Natural Product Research最新文献_第6页

Potential anti-gout properties and determined by UPLC-Q/TOF-MS of total saponins from Smilax nipponica Miq. 菝葜总皂苷的抗痛风活性及UPLC-Q/TOF-MS测定。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2565701

Chengjun Yuan, Heying Chen, Zhuobin Zhao, Zexi Wang, Lanlan Zhong, Yulan Xing, Chen Jin

引用次数: 0

Computational investigation of minor alkaloids of Mitragyna speciosa Korth leaves as natural opioid analgesics. 天然阿片类镇痛药密天麻叶中微量生物碱的计算研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2570504

Ihsanul Arief, Gagus Ketut Sunnardianto, Lala Adetia Marlina, Syahrul Khairi, Herlina Rasyid, Wahyu Dita Saputri

{"title":"Computational investigation of minor alkaloids of Mitragyna speciosa Korth leaves as natural opioid analgesics.","authors":"Ihsanul Arief, Gagus Ketut Sunnardianto, Lala Adetia Marlina, Syahrul Khairi, Herlina Rasyid, Wahyu Dita Saputri","doi":"10.1080/14786419.2025.2570504","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570504","url":null,"abstract":"Mitragynine is the most abundant compound in kratom (Mitragyna speciosa Korth). Furthermore, it is not explicitly mentioned which compound(s) essentially contribute to the opioid activity of this plant. In this work, we identify the compounds that are most responsible for the opioid activity. This study was completed with a comprehensive computational framework consisting of virtual screening, frontier molecular orbital profiling, prediction of ADMET properties, and validated using molecular dynamics simulations for 100 ns. The results showed that the most contributing compounds interacting with each opioid receptor are 9-methoxy-mitralactonine (δ-opioid receptor), isomitraphylline (ƙ-opioid receptor), and mitraphylline (μ-opioid receptor). The ADMET profile indicated that the three compounds were predicted to pass the Lipinski rule of five, having a good lead likeness and being relatively non-toxic. The molecular dynamics results exhibited stable complexes between the three receptors and each compound based on the profiles of RMSD and RMSF during the simulations.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new xanthone compounds from Aspergillus puniceus and their PTP1B inhibitory activities and cytotoxicities. 从曲霉中分离的两种新的山酮化合物及其对PTP1B的抑制活性和细胞毒性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2567642

Yi-Fan Bai, Ren-Qin Tang, Qian Mao, Yan Liu, Qiang-Su Qin, Jing-Tao Liu, Cheng-Xiong Liu, Nian-Yu Huang, Lei Wang

{"title":"Two new xanthone compounds from Aspergillus puniceus and their PTP1B inhibitory activities and cytotoxicities.","authors":"Yi-Fan Bai, Ren-Qin Tang, Qian Mao, Yan Liu, Qiang-Su Qin, Jing-Tao Liu, Cheng-Xiong Liu, Nian-Yu Huang, Lei Wang","doi":"10.1080/14786419.2025.2567642","DOIUrl":"https://doi.org/10.1080/14786419.2025.2567642","url":null,"abstract":"Two new xanthone compounds, austocystin S (1) and austocystin R (2), as well as three known xanthones (3-5), originated from endophytic Aspergillus puniceus strains isolated from Eupatorium chinense tissues. Structural elucidation of the compounds was achieved by employing spectroscopic methods such as NMR, MS, CD, and X-ray diffraction. Each of the five compounds exhibited inhibitory effects on Protein Tyrosine Phosphatase 1B (PTP1B). Both compound 1 (IC50 = 2.89 μM) and compound 2 (IC50 = 0.78 μM) displayed notable inhibition effects. The inhibitory profiles of compounds 2 and 3 varied among the nine tested tumour cell lines, though both showed preferential activity against MDA-MB-231 cells (1.45 μM and 1.28 μM IC50 values, respectively). Molecular docking studies were performed to assess the binding interactions of compounds 1 and 2 with PTP1B.The calculated results showed that both compounds 1 and 2 had strong binding affinity for PTP1B.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two new compounds with anticancer and antibacterial activities purified from Fusarium oxysporum LZC03. 从尖孢镰刀菌LZC03中分离纯化的两个具有抗癌和抗菌活性的新化合物。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2570891

Bing Liu, Lijing Zhang, Ruiyang Lu, Ting Zhu, Yuxin Wang, Xue Tian, Yuchen Liu, Ning Chen, Wenlan Li

