Natural Product Research最新文献_第6页

LC-MS/MS analysis and α-glucosidase inhibitory effect of majonoside R2 in Vietnamese ginseng (Panax vietnamensis Ha & Grushv.). LC-MS/MS 分析和越南人参（Panax vietnamensis Ha & Grushv.）

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2429124

Hoang Hiep Dang, Manh Dung Doan, Thi Ngan Dang, Thi Hoang Anh Nguyen, Thien Thuong Phuong, Tuan Vu Van, Hieu Nguyen Ngoc, Huu Tung Nguyen

{"title":"LC-MS/MS analysis and α-glucosidase inhibitory effect of majonoside R2 in Vietnamese ginseng (Panax vietnamensis Ha & Grushv.).","authors":"Hoang Hiep Dang, Manh Dung Doan, Thi Ngan Dang, Thi Hoang Anh Nguyen, Thien Thuong Phuong, Tuan Vu Van, Hieu Nguyen Ngoc, Huu Tung Nguyen","doi":"10.1080/14786419.2024.2429124","DOIUrl":"10.1080/14786419.2024.2429124","url":null,"abstract":"Majonoside R2 (MR2), the principal saponin of Vietnamese ginseng (Panax vietnamensis Ha & Grushv.), has the unique structure of ocotillol-type dammarane and showed remarkable biological activities. This paper deals with the new findings in the chemical analysis MR2 by the tandem LC-MS/MS and, especially, its inhibitory activities on α-glucosidase for diabetic management. The developed LC-MS/MS method revealed advantages of high selectivity with specific mass transition from precursor [M + H]+ ion (m/z 784.4) into product ion (m/z 475.1), high sensitivity (calibration range: 5-250 ppb; LOD: 1.5 ppb; LOQ: 5.0 ppb), and high accuracy to support further pharmaceutical analysis of MR2. MR2 and its aglycone ocotillol relatively showed certain inhibitory effects on α-glucosidase in vitro with the IC50 values of 353.05 and 219.64 µg/mL and supported by molecular docking analysis, in which MR2 and ocotillol could play as allosteric inhibitors with high binding affinity (-7.8 and -8.1 kcal/mol) evidenced by bonding interactions.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of chemical composition in Zanthoxylum avicennae leaves and branches based on UPLC-Q-Orbitrap HRMS, and evaluation of their antioxidant activities. 基于 UPLC-Q-Orbitrap HRMS 的 Zanthoxylum avicennae 叶片和枝条化学成分比较分析及其抗氧化活性评价。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2430324

Liang-Qian Zhang, Yuan Tian, Li-Ping Dai, Xing-Er Ye, Yi-Qin Zheng, Nan-Chen Lai, Wei Dai, Qi Wang

{"title":"Comparative analysis of chemical composition in Zanthoxylum avicennae leaves and branches based on UPLC-Q-Orbitrap HRMS, and evaluation of their antioxidant activities.","authors":"Liang-Qian Zhang, Yuan Tian, Li-Ping Dai, Xing-Er Ye, Yi-Qin Zheng, Nan-Chen Lai, Wei Dai, Qi Wang","doi":"10.1080/14786419.2024.2430324","DOIUrl":"10.1080/14786419.2024.2430324","url":null,"abstract":"This study comprehensively analyzes the chemical constituents of Zanthoxylum avicennae leaves and branches using UPLC-Q-Orbitrap HRMS. A total of 64 components were identified, with fragmentation patterns summarised for key compounds. Notably, 51 of these components were newly discovered in this plant. The predominant compound classes were alkaloids (31.25%) and flavonoids (25.00%). Visualisation results revealed significant differences in chemical composition between leaves and branches, with an overlap rate of only 26.60%. Leaves were rich in flavonoids such as neohesperidin, while branches contained more alkaloids, such as schinifoline. Antioxidant activity, assessed using DPPH and ABTS assays, indicated that methanol extracts had notable antioxidant potential. The leaf extract demonstrated superior antioxidant activity (ABTS: IC50 = 0.098 ± 0.006 mg/mL; DPPH: IC50 = 3.624 ± 0.070 mg/mL) compared to the branch extract (ABTS: IC50 = 0.303 ± 0.004 mg/mL; DPPH: IC50 = 3.265 ± 0.075 mg/mL), likely due to differences in the content and variety of flavonoids.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavone glycosides from a Cyclanthera pedata landrace of Camonica Valley (Northern Italy). 来自卡莫尼卡山谷（意大利北部）的 Cyclanthera pedata 陆种植物的黄酮苷。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2430326

