Natural Product Research最新文献_第5页

Natural benzofuran derivatives as promising scaffold for alleviating Alzheimer symptoms: acetylcholinesterase inhibition, structure activity relationship and in silico studies. 天然苯并呋喃衍生物作为缓解阿尔茨海默病症状的前景广阔的支架：乙酰胆碱酯酶抑制作用、结构活性关系和硅学研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-21 DOI: 10.1080/14786419.2024.2431998

Ahmed A M A Selim, Marwa A Ibrahim

{"title":"Natural benzofuran derivatives as promising scaffold for alleviating Alzheimer symptoms: acetylcholinesterase inhibition, structure activity relationship and in silico studies.","authors":"Ahmed A M A Selim, Marwa A Ibrahim","doi":"10.1080/14786419.2024.2431998","DOIUrl":"https://doi.org/10.1080/14786419.2024.2431998","url":null,"abstract":"Three isolated natural benzofuran compounds 1a-c and four semi-synthesized benzofuran derivatives 2a,b and 3a,b were evaluated for their in vitro acetylcholinesterase inhibition assay. Most of the tested compounds showed moderate activity with IC50 ranged from 102.4 ± 5.72 µM to 565.75 ± 4.17 µM, the most potent compound was kellin 1a with IC50 102.4 ± 5.72 µM. The kellin derivatives 1a, 2a and 3a bearing additional methoxyl group showed more inhibition activity than its analogues of visnagin derivatives 1b,c, 2b and 3b. The in silico investigation on the seven benzofuran derivatives matched our in vitro acetylcholinesterase results and explains the similarity in structures between the benzofuran compounds and donepezil drug. khellin had the best pharmacophore features among the studied compounds, the best fit score 1.862 and best dock score -9.135. In addition, our in silico study showed clearly that compounds carrying additional hydrophobic group had more potent activity through matched more ligand features.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypericum brasiliense: assessment of the antioxidant potential in UVA-induced in vitro phototoxicity. 巴西金丝桃：评估在 UVA 诱导的体外光毒性中的抗氧化潜力。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-21 DOI: 10.1080/14786419.2024.2427808

Raquel Anacleto Dos Anjos, Juliana Teixeira Araújo Gonçalves da Silva, Bruno Mançano Class, Lucas Oliveira da Silva, Lavinia Ferreira Leal, Sarah Bitler Delatorre Rosa, Francisco Paiva Machado, Hildegardo Seibert França, Andréa Monte Alto Costa, Leandro Machado Rocha, Gleyce Moreno Barbosa

{"title":"Hypericum brasiliense: assessment of the antioxidant potential in UVA-induced in vitro phototoxicity.","authors":"Raquel Anacleto Dos Anjos, Juliana Teixeira Araújo Gonçalves da Silva, Bruno Mançano Class, Lucas Oliveira da Silva, Lavinia Ferreira Leal, Sarah Bitler Delatorre Rosa, Francisco Paiva Machado, Hildegardo Seibert França, Andréa Monte Alto Costa, Leandro Machado Rocha, Gleyce Moreno Barbosa","doi":"10.1080/14786419.2024.2427808","DOIUrl":"https://doi.org/10.1080/14786419.2024.2427808","url":null,"abstract":"Photoaging induced by ultraviolet A (UVA) radiation is mainly caused by the reactive oxygen species (ROS) increase, which trigger undesirable changes in the skin, such as inflammatory reactions, wrinkles, hyperpigmentation, and loss of elasticity. In this context, plant ingredients have been highlighted in recent decades due to their antioxidant mechanisms. This study investigated the potential of Hypericum brasiliense ethanolic extract against UVA-induced damage in 3T3 fibroblasts. Cells exposed to a single UVA dose (4 J/cm2, 30 min) were treated with different extract concentrations. The results showed that H. brasiliense extract has antioxidant potential, mitigating UVA-induced stress by reducing ROS and lipid peroxidation. Furthermore, the extract stimulated fibroblast proliferation, suggesting its potential to restore cell viability after radiation-induced damage. The search for replacing synthetic actives with natural ones reinforces the importance of these findings on the antioxidant and regenerative properties of H. brasiliense extract, making it a promising anti-aging ingredient or a sunscreen adjuvant.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibiting hydrolytic enzyme activity and slowing carbohydrate digestion using lotus seed epicarp phenolic extracts. 利用莲子表皮酚类提取物抑制水解酶活性并减缓碳水化合物的消化。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-21 DOI: 10.1080/14786419.2024.2426066