{"title":"Two new compounds with anticancer and antibacterial activities purified from Fusarium oxysporum LZC03.","authors":"Bing Liu, Lijing Zhang, Ruiyang Lu, Ting Zhu, Yuxin Wang, Xue Tian, Yuchen Liu, Ning Chen, Wenlan Li","doi":"10.1080/14786419.2025.2570891","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570891","url":null,"abstract":"In the course of investigating endophytic fungi derived from medicinal plants, a fungal strain identified as Fusarium oxysporum (designated LZC03) was successfully isolated from Salvia plebeia R. Brown. Comprehensive chemical analysis of its fermentation metabolites, employing a series of chromatographic separation techniques, led to the isolation and structural characterisation of two previously undescribed compounds: (S)-(+)-methyl-5-(3,4-dihydroxybutyl) picolinate (1), (S)-(+)-butyl -5-(3,4-dihydroxybutyl) picolinate (2), and one known compound, (S)-(+)-methyl fusarinolate (3). Compounds 1 and 2 demonstrated moderate cytotoxic effects against the HCT-116 human colon cancer cell line, with IC50 values of 59.27 and 55.86 μg/mL, respectively. Compounds 1-3 exhibited differential inhibitory effects against Staphylococcus aureus (CMCC(B)26003), Bacillus subtilis (CMCC(B)63534), Escherichia coli (CMCC(B)44102), and Pseudomonas aeruginosa (CMCC(B)10104), and predominantly targeted Gram-positive strains. Moreover, compounds 1 and 2 exhibited significant antibacterial activity against S. aureus, with minimum inhibitory concentrations (MICs) lower than that of the reference drug, suggesting their potential as bifunctional bioactive agents.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotransformation of oleanonic acid by circinella muscae to produce novel 11,12-epoxy-13,28-lactonized derivatives and their anti-neuroinflammatory activity. 齐墩果酸经肌肉线虫生物转化生成新型11,12-环氧-13,28-内酯衍生物及其抗神经炎活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2570509

Wei Liu, Li Yang, Liu-Tong Guan, Jia-Hui Wang, Yao-Yu Liu, Yan Song, Jian-Lin Li, Wen-Li Wang, Bo-Yi Fan, Guang-Tong Chen

{"title":"Biotransformation of oleanonic acid by circinella muscae to produce novel 11,12-epoxy-13,28-lactonized derivatives and their anti-neuroinflammatory activity.","authors":"Wei Liu, Li Yang, Liu-Tong Guan, Jia-Hui Wang, Yao-Yu Liu, Yan Song, Jian-Lin Li, Wen-Li Wang, Bo-Yi Fan, Guang-Tong Chen","doi":"10.1080/14786419.2025.2570509","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570509","url":null,"abstract":"Biotransformation of oleanonic acid by Circinella muscae CGMCC 3.2695 yielded two novel 11, 12-epoxidized and 13, 28-lactonized metabolites (compounds 5 and 6) alongside four previously identified compounds. Structural elucidation was conducted through comprehensive spectroscopic analyses and single-crystal X-ray diffraction. The fungus C. muscae demonstrates catalytic capability in mediating the structural transformation of oleanonic acid, facilitating the generation of both 11α, 12α- and 11β, 12β-trimeric oxygen-containing cyclic structures, in addition to producing 13β, 28β-lactone derivatives. Furthermore, the potential anti-neuroinflammatory activity of metabolites was investigated by assessing their ability to inhibit nitric oxide (NO) production in BV-2 microglial cells stimulated by lipopolysaccharide (LPS). Compounds 1, 2, and 6 exhibited significant inhibitory effects, with IC50 values of 25.70, 34.64, and 5.25, respectively. These results suggested that biotransformation derivatives of oleanonic acid might be served as potential neuroinflammatory inhibitors.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aralianudasides C-E: three undescribed triterpenoid saponins from the buds of Aralia elata and its airway inflammation inhibitory activity. 楤木皂苷C-E：从楤木芽中提取的三种未描述的三萜皂苷及其气道炎症抑制活性。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2568207

Juan Wang, Zhixiao Yang, Shuangya Xu, Yuhuai Long, Yuan Yuan, Yufan Chen, Die Zhang, Bang Chen, Hongping He, Baojing Li

引用次数: 0

Metabolic profiling for analysing chemotype variation in vegetative parts of Valeriana jatamansi Jones using NMR, GC-MS and UPLC/ESI-MS/MS. 利用核磁共振、气相色谱-质谱和UPLC/ESI-MS/MS分析白菖豆营养部分化学型变异的代谢谱分析

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2568208

Antim K Maurya, Priya, Vijai K Agnihotri

{"title":"Metabolic profiling for analysing chemotype variation in vegetative parts of Valeriana jatamansi Jones using NMR, GC-MS and UPLC/ESI-MS/MS.","authors":"Antim K Maurya, Priya, Vijai K Agnihotri","doi":"10.1080/14786419.2025.2568208","DOIUrl":"https://doi.org/10.1080/14786419.2025.2568208","url":null,"abstract":"Valeriana jatamansi Jones, a well-documented Ayurvedic herb, was studied to compare metabolite diversity across its vegetative (rhizomes, leaves, flowers, and seeds) parts using GC-MS, UPLC and NMR. Notably, this study represents the first comprehensive metabolomics analysis of this herb exploring all vegetative parts, including the previously overlooked flowers and seeds utilising modern analytical techniques. A comprehensive metabolic analysis resulted in a total of 103 metabolites, with 28, 50 and 25 metabolites identified using GC-MS, UPLC and NMR techniques, respectively. Key nutraceutical, cosmeceutical, herbal, and pharmaceutically active compounds, such as caproic acid, isovaleric acid, linoleic acid, lauric acid, oleic acid, myristic acid, palmitic acid, γ-tocopherol, phytol and patchouli alcohol, were identified in n-hexane extracts, while health-promoting metabolites like trehalose (1.04-7.06 mg/g), choline (1.80-15.33 mg/g), chlorogenic acid (2.04 mg/g) and sucrose (17.80-36.88 mg/g) were found in aqueous fractions. The employed analytical techniques successfully discriminated metabolites composition among the samples.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary study on metabolite profiling and antioxidant activity of Syzygium vrieseanum (Miq.) Amshoff, a critically endangered species from Indonesia. 水杨酸（Syzygium vrieseanum）代谢谱及抗氧化活性的初步研究一种来自印度尼西亚的极度濒危物种。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2565817

