling strategy. KAB levels were calculated from a structured scoring system. Descriptive statistics and multivariate logistic regressions were used to assess KAB levels and their sociodemographic determinants. RESULTS: Among 10,500 individuals approached, 1,388 completed the survey (79.6% HCL professionals, 6.4% patients, 14% farmers-bakers’ customers). Only 3% demonstrated an adequate overall KAB score; knowledge adequacy was observed in 61%, while attitude and behavior adequacy remained critically low (3.5% and 0.2%, respectively). Inadequate KAB was significantly associated with omnivorous diets (OR = 3.38), female gender (OR = 2.54), patient status (OR = 13.84), while low food budgets increased risk (≤ 50 €/week, reference OR = 1) and higher weekly expenses were protective (OR range 0.42–0.57). Protective factors included older age (≥ 60 years; OR = 0.17) and higher weekly food expenses (>€100). CONCLUSIONS: Although awareness of sustainable diets is rising, behavioral adherence to the PHD remains poor, highlighting a pronounced knowledge–action gap. Cultural norms, economic limitations, and institutional structures still delay dietary change. Policy efforts must extend beyond education to include economic answers, culturally adapted messages, and systemic reforms to enable a fair and sustainable food transition. </p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}