Congcong Wang, Rui Chen, Lingxiao Gong, Hong Xu, Jie Liu, Huijuan Zhang

{"title":"Inhibiting hydrolytic enzyme activity and slowing carbohydrate digestion using lotus seed epicarp phenolic extracts.","authors":"Congcong Wang, Rui Chen, Lingxiao Gong, Hong Xu, Jie Liu, Huijuan Zhang","doi":"10.1080/14786419.2024.2426066","DOIUrl":"https://doi.org/10.1080/14786419.2024.2426066","url":null,"abstract":"This study investigated the hypoglycaemic activity of lotus seed epicarp phenolic extract (LSEPE) by inhibiting starch hydrolytic enzyme activity and slowing down carbohydrate digestion. Total phenolic and flavonoid contents in LSEPE were 620.37 ± 10.45 mg GAE/g DW and 422.69 ± 23.57 mg RE/g DW, respectively. A total of 57 phenolic compounds were first identified in LSEPE. The IC50 of LSEPE for inhibiting α-amylase and α-glucosidase were 124.44 ± 2.89 μg/mL and 0.99 ± 0.02 μg/mL, approximately 3.28 to 1.61 times that of acarbose. LSEPE acted as a mixed-type inhibitor of α-amylase and an anti-competitive-type inhibitor of α-glucosidase. UV spectroscopy, fluorescence quenching, and CD analysis showed that LSEPE could change the enzymes' microenvironment and hydrophobicity. Moreover, LSEPE slowed the starch hydrolysis rate in vitro and increased the proportions of slowly digestible starch (SDS) and resistant starch (RS) by 60.51% and 19.98%. Therefore, the lotus seed epicarppolyphenols could be the potential natural ingredients for developing anti-hyperglycemic functional foods.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of phytochemical content, antioxidant, and anti-inflammatory properties of Merremia hirta Merr. mature plant and microgreen. Merremia hirta Merr.成熟植株和小绿叶植物化学成分含量、抗氧化和抗炎特性的比较研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-21 DOI: 10.1080/14786419.2024.2425795

Dian Kurniati, Rahma Naifa Septiany, Elazmanawati Lembong, Indira Lanti Kayaputri, Gemilang Lara Utama

{"title":"Comparative study of phytochemical content, antioxidant, and anti-inflammatory properties of Merremia hirta Merr. mature plant and microgreen.","authors":"Dian Kurniati, Rahma Naifa Septiany, Elazmanawati Lembong, Indira Lanti Kayaputri, Gemilang Lara Utama","doi":"10.1080/14786419.2024.2425795","DOIUrl":"https://doi.org/10.1080/14786419.2024.2425795","url":null,"abstract":"Merremia hirta Merr. is a plant belonging to the Convolvulaceae family, commonly used as a vegetable in Southeast Asia. The plant harbours diverse bioactive constituents, including polyphenols and flavonoids. Microgreens have gained popularity as a cultivation trend. They are referred to as superfoods due to their high bioactive content, which is estimated to be up to 10 times greater than mature plants. M. hirta Merr. microgreen and mature plant were investigated to determine their total phenol content using the Folin Ciocalteu method, total flavonoid content using AlCl3, antioxidant activity using 2,2-diphenyl-1- picrylhydrazyl and ferric reducing antioxidant power, and anti-inflammatory activity by protein denaturation inhibition in vitro. Microgreen demonstrated greater total phenolic content, directly associated with its high antioxidant activity compared to mature plants. However, the mature stage of M. hirta Merr. remains superior in terms of overall flavonoid content and anti-inflammatory activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoquinoline alkaloids with bioactive constituents from the roots and rhizomes of Hylomecon japonica. 从 Hylomecon japonica 的根和根茎中提取的具有生物活性成分的异喹啉生物碱。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-20 DOI: 10.1080/14786419.2024.2429122