Marco Zuccolo, Angela Bassoli, Gigliola Borgonovo, Luca Giupponi, Annamaria Giorgi

引用次数: 0

An overview of extraction, isolation and characterization techniques of phytocompounds from medicinal plants. 药用植物中植物化合物的提取、分离和表征技术概览。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2426059

Susmita Mondal, Manosi Das, Sudipto Debnath, Biresh Kumar Sarkar, Gajji Babu

{"title":"An overview of extraction, isolation and characterization techniques of phytocompounds from medicinal plants.","authors":"Susmita Mondal, Manosi Das, Sudipto Debnath, Biresh Kumar Sarkar, Gajji Babu","doi":"10.1080/14786419.2024.2426059","DOIUrl":"10.1080/14786419.2024.2426059","url":null,"abstract":"Medicinal plants have been used since time immemorial for the treatment of many types of diseases along with epidemics. They show many biological activities like anti-inflammatory, antioxidant, anti-insecticidal, antibiotic, anti-parasitic, anti-hemolytic properties etc. Different types of bioactive compounds, present in the medicinal plants, play a key role in prevention of diseases and also used for manufacturing medicines. Thus, phytochemicals have an immense value to communities worldwide. The present review focused on the extraction, purification and characterisation method for isolation of phytocompounds. Both the conventional like maceration, percolation, digestion, infusion a decoction, soxhlet and reflux, hydro distillation and steam distillation method and modern technique of extraction like ASE, microwave- and ultrasound-assisted extraction, supercritical fluid extraction, enzyme-assisted fluid extraction, pressurised hot water extraction are elaborately explained in the present review. The methodology of purification by LLF & LLP, recrystallization, different chromatographic techniques like TLC, prep-TLC, column chromatography, flash column chromatography, SEC, counter current chromatography, HPLC & prep-GC are also included in the present review. Structure elucidation by UV-Vis spectroscopy, FTIR, NMR spectroscopy, mass spectroscopy and X-ray crystallography are also discussed here.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, characterisation and evaluation of kaempferol phospholipid complex and its application in preventing the deterioration of soybean oil. 山奈酚磷脂复合物的制备、表征和评估及其在防止大豆油变质中的应用。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2431125

Ruiyang Xu, Honghui Zhao, Lingling Wang, Dezhi Gao, Xu Zhao

引用次数: 0

Megastigmane and hydroxybenzoic acid derivatives from aqueous leaves extract of Artocarpus heterophyllus lam. 从叶桉叶水溶液提取物中提取巨石榴烯和羟基苯甲酸衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429520

K S S P Fernando, M I Choudhary, A M Abeysekera, C Padumadasa, Achyuth Adhikari, U G Chandrika

{"title":"Megastigmane and hydroxybenzoic acid derivatives from aqueous leaves extract of Artocarpus heterophyllus lam.","authors":"K S S P Fernando, M I Choudhary, A M Abeysekera, C Padumadasa, Achyuth Adhikari, U G Chandrika","doi":"10.1080/14786419.2024.2429520","DOIUrl":"10.1080/14786419.2024.2429520","url":null,"abstract":"The hot water extract of senescent leaves from Artocarpus heterophyllus is used in traditional Sri Lankan medicine for treating diabetes mellitus. This study aimed to isolate phytochemicals in the ethyl acetate soluble fraction of the hot water extract. Bioassay-guided fractionation led to the isolation of three megastigmane derivatives and two hydroxybenzoic acid derivatives from fractions, demonstrating both hypoglycaemic and antidiabetic activities. The elucidated compounds were identified as 3,4-dihydroxy-7-ene-megastigman-9-one, 3,4,6-trihydroxy-7-ene-megastigman-9-one, 9,13-dihydroxy-4,7-dien-megastigman-3-one, 4-hydroxybenzoic acid, and 3,4-dihydroxybenzoic acid. Structural confirmation was carried out by 1H NMR, 2D NMR, 13 C NMR, IR, UV-Vis and mass spectrometry. Notably, while these compounds have been well-documented for their antidiabetic activity, their presence in the A. heterophyllus species is novel, expanding our understanding. Furthermore, their well-established antidiabetic activity profiles highlight their essential role in the observed effects of the hot water extract for diabetes management, reinforcing its traditional remedy status.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of resveratrol and autologous chondrocytes in male rat knee joint cartilage repair. 白藜芦醇和自体软骨细胞在雄性大鼠膝关节软骨修复中的治疗潜力