Jeprianto Manurung, Inggit Puji Astuti, Lily Ismaini, Intani Quarta Lailaty, Endah Dwi Hartuti, Lira Windriawati Listriyani, Ari Satia Nugraha, Muhammad Imam Surya

{"title":"Preliminary study on metabolite profiling and antioxidant activity of Syzygium vrieseanum (Miq.) Amshoff, a critically endangered species from Indonesia.","authors":"Jeprianto Manurung, Inggit Puji Astuti, Lily Ismaini, Intani Quarta Lailaty, Endah Dwi Hartuti, Lira Windriawati Listriyani, Ari Satia Nugraha, Muhammad Imam Surya","doi":"10.1080/14786419.2025.2565817","DOIUrl":"https://doi.org/10.1080/14786419.2025.2565817","url":null,"abstract":"This study investigates the chemical composition and medicinal potential of Syzygium vrieseanum (Miq.) Amshoff, a critically endangered species native to Indonesia. Compounds from methanol, ethanol, chloroform, and toluene extracts of leaves and twigs were identified using untargeted Gas Chromatography-Mass Spectrometry (GC-MS). The most abundant compound classes included Alkanes, Carboxylic acids, Ketones, Lactones, Amines, Fatty acids, Terpenes, Aldehydes, and Benzene derivatives. Methanol extracts showed the highest flavonoid and phenol concentrations in leaves (169.80 mg/L and 366.40 mg GAE/g extract, respectively) and twigs (26.60 mg/L and 159.10 mg GAE/g extract, respectively). Antioxidant activity via the DPPH assay showed methanolic and ethanolic leaf extracts as most potent, with IC50 values of 0.138 ± 0.003 and 0.158 ± 0.011 mg/ml, followed by twigs (0.221 ± 0.013 and 0.348 ± 0.025 mg/ml). The results highlight solvent selection for optimising bioactive compound extraction and S. vrieseanum's pharmaceutical potential, offering a biochemical framework for future conservation efforts.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of flavonoid glucosides from Ardisia and Damnacanthus spp. using UPLC-DAD-QToF/mS. UPLC-DAD-QToF/mS分析紫荆属和丹参属黄酮类苷。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-06 DOI: 10.1080/14786419.2025.2570893

Gelila Asamenew, Heon-Woong Kim, Soo Mug Cho, Jung Bong Kim, Stefan Kehraus, Max Crüsemann, Gabriele M König

{"title":"Analysis of flavonoid glucosides from Ardisia and Damnacanthus spp. using UPLC-DAD-QToF/mS.","authors":"Gelila Asamenew, Heon-Woong Kim, Soo Mug Cho, Jung Bong Kim, Stefan Kehraus, Max Crüsemann, Gabriele M König","doi":"10.1080/14786419.2025.2570893","DOIUrl":"https://doi.org/10.1080/14786419.2025.2570893","url":null,"abstract":"In order to investigate the compositional characteristics of leaves and fruits from Ardisia crenata, source of the potent Gq inhibitor FR900359, as well as leaves of other related Ardisia and rarely investigated Damnacanthus species, we report the structural identification and quantification of flavonoid glycosides from these plants. Seven different samples, including leaves of three Ardisia species (A. crenata, A. japonica and A. pusilla), leaves of two Damnacathus species (D. major and D. indicus), and two fruits of Ardisia crenata (red and white), were investigated. A total of forty-six flavonoid glycosides were identified and their quantitative results based on the internal standard, 2,4,5-trimethoxycinnamic acid, are reported for the first time. Also, among these samples, the leaves of the red fruit Ardisia crenata showed the highest content of 20 types of flavonoids including kaempferol 3-O-glucoside (astragalin), at 503.8 ± 11.9 mg/100 g.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acid profile and biological activity of supercritical fluid extract of Rosa canina L. seeds. 玫瑰种子超临界流体提取物的脂肪酸谱及生物活性研究。

IF 1.6 3区化学

Natural Product Research Pub Date : 2025-10-04 DOI: 10.1080/14786419.2025.2568203

A Ibba, A Rosa, A Fais, B Era, S Porcedda, A Piras

引用次数: 0