Zhen Cao, Shang-Jun Zhu, Zhao-Wei Xue, Lu-Ye Yao, Xin-Xin Zhang, Zeng-Jun Guo

{"title":"Isoquinoline alkaloids with bioactive constituents from the roots and rhizomes of Hylomecon japonica.","authors":"Zhen Cao, Shang-Jun Zhu, Zhao-Wei Xue, Lu-Ye Yao, Xin-Xin Zhang, Zeng-Jun Guo","doi":"10.1080/14786419.2024.2429122","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429122","url":null,"abstract":"Isoquinoline alkaloids are important effective chemical components separated from the Hylomecon japonica, which were mostly reported as planar structures. By using chiral HPLC, we have concluded that some natural isoquinoline alkaloids exist as enantiomeric mixtures, providing a novel direction for future research on isoquinoline alkaloids. Finally, three pairs of enantiomeric isoquinoline alkaloids (1-3, including five undescribed compounds-1a/1b, 3a/3b and 2b), together with another eight known isoquinoline alkaloids (4-9) were isolated from the roots and rhizomes of Hylomecon japonica. Their structures were elucidated by NMR, HRESIMS, UV, IR, and their absolute configurations were further defined by quantum chemical calculations of ECD spectra. The cytotoxic activities of these isolated compounds in MCF-7 cells were evaluated by MTT methods. Among them, the alkaloids 1a, 1b, 2b, 3b and other known alkaloids 5a and 5b had good inhibitory effects on MCF-7 cells of breast cancer in vitro, with an IC50 lower than 20 μM.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended-spectrum β - lactamase inhibitory potential of Dichrocephala integrifolia: an in vitro and computational studies. Dichrocephala integrifolia 的广谱 β - 内酰胺酶抑制潜力：体外和计算研究。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-20 DOI: 10.1080/14786419.2024.2429529

Anupama Moirangthem, Taranga Jyoti Baruah, Mridusmita Paul, Birson Ingti, Amitabha Bhattacharjee, Anand Prakash Maurya, Susmita Paul, Bhaskar Jyoti Das

{"title":"Extended-spectrum β - lactamase inhibitory potential of Dichrocephala integrifolia: an in vitro and computational studies.","authors":"Anupama Moirangthem, Taranga Jyoti Baruah, Mridusmita Paul, Birson Ingti, Amitabha Bhattacharjee, Anand Prakash Maurya, Susmita Paul, Bhaskar Jyoti Das","doi":"10.1080/14786419.2024.2429529","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429529","url":null,"abstract":"Extended-spectrum β-lactamases (ESBL) producing enterobacteriales are a major global health concern since they often result in the ineffectiveness of empirical antibiotic therapy with β-lactams. This study aims to identify potential medicinal plants that can inhibit β-lactamase and subsequently enhance the activity of the β-lactams against resistant bacterial strains. A synergistic study of Dichrocephala integrifolia extract exhibited good synergistic activity against a CTX-M-producing organism, which was confirmed using an agar-based diffusion bioassay method. Further validation was done by Molecular docking in which, the phytocompound Propanamide, N-[4-(4-chlorophenyl)-2-thiazolyl]-3-(1-pyrrolidinyl)-/NSC339591, obtained from the GC-MS study showed a good binding affinity with favourable hydrogen bond interactions with the active sites of CTX-M-14. This phytocompound was further selected for a Molecular Dynamic Simulation (MD) study with CTX-M-14, where the complex exhibited good stability and maintained a consistent conformation throughout the simulation. NSC339591 cleared the drug-likeness filters.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portraying phytochemical and genetic components of elite cultivated chilli (Capsicum annuum L.) genotypes. 描绘辣椒（Capsicum annuum L.）精英栽培基因型的植物化学成分和遗传成分。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-20 DOI: 10.1080/14786419.2024.2429129

Fauzia Anjum, Urvashi Bhardwaj, Sayeed A H Patel, Salesh Kumar Jindal, Ramandeep Kaur, Neena Chawla