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429111

Alireza Akhlagh, Aida Iraji, Seyyed Sajad Daneshi, Mehdi Kian, Akram Jamshidzadeh, Shahrokh Zare, Nader Tanideh, Maryam Naseh, Nadiar M Mussin, Madina A Kurmanalina, Amin Tamadon

{"title":"Therapeutic potential of resveratrol and autologous chondrocytes in male rat knee joint cartilage repair.","authors":"Alireza Akhlagh, Aida Iraji, Seyyed Sajad Daneshi, Mehdi Kian, Akram Jamshidzadeh, Shahrokh Zare, Nader Tanideh, Maryam Naseh, Nadiar M Mussin, Madina A Kurmanalina, Amin Tamadon","doi":"10.1080/14786419.2024.2429111","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429111","url":null,"abstract":"Osteochondral defects (OCDs) in synovial joints are caused by trauma or inflammatory joint diseases, with no definitive treatment available. This study examined the effects of resveratrol and chondrocyte injections in a rat model of OCD. Twenty-four male Sprague-Dawley rats were divided into four groups: a control group, a resveratrol-only group (10 mg/kg), a chondrocyte-only group (1 × 105 cells), and a combined treatment group that received both treatments. After two months, the rats were euthanized, and their knee joints were analysed histologically and immunohistochemically. The results showed that the combined resveratrol and chondrocyte treatment significantly reduced fibrous tissue, increased cartilage tissue volume, improved cellular distribution, and enhanced the regularity of the articular surface. Collagen types I and II and proteoglycan levels were also elevated. These findings suggest that the combination of resveratrol and chondrocytes has a synergistic effect, promoting effective OCD repair in this rat model, offering potential for future therapeutic approaches.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new tyrosine derivative isolated from an actinomycin D producing mangrove rhizosphere soil-derived Streptomyces parvulus A-30. 从产生放线菌素 D 的红树林根瘤土壤源链霉菌 A-30 中分离出一种新的酪氨酸衍生物。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429114

Jingjing Ye, Juren Cen, Jingwan Wu, Zhenchang Wen, Hongjun Chen, Jing Xu

{"title":"A new tyrosine derivative isolated from an actinomycin D producing mangrove rhizosphere soil-derived Streptomyces parvulus A-30.","authors":"Jingjing Ye, Juren Cen, Jingwan Wu, Zhenchang Wen, Hongjun Chen, Jing Xu","doi":"10.1080/14786419.2024.2429114","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429114","url":null,"abstract":"Chemical investigation of Streptomyces parvulus A-30, isolated from the mangrove plant Rhizophora apiculata rhizosphere soil resulted in the isolation of an optically new metabolite (R)-N-(5-amino-2-hydroxy-1-oxopentyl)-tyrosine (2), and seven known metabolites, including actinomycin D (1), (S)-2-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (3), uracil (4), N-acetyltyramine (5), bis (2-ethylhexyl) phthalate (6), diorcinol (7), and 4-hydroxyphenethyl alcohol (8). Amongst, actinomycin D (1) was found to be a major component (1 g, 5.13%) and compound 3 was isolated as a natural product for the first time. Their structures were unambiguously elucidated on the basis of extensive spectroscopic data and comparison with the data of literature. All compounds isolated were subjected to immunosuppressive and cytotoxic activities evaluation. Compound 1 exhibited significant cytotoxicity against HepG-2 and Hela with IC50 values of 2.62 ± 0.22 and 0.37 ± 0.88 µM, respectively, indicating it is principally responsible for the significant total cytotoxic effect of S. parvulus A-30.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactivity, chemical profiling, and validation of Moringa oleifera cultivated in Suncheon (KR). 顺天（韩国）种植的辣木的生物活性、化学成分分析和验证。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2426778

Duc Dat Le, Mina Lee

引用次数: 0

Exploring hesperidin: an effective naturalphytomedicine for combating breast cancer. 探索橙皮甙：抗击乳腺癌的有效天然药物

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-18 DOI: 10.1080/14786419.2024.2429120

Chitra Shivalingam, Saheb Ali

引用次数: 0