{"title":"Portraying phytochemical and genetic components of elite cultivated chilli (Capsicum annuum L.) genotypes.","authors":"Fauzia Anjum, Urvashi Bhardwaj, Sayeed A H Patel, Salesh Kumar Jindal, Ramandeep Kaur, Neena Chawla","doi":"10.1080/14786419.2024.2429129","DOIUrl":"https://doi.org/10.1080/14786419.2024.2429129","url":null,"abstract":"Chilli has numerous bioactive components and served since ages in global cuisine and therapeutics. To meet demands of food and various industries, potential genotypes with finest bioactive components is needed. Hence, the objective was to unravel the natural phytochemical variation of 25 chilli genotypes available from the northwestern region of India. The genotypes PT (1.28%), PAU-114 (1.17%) and PL (1.16%) contain high capsaicin, while PL (8.9%), PS (8.2%) and HM-242 (7.8%) have high oleoresin content. PC-431, SB-493 and SM-481 were identified as promising genotypes exhibiting potential antioxidant properties. The correlation matrix depicted a significant association between traits that assist in breeding program. Oleoresin has a negative association with total phenolics. The genetic components revealed less influence of environmental factors and thus improvement through pure line selection method is possible. Phytochemically enriched genotypes can be utilised in diverse areas, viz. nutritional, food processing, therapeutics, cosmetics and in breeding programmes.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the neuroprotective effects of alkaloids from Galanthus woronowii as a potential treatment for Alzheimer's disease. 研究从 Galanthus woronowii 中提取的生物碱对神经的保护作用，作为阿尔茨海默氏症的一种潜在治疗方法。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-20 DOI: 10.1080/14786419.2024.2431124

Priyadharsan Arumugam

引用次数: 0

Antitumoral effect thought ROS production of the sesquiterpene lactone centratherin isolated from Eremanthus crotonoides, an endemic plant from Brazil. 从巴西特有植物 Eremanthus crotonoides 中分离出的倍半萜内酯 centratherin 的抗肿瘤作用认为会产生 ROS。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-20 DOI: 10.1080/14786419.2024.2427812

Francisco Paiva Machado, Guilherme Freimann Wermelinger, Alex de Souza Cruz Lopes Canuto, Anna Carolina Carvalho da Fonseca, Diogo Folly, Afonso Thales Sousa Arruda, Leandro Rocha, Bruno Kaufmann Robbs

{"title":"Antitumoral effect thought ROS production of the sesquiterpene lactone centratherin isolated from Eremanthus crotonoides, an endemic plant from Brazil.","authors":"Francisco Paiva Machado, Guilherme Freimann Wermelinger, Alex de Souza Cruz Lopes Canuto, Anna Carolina Carvalho da Fonseca, Diogo Folly, Afonso Thales Sousa Arruda, Leandro Rocha, Bruno Kaufmann Robbs","doi":"10.1080/14786419.2024.2427812","DOIUrl":"https://doi.org/10.1080/14786419.2024.2427812","url":null,"abstract":"Cancer is a global public health problem, requiring the development of new and more effective drugs for treatment. Eremanthus crotonoides, is a common plant found in the Brazilian Cerrado and Atlantic Forest and is used as a traditional medicinal plant in some regions. This study evaluated the potential antitumor effect of centratherin, a compound isolated from E. crotonoides leaves, against cancer cells. In colorectal cancer cells, centratherin showed greater toxicity than carboplatin while maintaining comparable selectivity to the control. Although centratherin did not induce classical apoptotic phenotypes and was not inhibited by Zvad, it did induce elevated levels of reactive oxygen species (ROS) that was responsible for cell death explaining its toxicity. in silico analysis, showed that this substance has high oral bioavailability and intestinal absorption. Centratherin was found to be selective against colon cancer cells and, therefore may be considered for future studies on colorectal cancer (CRC) studies.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial polyketides from an endophytic fungus Arcopilus aureus HJ-7 from Ardisia mamillata Hance. 来自 Ardisia mamillata Hance 的内生真菌 Arcopilus aureus HJ-7 的抗菌多酮。

IF 1.9 3区化学

Natural Product Research Pub Date : 2024-11-19 DOI: 10.1080/14786419.2024.2429119

Li-Qi Liang, Xian-Hua He, Chun-Yan Wei, Jing-Xian Zhao, Qian Wu, Min Liang, Jun Li, Yan Luo, Wei-Feng Xu, Rui-Yun Yang

引用次数: 0